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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP12
Full Name:
Rho GTPase-activating protein 12
Alias:
ARHGAP12 protein; FLJ10971; FLJ20737; FLJ21785; RH12; RHG12; Rho GTPase activating protein 12; RhoGAP 12; Rho-GTPase-activating protein 12; Rho-type GTPase-activating protein 12
Type:
GTPase-activating protein for G protein
Mass (Da):
96254
Number AA:
846
UniProt ID:
Q8IWW6
International Prot ID:
IPI00328279
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
K
I
I
P
G
Q
V
Y
I
E
V
E
Y
D
Y
Site 2
Y23
Y
I
E
V
E
Y
D
Y
E
Y
E
A
K
D
R
Site 3
Y25
E
V
E
Y
D
Y
E
Y
E
A
K
D
R
K
I
Site 4
Y63
D
E
N
S
K
A
F
Y
V
P
A
Q
Y
V
K
Site 5
Y68
A
F
Y
V
P
A
Q
Y
V
K
E
V
T
R
K
Site 6
S91
V
A
G
L
P
N
N
S
T
K
I
M
Q
S
L
Site 7
T92
A
G
L
P
N
N
S
T
K
I
M
Q
S
L
H
Site 8
S97
N
S
T
K
I
M
Q
S
L
H
L
Q
R
S
T
Site 9
S103
Q
S
L
H
L
Q
R
S
T
E
N
V
N
K
L
Site 10
T104
S
L
H
L
Q
R
S
T
E
N
V
N
K
L
P
Site 11
S114
V
N
K
L
P
E
L
S
S
F
G
K
P
S
S
Site 12
S115
N
K
L
P
E
L
S
S
F
G
K
P
S
S
S
Site 13
S120
L
S
S
F
G
K
P
S
S
S
V
Q
G
T
G
Site 14
S121
S
S
F
G
K
P
S
S
S
V
Q
G
T
G
L
Site 15
S122
S
F
G
K
P
S
S
S
V
Q
G
T
G
L
I
Site 16
T126
P
S
S
S
V
Q
G
T
G
L
I
R
D
A
N
Site 17
Y140
N
Q
N
F
G
P
S
Y
N
Q
G
Q
T
V
N
Site 18
T145
P
S
Y
N
Q
G
Q
T
V
N
L
S
L
D
L
Site 19
S149
Q
G
Q
T
V
N
L
S
L
D
L
T
H
N
N
Site 20
T153
V
N
L
S
L
D
L
T
H
N
N
G
K
F
N
Site 21
S163
N
G
K
F
N
N
D
S
H
S
P
K
V
S
S
Site 22
S165
K
F
N
N
D
S
H
S
P
K
V
S
S
Q
N
Site 23
S169
D
S
H
S
P
K
V
S
S
Q
N
R
T
R
S
Site 24
S170
S
H
S
P
K
V
S
S
Q
N
R
T
R
S
F
Site 25
T174
K
V
S
S
Q
N
R
T
R
S
F
G
H
F
P
Site 26
S176
S
S
Q
N
R
T
R
S
F
G
H
F
P
G
P
Site 27
T191
E
F
L
D
V
E
K
T
S
F
S
Q
E
Q
S
Site 28
S192
F
L
D
V
E
K
T
S
F
S
Q
E
Q
S
C
Site 29
S194
D
V
E
K
T
S
F
S
Q
E
Q
S
C
D
S
Site 30
S198
T
S
F
S
Q
E
Q
S
C
D
S
A
G
E
G
Site 31
S201
S
Q
E
Q
S
C
D
S
A
G
E
G
S
E
R
Site 32
S206
C
D
S
A
G
E
G
S
E
R
I
H
Q
D
S
Site 33
S213
S
E
R
I
H
Q
D
S
E
S
G
D
E
L
S
Site 34
S215
R
I
H
Q
D
S
E
S
G
D
E
L
S
S
S
Site 35
S220
S
E
S
G
D
E
L
S
S
S
S
T
E
Q
I
Site 36
S222
S
G
D
E
L
S
S
S
S
T
E
Q
I
R
A
Site 37
S223
G
D
E
L
S
S
S
S
T
E
Q
I
R
A
T
Site 38
T224
D
E
L
S
S
S
S
T
E
Q
I
R
A
T
T
Site 39
T230
S
T
E
Q
I
R
A
T
T
P
P
N
Q
G
R
Site 40
T231
T
E
Q
I
R
A
T
T
P
P
N
Q
G
R
P
Site 41
S240
P
N
Q
G
R
P
D
S
P
V
Y
A
N
L
Q
Site 42
Y243
G
R
P
D
S
P
V
Y
A
N
L
Q
E
L
K
Site 43
S252
N
L
Q
E
L
K
I
S
Q
S
A
L
P
P
L
Site 44
S254
Q
E
L
K
I
S
Q
S
A
L
P
P
L
P
G
Site 45
S262
A
L
P
P
L
P
G
S
P
A
I
Q
I
N
G
Site 46
T273
Q
I
N
G
E
W
E
T
H
K
D
S
S
G
R
Site 47
Y282
K
D
S
S
G
R
C
Y
Y
Y
N
R
G
T
Q
Site 48
Y283
D
S
S
G
R
C
Y
Y
Y
N
R
G
T
Q
E
Site 49
Y284
S
S
G
R
C
Y
Y
Y
N
R
G
T
Q
E
R
Site 50
T299
T
W
K
P
P
R
W
T
R
D
A
S
I
S
K
Site 51
S303
P
R
W
T
R
D
A
S
I
S
K
G
D
F
Q
Site 52
S305
W
T
R
D
A
S
I
S
K
G
D
F
Q
N
P
Site 53
S319
P
G
D
Q
E
L
L
S
S
E
E
N
Y
Y
S
Site 54
S320
G
D
Q
E
L
L
S
S
E
E
N
Y
Y
S
T
Site 55
Y324
L
L
S
S
E
E
N
Y
Y
S
T
S
Y
S
Q
Site 56
Y325
L
S
S
E
E
N
Y
Y
S
T
S
Y
S
Q
S
Site 57
S326
S
S
E
E
N
Y
Y
S
T
S
Y
S
Q
S
D
Site 58
S328
E
E
N
Y
Y
S
T
S
Y
S
Q
S
D
S
Q
Site 59
S330
N
Y
Y
S
T
S
Y
S
Q
S
D
S
Q
C
G
Site 60
S332
Y
S
T
S
Y
S
Q
S
D
S
Q
C
G
S
P
Site 61
S334
T
S
Y
S
Q
S
D
S
Q
C
G
S
P
P
R
Site 62
S338
Q
S
D
S
Q
C
G
S
P
P
R
G
W
S
E
Site 63
S344
G
S
P
P
R
G
W
S
E
E
L
D
E
R
G
Site 64
T353
E
L
D
E
R
G
H
T
L
Y
T
S
D
Y
T
Site 65
Y355
D
E
R
G
H
T
L
Y
T
S
D
Y
T
N
E
Site 66
T356
E
R
G
H
T
L
Y
T
S
D
Y
T
N
E
K
Site 67
S357
R
G
H
T
L
Y
T
S
D
Y
T
N
E
K
W
Site 68
Y359
H
T
L
Y
T
S
D
Y
T
N
E
K
W
L
K
Site 69
T360
T
L
Y
T
S
D
Y
T
N
E
K
W
L
K
H
Site 70
Y375
V
D
D
Q
G
R
Q
Y
Y
Y
S
A
D
G
S
Site 71
Y376
D
D
Q
G
R
Q
Y
Y
Y
S
A
D
G
S
R
Site 72
Y377
D
Q
G
R
Q
Y
Y
Y
S
A
D
G
S
R
S
Site 73
S378
Q
G
R
Q
Y
Y
Y
S
A
D
G
S
R
S
E
Site 74
S382
Y
Y
Y
S
A
D
G
S
R
S
E
W
E
L
P
Site 75
S384
Y
S
A
D
G
S
R
S
E
W
E
L
P
K
Y
Site 76
Y391
S
E
W
E
L
P
K
Y
N
A
S
S
Q
Q
Q
Site 77
S395
L
P
K
Y
N
A
S
S
Q
Q
Q
R
E
I
I
Site 78
S404
Q
Q
R
E
I
I
K
S
R
S
L
D
R
R
L
Site 79
S406
R
E
I
I
K
S
R
S
L
D
R
R
L
Q
E
Site 80
S423
V
L
T
K
W
R
H
S
T
I
V
L
D
T
N
Site 81
T424
L
T
K
W
R
H
S
T
I
V
L
D
T
N
D
Site 82
T429
H
S
T
I
V
L
D
T
N
D
K
E
S
P
T
Site 83
S434
L
D
T
N
D
K
E
S
P
T
A
S
K
P
C
Site 84
S438
D
K
E
S
P
T
A
S
K
P
C
F
P
E
N
Site 85
S447
P
C
F
P
E
N
E
S
S
P
S
S
P
K
H
Site 86
S448
C
F
P
E
N
E
S
S
P
S
S
P
K
H
Q
Site 87
S450
P
E
N
E
S
S
P
S
S
P
K
H
Q
D
T
Site 88
S451
E
N
E
S
S
P
S
S
P
K
H
Q
D
T
A
Site 89
T457
S
S
P
K
H
Q
D
T
A
S
S
P
K
D
Q
Site 90
S459
P
K
H
Q
D
T
A
S
S
P
K
D
Q
E
K
Site 91
S460
K
H
Q
D
T
A
S
S
P
K
D
Q
E
K
Y
Site 92
S488
K
V
R
K
N
W
L
S
S
W
A
V
L
Q
G
Site 93
T501
Q
G
S
S
L
L
F
T
K
T
Q
G
S
S
T
Site 94
T503
S
S
L
L
F
T
K
T
Q
G
S
S
T
S
W
Site 95
S506
L
F
T
K
T
Q
G
S
S
T
S
W
F
G
S
Site 96
S509
K
T
Q
G
S
S
T
S
W
F
G
S
N
Q
S
Site 97
S513
S
S
T
S
W
F
G
S
N
Q
S
K
P
E
F
Site 98
S516
S
W
F
G
S
N
Q
S
K
P
E
F
T
V
D
Site 99
T521
N
Q
S
K
P
E
F
T
V
D
L
K
G
A
T
Site 100
S533
G
A
T
I
E
M
A
S
K
D
K
S
S
K
K
Site 101
S537
E
M
A
S
K
D
K
S
S
K
K
N
V
F
E
Site 102
T551
E
L
K
T
R
Q
G
T
E
L
L
I
Q
S
D
Site 103
S557
G
T
E
L
L
I
Q
S
D
N
D
T
V
I
N
Site 104
S592
I
E
E
E
I
P
D
S
P
G
I
E
K
H
D
Site 105
S612
K
D
P
K
K
L
R
S
F
K
V
S
S
I
D
Site 106
S616
K
L
R
S
F
K
V
S
S
I
D
S
S
E
Q
Site 107
S617
L
R
S
F
K
V
S
S
I
D
S
S
E
Q
K
Site 108
S620
F
K
V
S
S
I
D
S
S
E
Q
K
K
T
K
Site 109
S621
K
V
S
S
I
D
S
S
E
Q
K
K
T
K
K
Site 110
T626
D
S
S
E
Q
K
K
T
K
K
N
L
K
K
F
Site 111
T635
K
N
L
K
K
F
L
T
R
R
P
T
L
Q
A
Site 112
T639
K
F
L
T
R
R
P
T
L
Q
A
V
R
E
K
Site 113
S718
E
K
L
D
L
N
D
S
K
W
E
D
I
H
V
Site 114
T743
E
L
P
E
P
L
F
T
F
N
H
F
N
D
F
Site 115
T779
L
P
K
P
N
Q
D
T
M
Q
I
L
F
R
H
Site 116
T800
N
G
E
K
N
R
M
T
Y
Q
S
I
A
I
V
Site 117
Y801
G
E
K
N
R
M
T
Y
Q
S
I
A
I
V
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation