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Updated November 2019
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Protein Info
Short Name:
HT008
Full Name:
Testis-expressed sequence 2 protein
Alias:
KIAA1738; LOC55852; Testis expressed 2; Testis-expressed sequence 2 protein: Testis-expressed sequence 2 protein; TEX2; TMEM96; Transmembrane protein 96
Type:
Unknown function
Mass (Da):
125303
Number AA:
1127
UniProt ID:
Q8IWB9
International Prot ID:
IPI00761041
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
GO:0006665
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
Y
G
R
H
A
E
K
T
T
D
M
P
K
P
S
Site 2
T13
G
R
H
A
E
K
T
T
D
M
P
K
P
S
A
Site 3
S19
T
T
D
M
P
K
P
S
A
P
K
V
H
V
Q
Site 4
S28
P
K
V
H
V
Q
R
S
V
S
R
D
T
I
A
Site 5
S30
V
H
V
Q
R
S
V
S
R
D
T
I
A
I
H
Site 6
T33
Q
R
S
V
S
R
D
T
I
A
I
H
F
S
A
Site 7
S39
D
T
I
A
I
H
F
S
A
S
G
E
E
E
E
Site 8
Y55
E
E
E
E
F
R
E
Y
F
E
E
G
L
D
D
Site 9
S64
E
E
G
L
D
D
Q
S
I
V
T
G
L
E
A
Site 10
Y76
L
E
A
K
E
D
L
Y
L
E
P
Q
V
G
H
Site 11
S91
D
P
A
G
P
A
A
S
P
V
L
A
D
G
L
Site 12
S119
N
T
V
K
L
L
E
S
P
V
P
A
A
Q
V
Site 13
S135
S
T
V
P
L
A
V
S
P
G
S
S
S
S
G
Site 14
S140
A
V
S
P
G
S
S
S
S
G
P
L
A
S
S
Site 15
S141
V
S
P
G
S
S
S
S
G
P
L
A
S
S
P
Site 16
S146
S
S
S
G
P
L
A
S
S
P
S
V
S
S
L
Site 17
S147
S
S
G
P
L
A
S
S
P
S
V
S
S
L
S
Site 18
S149
G
P
L
A
S
S
P
S
V
S
S
L
S
E
Q
Site 19
S151
L
A
S
S
P
S
V
S
S
L
S
E
Q
K
T
Site 20
S152
A
S
S
P
S
V
S
S
L
S
E
Q
K
T
S
Site 21
S154
S
P
S
V
S
S
L
S
E
Q
K
T
S
S
S
Site 22
T158
S
S
L
S
E
Q
K
T
S
S
S
S
P
L
S
Site 23
S159
S
L
S
E
Q
K
T
S
S
S
S
P
L
S
S
Site 24
S160
L
S
E
Q
K
T
S
S
S
S
P
L
S
S
P
Site 25
S161
S
E
Q
K
T
S
S
S
S
P
L
S
S
P
S
Site 26
S162
E
Q
K
T
S
S
S
S
P
L
S
S
P
S
K
Site 27
S165
T
S
S
S
S
P
L
S
S
P
S
K
S
P
I
Site 28
S166
S
S
S
S
P
L
S
S
P
S
K
S
P
I
L
Site 29
S168
S
S
P
L
S
S
P
S
K
S
P
I
L
S
S
Site 30
S170
P
L
S
S
P
S
K
S
P
I
L
S
S
S
A
Site 31
S174
P
S
K
S
P
I
L
S
S
S
A
S
T
S
T
Site 32
S175
S
K
S
P
I
L
S
S
S
A
S
T
S
T
L
Site 33
S176
K
S
P
I
L
S
S
S
A
S
T
S
T
L
S
Site 34
T179
I
L
S
S
S
A
S
T
S
T
L
S
S
A
K
Site 35
S180
L
S
S
S
A
S
T
S
T
L
S
S
A
K
P
Site 36
T181
S
S
S
A
S
T
S
T
L
S
S
A
K
P
F
Site 37
S183
S
A
S
T
S
T
L
S
S
A
K
P
F
M
S
Site 38
S190
S
S
A
K
P
F
M
S
L
V
K
S
L
S
T
Site 39
S196
M
S
L
V
K
S
L
S
T
E
V
E
P
K
E
Site 40
S204
T
E
V
E
P
K
E
S
P
H
P
A
R
H
R
Site 41
T216
R
H
R
H
L
M
K
T
L
V
K
S
L
S
T
Site 42
S220
L
M
K
T
L
V
K
S
L
S
T
D
T
S
R
Site 43
S222
K
T
L
V
K
S
L
S
T
D
T
S
R
Q
E
Site 44
T223
T
L
V
K
S
L
S
T
D
T
S
R
Q
E
S
Site 45
T225
V
K
S
L
S
T
D
T
S
R
Q
E
S
D
T
Site 46
S226
K
S
L
S
T
D
T
S
R
Q
E
S
D
T
V
Site 47
S230
T
D
T
S
R
Q
E
S
D
T
V
S
Y
K
P
Site 48
T232
T
S
R
Q
E
S
D
T
V
S
Y
K
P
P
D
Site 49
S234
R
Q
E
S
D
T
V
S
Y
K
P
P
D
S
K
Site 50
Y235
Q
E
S
D
T
V
S
Y
K
P
P
D
S
K
L
Site 51
S240
V
S
Y
K
P
P
D
S
K
L
N
L
H
L
F
Site 52
T251
L
H
L
F
K
Q
F
T
Q
P
R
N
T
G
G
Site 53
T256
Q
F
T
Q
P
R
N
T
G
G
D
S
K
T
A
Site 54
S260
P
R
N
T
G
G
D
S
K
T
A
P
S
S
P
Site 55
T262
N
T
G
G
D
S
K
T
A
P
S
S
P
L
T
Site 56
S265
G
D
S
K
T
A
P
S
S
P
L
T
S
P
S
Site 57
S266
D
S
K
T
A
P
S
S
P
L
T
S
P
S
D
Site 58
T269
T
A
P
S
S
P
L
T
S
P
S
D
T
R
S
Site 59
S270
A
P
S
S
P
L
T
S
P
S
D
T
R
S
F
Site 60
S272
S
S
P
L
T
S
P
S
D
T
R
S
F
F
K
Site 61
T274
P
L
T
S
P
S
D
T
R
S
F
F
K
V
P
Site 62
S276
T
S
P
S
D
T
R
S
F
F
K
V
P
E
M
Site 63
T290
M
E
A
K
I
E
D
T
K
R
R
L
S
E
V
Site 64
S295
E
D
T
K
R
R
L
S
E
V
I
Y
E
P
F
Site 65
Y299
R
R
L
S
E
V
I
Y
E
P
F
Q
L
L
S
Site 66
S306
Y
E
P
F
Q
L
L
S
K
I
I
G
E
E
S
Site 67
S315
I
I
G
E
E
S
G
S
H
R
P
K
A
L
S
Site 68
S322
S
H
R
P
K
A
L
S
S
S
A
S
E
L
S
Site 69
S323
H
R
P
K
A
L
S
S
S
A
S
E
L
S
N
Site 70
S324
R
P
K
A
L
S
S
S
A
S
E
L
S
N
L
Site 71
S326
K
A
L
S
S
S
A
S
E
L
S
N
L
S
S
Site 72
S329
S
S
S
A
S
E
L
S
N
L
S
S
L
N
G
Site 73
S332
A
S
E
L
S
N
L
S
S
L
N
G
H
L
E
Site 74
S333
S
E
L
S
N
L
S
S
L
N
G
H
L
E
S
Site 75
S340
S
L
N
G
H
L
E
S
N
N
N
Y
S
I
K
Site 76
Y344
H
L
E
S
N
N
N
Y
S
I
K
E
E
E
C
Site 77
S345
L
E
S
N
N
N
Y
S
I
K
E
E
E
C
D
Site 78
S353
I
K
E
E
E
C
D
S
E
G
D
G
Y
G
S
Site 79
Y358
C
D
S
E
G
D
G
Y
G
S
D
S
N
I
P
Site 80
S360
S
E
G
D
G
Y
G
S
D
S
N
I
P
R
S
Site 81
S362
G
D
G
Y
G
S
D
S
N
I
P
R
S
D
H
Site 82
S367
S
D
S
N
I
P
R
S
D
H
P
K
S
T
G
Site 83
S372
P
R
S
D
H
P
K
S
T
G
E
P
T
R
E
Site 84
T373
R
S
D
H
P
K
S
T
G
E
P
T
R
E
I
Site 85
S384
T
R
E
I
E
L
K
S
S
Q
G
S
S
L
K
Site 86
S385
R
E
I
E
L
K
S
S
Q
G
S
S
L
K
D
Site 87
S388
E
L
K
S
S
Q
G
S
S
L
K
D
L
G
L
Site 88
S389
L
K
S
S
Q
G
S
S
L
K
D
L
G
L
K
Site 89
T397
L
K
D
L
G
L
K
T
S
S
L
V
L
E
K
Site 90
S398
K
D
L
G
L
K
T
S
S
L
V
L
E
K
C
Site 91
S399
D
L
G
L
K
T
S
S
L
V
L
E
K
C
S
Site 92
S412
C
S
L
S
A
L
V
S
K
E
D
E
E
F
C
Site 93
Y422
D
E
E
F
C
E
L
Y
T
E
D
F
D
L
E
Site 94
T430
T
E
D
F
D
L
E
T
E
G
E
S
K
V
D
Site 95
S440
E
S
K
V
D
K
L
S
D
I
P
L
K
P
E
Site 96
S458
E
D
G
V
V
L
D
S
E
D
E
V
D
S
A
Site 97
Y524
T
P
P
S
A
H
K
Y
H
K
L
H
K
N
L
Site 98
S538
L
R
H
W
N
T
R
S
L
D
I
K
E
P
E
Site 99
Y555
K
G
W
M
N
E
I
Y
N
Y
D
P
E
T
Y
Site 100
T565
D
P
E
T
Y
H
A
T
L
T
H
S
V
F
V
Site 101
T578
F
V
R
L
E
G
G
T
L
R
L
S
K
P
N
Site 102
S582
E
G
G
T
L
R
L
S
K
P
N
K
N
I
S
Site 103
S589
S
K
P
N
K
N
I
S
R
R
A
S
Y
N
E
Site 104
S593
K
N
I
S
R
R
A
S
Y
N
E
P
K
P
E
Site 105
Y594
N
I
S
R
R
A
S
Y
N
E
P
K
P
E
V
Site 106
Y603
E
P
K
P
E
V
T
Y
I
S
Q
K
I
Y
D
Site 107
S605
K
P
E
V
T
Y
I
S
Q
K
I
Y
D
L
S
Site 108
Y609
T
Y
I
S
Q
K
I
Y
D
L
S
D
S
K
I
Site 109
S612
S
Q
K
I
Y
D
L
S
D
S
K
I
Y
L
V
Site 110
S614
K
I
Y
D
L
S
D
S
K
I
Y
L
V
P
K
Site 111
Y617
D
L
S
D
S
K
I
Y
L
V
P
K
T
L
A
Site 112
T622
K
I
Y
L
V
P
K
T
L
A
R
K
R
I
W
Site 113
Y633
K
R
I
W
N
K
K
Y
P
I
C
I
E
L
G
Site 114
S647
G
Q
Q
D
D
F
M
S
K
A
Q
T
D
K
E
Site 115
T651
D
F
M
S
K
A
Q
T
D
K
E
T
S
E
E
Site 116
S665
E
K
P
P
A
E
G
S
E
D
P
K
K
P
P
Site 117
T678
P
P
R
P
Q
E
G
T
R
S
S
Q
R
D
Q
Site 118
S680
R
P
Q
E
G
T
R
S
S
Q
R
D
Q
I
L
Site 119
S681
P
Q
E
G
T
R
S
S
Q
R
D
Q
I
L
Y
Site 120
Y688
S
Q
R
D
Q
I
L
Y
L
F
G
R
T
G
R
Site 121
S708
F
R
R
F
I
L
A
S
K
L
K
S
E
I
K
Site 122
S712
I
L
A
S
K
L
K
S
E
I
K
K
S
S
G
Site 123
S717
L
K
S
E
I
K
K
S
S
G
V
S
G
G
K
Site 124
S718
K
S
E
I
K
K
S
S
G
V
S
G
G
K
P
Site 125
S721
I
K
K
S
S
G
V
S
G
G
K
P
G
L
L
Site 126
S732
P
G
L
L
P
A
H
S
R
H
N
S
P
S
G
Site 127
S736
P
A
H
S
R
H
N
S
P
S
G
H
L
T
H
Site 128
S738
H
S
R
H
N
S
P
S
G
H
L
T
H
S
R
Site 129
T742
N
S
P
S
G
H
L
T
H
S
R
S
S
S
K
Site 130
S744
P
S
G
H
L
T
H
S
R
S
S
S
K
G
S
Site 131
S746
G
H
L
T
H
S
R
S
S
S
K
G
S
V
E
Site 132
S747
H
L
T
H
S
R
S
S
S
K
G
S
V
E
E
Site 133
S748
L
T
H
S
R
S
S
S
K
G
S
V
E
E
I
Site 134
S751
S
R
S
S
S
K
G
S
V
E
E
I
M
S
Q
Site 135
S757
G
S
V
E
E
I
M
S
Q
P
K
Q
K
E
L
Site 136
S767
K
Q
K
E
L
A
G
S
V
R
Q
K
M
L
L
Site 137
Y776
R
Q
K
M
L
L
D
Y
S
V
Y
M
G
R
C
Site 138
S788
G
R
C
V
P
Q
E
S
R
S
P
Q
R
S
P
Site 139
S790
C
V
P
Q
E
S
R
S
P
Q
R
S
P
L
Q
Site 140
S794
E
S
R
S
P
Q
R
S
P
L
Q
S
A
E
S
Site 141
S798
P
Q
R
S
P
L
Q
S
A
E
S
S
P
T
A
Site 142
S801
S
P
L
Q
S
A
E
S
S
P
T
A
G
K
K
Site 143
S802
P
L
Q
S
A
E
S
S
P
T
A
G
K
K
L
Site 144
T804
Q
S
A
E
S
S
P
T
A
G
K
K
L
P
E
Site 145
S815
K
L
P
E
V
P
P
S
E
E
E
E
Q
E
A
Site 146
Y840
W
D
F
L
G
E
K
Y
W
S
D
L
V
S
K
Site 147
S842
F
L
G
E
K
Y
W
S
D
L
V
S
K
K
I
Site 148
S854
K
K
I
Q
M
K
L
S
K
I
K
L
P
Y
F
Site 149
T866
P
Y
F
M
N
E
L
T
L
T
E
L
D
M
G
Site 150
Y886
I
L
Q
A
F
K
P
Y
V
D
H
Q
G
L
W
Site 151
T907
Y
N
G
S
F
L
M
T
L
E
T
K
M
N
L
Site 152
S946
R
A
F
C
L
A
D
S
D
E
E
S
S
S
A
Site 153
S950
L
A
D
S
D
E
E
S
S
S
A
G
S
S
E
Site 154
S951
A
D
S
D
E
E
S
S
S
A
G
S
S
E
E
Site 155
S952
D
S
D
E
E
S
S
S
A
G
S
S
E
E
D
Site 156
S955
E
E
S
S
S
A
G
S
S
E
E
D
D
A
P
Site 157
S956
E
S
S
S
A
G
S
S
E
E
D
D
A
P
E
Site 158
Y978
L
L
P
G
A
E
G
Y
V
G
G
H
R
T
S
Site 159
T995
M
R
F
V
D
K
I
T
K
S
K
Y
F
Q
K
Site 160
Y999
D
K
I
T
K
S
K
Y
F
Q
K
A
T
E
T
Site 161
T1024
S
N
T
P
L
L
L
T
V
E
V
Q
E
C
R
Site 162
T1033
E
V
Q
E
C
R
G
T
L
A
V
N
I
P
P
Site 163
T1043
V
N
I
P
P
P
P
T
D
R
V
W
Y
G
F
Site 164
Y1048
P
P
T
D
R
V
W
Y
G
F
R
K
P
P
H
Site 165
T1070
K
L
G
E
R
E
V
T
L
V
H
V
T
D
W
Site 166
S1111
H
S
A
M
D
P
R
S
T
S
C
L
L
K
D
Site 167
T1112
S
A
M
D
P
R
S
T
S
C
L
L
K
D
P
Site 168
S1113
A
M
D
P
R
S
T
S
C
L
L
K
D
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation