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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC8A
Full Name:
Leucine-rich repeat-containing protein 8A
Alias:
Type:
Uncharacterized protein
Mass (Da):
94199
Number AA:
810
UniProt ID:
Q8IWT6
International Prot ID:
IPI00002070
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0002329
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
I
P
V
T
E
L
R
Y
F
A
D
T
Q
P
A
Site 2
T13
E
L
R
Y
F
A
D
T
Q
P
A
Y
R
I
L
Site 3
Y17
F
A
D
T
Q
P
A
Y
R
I
L
K
P
W
W
Site 4
S64
C
K
W
V
T
K
D
S
C
N
D
S
F
R
G
Site 5
S68
T
K
D
S
C
N
D
S
F
R
G
W
A
A
P
Site 6
T80
A
A
P
G
P
E
P
T
Y
P
N
S
T
I
L
Site 7
Y81
A
P
G
P
E
P
T
Y
P
N
S
T
I
L
P
Site 8
S84
P
E
P
T
Y
P
N
S
T
I
L
P
T
P
D
Site 9
T85
E
P
T
Y
P
N
S
T
I
L
P
T
P
D
T
Site 10
T89
P
N
S
T
I
L
P
T
P
D
T
G
P
T
G
Site 11
T92
T
I
L
P
T
P
D
T
G
P
T
G
I
K
Y
Site 12
Y99
T
G
P
T
G
I
K
Y
D
L
D
R
H
Q
Y
Site 13
Y106
Y
D
L
D
R
H
Q
Y
N
Y
V
D
A
V
C
Site 14
Y108
L
D
R
H
Q
Y
N
Y
V
D
A
V
C
Y
E
Site 15
T149
F
W
F
K
F
P
R
T
S
S
K
L
E
H
F
Site 16
S150
W
F
K
F
P
R
T
S
S
K
L
E
H
F
V
Site 17
S151
F
K
F
P
R
T
S
S
K
L
E
H
F
V
S
Site 18
T169
K
C
F
D
S
P
W
T
T
R
A
L
S
E
T
Site 19
T170
C
F
D
S
P
W
T
T
R
A
L
S
E
T
V
Site 20
S174
P
W
T
T
R
A
L
S
E
T
V
V
E
E
S
Site 21
T176
T
T
R
A
L
S
E
T
V
V
E
E
S
D
P
Site 22
S181
S
E
T
V
V
E
E
S
D
P
K
P
A
F
S
Site 23
S188
S
D
P
K
P
A
F
S
K
M
N
G
S
M
D
Site 24
S193
A
F
S
K
M
N
G
S
M
D
K
K
S
S
T
Site 25
S198
N
G
S
M
D
K
K
S
S
T
V
S
E
D
V
Site 26
S199
G
S
M
D
K
K
S
S
T
V
S
E
D
V
E
Site 27
T200
S
M
D
K
K
S
S
T
V
S
E
D
V
E
A
Site 28
S202
D
K
K
S
S
T
V
S
E
D
V
E
A
T
V
Site 29
T208
V
S
E
D
V
E
A
T
V
P
M
L
Q
R
T
Site 30
T215
T
V
P
M
L
Q
R
T
K
S
R
I
E
Q
G
Site 31
S217
P
M
L
Q
R
T
K
S
R
I
E
Q
G
I
V
Site 32
S227
E
Q
G
I
V
D
R
S
E
T
G
V
L
D
K
Site 33
T229
G
I
V
D
R
S
E
T
G
V
L
D
K
K
E
Site 34
Y261
V
E
E
G
D
I
V
Y
R
L
Y
M
R
Q
T
Site 35
Y264
G
D
I
V
Y
R
L
Y
M
R
Q
T
I
I
K
Site 36
S301
D
C
T
V
D
I
E
S
L
T
G
Y
R
T
Y
Site 37
T303
T
V
D
I
E
S
L
T
G
Y
R
T
Y
R
C
Site 38
Y305
D
I
E
S
L
T
G
Y
R
T
Y
R
C
A
H
Site 39
T307
E
S
L
T
G
Y
R
T
Y
R
C
A
H
P
L
Site 40
Y308
S
L
T
G
Y
R
T
Y
R
C
A
H
P
L
A
Site 41
Y351
L
R
R
S
L
K
K
Y
S
F
E
S
I
R
E
Site 42
S352
R
R
S
L
K
K
Y
S
F
E
S
I
R
E
E
Site 43
S355
L
K
K
Y
S
F
E
S
I
R
E
E
S
S
Y
Site 44
S360
F
E
S
I
R
E
E
S
S
Y
S
D
I
P
D
Site 45
S361
E
S
I
R
E
E
S
S
Y
S
D
I
P
D
V
Site 46
Y362
S
I
R
E
E
S
S
Y
S
D
I
P
D
V
K
Site 47
S363
I
R
E
E
S
S
Y
S
D
I
P
D
V
K
N
Site 48
Y382
M
L
H
L
I
D
Q
Y
D
P
L
Y
S
K
R
Site 49
Y386
I
D
Q
Y
D
P
L
Y
S
K
R
F
A
V
F
Site 50
S387
D
Q
Y
D
P
L
Y
S
K
R
F
A
V
F
L
Site 51
S395
K
R
F
A
V
F
L
S
E
V
S
E
N
K
L
Site 52
T412
L
N
L
N
N
E
W
T
L
D
K
L
R
Q
R
Site 53
T421
D
K
L
R
Q
R
L
T
K
N
A
Q
D
K
L
Site 54
Y477
G
L
K
E
L
W
L
Y
H
T
A
A
K
I
E
Site 55
T524
T
L
E
E
L
H
L
T
G
N
L
S
A
E
N
Site 56
S528
L
H
L
T
G
N
L
S
A
E
N
N
R
Y
I
Site 57
Y534
L
S
A
E
N
N
R
Y
I
V
I
D
G
L
R
Site 58
S553
L
K
V
L
R
L
K
S
N
L
S
K
L
P
Q
Site 59
S556
L
R
L
K
S
N
L
S
K
L
P
Q
V
V
T
Site 60
S573
G
V
H
L
Q
K
L
S
I
N
N
E
G
T
K
Site 61
S609
D
L
E
R
I
P
H
S
I
F
S
L
H
N
L
Site 62
S612
R
I
P
H
S
I
F
S
L
H
N
L
Q
E
I
Site 63
T628
L
K
D
N
N
L
K
T
I
E
E
I
I
S
F
Site 64
S634
K
T
I
E
E
I
I
S
F
Q
H
L
H
R
L
Site 65
Y648
L
T
C
L
K
L
W
Y
N
H
I
A
Y
I
P
Site 66
Y653
L
W
Y
N
H
I
A
Y
I
P
I
Q
I
G
N
Site 67
Y668
L
T
N
L
E
R
L
Y
L
N
R
N
K
I
E
Site 68
T679
N
K
I
E
K
I
P
T
Q
L
F
Y
C
R
K
Site 69
Y683
K
I
P
T
Q
L
F
Y
C
R
K
L
R
Y
L
Site 70
Y689
F
Y
C
R
K
L
R
Y
L
D
L
S
H
N
N
Site 71
S693
K
L
R
Y
L
D
L
S
H
N
N
L
T
F
L
Site 72
T698
D
L
S
H
N
N
L
T
F
L
P
A
D
I
G
Site 73
T722
I
T
A
N
R
I
E
T
L
P
P
E
L
F
Q
Site 74
S745
L
G
N
N
V
L
Q
S
L
P
S
R
V
G
E
Site 75
S748
N
V
L
Q
S
L
P
S
R
V
G
E
L
T
N
Site 76
T754
P
S
R
V
G
E
L
T
N
L
T
Q
I
E
L
Site 77
T793
V
E
E
D
L
F
N
T
L
P
P
E
V
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation