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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GCC2
Full Name:
GRIP and coiled-coil domain-containing protein 2
Alias:
CLL-associated antigen KW-11; CTCL tumor antigen se1-1; Golgi coiled coil protein GCC185; Golgi coiled-coil protein GCC185; NY-REN-53 antigen
Type:
Uncharacterized
Mass (Da):
184657
Number AA:
1583
UniProt ID:
Q8IWJ2
International Prot ID:
IPI00005631
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
K
Q
E
V
E
D
S
V
T
K
M
G
D
A
Site 2
T10
Q
E
V
E
D
S
V
T
K
M
G
D
A
H
K
Site 3
S22
A
H
K
E
L
E
Q
S
H
I
N
Y
V
K
E
Site 4
Y26
L
E
Q
S
H
I
N
Y
V
K
E
I
E
N
L
Site 5
S42
N
E
L
M
A
V
R
S
K
Y
S
E
D
K
A
Site 6
Y44
L
M
A
V
R
S
K
Y
S
E
D
K
A
N
L
Site 7
T61
Q
L
E
E
A
M
N
T
Q
L
E
L
S
E
Q
Site 8
Y99
G
F
E
E
Q
I
L
Y
L
Q
K
Q
L
D
A
Site 9
T114
T
T
D
E
K
K
E
T
V
T
Q
L
Q
N
I
Site 10
S186
L
V
K
Q
C
E
A
S
E
K
N
I
Q
K
K
Site 11
Y194
E
K
N
I
Q
K
K
Y
E
C
E
L
E
N
L
Site 12
T205
L
E
N
L
R
K
A
T
S
N
A
N
Q
D
N
Site 13
S206
E
N
L
R
K
A
T
S
N
A
N
Q
D
N
Q
Site 14
T239
K
V
K
H
L
E
D
T
L
K
E
L
E
S
Q
Site 15
S245
D
T
L
K
E
L
E
S
Q
H
S
I
L
K
D
Site 16
S248
K
E
L
E
S
Q
H
S
I
L
K
D
E
V
T
Site 17
T255
S
I
L
K
D
E
V
T
Y
M
N
N
L
K
L
Site 18
S305
C
V
I
E
K
L
K
S
E
L
A
G
L
N
K
Site 19
Y316
G
L
N
K
Q
F
C
Y
T
V
E
Q
H
N
R
Site 20
T342
E
I
S
E
L
N
E
T
F
L
S
D
S
E
K
Site 21
S345
E
L
N
E
T
F
L
S
D
S
E
K
E
K
L
Site 22
S347
N
E
T
F
L
S
D
S
E
K
E
K
L
T
L
Site 23
Y379
K
Q
E
A
I
L
N
Y
E
S
L
R
E
I
M
Site 24
S381
E
A
I
L
N
Y
E
S
L
R
E
I
M
E
I
Site 25
T391
E
I
M
E
I
L
Q
T
E
L
G
E
S
A
G
Site 26
S396
L
Q
T
E
L
G
E
S
A
G
K
I
S
Q
E
Site 27
S401
G
E
S
A
G
K
I
S
Q
E
F
E
S
M
K
Site 28
S413
S
M
K
Q
Q
Q
A
S
D
V
H
E
L
Q
Q
Site 29
T435
E
K
D
A
L
L
E
T
V
N
R
L
Q
G
E
Site 30
S448
G
E
N
E
K
L
L
S
Q
Q
E
L
V
P
E
Site 31
T459
L
V
P
E
L
E
N
T
I
K
N
L
Q
E
K
Site 32
Y470
L
Q
E
K
N
G
V
Y
L
L
S
L
S
Q
R
Site 33
S473
K
N
G
V
Y
L
L
S
L
S
Q
R
D
T
M
Site 34
S475
G
V
Y
L
L
S
L
S
Q
R
D
T
M
L
K
Site 35
T479
L
S
L
S
Q
R
D
T
M
L
K
E
L
E
G
Site 36
S490
E
L
E
G
K
I
N
S
L
T
E
E
K
D
D
Site 37
T492
E
G
K
I
N
S
L
T
E
E
K
D
D
F
I
Site 38
S583
S
E
D
K
E
V
L
S
A
E
V
K
S
L
Y
Site 39
S588
V
L
S
A
E
V
K
S
L
Y
E
E
N
N
K
Site 40
Y590
S
A
E
V
K
S
L
Y
E
E
N
N
K
L
S
Site 41
S597
Y
E
E
N
N
K
L
S
S
E
K
K
Q
L
S
Site 42
S604
S
S
E
K
K
Q
L
S
R
D
L
E
V
F
L
Site 43
S612
R
D
L
E
V
F
L
S
Q
K
E
D
V
I
L
Site 44
S667
G
F
L
K
E
M
G
S
E
V
S
E
D
S
E
Site 45
S673
G
S
E
V
S
E
D
S
E
E
K
D
V
V
N
Site 46
S721
I
K
C
L
Q
E
E
S
V
V
Q
C
E
E
L
Site 47
S730
V
Q
C
E
E
L
K
S
L
L
R
D
Y
E
Q
Site 48
Y735
L
K
S
L
L
R
D
Y
E
Q
E
K
V
L
L
Site 49
S751
K
E
L
E
E
I
Q
S
E
K
E
A
L
Q
S
Site 50
S758
S
E
K
E
A
L
Q
S
D
L
L
E
M
K
N
Site 51
S785
L
I
Q
V
E
E
V
S
Q
T
C
S
K
S
E
Site 52
T787
Q
V
E
E
V
S
Q
T
C
S
K
S
E
I
H
Site 53
S789
E
E
V
S
Q
T
C
S
K
S
E
I
H
N
E
Site 54
S791
V
S
Q
T
C
S
K
S
E
I
H
N
E
K
E
Site 55
S834
L
K
D
S
L
A
K
S
P
S
V
K
N
D
P
Site 56
S836
D
S
L
A
K
S
P
S
V
K
N
D
P
L
S
Site 57
S843
S
V
K
N
D
P
L
S
S
V
K
E
L
E
E
Site 58
S844
V
K
N
D
P
L
S
S
V
K
E
L
E
E
K
Site 59
S882
K
A
K
K
E
L
D
S
S
R
K
E
T
Q
T
Site 60
S883
A
K
K
E
L
D
S
S
R
K
E
T
Q
T
V
Site 61
T887
L
D
S
S
R
K
E
T
Q
T
V
K
E
E
L
Site 62
T889
S
S
R
K
E
T
Q
T
V
K
E
E
L
E
S
Site 63
S896
T
V
K
E
E
L
E
S
L
R
S
E
K
D
Q
Site 64
S899
E
E
L
E
S
L
R
S
E
K
D
Q
L
S
A
Site 65
S905
R
S
E
K
D
Q
L
S
A
S
M
R
D
L
I
Site 66
S907
E
K
D
Q
L
S
A
S
M
R
D
L
I
Q
G
Site 67
Y925
Y
K
N
L
L
L
E
Y
E
K
Q
S
E
Q
L
Site 68
T950
E
H
R
I
E
D
L
T
R
Q
L
R
N
S
T
Site 69
S956
L
T
R
Q
L
R
N
S
T
L
Q
C
E
T
I
Site 70
T957
T
R
Q
L
R
N
S
T
L
Q
C
E
T
I
N
Site 71
S965
L
Q
C
E
T
I
N
S
D
N
E
D
L
L
A
Site 72
T976
D
L
L
A
R
I
E
T
L
Q
S
N
A
K
L
Site 73
S979
A
R
I
E
T
L
Q
S
N
A
K
L
L
E
V
Site 74
T1019
K
I
K
E
H
A
T
T
V
N
E
L
E
E
L
Site 75
Y1064
M
N
M
E
I
A
D
Y
E
R
L
M
K
E
L
Site 76
T1104
E
T
L
Q
E
E
I
T
S
L
Q
S
S
V
Q
Site 77
S1105
T
L
Q
E
E
I
T
S
L
Q
S
S
V
Q
Q
Site 78
S1109
E
I
T
S
L
Q
S
S
V
Q
Q
Y
E
E
K
Site 79
Y1113
L
Q
S
S
V
Q
Q
Y
E
E
K
N
T
K
I
Site 80
S1134
T
K
K
E
L
A
D
S
K
Q
A
E
T
D
H
Site 81
S1147
D
H
L
I
L
Q
A
S
L
K
G
E
L
E
A
Site 82
S1155
L
K
G
E
L
E
A
S
Q
Q
Q
V
E
V
Y
Site 83
S1171
I
Q
L
A
E
I
T
S
E
K
H
K
I
H
E
Site 84
T1182
K
I
H
E
H
L
K
T
S
A
E
Q
H
Q
R
Site 85
S1192
E
Q
H
Q
R
T
L
S
A
Y
Q
Q
R
V
T
Site 86
Y1194
H
Q
R
T
L
S
A
Y
Q
Q
R
V
T
A
L
Site 87
T1199
S
A
Y
Q
Q
R
V
T
A
L
Q
E
E
C
R
Site 88
S1221
T
V
T
S
E
F
E
S
Y
K
V
R
V
H
N
Site 89
Y1222
V
T
S
E
F
E
S
Y
K
V
R
V
H
N
V
Site 90
S1237
L
K
Q
Q
K
N
K
S
M
S
Q
A
E
T
E
Site 91
S1239
Q
Q
K
N
K
S
M
S
Q
A
E
T
E
G
A
Site 92
T1243
K
S
M
S
Q
A
E
T
E
G
A
K
Q
E
R
Site 93
S1267
L
K
I
K
L
Q
D
S
Q
N
N
L
Q
I
N
Site 94
S1276
N
N
L
Q
I
N
V
S
E
L
Q
T
L
Q
S
Site 95
T1280
I
N
V
S
E
L
Q
T
L
Q
S
E
H
D
T
Site 96
S1283
S
E
L
Q
T
L
Q
S
E
H
D
T
L
L
E
Site 97
T1287
T
L
Q
S
E
H
D
T
L
L
E
R
H
N
K
Site 98
T1299
H
N
K
M
L
Q
E
T
V
S
K
E
A
E
L
Site 99
S1301
K
M
L
Q
E
T
V
S
K
E
A
E
L
R
E
Site 100
S1312
E
L
R
E
K
L
C
S
I
Q
S
E
N
M
M
Site 101
S1322
S
E
N
M
M
M
K
S
E
H
T
Q
T
V
S
Site 102
T1327
M
K
S
E
H
T
Q
T
V
S
Q
L
T
S
Q
Site 103
S1329
S
E
H
T
Q
T
V
S
Q
L
T
S
Q
N
E
Site 104
S1333
Q
T
V
S
Q
L
T
S
Q
N
E
V
L
R
N
Site 105
S1341
Q
N
E
V
L
R
N
S
F
R
D
Q
V
R
H
Site 106
T1356
L
Q
E
E
H
R
K
T
V
E
T
L
Q
Q
Q
Site 107
T1359
E
H
R
K
T
V
E
T
L
Q
Q
Q
L
S
K
Site 108
S1365
E
T
L
Q
Q
Q
L
S
K
M
E
A
Q
L
F
Site 109
T1379
F
Q
L
K
N
E
P
T
T
R
S
P
V
S
S
Site 110
T1380
Q
L
K
N
E
P
T
T
R
S
P
V
S
S
Q
Site 111
S1382
K
N
E
P
T
T
R
S
P
V
S
S
Q
Q
S
Site 112
S1385
P
T
T
R
S
P
V
S
S
Q
Q
S
L
K
N
Site 113
S1386
T
T
R
S
P
V
S
S
Q
Q
S
L
K
N
L
Site 114
S1389
S
P
V
S
S
Q
Q
S
L
K
N
L
R
E
R
Site 115
T1399
N
L
R
E
R
R
N
T
D
L
P
L
L
D
M
Site 116
T1408
L
P
L
L
D
M
H
T
V
T
R
E
E
G
E
Site 117
T1419
E
E
G
E
G
M
E
T
T
D
T
E
S
V
S
Site 118
T1420
E
G
E
G
M
E
T
T
D
T
E
S
V
S
S
Site 119
T1422
E
G
M
E
T
T
D
T
E
S
V
S
S
A
S
Site 120
S1424
M
E
T
T
D
T
E
S
V
S
S
A
S
T
Y
Site 121
S1427
T
D
T
E
S
V
S
S
A
S
T
Y
T
Q
S
Site 122
T1430
E
S
V
S
S
A
S
T
Y
T
Q
S
L
E
Q
Site 123
Y1431
S
V
S
S
A
S
T
Y
T
Q
S
L
E
Q
L
Site 124
S1434
S
A
S
T
Y
T
Q
S
L
E
Q
L
L
N
S
Site 125
S1441
S
L
E
Q
L
L
N
S
P
E
T
K
L
E
P
Site 126
S1465
E
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
Site 127
S1466
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
H
Site 128
S1470
K
L
S
S
T
T
K
S
A
D
H
L
N
G
L
Site 129
T1484
L
L
R
E
T
E
A
T
N
A
I
L
M
E
Q
Site 130
S1497
E
Q
I
K
L
L
K
S
E
I
R
R
L
E
R
Site 131
S1511
R
N
Q
E
R
E
K
S
A
A
N
L
E
Y
L
Site 132
Y1517
K
S
A
A
N
L
E
Y
L
K
N
V
L
L
Q
Site 133
S1532
F
I
F
L
K
P
G
S
E
R
E
R
L
L
P
Site 134
S1548
I
N
T
M
L
Q
L
S
P
E
E
K
G
K
L
Site 135
S1567
Q
G
E
E
E
N
A
S
R
S
S
G
W
A
S
Site 136
S1569
E
E
E
N
A
S
R
S
S
G
W
A
S
Y
L
Site 137
S1570
E
E
N
A
S
R
S
S
G
W
A
S
Y
L
H
Site 138
S1574
S
R
S
S
G
W
A
S
Y
L
H
S
W
S
G
Site 139
Y1575
R
S
S
G
W
A
S
Y
L
H
S
W
S
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation