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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SULF2
Full Name:
Extracellular sulfatase Sulf-2
Alias:
extracellular sulfatase Sulf-2; HSULF-2; KIAA1247; SULF-2; sulfatase 2
Type:
Hydrolase; EC 3.1.6.-
Mass (Da):
100450
Number AA:
UniProt ID:
Q8IWU5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005795
GO:0009986
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0004065
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0030201
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
V
L
C
L
L
S
A
T
V
F
S
L
L
G
G
Site 2
S27
G
G
S
S
A
F
L
S
H
H
R
L
K
G
R
Site 3
T67
S
M
Q
V
M
N
K
T
R
R
I
M
E
Q
G
Site 4
S91
T
T
P
M
C
C
P
S
R
S
S
I
L
T
G
Site 5
S93
P
M
C
C
P
S
R
S
S
I
L
T
G
K
Y
Site 6
T97
P
S
R
S
S
I
L
T
G
K
Y
V
H
N
H
Site 7
Y100
S
S
I
L
T
G
K
Y
V
H
N
H
N
T
Y
Site 8
T126
Q
A
Q
H
E
S
R
T
F
A
V
Y
L
N
S
Site 9
Y130
E
S
R
T
F
A
V
Y
L
N
S
T
G
Y
R
Site 10
Y136
V
Y
L
N
S
T
G
Y
R
T
A
F
F
G
K
Site 11
Y144
R
T
A
F
F
G
K
Y
L
N
E
Y
N
G
S
Site 12
Y148
F
G
K
Y
L
N
E
Y
N
G
S
Y
V
P
P
Site 13
Y152
L
N
E
Y
N
G
S
Y
V
P
P
G
W
K
E
Site 14
Y170
L
L
K
N
S
R
F
Y
N
Y
T
L
C
R
N
Site 15
S185
G
V
K
E
K
H
G
S
D
Y
S
K
D
Y
L
Site 16
Y187
K
E
K
H
G
S
D
Y
S
K
D
Y
L
T
D
Site 17
S188
E
K
H
G
S
D
Y
S
K
D
Y
L
T
D
L
Site 18
Y191
G
S
D
Y
S
K
D
Y
L
T
D
L
I
T
N
Site 19
T193
D
Y
S
K
D
Y
L
T
D
L
I
T
N
D
S
Site 20
S200
T
D
L
I
T
N
D
S
V
S
F
F
R
T
S
Site 21
S202
L
I
T
N
D
S
V
S
F
F
R
T
S
K
K
Site 22
T206
D
S
V
S
F
F
R
T
S
K
K
M
Y
P
H
Site 23
S207
S
V
S
F
F
R
T
S
K
K
M
Y
P
H
R
Site 24
Y211
F
R
T
S
K
K
M
Y
P
H
R
P
V
L
M
Site 25
S231
A
P
H
G
P
E
D
S
A
P
Q
Y
S
R
L
Site 26
Y235
P
E
D
S
A
P
Q
Y
S
R
L
F
P
N
A
Site 27
S243
S
R
L
F
P
N
A
S
Q
H
I
T
P
S
Y
Site 28
T247
P
N
A
S
Q
H
I
T
P
S
Y
N
Y
A
P
Site 29
S249
A
S
Q
H
I
T
P
S
Y
N
Y
A
P
N
P
Site 30
Y250
S
Q
H
I
T
P
S
Y
N
Y
A
P
N
P
D
Site 31
T286
L
Q
R
K
R
L
Q
T
L
M
S
V
D
D
S
Site 32
S289
K
R
L
Q
T
L
M
S
V
D
D
S
M
E
T
Site 33
Y298
D
D
S
M
E
T
I
Y
N
M
L
V
E
T
G
Site 34
T310
E
T
G
E
L
D
N
T
Y
I
V
Y
T
A
D
Site 35
Y311
T
G
E
L
D
N
T
Y
I
V
Y
T
A
D
H
Site 36
Y314
L
D
N
T
Y
I
V
Y
T
A
D
H
G
Y
H
Site 37
Y320
V
Y
T
A
D
H
G
Y
H
I
G
Q
F
G
L
Site 38
S332
F
G
L
V
K
G
K
S
M
P
Y
E
F
D
I
Site 39
Y344
F
D
I
R
V
P
F
Y
V
R
G
P
N
V
E
Site 40
S385
P
A
D
M
D
G
K
S
I
L
K
L
L
D
T
Site 41
T392
S
I
L
K
L
L
D
T
E
R
P
V
N
R
F
Site 42
S411
K
M
R
V
W
R
D
S
F
L
V
E
R
G
K
Site 43
Y439
E
E
N
F
L
P
K
Y
Q
R
V
K
D
L
C
Site 44
Y451
D
L
C
Q
R
A
E
Y
Q
T
A
C
E
Q
L
Site 45
T469
W
Q
C
V
E
D
A
T
G
K
L
K
L
H
K
Site 46
S490
L
G
G
S
R
A
L
S
N
L
V
P
K
Y
Y
Site 47
Y496
L
S
N
L
V
P
K
Y
Y
G
Q
G
S
E
A
Site 48
Y497
S
N
L
V
P
K
Y
Y
G
Q
G
S
E
A
C
Site 49
S501
P
K
Y
Y
G
Q
G
S
E
A
C
T
C
D
S
Site 50
T505
G
Q
G
S
E
A
C
T
C
D
S
G
D
Y
K
Site 51
S508
S
E
A
C
T
C
D
S
G
D
Y
K
L
S
L
Site 52
Y511
C
T
C
D
S
G
D
Y
K
L
S
L
A
G
R
Site 53
S514
D
S
G
D
Y
K
L
S
L
A
G
R
R
K
K
Site 54
Y527
K
K
L
F
K
K
K
Y
K
A
S
Y
V
R
S
Site 55
S530
F
K
K
K
Y
K
A
S
Y
V
R
S
R
S
I
Site 56
Y531
K
K
K
Y
K
A
S
Y
V
R
S
R
S
I
R
Site 57
S534
Y
K
A
S
Y
V
R
S
R
S
I
R
S
V
A
Site 58
S536
A
S
Y
V
R
S
R
S
I
R
S
V
A
I
E
Site 59
S539
V
R
S
R
S
I
R
S
V
A
I
E
V
D
G
Site 60
T563
A
A
Q
P
R
N
L
T
K
R
H
W
P
G
A
Site 61
S583
D
K
D
G
G
D
F
S
G
T
G
G
L
P
D
Site 62
Y591
G
T
G
G
L
P
D
Y
S
A
A
N
P
I
K
Site 63
S592
T
G
G
L
P
D
Y
S
A
A
N
P
I
K
V
Site 64
Y604
I
K
V
T
H
R
C
Y
I
L
E
N
D
T
V
Site 65
Y618
V
Q
C
D
L
D
L
Y
K
S
L
Q
A
W
K
Site 66
S680
G
R
L
K
H
R
G
S
S
L
H
P
F
R
K
Site 67
S681
R
L
K
H
R
G
S
S
L
H
P
F
R
K
G
Site 68
T719
K
R
L
Q
N
N
D
T
C
S
M
P
G
L
T
Site 69
Y781
F
A
T
G
F
L
E
Y
F
D
L
N
T
D
P
Site 70
Y789
F
D
L
N
T
D
P
Y
Q
L
M
N
A
V
N
Site 71
Y819
E
L
R
S
C
K
G
Y
K
Q
C
N
P
R
T
Site 72
S838
L
G
L
K
D
G
G
S
Y
E
Q
Y
R
Q
F
Site 73
Y842
D
G
G
S
Y
E
Q
Y
R
Q
F
Q
R
R
K
Site 74
S857
W
P
E
M
K
R
P
S
S
K
S
L
G
Q
L
Site 75
S858
P
E
M
K
R
P
S
S
K
S
L
G
Q
L
W
Site 76
S860
M
K
R
P
S
S
K
S
L
G
Q
L
W
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation