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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LOXHD1
Full Name:
Lipoxygenase homology domain-containing protein 1
Alias:
LOXH1
Type:
Uncharacterized protein
Mass (Da):
221869
Number AA:
1947
UniProt ID:
Q8IVV2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y39
A
G
T
K
S
K
I
Y
L
V
M
Y
G
A
R
Site 2
Y43
S
K
I
Y
L
V
M
Y
G
A
R
G
N
K
N
Site 3
S51
G
A
R
G
N
K
N
S
G
K
I
F
L
E
G
Site 4
T66
G
V
F
D
R
G
R
T
D
I
F
H
I
E
L
Site 5
Y134
G
L
I
E
R
Q
L
Y
E
M
V
S
L
R
K
Site 6
S138
R
Q
L
Y
E
M
V
S
L
R
K
K
R
L
K
Site 7
Y172
S
P
I
F
I
Q
I
Y
G
Q
K
G
R
T
D
Site 8
Y209
L
P
D
L
G
R
F
Y
K
I
R
V
W
H
D
Site 9
S219
R
V
W
H
D
K
R
S
S
G
S
G
W
H
L
Site 10
S220
V
W
H
D
K
R
S
S
G
S
G
W
H
L
E
Site 11
T230
G
W
H
L
E
R
M
T
L
M
N
T
L
N
K
Site 12
T234
E
R
M
T
L
M
N
T
L
N
K
D
K
Y
N
Site 13
T262
N
E
I
V
R
E
M
T
A
E
G
P
T
V
R
Site 14
T267
E
M
T
A
E
G
P
T
V
R
R
I
M
G
M
Site 15
T280
G
M
A
R
Y
H
V
T
V
C
T
G
E
L
E
Site 16
T306
L
F
G
D
V
G
D
T
G
E
R
L
L
Y
N
Site 17
Y312
D
T
G
E
R
L
L
Y
N
C
R
N
N
T
D
Site 18
T318
L
Y
N
C
R
N
N
T
D
L
F
E
K
G
N
Site 19
T330
K
G
N
A
D
E
F
T
I
E
S
V
T
M
R
Site 20
S333
A
D
E
F
T
I
E
S
V
T
M
R
N
V
R
Site 21
S351
I
R
H
D
G
K
D
S
G
S
G
W
Y
L
D
Site 22
S353
H
D
G
K
D
S
G
S
G
W
Y
L
D
R
V
Site 23
Y356
K
D
S
G
S
G
W
Y
L
D
R
V
L
V
R
Site 24
S370
R
E
E
G
Q
P
E
S
D
N
V
E
F
P
C
Site 25
S397
L
V
R
E
L
L
P
S
D
S
S
A
T
L
K
Site 26
S399
R
E
L
L
P
S
D
S
S
A
T
L
K
N
F
Site 27
S400
E
L
L
P
S
D
S
S
A
T
L
K
N
F
R
Site 28
Y408
A
T
L
K
N
F
R
Y
H
I
S
L
K
T
G
Site 29
S411
K
N
F
R
Y
H
I
S
L
K
T
G
D
V
S
Site 30
T414
R
Y
H
I
S
L
K
T
G
D
V
S
G
A
S
Site 31
S418
S
L
K
T
G
D
V
S
G
A
S
T
D
S
R
Site 32
T422
G
D
V
S
G
A
S
T
D
S
R
V
Y
I
K
Site 33
S424
V
S
G
A
S
T
D
S
R
V
Y
I
K
L
Y
Site 34
Y427
A
S
T
D
S
R
V
Y
I
K
L
Y
G
D
K
Site 35
Y431
S
R
V
Y
I
K
L
Y
G
D
K
S
D
T
I
Site 36
S435
I
K
L
Y
G
D
K
S
D
T
I
K
Q
V
L
Site 37
S445
I
K
Q
V
L
L
V
S
D
N
N
L
K
D
Y
Site 38
Y452
S
D
N
N
L
K
D
Y
F
E
R
G
R
V
D
Site 39
T462
R
G
R
V
D
E
F
T
L
E
T
L
N
I
G
Site 40
S486
D
S
T
G
M
H
V
S
W
F
L
G
S
V
Q
Site 41
Y503
V
P
R
Q
G
K
Q
Y
T
F
P
A
N
R
W
Site 42
T504
P
R
Q
G
K
Q
Y
T
F
P
A
N
R
W
L
Site 43
S527
L
E
V
E
L
Y
P
S
E
V
V
E
I
Q
K
Site 44
Y538
E
I
Q
K
L
V
H
Y
E
V
E
I
W
T
G
Site 45
Y557
A
G
T
S
A
R
V
Y
M
Q
I
Y
G
E
K
Site 46
Y561
A
R
V
Y
M
Q
I
Y
G
E
K
G
K
T
E
Site 47
T567
I
Y
G
E
K
G
K
T
E
V
L
F
L
S
S
Site 48
S573
K
T
E
V
L
F
L
S
S
R
S
K
V
F
E
Site 49
S574
T
E
V
L
F
L
S
S
R
S
K
V
F
E
R
Site 50
S583
S
K
V
F
E
R
A
S
K
D
T
F
Q
L
E
Site 51
T586
F
E
R
A
S
K
D
T
F
Q
L
E
A
A
D
Site 52
Y598
A
A
D
V
G
E
V
Y
K
L
R
L
G
H
T
Site 53
T605
Y
K
L
R
L
G
H
T
G
E
G
F
G
P
S
Site 54
T631
V
V
R
E
V
D
L
T
P
E
E
E
A
R
K
Site 55
S668
K
K
K
K
R
K
G
S
D
E
E
D
E
G
E
Site 56
S679
D
E
G
E
E
E
E
S
S
S
S
E
E
S
S
Site 57
S680
E
G
E
E
E
E
S
S
S
S
E
E
S
S
T
Site 58
S681
G
E
E
E
E
S
S
S
S
E
E
S
S
T
E
Site 59
S682
E
E
E
E
S
S
S
S
E
E
S
S
T
E
E
Site 60
S685
E
S
S
S
S
E
E
S
S
T
E
E
E
E
M
Site 61
S686
S
S
S
S
E
E
S
S
T
E
E
E
E
M
E
Site 62
T687
S
S
S
E
E
S
S
T
E
E
E
E
M
E
E
Site 63
T745
K
P
G
P
E
R
N
T
Y
E
V
Q
V
V
T
Site 64
Y746
P
G
P
E
R
N
T
Y
E
V
Q
V
V
T
G
Site 65
Y765
A
G
T
D
A
N
G
Y
L
T
I
Y
G
E
E
Site 66
Y769
A
N
G
Y
L
T
I
Y
G
E
E
Y
G
D
T
Site 67
Y773
L
T
I
Y
G
E
E
Y
G
D
T
G
E
R
P
Site 68
T776
Y
G
E
E
Y
G
D
T
G
E
R
P
L
K
K
Site 69
S784
G
E
R
P
L
K
K
S
D
K
S
N
K
F
E
Site 70
S787
P
L
K
K
S
D
K
S
N
K
F
E
Q
G
Q
Site 71
T795
N
K
F
E
Q
G
Q
T
D
T
F
T
I
Y
A
Site 72
T797
F
E
Q
G
Q
T
D
T
F
T
I
Y
A
I
D
Site 73
T799
Q
G
Q
T
D
T
F
T
I
Y
A
I
D
L
G
Site 74
T809
A
I
D
L
G
A
L
T
K
I
R
I
R
H
D
Site 75
T818
I
R
I
R
H
D
N
T
G
N
R
A
G
W
F
Site 76
S867
E
L
L
P
V
D
E
S
Y
V
L
P
Q
S
E
Site 77
Y868
L
L
P
V
D
E
S
Y
V
L
P
Q
S
E
E
Site 78
S873
E
S
Y
V
L
P
Q
S
E
E
G
G
G
G
G
Site 79
S896
A
L
E
Q
K
D
K
S
T
T
F
S
V
T
I
Site 80
T898
E
Q
K
D
K
S
T
T
F
S
V
T
I
K
T
Site 81
S900
K
D
K
S
T
T
F
S
V
T
I
K
T
G
V
Site 82
T928
L
F
G
T
Q
D
D
T
G
M
T
L
L
K
S
Site 83
T931
T
Q
D
D
T
G
M
T
L
L
K
S
S
K
T
Site 84
S935
T
G
M
T
L
L
K
S
S
K
T
N
S
D
K
Site 85
S936
G
M
T
L
L
K
S
S
K
T
N
S
D
K
F
Site 86
T938
T
L
L
K
S
S
K
T
N
S
D
K
F
E
R
Site 87
S940
L
K
S
S
K
T
N
S
D
K
F
E
R
D
S
Site 88
S947
S
D
K
F
E
R
D
S
I
E
I
F
T
V
E
Site 89
T971
V
R
L
G
N
D
N
T
G
K
A
P
G
W
F
Site 90
S1009
A
K
N
E
D
D
G
S
I
I
R
D
L
F
H
Site 91
Y1024
A
E
L
Q
T
R
L
Y
T
P
F
V
P
Y
E
Site 92
T1025
E
L
Q
T
R
L
Y
T
P
F
V
P
Y
E
I
Site 93
Y1064
A
V
C
T
Q
Q
K
Y
L
C
T
N
K
R
E
Site 94
S1080
K
Q
F
F
E
R
K
S
A
S
R
F
I
V
E
Site 95
T1132
K
D
G
A
E
T
L
T
F
P
C
D
R
W
L
Site 96
S1142
C
D
R
W
L
A
T
S
E
D
D
K
K
T
V
Site 97
T1148
T
S
E
D
D
K
K
T
V
R
E
L
V
P
Y
Site 98
Y1155
T
V
R
E
L
V
P
Y
D
I
F
T
E
K
Y
Site 99
Y1162
Y
D
I
F
T
E
K
Y
M
K
D
G
S
L
R
Site 100
S1167
E
K
Y
M
K
D
G
S
L
R
Q
V
Y
K
E
Site 101
Y1172
D
G
S
L
R
Q
V
Y
K
E
V
E
E
P
L
Site 102
T1213
I
Y
G
D
L
G
D
T
G
E
R
Y
L
G
K
Site 103
Y1217
L
G
D
T
G
E
R
Y
L
G
K
S
E
N
R
Site 104
S1221
G
E
R
Y
L
G
K
S
E
N
R
T
N
K
F
Site 105
T1225
L
G
K
S
E
N
R
T
N
K
F
E
R
G
T
Site 106
T1232
T
N
K
F
E
R
G
T
A
D
T
F
I
I
E
Site 107
T1235
F
E
R
G
T
A
D
T
F
I
I
E
A
A
D
Site 108
Y1247
A
A
D
L
G
V
I
Y
K
I
K
L
R
H
D
Site 109
T1273
K
V
E
I
W
N
D
T
N
E
D
E
F
L
F
Site 110
S1287
F
L
C
G
R
W
L
S
L
K
K
E
D
G
R
Site 111
Y1300
G
R
L
E
R
L
F
Y
E
K
E
Y
T
G
D
Site 112
Y1304
R
L
F
Y
E
K
E
Y
T
G
D
R
S
S
N
Site 113
T1305
L
F
Y
E
K
E
Y
T
G
D
R
S
S
N
C
Site 114
S1309
K
E
Y
T
G
D
R
S
S
N
C
S
S
P
A
Site 115
S1310
E
Y
T
G
D
R
S
S
N
C
S
S
P
A
D
Site 116
S1313
G
D
R
S
S
N
C
S
S
P
A
D
F
W
E
Site 117
S1314
D
R
S
S
N
C
S
S
P
A
D
F
W
E
I
Site 118
S1324
D
F
W
E
I
A
L
S
S
K
M
A
D
V
D
Site 119
Y1352
E
G
P
I
I
P
Y
Y
V
S
V
T
T
G
K
Site 120
S1354
P
I
I
P
Y
Y
V
S
V
T
T
G
K
H
K
Site 121
T1365
G
K
H
K
D
A
A
T
D
S
R
A
F
I
F
Site 122
Y1388
S
K
R
I
W
L
D
Y
P
R
G
K
R
G
F
Site 123
S1396
P
R
G
K
R
G
F
S
R
G
S
V
E
E
F
Site 124
S1399
K
R
G
F
S
R
G
S
V
E
E
F
Y
V
A
Site 125
S1424
E
L
G
H
D
G
A
S
P
E
S
C
W
L
V
Site 126
S1427
H
D
G
A
S
P
E
S
C
W
L
V
E
E
L
Site 127
T1462
K
D
R
G
D
G
I
T
S
R
V
F
D
L
L
Site 128
T1503
T
D
S
N
I
F
M
T
L
Y
G
I
N
G
S
Site 129
Y1505
S
N
I
F
M
T
L
Y
G
I
N
G
S
T
E
Site 130
T1530
F
E
R
E
Q
N
D
T
F
I
M
E
I
L
D
Site 131
Y1576
T
G
D
L
T
M
F
Y
Y
G
D
W
L
S
Q
Site 132
Y1577
G
D
L
T
M
F
Y
Y
G
D
W
L
S
Q
R
Site 133
T1589
S
Q
R
K
G
K
K
T
L
V
C
E
M
C
A
Site 134
Y1609
E
M
M
E
W
T
S
Y
T
V
A
V
K
T
S
Site 135
T1610
M
M
E
W
T
S
Y
T
V
A
V
K
T
S
D
Site 136
S1638
I
F
G
E
N
G
D
S
G
T
L
A
L
K
Q
Site 137
T1640
G
E
N
G
D
S
G
T
L
A
L
K
Q
S
A
Site 138
T1657
N
K
F
E
R
N
N
T
D
T
F
N
F
P
D
Site 139
T1659
F
E
R
N
N
T
D
T
F
N
F
P
D
M
L
Site 140
Y1691
F
P
G
W
H
L
S
Y
V
D
V
K
D
N
S
Site 141
S1698
Y
V
D
V
K
D
N
S
R
D
E
T
F
H
F
Site 142
T1720
K
S
E
G
D
G
Q
T
V
R
D
F
A
C
A
Site 143
T1738
I
C
D
E
L
E
E
T
T
Y
E
I
V
I
E
Site 144
Y1740
D
E
L
E
E
T
T
Y
E
I
V
I
E
T
G
Site 145
S1767
L
E
G
R
K
N
R
S
K
E
F
L
M
E
N
Site 146
S1775
K
E
F
L
M
E
N
S
S
R
Q
R
A
F
R
Site 147
S1776
E
F
L
M
E
N
S
S
R
Q
R
A
F
R
K
Site 148
T1785
Q
R
A
F
R
K
G
T
T
D
T
F
E
F
D
Site 149
T1788
F
R
K
G
T
T
D
T
F
E
F
D
S
I
Y
Site 150
Y1853
P
L
K
R
K
R
K
Y
F
K
V
F
E
V
T
Site 151
T1862
K
V
F
E
V
T
K
T
T
E
S
F
A
S
K
Site 152
S1865
E
V
T
K
T
T
E
S
F
A
S
K
V
Q
S
Site 153
S1868
K
T
T
E
S
F
A
S
K
V
Q
S
L
V
P
Site 154
S1872
S
F
A
S
K
V
Q
S
L
V
P
V
K
Y
E
Site 155
Y1886
E
V
I
V
T
T
G
Y
E
P
G
A
G
T
D
Site 156
S1924
R
N
L
F
E
R
G
S
T
D
R
F
F
L
E
Site 157
T1925
N
L
F
E
R
G
S
T
D
R
F
F
L
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation