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Updated November 2019
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Protein Info
Short Name:
SgK307
Full Name:
Testis-expressed protein 14
Alias:
Testis protein TEX14; testis-expressed protein 14; TEX14
Type:
Protein-serine kinase, Other group, NKF5 family
Mass (Da):
167901
Number AA:
957
UniProt ID:
Q8IWB6
International Prot ID:
IPI00217259
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
C
P
V
Q
L
G
T
L
R
N
D
S
L
E
Site 2
S22
L
G
T
L
R
N
D
S
L
E
A
Q
L
H
E
Site 3
Y30
L
E
A
Q
L
H
E
Y
V
K
Q
G
N
Y
V
Site 4
Y36
E
Y
V
K
Q
G
N
Y
V
K
V
K
K
I
L
Site 5
Y78
F
V
D
V
L
V
D
Y
G
S
D
P
N
H
R
Site 6
T91
H
R
C
F
D
G
S
T
P
V
H
A
A
A
F
Site 7
S106
S
G
N
Q
W
I
L
S
K
L
L
D
A
G
G
Site 8
T127
E
R
G
Q
N
P
K
T
W
A
L
T
A
G
K
Site 9
T138
T
A
G
K
E
R
S
T
Q
I
V
E
F
M
Q
Site 10
S168
D
L
L
K
K
I
D
S
P
Q
R
L
V
Y
S
Site 11
Y174
D
S
P
Q
R
L
V
Y
S
P
S
W
C
G
G
Site 12
S175
S
P
Q
R
L
V
Y
S
P
S
W
C
G
G
L
Site 13
S177
Q
R
L
V
Y
S
P
S
W
C
G
G
L
V
Q
Site 14
S190
V
Q
G
N
P
N
G
S
P
N
R
L
L
K
A
Site 15
T249
I
Q
A
D
D
E
P
T
F
S
F
F
S
G
P
Site 16
S251
A
D
D
E
P
T
F
S
F
F
S
G
P
Y
M
Site 17
T271
V
W
N
G
S
R
V
T
V
K
E
L
N
L
P
Site 18
S299
L
I
A
E
Q
E
H
S
S
K
L
R
H
P
Y
Site 19
S316
Q
L
M
A
V
C
L
S
Q
D
L
E
K
T
R
Site 20
Y326
L
E
K
T
R
L
V
Y
E
R
I
T
I
G
T
Site 21
S343
S
V
L
H
E
R
R
S
Q
F
P
V
L
H
M
Site 22
S376
F
Q
G
F
I
H
R
S
L
S
S
Y
A
V
H
Site 23
T393
S
P
G
E
A
R
L
T
N
L
E
Y
M
L
E
Site 24
Y397
A
R
L
T
N
L
E
Y
M
L
E
S
E
D
R
Site 25
T411
R
G
V
Q
R
D
L
T
R
V
P
L
P
T
Q
Site 26
S437
Q
K
A
A
T
V
K
S
D
I
Y
S
F
S
M
Site 27
S441
T
V
K
S
D
I
Y
S
F
S
M
I
M
Q
E
Site 28
Y484
D
V
R
L
P
K
P
Y
Y
D
I
V
K
S
G
Site 29
Y485
V
R
L
P
K
P
Y
Y
D
I
V
K
S
G
I
Site 30
T500
H
V
K
Q
K
D
R
T
M
N
L
Q
D
I
R
Site 31
Y508
M
N
L
Q
D
I
R
Y
I
L
K
N
D
L
K
Site 32
T518
K
N
D
L
K
D
F
T
G
A
Q
R
T
Q
P
Site 33
T526
G
A
Q
R
T
Q
P
T
E
S
P
R
V
Q
R
Site 34
S528
Q
R
T
Q
P
T
E
S
P
R
V
Q
R
Y
G
Site 35
Y543
L
H
P
D
V
N
V
Y
L
G
L
T
S
E
H
Site 36
T554
T
S
E
H
P
R
E
T
P
D
M
E
I
I
E
Site 37
S567
I
E
L
K
E
M
G
S
Q
P
H
S
P
R
V
Site 38
S571
E
M
G
S
Q
P
H
S
P
R
V
H
S
L
F
Site 39
S576
P
H
S
P
R
V
H
S
L
F
T
E
G
T
L
Site 40
T582
H
S
L
F
T
E
G
T
L
D
P
Q
A
P
D
Site 41
T597
P
C
L
M
A
R
E
T
Q
N
Q
D
A
P
C
Site 42
S614
P
F
M
A
E
E
A
S
S
P
S
T
G
Q
P
Site 43
S615
F
M
A
E
E
A
S
S
P
S
T
G
Q
P
S
Site 44
T618
E
E
A
S
S
P
S
T
G
Q
P
S
L
C
S
Site 45
S622
S
P
S
T
G
Q
P
S
L
C
S
F
E
I
N
Site 46
S625
T
G
Q
P
S
L
C
S
F
E
I
N
E
I
Y
Site 47
S651
E
P
P
G
A
A
S
S
L
E
A
D
G
P
N
Site 48
S665
N
Q
V
D
E
L
K
S
M
E
E
E
L
D
K
Site 49
S682
R
E
A
C
C
F
G
S
E
D
E
S
S
S
K
Site 50
S686
C
F
G
S
E
D
E
S
S
S
K
A
E
T
E
Site 51
S687
F
G
S
E
D
E
S
S
S
K
A
E
T
E
Y
Site 52
S688
G
S
E
D
E
S
S
S
K
A
E
T
E
Y
S
Site 53
T692
E
S
S
S
K
A
E
T
E
Y
S
F
D
D
W
Site 54
S705
D
W
D
W
Q
N
G
S
L
S
S
L
S
L
P
Site 55
S707
D
W
Q
N
G
S
L
S
S
L
S
L
P
E
S
Site 56
S708
W
Q
N
G
S
L
S
S
L
S
L
P
E
S
T
Site 57
S710
N
G
S
L
S
S
L
S
L
P
E
S
T
R
E
Site 58
S714
S
S
L
S
L
P
E
S
T
R
E
A
K
S
N
Site 59
T727
S
N
L
N
N
M
S
T
T
E
E
Y
L
I
S
Site 60
T728
N
L
N
N
M
S
T
T
E
E
Y
L
I
S
K
Site 61
S734
T
T
E
E
Y
L
I
S
K
C
V
L
D
L
K
Site 62
S776
K
E
Q
E
E
R
M
S
L
W
A
T
S
R
E
Site 63
T780
E
R
M
S
L
W
A
T
S
R
E
F
T
N
A
Site 64
T785
W
A
T
S
R
E
F
T
N
A
Y
K
L
P
L
Site 65
Y788
S
R
E
F
T
N
A
Y
K
L
P
L
A
V
G
Site 66
S809
I
P
P
V
L
Q
L
S
G
G
Q
K
P
D
T
Site 67
T816
S
G
G
Q
K
P
D
T
S
G
N
Y
P
T
L
Site 68
S817
G
G
Q
K
P
D
T
S
G
N
Y
P
T
L
P
Site 69
Y820
K
P
D
T
S
G
N
Y
P
T
L
P
R
F
P
Site 70
T822
D
T
S
G
N
Y
P
T
L
P
R
F
P
R
M
Site 71
T832
R
F
P
R
M
L
P
T
L
C
D
P
G
K
Q
Site 72
S854
C
T
Q
G
A
K
D
S
L
E
T
S
R
I
Q
Site 73
S858
A
K
D
S
L
E
T
S
R
I
Q
N
T
S
S
Site 74
S864
T
S
R
I
Q
N
T
S
S
Q
G
R
P
R
E
Site 75
S865
S
R
I
Q
N
T
S
S
Q
G
R
P
R
E
S
Site 76
S872
S
Q
G
R
P
R
E
S
T
A
Q
A
K
A
T
Site 77
T873
Q
G
R
P
R
E
S
T
A
Q
A
K
A
T
Q
Site 78
T879
S
T
A
Q
A
K
A
T
Q
F
N
S
A
L
F
Site 79
T887
Q
F
N
S
A
L
F
T
L
S
S
H
R
Q
G
Site 80
S889
N
S
A
L
F
T
L
S
S
H
R
Q
G
P
S
Site 81
S890
S
A
L
F
T
L
S
S
H
R
Q
G
P
S
A
Site 82
S896
S
S
H
R
Q
G
P
S
A
S
P
S
C
H
W
Site 83
S898
H
R
Q
G
P
S
A
S
P
S
C
H
W
D
S
Site 84
S900
Q
G
P
S
A
S
P
S
C
H
W
D
S
T
R
Site 85
S905
S
P
S
C
H
W
D
S
T
R
M
S
V
E
P
Site 86
S909
H
W
D
S
T
R
M
S
V
E
P
V
S
S
E
Site 87
S914
R
M
S
V
E
P
V
S
S
E
I
Y
N
A
E
Site 88
S915
M
S
V
E
P
V
S
S
E
I
Y
N
A
E
S
Site 89
Y918
E
P
V
S
S
E
I
Y
N
A
E
S
R
N
K
Site 90
T951
K
A
A
T
G
Q
L
T
V
P
P
W
H
P
Q
Site 91
S959
V
P
P
W
H
P
Q
S
S
L
T
L
E
S
E
Site 92
S960
P
P
W
H
P
Q
S
S
L
T
L
E
S
E
A
Site 93
T962
W
H
P
Q
S
S
L
T
L
E
S
E
A
E
N
Site 94
S981
L
L
Q
P
P
I
R
S
P
E
N
T
D
W
Q
Site 95
T985
P
I
R
S
P
E
N
T
D
W
Q
R
V
I
E
Site 96
Y993
D
W
Q
R
V
I
E
Y
H
R
E
N
D
E
P
Site 97
T1009
G
N
G
K
F
D
K
T
G
N
N
D
C
D
S
Site 98
S1016
T
G
N
N
D
C
D
S
D
Q
H
G
R
Q
P
Site 99
S1027
G
R
Q
P
R
L
G
S
F
T
S
I
R
H
P
Site 100
T1029
Q
P
R
L
G
S
F
T
S
I
R
H
P
S
P
Site 101
S1030
P
R
L
G
S
F
T
S
I
R
H
P
S
P
R
Site 102
S1035
F
T
S
I
R
H
P
S
P
R
Q
K
E
Q
P
Site 103
T1054
A
F
Q
A
S
S
D
T
L
V
A
V
E
K
S
Site 104
S1061
T
L
V
A
V
E
K
S
Y
S
H
Q
S
M
Q
Site 105
S1063
V
A
V
E
K
S
Y
S
H
Q
S
M
Q
S
T
Site 106
S1066
E
K
S
Y
S
H
Q
S
M
Q
S
T
C
S
P
Site 107
S1069
Y
S
H
Q
S
M
Q
S
T
C
S
P
E
S
S
Site 108
T1070
S
H
Q
S
M
Q
S
T
C
S
P
E
S
S
E
Site 109
S1072
Q
S
M
Q
S
T
C
S
P
E
S
S
E
D
I
Site 110
S1076
S
T
C
S
P
E
S
S
E
D
I
T
D
E
F
Site 111
T1080
P
E
S
S
E
D
I
T
D
E
F
L
T
P
D
Site 112
T1085
D
I
T
D
E
F
L
T
P
D
G
E
Y
F
Y
Site 113
Y1090
F
L
T
P
D
G
E
Y
F
Y
S
S
T
A
Q
Site 114
S1093
P
D
G
E
Y
F
Y
S
S
T
A
Q
E
N
L
Site 115
S1105
E
N
L
A
L
E
T
S
S
P
I
E
E
D
F
Site 116
S1106
N
L
A
L
E
T
S
S
P
I
E
E
D
F
E
Site 117
S1125
A
F
A
Q
P
Q
V
S
G
E
E
K
F
Q
M
Site 118
S1146
N
A
E
I
L
P
R
S
Q
F
Q
P
V
R
S
Site 119
S1153
S
Q
F
Q
P
V
R
S
T
E
D
E
Q
E
E
Site 120
T1154
Q
F
Q
P
V
R
S
T
E
D
E
Q
E
E
T
Site 121
T1161
T
E
D
E
Q
E
E
T
S
K
E
S
P
K
E
Site 122
S1165
Q
E
E
T
S
K
E
S
P
K
E
L
K
E
K
Site 123
S1175
E
L
K
E
K
D
I
S
L
T
D
I
Q
D
L
Site 124
T1177
K
E
K
D
I
S
L
T
D
I
Q
D
L
S
S
Site 125
S1183
L
T
D
I
Q
D
L
S
S
I
S
Y
E
P
D
Site 126
S1184
T
D
I
Q
D
L
S
S
I
S
Y
E
P
D
S
Site 127
S1186
I
Q
D
L
S
S
I
S
Y
E
P
D
S
S
F
Site 128
Y1187
Q
D
L
S
S
I
S
Y
E
P
D
S
S
F
K
Site 129
S1191
S
I
S
Y
E
P
D
S
S
F
K
E
A
S
C
Site 130
S1192
I
S
Y
E
P
D
S
S
F
K
E
A
S
C
K
Site 131
T1200
F
K
E
A
S
C
K
T
P
K
I
N
H
A
P
Site 132
T1208
P
K
I
N
H
A
P
T
S
V
S
T
P
L
S
Site 133
S1209
K
I
N
H
A
P
T
S
V
S
T
P
L
S
P
Site 134
S1211
N
H
A
P
T
S
V
S
T
P
L
S
P
G
S
Site 135
T1212
H
A
P
T
S
V
S
T
P
L
S
P
G
S
V
Site 136
S1215
T
S
V
S
T
P
L
S
P
G
S
V
S
S
A
Site 137
S1218
S
T
P
L
S
P
G
S
V
S
S
A
A
S
Q
Site 138
S1220
P
L
S
P
G
S
V
S
S
A
A
S
Q
Y
K
Site 139
S1221
L
S
P
G
S
V
S
S
A
A
S
Q
Y
K
D
Site 140
S1224
G
S
V
S
S
A
A
S
Q
Y
K
D
C
L
E
Site 141
T1234
K
D
C
L
E
S
I
T
F
Q
V
K
T
E
F
Site 142
T1253
N
S
Q
E
F
I
Q
T
L
S
D
D
F
I
S
Site 143
S1255
Q
E
F
I
Q
T
L
S
D
D
F
I
S
V
R
Site 144
S1260
T
L
S
D
D
F
I
S
V
R
E
R
A
K
K
Site 145
S1270
E
R
A
K
K
L
D
S
L
L
T
S
S
E
T
Site 146
T1273
K
K
L
D
S
L
L
T
S
S
E
T
P
P
S
Site 147
S1274
K
L
D
S
L
L
T
S
S
E
T
P
P
S
R
Site 148
S1275
L
D
S
L
L
T
S
S
E
T
P
P
S
R
L
Site 149
T1277
S
L
L
T
S
S
E
T
P
P
S
R
L
T
G
Site 150
S1280
T
S
S
E
T
P
P
S
R
L
T
G
L
K
R
Site 151
T1283
E
T
P
P
S
R
L
T
G
L
K
R
L
S
S
Site 152
S1290
T
G
L
K
R
L
S
S
F
I
G
A
G
S
P
Site 153
S1305
S
L
V
K
A
C
D
S
S
P
P
H
A
T
Q
Site 154
S1306
L
V
K
A
C
D
S
S
P
P
H
A
T
Q
R
Site 155
T1311
D
S
S
P
P
H
A
T
Q
R
R
S
L
P
K
Site 156
S1315
P
H
A
T
Q
R
R
S
L
P
K
V
E
A
F
Site 157
S1334
I
D
E
L
P
P
P
S
Q
E
L
L
D
D
I
Site 158
T1352
K
Q
Q
Q
G
S
S
T
V
L
H
E
N
T
A
Site 159
T1358
S
T
V
L
H
E
N
T
A
S
D
G
G
G
T
Site 160
S1360
V
L
H
E
N
T
A
S
D
G
G
G
T
A
N
Site 161
T1377
R
H
L
E
E
Q
E
T
D
S
K
K
E
D
S
Site 162
S1379
L
E
E
Q
E
T
D
S
K
K
E
D
S
S
M
Site 163
S1384
T
D
S
K
K
E
D
S
S
M
L
L
S
K
E
Site 164
S1385
D
S
K
K
E
D
S
S
M
L
L
S
K
E
T
Site 165
S1389
E
D
S
S
M
L
L
S
K
E
T
E
D
L
G
Site 166
T1399
T
E
D
L
G
E
D
T
E
R
A
H
S
T
L
Site 167
S1404
E
D
T
E
R
A
H
S
T
L
D
E
D
L
E
Site 168
T1405
D
T
E
R
A
H
S
T
L
D
E
D
L
E
R
Site 169
S1420
W
L
Q
P
P
E
E
S
V
E
L
Q
D
L
P
Site 170
S1430
L
Q
D
L
P
K
G
S
E
R
E
T
N
I
K
Site 171
T1434
P
K
G
S
E
R
E
T
N
I
K
D
Q
K
V
Site 172
S1451
E
K
R
K
R
E
D
S
I
T
P
E
R
R
K
Site 173
T1453
R
K
R
E
D
S
I
T
P
E
R
R
K
S
E
Site 174
S1459
I
T
P
E
R
R
K
S
E
G
V
L
G
T
S
Site 175
S1466
S
E
G
V
L
G
T
S
E
E
D
E
L
K
S
Site 176
S1473
S
E
E
D
E
L
K
S
C
F
W
K
R
L
G
Site 177
S1482
F
W
K
R
L
G
W
S
E
S
S
R
I
I
V
Site 178
S1484
K
R
L
G
W
S
E
S
S
R
I
I
V
L
D
Site 179
S1493
R
I
I
V
L
D
Q
S
D
L
S
D
_
_
_
Site 180
S1496
V
L
D
Q
S
D
L
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation