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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADHFE1
Full Name:
Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Alias:
ADH8; ADHFe1; Alcohol dehydrogenase 8; Alcohol dehydrogenase, iron containing, 1; Fe-containing alcohol dehydrogenase; Fe-containing alcohol dehydrogenase 1; FLJ32430
Type:
Mitochondrial; EC 1.1.1.244; Oxidoreductase
Mass (Da):
50308
Number AA:
467
UniProt ID:
Q8IWW8
International Prot ID:
IPI00217420
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0047988
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0015993
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
A
A
R
A
R
V
A
Y
L
L
R
Q
L
Q
R
Site 2
T25
R
A
A
C
Q
C
P
T
H
S
H
T
Y
S
Q
Site 3
T29
Q
C
P
T
H
S
H
T
Y
S
Q
A
P
G
L
Site 4
S31
P
T
H
S
H
T
Y
S
Q
A
P
G
L
S
P
Site 5
S37
Y
S
Q
A
P
G
L
S
P
S
G
K
T
T
D
Site 6
T43
L
S
P
S
G
K
T
T
D
Y
A
F
E
M
A
Site 7
Y45
P
S
G
K
T
T
D
Y
A
F
E
M
A
V
S
Site 8
S85
L
M
T
D
K
N
L
S
K
L
P
P
V
Q
V
Site 9
Y107
N
G
I
P
F
T
V
Y
D
N
V
R
V
E
P
Site 10
S117
V
R
V
E
P
T
D
S
S
F
M
E
A
I
E
Site 11
S118
R
V
E
P
T
D
S
S
F
M
E
A
I
E
F
Site 12
T145
G
G
G
S
T
M
D
T
C
K
A
A
N
L
Y
Site 13
Y152
T
C
K
A
A
N
L
Y
A
S
S
P
H
S
D
Site 14
S155
A
A
N
L
Y
A
S
S
P
H
S
D
F
L
D
Site 15
S158
L
Y
A
S
S
P
H
S
D
F
L
D
Y
V
S
Site 16
Y163
P
H
S
D
F
L
D
Y
V
S
A
P
I
G
K
Site 17
S165
S
D
F
L
D
Y
V
S
A
P
I
G
K
G
K
Site 18
T186
K
P
L
I
A
V
P
T
T
S
G
T
G
S
E
Site 19
S192
P
T
T
S
G
T
G
S
E
T
T
G
V
A
I
Site 20
T219
T
S
R
A
I
K
P
T
L
G
L
I
D
P
L
Site 21
T253
H
A
L
E
S
Y
T
T
L
P
Y
H
L
R
S
Site 22
Y256
E
S
Y
T
T
L
P
Y
H
L
R
S
P
C
P
Site 23
S260
T
L
P
Y
H
L
R
S
P
C
P
S
N
P
I
Site 24
S264
H
L
R
S
P
C
P
S
N
P
I
T
R
P
A
Site 25
T268
P
C
P
S
N
P
I
T
R
P
A
Y
Q
G
S
Site 26
Y272
N
P
I
T
R
P
A
Y
Q
G
S
N
P
I
S
Site 27
S275
T
R
P
A
Y
Q
G
S
N
P
I
S
D
I
W
Site 28
Y293
A
L
R
I
V
A
K
Y
L
K
R
A
V
R
N
Site 29
Y334
H
L
C
H
G
M
S
Y
P
I
S
G
L
V
K
Site 30
Y343
I
S
G
L
V
K
M
Y
K
A
K
D
Y
N
V
Site 31
Y348
K
M
Y
K
A
K
D
Y
N
V
D
H
P
L
V
Site 32
T372
S
P
A
V
F
T
F
T
A
Q
M
F
P
E
R
Site 33
T393
I
L
G
A
D
T
R
T
A
R
I
Q
D
A
G
Site 34
T444
T
L
P
Q
E
R
V
T
K
L
A
P
C
P
Q
Site 35
S452
K
L
A
P
C
P
Q
S
E
E
D
L
A
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation