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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBR2
Full Name:
E3 ubiquitin-protein ligase UBR2
Alias:
EC 6.3.2.-
Type:
Ubiquitin ligase complex, Nucleus protein
Mass (Da):
200538
Number AA:
1755
UniProt ID:
Q8IWV8
International Prot ID:
IPI00640085
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
V
Q
A
I
D
R
S
L
L
E
C
S
A
E
Site 2
T35
W
L
Q
A
T
D
L
T
R
E
V
Y
Q
H
L
Site 3
Y39
T
D
L
T
R
E
V
Y
Q
H
L
A
H
Y
V
Site 4
Y45
V
Y
Q
H
L
A
H
Y
V
P
K
I
Y
C
R
Site 5
Y50
A
H
Y
V
P
K
I
Y
C
R
G
P
N
P
F
Site 6
Y110
F
K
V
G
E
P
T
Y
S
C
R
D
C
A
V
Site 7
S111
K
V
G
E
P
T
Y
S
C
R
D
C
A
V
D
Site 8
Y138
S
I
H
R
D
H
R
Y
R
M
T
T
S
G
G
Site 9
T141
R
D
H
R
Y
R
M
T
T
S
G
G
G
G
F
Site 10
T142
D
H
R
Y
R
M
T
T
S
G
G
G
G
F
C
Site 11
S143
H
R
Y
R
M
T
T
S
G
G
G
G
F
C
D
Site 12
T154
G
F
C
D
C
G
D
T
E
A
W
K
E
G
P
Site 13
S171
Q
K
H
E
L
N
T
S
E
I
E
E
E
E
D
Site 14
S184
E
D
P
L
V
H
L
S
E
D
V
I
A
R
T
Site 15
T207
R
Y
A
V
E
I
L
T
W
E
K
E
S
E
L
Site 16
Y227
M
V
E
K
S
D
T
Y
Y
C
M
L
F
N
D
Site 17
Y228
V
E
K
S
D
T
Y
Y
C
M
L
F
N
D
E
Site 18
Y239
F
N
D
E
V
H
T
Y
E
Q
V
I
Y
T
L
Site 19
Y244
H
T
Y
E
Q
V
I
Y
T
L
Q
K
A
V
N
Site 20
T262
K
E
A
I
G
F
A
T
T
V
D
R
D
G
R
Site 21
T263
E
A
I
G
F
A
T
T
V
D
R
D
G
R
R
Site 22
S271
V
D
R
D
G
R
R
S
V
R
Y
G
D
F
Q
Site 23
Y274
D
G
R
R
S
V
R
Y
G
D
F
Q
Y
C
E
Site 24
Y279
V
R
Y
G
D
F
Q
Y
C
E
Q
A
K
S
V
Site 25
S285
Q
Y
C
E
Q
A
K
S
V
I
V
R
N
T
S
Site 26
T291
K
S
V
I
V
R
N
T
S
R
Q
T
K
P
L
Site 27
S292
S
V
I
V
R
N
T
S
R
Q
T
K
P
L
K
Site 28
T295
V
R
N
T
S
R
Q
T
K
P
L
K
V
Q
V
Site 29
S328
L
G
S
I
I
G
Y
S
D
G
L
R
R
I
L
Site 30
S350
G
P
D
G
E
N
S
S
L
V
D
R
L
M
L
Site 31
S358
L
V
D
R
L
M
L
S
D
S
K
L
W
K
G
Site 32
S360
D
R
L
M
L
S
D
S
K
L
W
K
G
A
R
Site 33
Y370
W
K
G
A
R
S
V
Y
H
Q
L
F
M
S
S
Site 34
Y396
A
V
R
F
A
K
N
Y
Q
Q
L
Q
R
D
F
Site 35
S413
D
D
H
E
R
A
V
S
V
T
A
L
S
V
Q
Site 36
T464
R
F
Q
F
E
R
Y
T
A
L
Q
A
F
K
F
Site 37
S476
F
K
F
R
R
V
Q
S
L
I
L
D
L
K
Y
Site 38
S493
I
S
K
P
T
E
W
S
D
E
L
R
Q
K
F
Site 39
T539
P
E
W
E
A
A
F
T
L
Q
M
K
L
T
H
Site 40
T588
T
D
G
E
Q
P
I
T
L
S
I
C
G
H
S
Site 41
S590
G
E
Q
P
I
T
L
S
I
C
G
H
S
V
E
Site 42
Y601
H
S
V
E
T
I
R
Y
C
V
S
Q
E
K
V
Site 43
S604
E
T
I
R
Y
C
V
S
Q
E
K
V
S
I
H
Site 44
Y632
L
S
K
S
E
V
A
Y
K
F
P
E
L
L
P
Site 45
Y679
F
S
L
V
N
Q
I
Y
Y
Y
H
N
V
K
C
Site 46
Y680
S
L
V
N
Q
I
Y
Y
Y
H
N
V
K
C
R
Site 47
Y681
L
V
N
Q
I
Y
Y
Y
H
N
V
K
C
R
R
Site 48
Y721
M
L
S
R
F
E
L
Y
Q
I
F
S
T
P
D
Site 49
S725
F
E
L
Y
Q
I
F
S
T
P
D
Y
G
K
R
Site 50
T726
E
L
Y
Q
I
F
S
T
P
D
Y
G
K
R
F
Site 51
Y729
Q
I
F
S
T
P
D
Y
G
K
R
F
S
S
E
Site 52
S734
P
D
Y
G
K
R
F
S
S
E
I
T
H
K
D
Site 53
S735
D
Y
G
K
R
F
S
S
E
I
T
H
K
D
V
Site 54
S787
R
E
I
I
H
Q
L
S
I
K
P
M
A
H
S
Site 55
S794
S
I
K
P
M
A
H
S
E
L
V
K
S
L
P
Site 56
S799
A
H
S
E
L
V
K
S
L
P
E
D
E
N
K
Site 57
T808
P
E
D
E
N
K
E
T
G
M
E
S
V
I
E
Site 58
T826
H
F
K
K
P
G
L
T
G
R
G
M
Y
E
L
Site 59
Y831
G
L
T
G
R
G
M
Y
E
L
K
P
E
C
A
Site 60
Y844
C
A
K
E
F
N
L
Y
F
Y
H
F
S
R
A
Site 61
Y846
K
E
F
N
L
Y
F
Y
H
F
S
R
A
E
Q
Site 62
T871
K
R
Q
N
R
E
D
T
A
L
P
P
P
V
L
Site 63
Y914
W
A
V
E
H
N
G
Y
A
W
S
E
S
M
L
Site 64
T951
E
E
H
V
V
T
F
T
F
T
Q
K
I
S
K
Site 65
S966
P
G
E
A
P
K
N
S
P
S
I
L
A
M
L
Site 66
Y981
E
T
L
Q
N
A
P
Y
L
E
V
H
K
D
M
Site 67
S1005
A
V
K
K
M
R
E
S
S
P
T
S
P
V
A
Site 68
S1006
V
K
K
M
R
E
S
S
P
T
S
P
V
A
E
Site 69
T1008
K
M
R
E
S
S
P
T
S
P
V
A
E
T
E
Site 70
S1009
M
R
E
S
S
P
T
S
P
V
A
E
T
E
G
Site 71
T1014
P
T
S
P
V
A
E
T
E
G
T
I
M
E
E
Site 72
T1017
P
V
A
E
T
E
G
T
I
M
E
E
S
S
R
Site 73
S1022
E
G
T
I
M
E
E
S
S
R
D
K
D
K
A
Site 74
S1073
Q
T
L
E
L
D
A
S
T
S
A
V
L
D
H
Site 75
S1075
L
E
L
D
A
S
T
S
A
V
L
D
H
S
P
Site 76
S1081
T
S
A
V
L
D
H
S
P
V
A
S
D
M
T
Site 77
T1097
T
A
L
G
P
A
Q
T
Q
V
P
E
Q
R
Q
Site 78
S1133
L
A
A
F
V
Q
R
S
T
V
L
S
K
N
R
Site 79
T1134
A
A
F
V
Q
R
S
T
V
L
S
K
N
R
S
Site 80
S1137
V
Q
R
S
T
V
L
S
K
N
R
S
K
F
I
Site 81
S1141
T
V
L
S
K
N
R
S
K
F
I
Q
D
P
E
Site 82
Y1150
F
I
Q
D
P
E
K
Y
D
P
L
F
M
H
P
Site 83
S1160
L
F
M
H
P
D
L
S
C
G
T
H
T
S
S
Site 84
T1163
H
P
D
L
S
C
G
T
H
T
S
S
C
G
H
Site 85
T1199
Q
Q
R
L
R
L
H
T
S
Y
D
V
E
N
G
Site 86
S1200
Q
R
L
R
L
H
T
S
Y
D
V
E
N
G
E
Site 87
Y1201
R
L
R
L
H
T
S
Y
D
V
E
N
G
E
F
Site 88
S1238
F
N
N
R
L
N
F
S
D
Q
P
N
L
T
Q
Site 89
T1244
F
S
D
Q
P
N
L
T
Q
W
I
R
T
I
S
Site 90
S1251
T
Q
W
I
R
T
I
S
Q
Q
I
K
A
L
Q
Site 91
S1265
Q
F
L
R
K
E
E
S
T
P
N
N
A
S
T
Site 92
T1266
F
L
R
K
E
E
S
T
P
N
N
A
S
T
K
Site 93
S1271
E
S
T
P
N
N
A
S
T
K
N
S
E
N
V
Site 94
S1275
N
N
A
S
T
K
N
S
E
N
V
D
E
L
Q
Site 95
Y1297
D
F
R
P
K
I
P
Y
S
E
S
I
K
E
M
Site 96
S1298
F
R
P
K
I
P
Y
S
E
S
I
K
E
M
L
Site 97
T1306
E
S
I
K
E
M
L
T
T
F
G
T
A
T
Y
Site 98
T1307
S
I
K
E
M
L
T
T
F
G
T
A
T
Y
K
Site 99
T1312
L
T
T
F
G
T
A
T
Y
K
V
G
L
K
V
Site 100
Y1313
T
T
F
G
T
A
T
Y
K
V
G
L
K
V
H
Site 101
S1342
S
C
A
Y
T
I
Q
S
I
E
R
I
L
S
D
Site 102
S1348
Q
S
I
E
R
I
L
S
D
E
D
K
P
L
F
Site 103
S1368
R
L
D
D
C
L
R
S
L
T
R
F
A
A
A
Site 104
T1370
D
D
C
L
R
S
L
T
R
F
A
A
A
H
W
Site 105
S1395
H
F
C
K
L
F
A
S
L
V
P
N
D
S
H
Site 106
S1401
A
S
L
V
P
N
D
S
H
E
E
L
P
C
I
Site 107
Y1484
E
S
A
V
L
A
L
Y
K
T
L
H
Q
Y
T
Site 108
S1500
S
A
L
K
E
I
P
S
G
W
H
L
W
R
S
Site 109
S1531
H
Y
L
N
G
V
P
S
P
P
D
I
Q
V
P
Site 110
S1548
S
H
F
E
H
L
C
S
Y
L
S
L
P
N
N
Site 111
Y1549
H
F
E
H
L
C
S
Y
L
S
L
P
N
N
L
Site 112
S1569
E
N
S
E
I
M
N
S
L
I
E
S
W
C
R
Site 113
S1578
I
E
S
W
C
R
N
S
E
V
K
R
Y
L
E
Site 114
Y1583
R
N
S
E
V
K
R
Y
L
E
G
E
R
D
A
Site 115
Y1593
G
E
R
D
A
I
R
Y
P
R
E
S
N
K
L
Site 116
S1597
A
I
R
Y
P
R
E
S
N
K
L
I
N
L
P
Site 117
Y1607
L
I
N
L
P
E
D
Y
S
S
L
I
N
Q
A
Site 118
S1608
I
N
L
P
E
D
Y
S
S
L
I
N
Q
A
S
Site 119
S1609
N
L
P
E
D
Y
S
S
L
I
N
Q
A
S
N
Site 120
S1615
S
S
L
I
N
Q
A
S
N
F
S
C
P
K
S
Site 121
S1618
I
N
Q
A
S
N
F
S
C
P
K
S
G
G
D
Site 122
S1622
S
N
F
S
C
P
K
S
G
G
D
K
S
R
A
Site 123
S1627
P
K
S
G
G
D
K
S
R
A
P
T
L
C
L
Site 124
T1631
G
D
K
S
R
A
P
T
L
C
L
V
C
G
S
Site 125
Y1645
S
L
L
C
S
Q
S
Y
C
C
Q
T
E
L
E
Site 126
Y1693
G
K
T
K
G
C
F
Y
S
P
P
Y
L
D
D
Site 127
S1694
K
T
K
G
C
F
Y
S
P
P
Y
L
D
D
Y
Site 128
Y1697
G
C
F
Y
S
P
P
Y
L
D
D
Y
G
E
T
Site 129
Y1701
S
P
P
Y
L
D
D
Y
G
E
T
D
Q
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation