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Updated November 2019
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Protein Info
Short Name:
ANKHD1
Full Name:
Ankyrin repeat and KH domain-containing protein 1
Alias:
ANKH1; Ankyrin repeat and KH domain containing 1; EMBL AAH40231.1; FLJ10042; FLJ11979; FLJ14127; FLJ20288; KIAA1085; MASK; Multiple ankyrin repeats single KH domain protein
Type:
Apoptosis
Mass (Da):
269458
Number AA:
866
UniProt ID:
Q8IWZ3
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
S
G
G
G
G
T
S
F
E
E
D
L
D
S
Site 2
S18
S
F
E
E
D
L
D
S
V
A
P
R
S
A
P
Site 3
S23
L
D
S
V
A
P
R
S
A
P
A
G
A
S
E
Site 4
S29
R
S
A
P
A
G
A
S
E
P
P
P
P
G
G
Site 5
S54
F
G
E
A
G
P
A
S
G
V
G
S
S
G
G
Site 6
S58
G
P
A
S
G
V
G
S
S
G
G
G
G
S
G
Site 7
S59
P
A
S
G
V
G
S
S
G
G
G
G
S
G
S
Site 8
S64
G
S
S
G
G
G
G
S
G
S
G
T
G
G
G
Site 9
S66
S
G
G
G
G
S
G
S
G
T
G
G
G
D
A
Site 10
T68
G
G
G
S
G
S
G
T
G
G
G
D
A
A
L
Site 11
S93
T
G
G
G
G
G
A
S
G
S
D
E
D
E
V
Site 12
S95
G
G
G
G
A
S
G
S
D
E
D
E
V
S
E
Site 13
S101
G
S
D
E
D
E
V
S
E
V
E
S
F
I
L
Site 14
S105
D
E
V
S
E
V
E
S
F
I
L
D
Q
E
D
Site 15
S122
N
P
V
L
K
T
T
S
E
I
F
L
S
S
T
Site 16
S127
T
T
S
E
I
F
L
S
S
T
A
E
G
A
D
Site 17
T137
A
E
G
A
D
L
R
T
V
D
P
E
T
Q
A
Site 18
T142
L
R
T
V
D
P
E
T
Q
A
R
L
E
A
L
Site 19
T176
P
E
V
L
R
R
L
T
S
S
V
S
C
A
L
Site 20
S177
E
V
L
R
R
L
T
S
S
V
S
C
A
L
D
Site 21
S178
V
L
R
R
L
T
S
S
V
S
C
A
L
D
E
Site 22
S180
R
R
L
T
S
S
V
S
C
A
L
D
E
A
A
Site 23
T191
D
E
A
A
A
A
L
T
R
M
K
A
E
N
S
Site 24
S198
T
R
M
K
A
E
N
S
H
N
A
G
Q
V
D
Site 25
S208
A
G
Q
V
D
T
R
S
L
A
E
A
C
S
D
Site 26
S214
R
S
L
A
E
A
C
S
D
G
D
V
N
A
V
Site 27
S230
K
L
L
D
E
G
R
S
V
N
E
H
T
E
E
Site 28
T274
R
G
N
K
G
D
I
T
P
L
M
A
A
S
S
Site 29
S300
L
H
D
A
D
V
N
S
Q
S
A
T
G
N
T
Site 30
S302
D
A
D
V
N
S
Q
S
A
T
G
N
T
A
L
Site 31
T304
D
V
N
S
Q
S
A
T
G
N
T
A
L
T
Y
Site 32
T340
D
H
N
E
N
G
H
T
P
L
M
E
A
A
S
Site 33
S368
G
A
G
I
N
T
H
S
N
E
F
K
E
S
A
Site 34
T377
E
F
K
E
S
A
L
T
L
A
C
Y
K
G
H
Site 35
T402
G
A
D
Q
E
H
K
T
D
E
M
H
T
A
L
Site 36
S437
Q
V
N
M
P
A
D
S
F
E
S
P
L
T
L
Site 37
T443
D
S
F
E
S
P
L
T
L
A
A
C
G
G
H
Site 38
Y472
E
E
V
N
D
E
G
Y
T
P
L
M
E
A
A
Site 39
T473
E
V
N
D
E
G
Y
T
P
L
M
E
A
A
R
Site 40
T507
Q
T
E
E
T
Q
E
T
A
L
T
L
A
C
C
Site 41
T537
D
I
E
L
G
C
S
T
P
L
M
E
A
S
Q
Site 42
S543
S
T
P
L
M
E
A
S
Q
E
G
H
L
E
L
Site 43
T573
A
T
G
D
T
A
L
T
Y
A
C
E
N
G
H
Site 44
Y574
T
G
D
T
A
L
T
Y
A
C
E
N
G
H
T
Site 45
T603
H
E
S
E
G
G
R
T
P
L
M
K
A
A
R
Site 46
T631
G
A
N
V
N
R
A
T
A
N
N
D
H
T
V
Site 47
T662
L
A
H
G
A
D
P
T
H
R
L
K
D
G
S
Site 48
S669
T
H
R
L
K
D
G
S
T
M
L
I
E
A
A
Site 49
T670
H
R
L
K
D
G
S
T
M
L
I
E
A
A
K
Site 50
S685
G
G
H
T
N
V
V
S
Y
L
L
D
Y
P
N
Site 51
Y686
G
H
T
N
V
V
S
Y
L
L
D
Y
P
N
N
Site 52
S696
D
Y
P
N
N
V
L
S
V
P
T
T
D
V
S
Site 53
T700
N
V
L
S
V
P
T
T
D
V
S
Q
L
P
P
Site 54
S703
S
V
P
T
T
D
V
S
Q
L
P
P
P
S
Q
Site 55
S709
V
S
Q
L
P
P
P
S
Q
D
Q
S
Q
V
P
Site 56
S713
P
P
P
S
Q
D
Q
S
Q
V
P
R
V
P
T
Site 57
T735
P
P
Q
E
P
D
R
T
S
Q
E
N
S
P
A
Site 58
S736
P
Q
E
P
D
R
T
S
Q
E
N
S
P
A
L
Site 59
S740
D
R
T
S
Q
E
N
S
P
A
L
L
G
V
Q
Site 60
S751
L
G
V
Q
K
G
T
S
K
Q
K
S
S
S
L
Site 61
S755
K
G
T
S
K
Q
K
S
S
S
L
Q
V
A
D
Site 62
S757
T
S
K
Q
K
S
S
S
L
Q
V
A
D
Q
D
Site 63
S768
A
D
Q
D
L
L
P
S
F
H
P
Y
Q
P
L
Site 64
S794
N
E
L
G
Q
R
I
S
A
I
E
K
A
Q
L
Site 65
S803
I
E
K
A
Q
L
K
S
L
E
L
I
Q
G
E
Site 66
T849
E
R
Q
L
Q
M
K
T
Q
Q
Q
F
T
K
E
Site 67
Y857
Q
Q
Q
F
T
K
E
Y
L
E
T
K
G
Q
K
Site 68
T866
E
T
K
G
Q
K
D
T
V
S
L
H
Q
Q
C
Site 69
S868
K
G
Q
K
D
T
V
S
L
H
Q
Q
C
S
H
Site 70
S874
V
S
L
H
Q
Q
C
S
H
R
G
V
F
P
E
Site 71
S887
P
E
G
E
G
D
G
S
L
P
E
D
H
F
S
Site 72
S894
S
L
P
E
D
H
F
S
E
L
P
Q
V
D
T
Site 73
S915
D
V
D
D
E
Q
Q
S
P
P
S
A
E
Q
I
Site 74
S918
D
E
Q
Q
S
P
P
S
A
E
Q
I
D
F
V
Site 75
S931
F
V
P
V
Q
P
L
S
S
P
Q
C
N
F
S
Site 76
S932
V
P
V
Q
P
L
S
S
P
Q
C
N
F
S
S
Site 77
S938
S
S
P
Q
C
N
F
S
S
D
L
G
S
N
G
Site 78
S939
S
P
Q
C
N
F
S
S
D
L
G
S
N
G
T
Site 79
S943
N
F
S
S
D
L
G
S
N
G
T
N
S
L
E
Site 80
T946
S
D
L
G
S
N
G
T
N
S
L
E
L
Q
K
Site 81
S948
L
G
S
N
G
T
N
S
L
E
L
Q
K
V
S
Site 82
T1009
A
V
S
T
R
V
P
T
G
S
N
S
S
S
Q
Site 83
S1011
S
T
R
V
P
T
G
S
N
S
S
S
Q
T
T
Site 84
S1013
R
V
P
T
G
S
N
S
S
S
Q
T
T
E
C
Site 85
S1015
P
T
G
S
N
S
S
S
Q
T
T
E
C
L
T
Site 86
T1017
G
S
N
S
S
S
Q
T
T
E
C
L
T
P
E
Site 87
T1018
S
N
S
S
S
Q
T
T
E
C
L
T
P
E
S
Site 88
T1022
S
Q
T
T
E
C
L
T
P
E
S
C
S
Q
T
Site 89
S1025
T
E
C
L
T
P
E
S
C
S
Q
T
T
S
N
Site 90
S1027
C
L
T
P
E
S
C
S
Q
T
T
S
N
V
A
Site 91
T1029
T
P
E
S
C
S
Q
T
T
S
N
V
A
S
Q
Site 92
S1031
E
S
C
S
Q
T
T
S
N
V
A
S
Q
S
M
Site 93
S1035
Q
T
T
S
N
V
A
S
Q
S
M
P
P
V
Y
Site 94
S1037
T
S
N
V
A
S
Q
S
M
P
P
V
Y
P
S
Site 95
Y1042
S
Q
S
M
P
P
V
Y
P
S
V
D
I
D
A
Site 96
S1044
S
M
P
P
V
Y
P
S
V
D
I
D
A
H
T
Site 97
T1051
S
V
D
I
D
A
H
T
E
S
N
H
D
T
A
Site 98
S1053
D
I
D
A
H
T
E
S
N
H
D
T
A
L
T
Site 99
T1057
H
T
E
S
N
H
D
T
A
L
T
L
A
C
A
Site 100
T1060
S
N
H
D
T
A
L
T
L
A
C
A
G
G
H
Site 101
T1090
H
R
D
K
K
G
F
T
P
L
I
L
A
A
T
Site 102
S1118
G
G
D
I
E
A
Q
S
E
R
T
K
D
T
P
Site 103
T1124
Q
S
E
R
T
K
D
T
P
L
S
L
A
C
S
Site 104
S1127
R
T
K
D
T
P
L
S
L
A
C
S
G
G
R
Site 105
S1154
N
K
E
H
R
N
V
S
D
Y
T
P
L
S
L
Site 106
Y1156
E
H
R
N
V
S
D
Y
T
P
L
S
L
A
A
Site 107
T1157
H
R
N
V
S
D
Y
T
P
L
S
L
A
A
S
Site 108
S1183
N
A
G
A
E
I
N
S
R
T
G
S
K
L
G
Site 109
S1187
E
I
N
S
R
T
G
S
K
L
G
I
S
P
L
Site 110
S1192
T
G
S
K
L
G
I
S
P
L
M
L
A
A
M
Site 111
T1226
Q
I
E
T
N
R
N
T
A
L
T
L
A
C
F
Site 112
T1229
T
N
R
N
T
A
L
T
L
A
C
F
Q
G
R
Site 113
S1241
Q
G
R
A
E
V
V
S
L
L
L
D
R
K
A
Site 114
T1256
N
V
E
H
R
A
K
T
G
L
T
P
L
M
E
Site 115
T1259
H
R
A
K
T
G
L
T
P
L
M
E
A
A
S
Site 116
S1290
V
N
A
P
P
V
P
S
S
R
D
T
A
L
T
Site 117
S1291
N
A
P
P
V
P
S
S
R
D
T
A
L
T
I
Site 118
T1294
P
V
P
S
S
R
D
T
A
L
T
I
A
A
D
Site 119
T1297
S
S
R
D
T
A
L
T
I
A
A
D
K
G
H
Site 120
T1327
V
R
N
K
K
G
N
T
P
L
W
L
A
S
N
Site 121
T1360
A
A
D
N
R
K
I
T
P
L
M
S
A
F
R
Site 122
S1364
R
K
I
T
P
L
M
S
A
F
R
K
G
H
V
Site 123
Y1376
G
H
V
K
V
V
Q
Y
L
V
K
E
V
N
Q
Site 124
Y1393
S
D
I
E
C
M
R
Y
I
A
T
I
T
D
K
Site 125
S1429
A
E
A
N
K
N
A
S
I
L
L
K
E
L
D
Site 126
S1440
K
E
L
D
L
E
K
S
R
E
E
S
R
K
Q
Site 127
S1444
L
E
K
S
R
E
E
S
R
K
Q
A
L
A
A
Site 128
S1483
E
N
K
P
K
E
N
S
E
L
P
E
D
E
D
Site 129
S1508
E
V
P
I
E
P
P
S
A
T
T
T
T
T
I
Site 130
T1512
E
P
P
S
A
T
T
T
T
T
I
G
I
S
A
Site 131
T1525
S
A
T
S
A
T
F
T
N
V
F
G
K
K
R
Site 132
T1537
K
K
R
A
N
V
V
T
T
P
S
T
N
R
K
Site 133
T1538
K
R
A
N
V
V
T
T
P
S
T
N
R
K
N
Site 134
S1540
A
N
V
V
T
T
P
S
T
N
R
K
N
K
K
Site 135
T1541
N
V
V
T
T
P
S
T
N
R
K
N
K
K
N
Site 136
T1550
R
K
N
K
K
N
K
T
K
E
T
P
P
T
A
Site 137
T1553
K
K
N
K
T
K
E
T
P
P
T
A
H
L
I
Site 138
T1556
K
T
K
E
T
P
P
T
A
H
L
I
L
P
E
Site 139
S1567
I
L
P
E
Q
H
M
S
L
A
Q
Q
K
A
D
Site 140
S1591
G
G
G
A
G
G
N
S
D
S
D
N
L
D
S
Site 141
S1593
G
A
G
G
N
S
D
S
D
N
L
D
S
T
D
Site 142
S1598
S
D
S
D
N
L
D
S
T
D
C
N
S
E
S
Site 143
T1599
D
S
D
N
L
D
S
T
D
C
N
S
E
S
S
Site 144
S1603
L
D
S
T
D
C
N
S
E
S
S
S
G
G
K
Site 145
S1605
S
T
D
C
N
S
E
S
S
S
G
G
K
S
Q
Site 146
S1607
D
C
N
S
E
S
S
S
G
G
K
S
Q
E
L
Site 147
S1611
E
S
S
S
G
G
K
S
Q
E
L
N
F
V
M
Site 148
S1622
N
F
V
M
D
V
N
S
S
K
Y
P
S
L
L
Site 149
Y1625
M
D
V
N
S
S
K
Y
P
S
L
L
L
H
S
Site 150
S1627
V
N
S
S
K
Y
P
S
L
L
L
H
S
Q
E
Site 151
S1632
Y
P
S
L
L
L
H
S
Q
E
E
K
T
S
T
Site 152
S1638
H
S
Q
E
E
K
T
S
T
A
T
S
K
T
Q
Site 153
T1639
S
Q
E
E
K
T
S
T
A
T
S
K
T
Q
T
Site 154
S1642
E
K
T
S
T
A
T
S
K
T
Q
T
R
L
E
Site 155
T1644
T
S
T
A
T
S
K
T
Q
T
R
L
E
G
E
Site 156
T1653
T
R
L
E
G
E
V
T
P
N
S
L
S
T
S
Site 157
S1656
E
G
E
V
T
P
N
S
L
S
T
S
Y
K
T
Site 158
S1658
E
V
T
P
N
S
L
S
T
S
Y
K
T
V
S
Site 159
S1660
T
P
N
S
L
S
T
S
Y
K
T
V
S
L
P
Site 160
Y1661
P
N
S
L
S
T
S
Y
K
T
V
S
L
P
L
Site 161
T1663
S
L
S
T
S
Y
K
T
V
S
L
P
L
S
S
Site 162
S1665
S
T
S
Y
K
T
V
S
L
P
L
S
S
P
N
Site 163
S1669
K
T
V
S
L
P
L
S
S
P
N
I
K
L
N
Site 164
S1670
T
V
S
L
P
L
S
S
P
N
I
K
L
N
L
Site 165
T1678
P
N
I
K
L
N
L
T
S
P
K
R
G
Q
K
Site 166
S1679
N
I
K
L
N
L
T
S
P
K
R
G
Q
K
R
Site 167
S1697
W
K
E
V
V
R
R
S
K
K
L
S
V
P
A
Site 168
S1701
V
R
R
S
K
K
L
S
V
P
A
S
V
V
S
Site 169
S1705
K
K
L
S
V
P
A
S
V
V
S
R
I
M
G
Site 170
S1708
S
V
P
A
S
V
V
S
R
I
M
G
R
G
G
Site 171
T1744
K
N
G
E
R
M
I
T
I
R
G
G
T
E
S
Site 172
T1749
M
I
T
I
R
G
G
T
E
S
T
R
Y
A
V
Site 173
S1751
T
I
R
G
G
T
E
S
T
R
Y
A
V
Q
L
Site 174
Y1754
G
G
T
E
S
T
R
Y
A
V
Q
L
I
N
A
Site 175
T1781
I
P
K
N
H
I
R
T
P
A
S
T
K
S
I
Site 176
S1784
N
H
I
R
T
P
A
S
T
K
S
I
H
A
N
Site 177
T1785
H
I
R
T
P
A
S
T
K
S
I
H
A
N
F
Site 178
S1787
R
T
P
A
S
T
K
S
I
H
A
N
F
S
S
Site 179
T1798
N
F
S
S
G
V
G
T
T
A
A
S
S
K
N
Site 180
S1823
T
S
Q
A
T
T
L
S
T
F
Q
P
A
N
K
Site 181
T1824
S
Q
A
T
T
L
S
T
F
Q
P
A
N
K
L
Site 182
T1837
K
L
N
K
N
V
P
T
N
V
R
S
S
F
P
Site 183
S1841
N
V
P
T
N
V
R
S
S
F
P
V
S
L
P
Site 184
T1880
P
M
A
Q
F
G
G
T
F
S
P
S
P
N
T
Site 185
S1882
A
Q
F
G
G
T
F
S
P
S
P
N
T
W
G
Site 186
S1884
F
G
G
T
F
S
P
S
P
N
T
W
G
P
F
Site 187
T1887
T
F
S
P
S
P
N
T
W
G
P
F
P
V
R
Site 188
S1903
V
N
P
G
N
T
N
S
S
P
K
H
N
N
T
Site 189
S1904
N
P
G
N
T
N
S
S
P
K
H
N
N
T
S
Site 190
T1910
S
S
P
K
H
N
N
T
S
R
L
P
N
Q
N
Site 191
T1919
R
L
P
N
Q
N
G
T
V
L
P
S
E
S
A
Site 192
S1923
Q
N
G
T
V
L
P
S
E
S
A
G
L
A
T
Site 193
T1950
A
S
Q
Q
L
C
V
T
N
T
R
T
P
S
S
Site 194
T1952
Q
Q
L
C
V
T
N
T
R
T
P
S
S
V
R
Site 195
T1954
L
C
V
T
N
T
R
T
P
S
S
V
R
K
Q
Site 196
S1956
V
T
N
T
R
T
P
S
S
V
R
K
Q
L
F
Site 197
S1957
T
N
T
R
T
P
S
S
V
R
K
Q
L
F
A
Site 198
T1974
P
K
T
S
P
P
A
T
V
I
S
S
V
T
S
Site 199
S1984
S
S
V
T
S
T
C
S
S
L
P
S
V
S
S
Site 200
S1991
S
S
L
P
S
V
S
S
A
P
I
T
S
G
Q
Site 201
T1995
S
V
S
S
A
P
I
T
S
G
Q
A
P
T
T
Site 202
T2002
T
S
G
Q
A
P
T
T
F
L
P
A
S
T
S
Site 203
S2007
P
T
T
F
L
P
A
S
T
S
Q
A
Q
L
S
Site 204
T2008
T
T
F
L
P
A
S
T
S
Q
A
Q
L
S
S
Site 205
S2009
T
F
L
P
A
S
T
S
Q
A
Q
L
S
S
Q
Site 206
S2014
S
T
S
Q
A
Q
L
S
S
Q
K
M
E
S
F
Site 207
S2015
T
S
Q
A
Q
L
S
S
Q
K
M
E
S
F
S
Site 208
S2020
L
S
S
Q
K
M
E
S
F
S
A
V
P
P
T
Site 209
S2022
S
Q
K
M
E
S
F
S
A
V
P
P
T
K
E
Site 210
T2027
S
F
S
A
V
P
P
T
K
E
K
V
S
T
Q
Site 211
T2033
P
T
K
E
K
V
S
T
Q
D
Q
P
M
A
N
Site 212
T2043
Q
P
M
A
N
L
C
T
P
S
S
T
A
N
S
Site 213
S2045
M
A
N
L
C
T
P
S
S
T
A
N
S
C
S
Site 214
S2046
A
N
L
C
T
P
S
S
T
A
N
S
C
S
S
Site 215
T2047
N
L
C
T
P
S
S
T
A
N
S
C
S
S
S
Site 216
S2050
T
P
S
S
T
A
N
S
C
S
S
S
A
S
N
Site 217
S2052
S
S
T
A
N
S
C
S
S
S
A
S
N
T
P
Site 218
S2053
S
T
A
N
S
C
S
S
S
A
S
N
T
P
G
Site 219
S2054
T
A
N
S
C
S
S
S
A
S
N
T
P
G
A
Site 220
S2056
N
S
C
S
S
S
A
S
N
T
P
G
A
P
E
Site 221
T2058
C
S
S
S
A
S
N
T
P
G
A
P
E
T
H
Site 222
T2064
N
T
P
G
A
P
E
T
H
P
S
S
S
P
T
Site 223
S2067
G
A
P
E
T
H
P
S
S
S
P
T
P
T
S
Site 224
S2068
A
P
E
T
H
P
S
S
S
P
T
P
T
S
S
Site 225
S2069
P
E
T
H
P
S
S
S
P
T
P
T
S
S
N
Site 226
T2071
T
H
P
S
S
S
P
T
P
T
S
S
N
T
Q
Site 227
T2073
P
S
S
S
P
T
P
T
S
S
N
T
Q
E
E
Site 228
S2074
S
S
S
P
T
P
T
S
S
N
T
Q
E
E
A
Site 229
S2075
S
S
P
T
P
T
S
S
N
T
Q
E
E
A
Q
Site 230
S2084
T
Q
E
E
A
Q
P
S
S
V
S
D
L
S
P
Site 231
S2085
Q
E
E
A
Q
P
S
S
V
S
D
L
S
P
M
Site 232
S2087
E
A
Q
P
S
S
V
S
D
L
S
P
M
S
M
Site 233
S2090
P
S
S
V
S
D
L
S
P
M
S
M
P
F
A
Site 234
S2093
V
S
D
L
S
P
M
S
M
P
F
A
S
N
S
Site 235
S2098
P
M
S
M
P
F
A
S
N
S
E
P
A
P
L
Site 236
S2100
S
M
P
F
A
S
N
S
E
P
A
P
L
T
L
Site 237
T2106
N
S
E
P
A
P
L
T
L
T
S
P
R
M
V
Site 238
S2121
A
A
D
N
Q
D
T
S
N
L
P
Q
L
A
V
Site 239
S2134
A
V
P
A
P
R
V
S
H
R
M
Q
P
R
G
Site 240
S2142
H
R
M
Q
P
R
G
S
F
Y
S
M
V
P
N
Site 241
S2145
Q
P
R
G
S
F
Y
S
M
V
P
N
A
T
I
Site 242
T2162
D
P
Q
S
I
F
V
T
N
P
V
T
L
T
P
Site 243
T2168
V
T
N
P
V
T
L
T
P
P
Q
G
P
P
A
Site 244
S2199
H
I
N
P
A
N
K
S
L
P
P
T
F
G
P
Site 245
T2208
P
P
T
F
G
P
A
T
L
F
N
H
F
S
S
Site 246
S2214
A
T
L
F
N
H
F
S
S
L
F
D
S
S
Q
Site 247
S2215
T
L
F
N
H
F
S
S
L
F
D
S
S
Q
V
Site 248
S2219
H
F
S
S
L
F
D
S
S
Q
V
P
A
N
Q
Site 249
S2220
F
S
S
L
F
D
S
S
Q
V
P
A
N
Q
G
Site 250
S2234
G
W
G
D
G
P
L
S
S
R
V
A
T
D
A
Site 251
S2235
W
G
D
G
P
L
S
S
R
V
A
T
D
A
S
Site 252
T2239
P
L
S
S
R
V
A
T
D
A
S
F
T
V
Q
Site 253
S2253
Q
S
A
F
L
G
N
S
V
L
G
H
L
E
N
Site 254
S2266
E
N
M
H
P
D
N
S
K
A
P
G
F
R
P
Site 255
S2275
A
P
G
F
R
P
P
S
Q
R
V
S
T
S
P
Site 256
S2279
R
P
P
S
Q
R
V
S
T
S
P
V
G
L
P
Site 257
T2280
P
P
S
Q
R
V
S
T
S
P
V
G
L
P
S
Site 258
S2281
P
S
Q
R
V
S
T
S
P
V
G
L
P
S
I
Site 259
S2287
T
S
P
V
G
L
P
S
I
D
P
S
G
S
S
Site 260
S2291
G
L
P
S
I
D
P
S
G
S
S
P
S
S
S
Site 261
S2293
P
S
I
D
P
S
G
S
S
P
S
S
S
S
A
Site 262
S2294
S
I
D
P
S
G
S
S
P
S
S
S
S
A
P
Site 263
S2296
D
P
S
G
S
S
P
S
S
S
S
A
P
L
A
Site 264
S2297
P
S
G
S
S
P
S
S
S
S
A
P
L
A
S
Site 265
S2298
S
G
S
S
P
S
S
S
S
A
P
L
A
S
F
Site 266
S2299
G
S
S
P
S
S
S
S
A
P
L
A
S
F
S
Site 267
T2323
Q
G
P
A
P
V
G
T
P
S
F
N
R
Q
H
Site 268
S2325
P
A
P
V
G
T
P
S
F
N
R
Q
H
F
S
Site 269
S2332
S
F
N
R
Q
H
F
S
P
H
P
W
T
S
A
Site 270
T2337
H
F
S
P
H
P
W
T
S
A
S
N
S
S
T
Site 271
S2338
F
S
P
H
P
W
T
S
A
S
N
S
S
T
S
Site 272
S2340
P
H
P
W
T
S
A
S
N
S
S
T
S
A
P
Site 273
S2342
P
W
T
S
A
S
N
S
S
T
S
A
P
P
T
Site 274
S2343
W
T
S
A
S
N
S
S
T
S
A
P
P
T
L
Site 275
T2344
T
S
A
S
N
S
S
T
S
A
P
P
T
L
G
Site 276
S2345
S
A
S
N
S
S
T
S
A
P
P
T
L
G
Q
Site 277
T2349
S
S
T
S
A
P
P
T
L
G
Q
P
K
G
V
Site 278
S2359
Q
P
K
G
V
S
A
S
Q
D
R
K
I
P
P
Site 279
S2381
A
R
I
R
Q
G
G
S
V
A
Q
A
P
A
G
Site 280
S2413
N
A
V
S
E
G
L
S
G
W
S
Q
S
V
M
Site 281
S2416
S
E
G
L
S
G
W
S
Q
S
V
M
G
N
H
Site 282
S2430
H
P
M
H
Q
Q
L
S
D
P
S
T
F
S
Q
Site 283
S2433
H
Q
Q
L
S
D
P
S
T
F
S
Q
H
Q
P
Site 284
T2434
Q
Q
L
S
D
P
S
T
F
S
Q
H
Q
P
M
Site 285
S2436
L
S
D
P
S
T
F
S
Q
H
Q
P
M
E
R
Site 286
S2446
Q
P
M
E
R
D
D
S
G
M
V
A
P
S
N
Site 287
T2478
P
I
S
M
Y
G
G
T
I
I
P
S
H
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation