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Updated November 2019
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Protein Info
Short Name:
RP1L1
Full Name:
Retinitis pigmentosa 1-like 1 protein
Alias:
Type:
Mass (Da):
261108
Number AA:
2480
UniProt ID:
Q8IWN7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
R
N
A
Q
A
P
S
H
R
E
C
F
L
P
Site 2
S20
H
R
E
C
F
L
P
S
V
A
R
T
P
S
V
Site 3
S26
P
S
V
A
R
T
P
S
V
T
K
V
T
P
A
Site 4
T31
T
P
S
V
T
K
V
T
P
A
K
K
I
T
F
Site 5
T37
V
T
P
A
K
K
I
T
F
L
K
R
G
D
P
Site 6
T60
V
H
Q
R
A
F
K
T
F
S
A
L
M
D
E
Site 7
S75
L
S
Q
R
V
P
L
S
F
G
V
R
S
V
T
Site 8
T82
S
F
G
V
R
S
V
T
T
P
R
G
L
H
S
Site 9
T83
F
G
V
R
S
V
T
T
P
R
G
L
H
S
L
Site 10
S89
T
T
P
R
G
L
H
S
L
S
A
L
E
Q
L
Site 11
S91
P
R
G
L
H
S
L
S
A
L
E
Q
L
E
D
Site 12
Y102
Q
L
E
D
G
G
C
Y
L
C
S
D
K
K
P
Site 13
S105
D
G
G
C
Y
L
C
S
D
K
K
P
P
K
T
Site 14
T112
S
D
K
K
P
P
K
T
P
S
G
P
G
R
P
Site 15
S114
K
K
P
P
K
T
P
S
G
P
G
R
P
Q
E
Site 16
T125
R
P
Q
E
R
N
P
T
A
Q
Q
L
R
D
V
Site 17
T141
G
Q
R
E
A
P
G
T
S
S
S
R
K
S
L
Site 18
S142
Q
R
E
A
P
G
T
S
S
S
R
K
S
L
K
Site 19
S143
R
E
A
P
G
T
S
S
S
R
K
S
L
K
T
Site 20
S144
E
A
P
G
T
S
S
S
R
K
S
L
K
T
P
Site 21
S147
G
T
S
S
S
R
K
S
L
K
T
P
R
R
I
Site 22
T150
S
S
R
K
S
L
K
T
P
R
R
I
L
L
I
Site 23
T167
M
D
P
R
L
Q
Q
T
V
V
L
S
H
R
N
Site 24
S171
L
Q
Q
T
V
V
L
S
H
R
N
T
R
N
L
Site 25
Y197
R
F
P
V
K
Q
L
Y
T
T
S
G
K
K
V
Site 26
S206
T
S
G
K
K
V
D
S
L
Q
A
L
L
H
S
Site 27
T227
A
G
H
E
A
F
R
T
P
A
M
K
N
A
R
Site 28
S236
A
M
K
N
A
R
R
S
E
A
E
T
L
S
G
Site 29
T240
A
R
R
S
E
A
E
T
L
S
G
L
T
S
R
Site 30
S242
R
S
E
A
E
T
L
S
G
L
T
S
R
N
K
Site 31
S246
E
T
L
S
G
L
T
S
R
N
K
N
G
S
W
Site 32
S252
T
S
R
N
K
N
G
S
W
G
P
K
T
K
P
Site 33
T257
N
G
S
W
G
P
K
T
K
P
S
V
I
H
S
Site 34
S260
W
G
P
K
T
K
P
S
V
I
H
S
R
S
P
Site 35
S264
T
K
P
S
V
I
H
S
R
S
P
P
G
S
T
Site 36
S266
P
S
V
I
H
S
R
S
P
P
G
S
T
P
R
Site 37
S270
H
S
R
S
P
P
G
S
T
P
R
L
P
E
R
Site 38
T271
S
R
S
P
P
G
S
T
P
R
L
P
E
R
P
Site 39
S281
L
P
E
R
P
G
P
S
N
P
P
V
G
P
A
Site 40
T296
P
G
R
H
P
Q
D
T
P
A
Q
S
G
P
L
Site 41
S300
P
Q
D
T
P
A
Q
S
G
P
L
V
A
G
D
Site 42
S320
V
R
M
N
E
D
G
S
L
S
V
E
M
K
V
Site 43
S322
M
N
E
D
G
S
L
S
V
E
M
K
V
R
F
Site 44
T336
F
H
L
V
G
E
D
T
L
L
W
S
R
R
M
Site 45
S340
G
E
D
T
L
L
W
S
R
R
M
G
R
A
S
Site 46
S347
S
R
R
M
G
R
A
S
A
L
T
A
A
S
G
Site 47
T350
M
G
R
A
S
A
L
T
A
A
S
G
E
D
P
Site 48
Y405
G
G
Q
P
G
P
K
Y
E
I
W
T
N
P
L
Site 49
T442
S
G
L
W
G
H
G
T
A
G
R
E
R
C
S
Site 50
S449
T
A
G
R
E
R
C
S
Q
D
S
A
S
P
A
Site 51
S452
R
E
R
C
S
Q
D
S
A
S
P
A
S
S
T
Site 52
S454
R
C
S
Q
D
S
A
S
P
A
S
S
T
G
L
Site 53
S457
Q
D
S
A
S
P
A
S
S
T
G
L
P
E
G
Site 54
S458
D
S
A
S
P
A
S
S
T
G
L
P
E
G
S
Site 55
T459
S
A
S
P
A
S
S
T
G
L
P
E
G
S
E
Site 56
S465
S
T
G
L
P
E
G
S
E
P
E
S
S
C
C
Site 57
S469
P
E
G
S
E
P
E
S
S
C
C
P
R
T
P
Site 58
S470
E
G
S
E
P
E
S
S
C
C
P
R
T
P
E
Site 59
T475
E
S
S
C
C
P
R
T
P
E
D
G
V
D
S
Site 60
S482
T
P
E
D
G
V
D
S
A
S
P
S
A
Q
I
Site 61
S484
E
D
G
V
D
S
A
S
P
S
A
Q
I
G
A
Site 62
S486
G
V
D
S
A
S
P
S
A
Q
I
G
A
E
R
Site 63
S498
A
E
R
K
A
G
G
S
L
G
E
D
P
G
L
Site 64
T522
P
E
Q
G
G
R
L
T
P
R
A
R
S
E
E
Site 65
S527
R
L
T
P
R
A
R
S
E
E
G
A
S
S
D
Site 66
S532
A
R
S
E
E
G
A
S
S
D
S
S
A
S
T
Site 67
S533
R
S
E
E
G
A
S
S
D
S
S
A
S
T
G
Site 68
S535
E
E
G
A
S
S
D
S
S
A
S
T
G
S
H
Site 69
S536
E
G
A
S
S
D
S
S
A
S
T
G
S
H
E
Site 70
T539
S
S
D
S
S
A
S
T
G
S
H
E
G
S
S
Site 71
S541
D
S
S
A
S
T
G
S
H
E
G
S
S
E
W
Site 72
S545
S
T
G
S
H
E
G
S
S
E
W
G
G
R
P
Site 73
S546
T
G
S
H
E
G
S
S
E
W
G
G
R
P
Q
Site 74
T563
P
G
K
A
R
A
E
T
S
Q
Q
E
A
S
E
Site 75
S564
G
K
A
R
A
E
T
S
Q
Q
E
A
S
E
G
Site 76
S576
S
E
G
G
D
P
A
S
P
A
L
S
L
S
S
Site 77
S580
D
P
A
S
P
A
L
S
L
S
S
L
R
S
D
Site 78
S582
A
S
P
A
L
S
L
S
S
L
R
S
D
D
L
Site 79
S583
S
P
A
L
S
L
S
S
L
R
S
D
D
L
Q
Site 80
S586
L
S
L
S
S
L
R
S
D
D
L
Q
A
E
T
Site 81
S616
E
P
L
V
L
G
L
S
C
S
W
D
S
E
G
Site 82
S621
G
L
S
C
S
W
D
S
E
G
A
S
S
T
P
Site 83
S625
S
W
D
S
E
G
A
S
S
T
P
S
T
C
T
Site 84
S626
W
D
S
E
G
A
S
S
T
P
S
T
C
T
S
Site 85
T627
D
S
E
G
A
S
S
T
P
S
T
C
T
S
S
Site 86
S629
E
G
A
S
S
T
P
S
T
C
T
S
S
Q
Q
Site 87
T630
G
A
S
S
T
P
S
T
C
T
S
S
Q
Q
G
Site 88
S633
S
T
P
S
T
C
T
S
S
Q
Q
G
Q
R
R
Site 89
S634
T
P
S
T
C
T
S
S
Q
Q
G
Q
R
R
H
Site 90
S643
Q
G
Q
R
R
H
R
S
R
A
S
A
M
S
S
Site 91
S646
R
R
H
R
S
R
A
S
A
M
S
S
P
S
S
Site 92
S649
R
S
R
A
S
A
M
S
S
P
S
S
P
G
L
Site 93
S650
S
R
A
S
A
M
S
S
P
S
S
P
G
L
G
Site 94
S652
A
S
A
M
S
S
P
S
S
P
G
L
G
R
V
Site 95
S653
S
A
M
S
S
P
S
S
P
G
L
G
R
V
A
Site 96
S668
P
R
G
H
P
R
H
S
H
Y
R
K
D
T
H
Site 97
Y670
G
H
P
R
H
S
H
Y
R
K
D
T
H
S
P
Site 98
T674
H
S
H
Y
R
K
D
T
H
S
P
L
D
S
S
Site 99
S676
H
Y
R
K
D
T
H
S
P
L
D
S
S
V
T
Site 100
S680
D
T
H
S
P
L
D
S
S
V
T
K
Q
V
P
Site 101
S681
T
H
S
P
L
D
S
S
V
T
K
Q
V
P
R
Site 102
S700
R
R
A
C
Q
D
G
S
V
P
R
Y
S
G
S
Site 103
Y704
Q
D
G
S
V
P
R
Y
S
G
S
S
S
S
T
Site 104
S705
D
G
S
V
P
R
Y
S
G
S
S
S
S
T
R
Site 105
S707
S
V
P
R
Y
S
G
S
S
S
S
T
R
T
Q
Site 106
S708
V
P
R
Y
S
G
S
S
S
S
T
R
T
Q
A
Site 107
S709
P
R
Y
S
G
S
S
S
S
T
R
T
Q
A
S
Site 108
S710
R
Y
S
G
S
S
S
S
T
R
T
Q
A
S
G
Site 109
T711
Y
S
G
S
S
S
S
T
R
T
Q
A
S
G
N
Site 110
T713
G
S
S
S
S
T
R
T
Q
A
S
G
N
L
R
Site 111
S716
S
S
T
R
T
Q
A
S
G
N
L
R
P
P
S
Site 112
S723
S
G
N
L
R
P
P
S
S
G
S
L
P
S
Q
Site 113
S724
G
N
L
R
P
P
S
S
G
S
L
P
S
Q
D
Site 114
S726
L
R
P
P
S
S
G
S
L
P
S
Q
D
L
L
Site 115
S729
P
S
S
G
S
L
P
S
Q
D
L
L
G
T
S
Site 116
T741
G
T
S
S
A
T
V
T
P
A
V
H
S
D
F
Site 117
S750
A
V
H
S
D
F
V
S
G
V
S
P
H
N
A
Site 118
S753
S
D
F
V
S
G
V
S
P
H
N
A
P
S
A
Site 119
S759
V
S
P
H
N
A
P
S
A
G
W
A
G
D
A
Site 120
S768
G
W
A
G
D
A
G
S
R
T
C
S
P
A
P
Site 121
T770
A
G
D
A
G
S
R
T
C
S
P
A
P
I
P
Site 122
S772
D
A
G
S
R
T
C
S
P
A
P
I
P
P
H
Site 123
T780
P
A
P
I
P
P
H
T
S
D
S
C
S
K
S
Site 124
S781
A
P
I
P
P
H
T
S
D
S
C
S
K
S
G
Site 125
S783
I
P
P
H
T
S
D
S
C
S
K
S
G
A
A
Site 126
S785
P
H
T
S
D
S
C
S
K
S
G
A
A
S
P
Site 127
S787
T
S
D
S
C
S
K
S
G
A
A
S
P
G
E
Site 128
S791
C
S
K
S
G
A
A
S
P
G
E
E
A
R
D
Site 129
T799
P
G
E
E
A
R
D
T
P
Q
P
S
S
P
L
Site 130
S803
A
R
D
T
P
Q
P
S
S
P
L
V
L
Q
V
Site 131
S804
R
D
T
P
Q
P
S
S
P
L
V
L
Q
V
G
Site 132
S823
G
A
V
G
P
H
R
S
H
C
C
S
Q
P
G
Site 133
S827
P
H
R
S
H
C
C
S
Q
P
G
T
Q
P
A
Site 134
T831
H
C
C
S
Q
P
G
T
Q
P
A
Q
E
A
Q
Site 135
S842
Q
E
A
Q
R
G
P
S
P
E
A
S
W
L
C
Site 136
S846
R
G
P
S
P
E
A
S
W
L
C
G
R
Y
C
Site 137
T855
L
C
G
R
Y
C
P
T
P
P
R
G
R
P
C
Site 138
S867
R
P
C
P
Q
R
R
S
S
S
C
G
S
T
G
Site 139
S868
P
C
P
Q
R
R
S
S
S
C
G
S
T
G
S
Site 140
S869
C
P
Q
R
R
S
S
S
C
G
S
T
G
S
S
Site 141
S872
R
R
S
S
S
C
G
S
T
G
S
S
H
Q
S
Site 142
T873
R
S
S
S
C
G
S
T
G
S
S
H
Q
S
T
Site 143
S875
S
S
C
G
S
T
G
S
S
H
Q
S
T
A
R
Site 144
S876
S
C
G
S
T
G
S
S
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L
G
S
L
A
P
T
E
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation