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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIM59
Full Name:
Tripartite motif-containing protein 59
Alias:
MRF1; RNF104; TRI59; TRIM57; tripartite motif-containing 57; tripartite motif-containing 59; TSBF1; tumor suppressor TSBF1
Type:
Unknown function
Mass (Da):
47114
Number AA:
403
UniProt ID:
Q8IWR1
International Prot ID:
IPI00432462
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
R
V
L
P
C
S
H
T
F
C
R
N
C
L
E
Site 2
Y45
L
Q
A
S
G
N
F
Y
I
W
R
P
L
R
I
Site 3
Y86
L
R
A
I
I
E
K
Y
Q
Q
E
D
H
P
D
Site 4
T96
E
D
H
P
D
I
V
T
C
P
E
H
Y
R
Q
Site 5
Y101
I
V
T
C
P
E
H
Y
R
Q
P
L
N
V
Y
Site 6
S136
H
P
I
D
D
L
Q
S
A
Y
L
K
E
K
D
Site 7
T144
A
Y
L
K
E
K
D
T
P
Q
K
L
L
E
Q
Site 8
T153
Q
K
L
L
E
Q
L
T
D
T
H
W
T
D
L
Site 9
T155
L
L
E
Q
L
T
D
T
H
W
T
D
L
T
H
Site 10
T161
D
T
H
W
T
D
L
T
H
L
I
E
K
L
K
Site 11
S172
E
K
L
K
E
Q
K
S
H
S
E
K
M
I
Q
Site 12
S174
L
K
E
Q
K
S
H
S
E
K
M
I
Q
G
D
Site 13
T195
Y
F
K
E
L
N
D
T
L
E
Q
K
K
K
S
Site 14
S202
T
L
E
Q
K
K
K
S
F
L
T
A
L
C
D
Site 15
Y218
G
N
L
I
N
Q
E
Y
T
P
Q
I
E
R
M
Site 16
T219
N
L
I
N
Q
E
Y
T
P
Q
I
E
R
M
K
Site 17
S246
T
I
S
L
Q
E
E
S
P
L
K
F
L
E
K
Site 18
Y278
E
V
Q
P
V
E
I
Y
P
R
V
S
K
I
L
Site 19
S282
V
E
I
Y
P
R
V
S
K
I
L
K
E
E
W
Site 20
S290
K
I
L
K
E
E
W
S
R
T
E
I
G
Q
I
Site 21
T292
L
K
E
E
W
S
R
T
E
I
G
Q
I
K
N
Site 22
S308
L
I
P
K
M
K
I
S
P
K
R
M
S
C
S
Site 23
S313
K
I
S
P
K
R
M
S
C
S
W
P
G
K
D
Site 24
S315
S
P
K
R
M
S
C
S
W
P
G
K
D
E
K
Site 25
S370
W
F
S
E
A
S
L
S
V
Y
Q
S
L
S
N
Site 26
Y372
S
E
A
S
L
S
V
Y
Q
S
L
S
N
S
L
Site 27
S374
A
S
L
S
V
Y
Q
S
L
S
N
S
L
H
K
Site 28
S376
L
S
V
Y
Q
S
L
S
N
S
L
H
K
V
K
Site 29
S378
V
Y
Q
S
L
S
N
S
L
H
K
V
K
N
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation