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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBR1
Full Name:
E3 ubiquitin-protein ligase UBR1
Alias:
Ubiquitin ligase E3 alpha-I; ubiquitin protein ligase E3 component n-recognin 1
Type:
EC 6.3.2.-; Ligase; Ubiquitin ligase; Ubiquitin conjugating system
Mass (Da):
200211
Number AA:
1749
UniProt ID:
Q8IWV7
International Prot ID:
IPI00217405
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
D
E
E
A
G
G
T
E
R
M
E
I
S
A
Site 2
S15
G
T
E
R
M
E
I
S
A
E
L
P
Q
T
P
Site 3
T21
I
S
A
E
L
P
Q
T
P
Q
R
L
A
S
W
Site 4
Y36
W
D
Q
Q
V
D
F
Y
T
A
F
L
H
H
L
Site 5
Y51
A
Q
L
V
P
E
I
Y
F
A
E
M
D
P
D
Site 6
S65
D
L
E
K
Q
E
E
S
V
Q
M
S
I
F
T
Site 7
S69
Q
E
E
S
V
Q
M
S
I
F
T
P
L
E
W
Site 8
Y77
I
F
T
P
L
E
W
Y
L
F
G
E
D
P
D
Site 9
S105
L
C
G
R
V
F
K
S
G
E
T
T
Y
S
C
Site 10
T109
V
F
K
S
G
E
T
T
Y
S
C
R
D
C
A
Site 11
S111
K
S
G
E
T
T
Y
S
C
R
D
C
A
I
D
Site 12
Y138
S
V
H
K
N
H
R
Y
K
M
H
T
S
T
G
Site 13
T142
N
H
R
Y
K
M
H
T
S
T
G
G
G
F
C
Site 14
T173
H
E
P
G
R
A
G
T
I
K
E
N
S
R
C
Site 15
S178
A
G
T
I
K
E
N
S
R
C
P
L
N
E
E
Site 16
Y226
I
R
E
K
N
E
R
Y
Y
C
V
L
F
N
D
Site 17
Y227
R
E
K
N
E
R
Y
Y
C
V
L
F
N
D
E
Site 18
Y238
F
N
D
E
H
H
S
Y
D
H
V
I
Y
S
L
Site 19
S288
E
A
K
E
D
I
K
S
H
S
E
N
V
S
Q
Site 20
S290
K
E
D
I
K
S
H
S
E
N
V
S
Q
H
P
Site 21
S294
K
S
H
S
E
N
V
S
Q
H
P
L
H
V
E
Site 22
S319
K
F
A
L
R
L
G
S
W
M
N
K
I
M
S
Site 23
S346
C
L
R
E
E
P
D
S
E
N
P
C
L
I
S
Site 24
Y384
S
F
F
M
E
M
E
Y
K
K
L
F
A
M
E
Site 25
Y395
F
A
M
E
F
V
K
Y
Y
K
Q
L
Q
K
E
Site 26
S405
Q
L
Q
K
E
Y
I
S
D
D
H
D
R
S
I
Site 27
S411
I
S
D
D
H
D
R
S
I
S
I
T
A
L
S
Site 28
S413
D
D
H
D
R
S
I
S
I
T
A
L
S
V
Q
Site 29
T423
A
L
S
V
Q
M
F
T
V
P
T
L
A
R
H
Site 30
T426
V
Q
M
F
T
V
P
T
L
A
R
H
L
I
E
Site 31
Y452
L
L
E
V
L
P
E
Y
L
D
R
N
N
K
F
Site 32
S465
K
F
N
F
Q
G
Y
S
Q
D
K
L
G
R
V
Site 33
Y473
Q
D
K
L
G
R
V
Y
A
V
I
C
D
L
K
Site 34
S575
H
K
A
V
M
R
C
S
T
S
F
I
S
S
S
Site 35
T576
K
A
V
M
R
C
S
T
S
F
I
S
S
S
K
Site 36
S577
A
V
M
R
C
S
T
S
F
I
S
S
S
K
T
Site 37
S580
R
C
S
T
S
F
I
S
S
S
K
T
V
V
Q
Site 38
S581
C
S
T
S
F
I
S
S
S
K
T
V
V
Q
S
Site 39
S582
S
T
S
F
I
S
S
S
K
T
V
V
Q
S
C
Site 40
T584
S
F
I
S
S
S
K
T
V
V
Q
S
C
G
H
Site 41
S588
S
S
K
T
V
V
Q
S
C
G
H
S
L
E
T
Site 42
S592
V
V
Q
S
C
G
H
S
L
E
T
K
S
Y
R
Site 43
S597
G
H
S
L
E
T
K
S
Y
R
V
S
E
D
L
Site 44
Y598
H
S
L
E
T
K
S
Y
R
V
S
E
D
L
V
Site 45
S601
E
T
K
S
Y
R
V
S
E
D
L
V
S
I
H
Site 46
S606
R
V
S
E
D
L
V
S
I
H
L
P
L
S
R
Site 47
S636
S
R
L
H
E
F
V
S
F
E
D
F
Q
V
E
Site 48
S673
R
N
G
L
S
L
I
S
Q
V
F
Y
Y
Q
D
Site 49
Y677
S
L
I
S
Q
V
F
Y
Y
Q
D
V
K
C
R
Site 50
Y678
L
I
S
Q
V
F
Y
Y
Q
D
V
K
C
R
E
Site 51
Y688
V
K
C
R
E
E
M
Y
D
K
D
I
I
M
L
Site 52
S784
C
I
E
P
M
P
H
S
A
I
A
K
N
L
P
Site 53
T798
P
E
N
E
N
N
E
T
G
L
E
N
V
I
N
Site 54
T809
N
V
I
N
K
V
A
T
F
K
K
P
G
V
S
Site 55
Y834
S
L
K
D
F
N
M
Y
F
Y
H
Y
S
K
T
Site 56
T901
V
F
E
R
A
I
D
T
D
S
N
L
W
T
E
Site 57
S903
E
R
A
I
D
T
D
S
N
L
W
T
E
G
M
Site 58
T938
K
A
P
E
E
E
V
T
F
D
F
Y
H
K
A
Site 59
Y942
E
E
V
T
F
D
F
Y
H
K
A
S
R
L
G
Site 60
S946
F
D
F
Y
H
K
A
S
R
L
G
S
S
A
M
Site 61
S950
H
K
A
S
R
L
G
S
S
A
M
N
I
Q
M
Site 62
T984
W
I
L
Q
M
F
D
T
V
K
R
L
R
E
K
Site 63
S1004
A
T
T
S
G
S
E
S
I
K
N
D
E
I
T
Site 64
T1011
S
I
K
N
D
E
I
T
H
D
K
E
K
A
E
Site 65
Y1052
I
E
T
H
K
L
M
Y
D
N
T
S
E
M
P
Site 66
T1055
H
K
L
M
Y
D
N
T
S
E
M
P
G
K
E
Site 67
S1056
K
L
M
Y
D
N
T
S
E
M
P
G
K
E
D
Site 68
S1064
E
M
P
G
K
E
D
S
I
M
E
E
E
S
T
Site 69
S1070
D
S
I
M
E
E
E
S
T
P
A
V
S
D
Y
Site 70
T1071
S
I
M
E
E
E
S
T
P
A
V
S
D
Y
S
Site 71
S1075
E
E
S
T
P
A
V
S
D
Y
S
R
I
A
L
Site 72
Y1077
S
T
P
A
V
S
D
Y
S
R
I
A
L
G
P
Site 73
S1089
L
G
P
K
R
G
P
S
V
T
E
K
E
V
L
Site 74
T1091
P
K
R
G
P
S
V
T
E
K
E
V
L
T
C
Site 75
S1117
E
N
N
A
M
V
L
S
A
C
V
Q
K
S
T
Site 76
S1123
L
S
A
C
V
Q
K
S
T
A
L
T
Q
H
R
Site 77
T1127
V
Q
K
S
T
A
L
T
Q
H
R
G
K
P
I
Site 78
Y1152
F
M
D
P
D
L
A
Y
G
T
Y
T
G
S
C
Site 79
T1154
D
P
D
L
A
Y
G
T
Y
T
G
S
C
G
H
Site 80
Y1155
P
D
L
A
Y
G
T
Y
T
G
S
C
G
H
V
Site 81
Y1171
H
A
V
C
W
Q
K
Y
F
E
A
V
Q
L
S
Site 82
S1178
Y
F
E
A
V
Q
L
S
S
Q
Q
R
I
H
V
Site 83
S1179
F
E
A
V
Q
L
S
S
Q
Q
R
I
H
V
D
Site 84
Y1195
F
D
L
E
S
G
E
Y
L
C
P
L
C
K
S
Site 85
S1244
Q
T
V
L
A
R
I
S
G
Y
N
I
R
H
A
Site 86
S1268
F
N
Q
G
M
G
D
S
T
L
E
F
H
S
I
Site 87
T1269
N
Q
G
M
G
D
S
T
L
E
F
H
S
I
L
Site 88
S1283
L
S
F
G
V
E
S
S
I
K
Y
S
N
S
I
Site 89
Y1286
G
V
E
S
S
I
K
Y
S
N
S
I
K
E
M
Site 90
S1287
V
E
S
S
I
K
Y
S
N
S
I
K
E
M
V
Site 91
Y1302
I
L
F
A
T
T
I
Y
R
I
G
L
K
V
P
Site 92
T1394
P
N
I
K
S
E
D
T
P
C
L
L
S
I
D
Site 93
S1427
D
P
V
D
L
Q
P
S
S
V
S
S
S
Y
N
Site 94
S1428
P
V
D
L
Q
P
S
S
V
S
S
S
Y
N
H
Site 95
S1430
D
L
Q
P
S
S
V
S
S
S
Y
N
H
L
Y
Site 96
S1431
L
Q
P
S
S
V
S
S
S
Y
N
H
L
Y
L
Site 97
S1432
Q
P
S
S
V
S
S
S
Y
N
H
L
Y
L
F
Site 98
S1467
L
A
Q
V
Q
E
D
S
E
E
A
H
S
A
S
Site 99
S1472
E
D
S
E
E
A
H
S
A
S
S
F
F
A
E
Site 100
S1475
E
E
A
H
S
A
S
S
F
F
A
E
I
S
Q
Site 101
S1481
S
S
F
F
A
E
I
S
Q
Y
T
S
G
S
I
Site 102
S1485
A
E
I
S
Q
Y
T
S
G
S
I
G
C
D
I
Site 103
S1487
I
S
Q
Y
T
S
G
S
I
G
C
D
I
P
G
Site 104
T1523
F
H
Y
L
L
G
V
T
P
P
E
E
L
H
T
Site 105
T1530
T
P
P
E
E
L
H
T
N
S
A
E
G
E
Y
Site 106
S1538
N
S
A
E
G
E
Y
S
A
L
C
S
Y
L
S
Site 107
S1542
G
E
Y
S
A
L
C
S
Y
L
S
L
P
T
N
Site 108
T1560
L
F
Q
E
Y
W
D
T
V
R
P
L
L
Q
R
Site 109
T1583
N
C
L
K
Q
K
N
T
V
V
R
Y
P
R
K
Site 110
Y1587
Q
K
N
T
V
V
R
Y
P
R
K
R
N
S
L
Site 111
S1593
R
Y
P
R
K
R
N
S
L
I
E
L
P
D
D
Site 112
S1602
I
E
L
P
D
D
Y
S
C
L
L
N
Q
A
S
Site 113
S1609
S
C
L
L
N
Q
A
S
H
F
R
C
P
R
S
Site 114
S1616
S
H
F
R
C
P
R
S
A
D
D
E
R
K
H
Site 115
Y1687
G
K
A
R
G
C
A
Y
P
A
P
Y
L
D
E
Site 116
Y1691
G
C
A
Y
P
A
P
Y
L
D
E
Y
G
E
T
Site 117
Y1695
P
A
P
Y
L
D
E
Y
G
E
T
D
P
G
L
Site 118
T1698
Y
L
D
E
Y
G
E
T
D
P
G
L
K
R
G
Site 119
S1711
R
G
N
P
L
H
L
S
R
E
R
Y
R
K
L
Site 120
Y1715
L
H
L
S
R
E
R
Y
R
K
L
H
L
V
W
Site 121
S1734
I
I
E
E
I
A
R
S
Q
E
T
N
Q
M
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation