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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPR125
Full Name:
Probable G-protein coupled receptor 125
Alias:
FLJ38547; G protein-coupled receptor 125; GP125; G-protein coupled receptor 125; PGR21
Type:
Receptor, GPCR
Mass (Da):
146151
Number AA:
1321
UniProt ID:
Q8IWK6
International Prot ID:
IPI00452590
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004930
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T78
A
Q
V
L
P
P
D
T
L
P
N
R
T
V
T
Site 2
T83
P
D
T
L
P
N
R
T
V
T
L
I
L
S
N
Site 3
T85
T
L
P
N
R
T
V
T
L
I
L
S
N
N
K
Site 4
S102
E
L
K
N
G
S
F
S
G
L
S
L
L
E
R
Site 5
S118
D
L
R
N
N
L
I
S
S
I
D
P
G
A
F
Site 6
S119
L
R
N
N
L
I
S
S
I
D
P
G
A
F
W
Site 7
T137
S
L
K
R
L
D
L
T
N
N
R
I
G
C
L
Site 8
S167
L
S
G
N
L
F
S
S
L
S
Q
G
T
F
D
Site 9
S169
G
N
L
F
S
S
L
S
Q
G
T
F
D
Y
L
Site 10
S178
G
T
F
D
Y
L
A
S
L
R
S
L
E
F
Q
Site 11
S181
D
Y
L
A
S
L
R
S
L
E
F
Q
T
E
Y
Site 12
T208
W
V
K
E
K
N
I
T
V
R
D
T
R
C
V
Site 13
T212
K
N
I
T
V
R
D
T
R
C
V
Y
P
K
S
Site 14
Y216
V
R
D
T
R
C
V
Y
P
K
S
L
Q
A
Q
Site 15
S219
T
R
C
V
Y
P
K
S
L
Q
A
Q
P
V
T
Site 16
T234
G
V
K
Q
E
L
L
T
C
D
P
P
L
E
L
Site 17
S243
D
P
P
L
E
L
P
S
F
Y
M
T
P
S
H
Site 18
Y245
P
L
E
L
P
S
F
Y
M
T
P
S
H
R
Q
Site 19
T247
E
L
P
S
F
Y
M
T
P
S
H
R
Q
V
V
Site 20
S289
R
I
V
E
T
D
E
S
Q
G
I
F
V
E
K
Site 21
T336
K
R
G
N
N
T
R
T
V
D
I
V
V
L
E
Site 22
Y348
V
L
E
S
S
A
Q
Y
C
P
P
E
R
V
V
Site 23
T366
G
D
F
R
W
P
R
T
L
A
G
I
T
A
Y
Site 24
S383
C
T
R
N
T
H
G
S
G
I
Y
P
G
N
P
Site 25
Y411
G
F
W
A
D
D
D
Y
S
R
C
Q
Y
A
N
Site 26
Y416
D
D
Y
S
R
C
Q
Y
A
N
D
V
T
R
V
Site 27
Y425
N
D
V
T
R
V
L
Y
M
F
N
Q
M
P
L
Site 28
T474
I
E
K
F
G
R
F
T
K
E
E
K
S
K
E
Site 29
S479
R
F
T
K
E
E
K
S
K
E
L
G
D
V
M
Site 30
Y533
L
A
G
G
A
H
V
Y
S
T
Y
S
P
N
I
Site 31
T535
G
G
A
H
V
Y
S
T
Y
S
P
N
I
A
L
Site 32
S537
A
H
V
Y
S
T
Y
S
P
N
I
A
L
E
A
Site 33
S566
V
F
Q
K
V
A
A
S
D
R
T
G
L
S
D
Site 34
Y574
D
R
T
G
L
S
D
Y
G
R
R
D
P
E
G
Site 35
S588
G
N
L
D
K
Q
L
S
F
K
C
N
V
S
N
Site 36
S598
C
N
V
S
N
T
F
S
S
L
A
L
K
N
T
Site 37
S599
N
V
S
N
T
F
S
S
L
A
L
K
N
T
I
Site 38
S616
A
S
I
Q
L
P
P
S
L
F
S
P
K
Q
K
Site 39
S619
Q
L
P
P
S
L
F
S
P
K
Q
K
R
E
L
Site 40
T629
Q
K
R
E
L
R
P
T
D
D
S
L
Y
K
L
Site 41
S632
E
L
R
P
T
D
D
S
L
Y
K
L
Q
L
I
Site 42
Y634
R
P
T
D
D
S
L
Y
K
L
Q
L
I
A
F
Site 43
T650
N
G
K
L
F
P
A
T
G
N
S
T
N
L
A
Site 44
T664
A
D
D
G
K
R
R
T
V
V
T
P
V
I
L
Site 45
T689
H
H
I
P
V
N
V
T
L
R
R
I
A
H
G
Site 46
Y724
S
D
G
C
H
I
L
Y
S
D
E
N
I
T
T
Site 47
T731
Y
S
D
E
N
I
T
T
I
Q
C
Y
S
L
S
Site 48
Y851
G
V
T
A
R
N
I
Y
K
Q
V
T
K
K
A
Site 49
Y950
K
R
H
P
E
R
K
Y
E
L
K
E
P
T
E
Site 50
S975
G
E
I
N
H
Q
D
S
M
S
L
S
L
I
S
Site 51
S977
I
N
H
Q
D
S
M
S
L
S
L
I
S
T
S
Site 52
S982
S
M
S
L
S
L
I
S
T
S
A
L
E
N
E
Site 53
T983
M
S
L
S
L
I
S
T
S
A
L
E
N
E
H
Site 54
S984
S
L
S
L
I
S
T
S
A
L
E
N
E
H
T
Site 55
T991
S
A
L
E
N
E
H
T
F
H
S
Q
L
L
G
Site 56
S994
E
N
E
H
T
F
H
S
Q
L
L
G
A
S
L
Site 57
S1067
T
C
C
P
G
R
S
S
Y
S
V
Q
V
N
V
Site 58
Y1068
C
C
P
G
R
S
S
Y
S
V
Q
V
N
V
Q
Site 59
S1079
V
N
V
Q
P
P
N
S
N
G
T
N
G
E
A
Site 60
S1092
E
A
P
K
C
P
N
S
S
A
E
S
S
C
T
Site 61
S1093
A
P
K
C
P
N
S
S
A
E
S
S
C
T
N
Site 62
S1096
C
P
N
S
S
A
E
S
S
C
T
N
K
S
A
Site 63
S1097
P
N
S
S
A
E
S
S
C
T
N
K
S
A
S
Site 64
T1099
S
S
A
E
S
S
C
T
N
K
S
A
S
S
F
Site 65
S1102
E
S
S
C
T
N
K
S
A
S
S
F
K
N
S
Site 66
S1104
S
C
T
N
K
S
A
S
S
F
K
N
S
S
Q
Site 67
S1105
C
T
N
K
S
A
S
S
F
K
N
S
S
Q
G
Site 68
S1109
S
A
S
S
F
K
N
S
S
Q
G
C
K
L
T
Site 69
S1110
A
S
S
F
K
N
S
S
Q
G
C
K
L
T
N
Site 70
S1129
A
A
Q
C
H
A
N
S
L
P
L
N
S
T
P
Site 71
S1134
A
N
S
L
P
L
N
S
T
P
Q
L
D
N
S
Site 72
T1135
N
S
L
P
L
N
S
T
P
Q
L
D
N
S
L
Site 73
S1141
S
T
P
Q
L
D
N
S
L
T
E
H
S
M
D
Site 74
T1143
P
Q
L
D
N
S
L
T
E
H
S
M
D
N
D
Site 75
T1164
P
L
E
V
Q
F
R
T
N
V
H
S
S
R
H
Site 76
S1168
Q
F
R
T
N
V
H
S
S
R
H
H
K
N
R
Site 77
S1176
S
R
H
H
K
N
R
S
K
G
H
R
A
S
R
Site 78
S1182
R
S
K
G
H
R
A
S
R
L
T
V
L
R
E
Site 79
T1185
G
H
R
A
S
R
L
T
V
L
R
E
Y
A
Y
Site 80
Y1190
R
L
T
V
L
R
E
Y
A
Y
D
V
P
T
S
Site 81
Y1192
T
V
L
R
E
Y
A
Y
D
V
P
T
S
V
E
Site 82
T1196
E
Y
A
Y
D
V
P
T
S
V
E
G
S
V
Q
Site 83
S1197
Y
A
Y
D
V
P
T
S
V
E
G
S
V
Q
N
Site 84
S1201
V
P
T
S
V
E
G
S
V
Q
N
G
L
P
K
Site 85
S1209
V
Q
N
G
L
P
K
S
R
L
G
N
N
E
G
Site 86
S1218
L
G
N
N
E
G
H
S
R
S
R
R
A
Y
L
Site 87
S1220
N
N
E
G
H
S
R
S
R
R
A
Y
L
A
Y
Site 88
Y1224
H
S
R
S
R
R
A
Y
L
A
Y
R
E
R
Q
Site 89
Y1227
S
R
R
A
Y
L
A
Y
R
E
R
Q
Y
N
P
Site 90
Y1232
L
A
Y
R
E
R
Q
Y
N
P
P
Q
Q
D
S
Site 91
S1240
N
P
P
Q
Q
D
S
S
D
A
C
S
T
L
P
Site 92
S1244
Q
D
S
S
D
A
C
S
T
L
P
K
S
S
R
Site 93
T1245
D
S
S
D
A
C
S
T
L
P
K
S
S
R
N
Site 94
S1249
A
C
S
T
L
P
K
S
S
R
N
F
E
K
P
Site 95
S1258
R
N
F
E
K
P
V
S
T
T
S
K
K
D
A
Site 96
S1280
E
L
E
N
Q
Q
K
S
Y
G
L
N
L
A
I
Site 97
S1294
I
Q
N
G
P
I
K
S
N
G
Q
E
G
P
L
Site 98
S1306
G
P
L
L
G
T
D
S
T
G
N
V
R
T
G
Site 99
T1307
P
L
L
G
T
D
S
T
G
N
V
R
T
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation