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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SFRS14
Full Name:
SURP and G-patch domain-containing protein 2
Alias:
Arginine/serine-rich 14 splicing factor; KIAA0365; SFR14; splicing factor, arginine/serine-rich 14
Type:
RNA binding protein
Mass (Da):
120237
Number AA:
1082
UniProt ID:
Q8IX01
International Prot ID:
IPI00158020
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
A
R
R
I
T
Q
E
T
F
D
A
V
Site 2
T10
A
R
R
I
T
Q
E
T
F
D
A
V
L
Q
E
Site 3
S27
K
R
Y
H
M
D
A
S
G
E
A
V
S
E
T
Site 4
S49
L
L
R
A
V
P
R
S
R
A
E
M
Y
D
D
Site 5
Y54
P
R
S
R
A
E
M
Y
D
D
V
H
S
D
G
Site 6
S59
E
M
Y
D
D
V
H
S
D
G
R
Y
S
L
S
Site 7
Y63
D
V
H
S
D
G
R
Y
S
L
S
G
S
V
A
Site 8
S64
V
H
S
D
G
R
Y
S
L
S
G
S
V
A
H
Site 9
S66
S
D
G
R
Y
S
L
S
G
S
V
A
H
S
R
Site 10
S68
G
R
Y
S
L
S
G
S
V
A
H
S
R
D
A
Site 11
S72
L
S
G
S
V
A
H
S
R
D
A
G
R
E
G
Site 12
S82
A
G
R
E
G
L
R
S
D
V
F
P
G
P
S
Site 13
S89
S
D
V
F
P
G
P
S
F
R
S
S
N
P
S
Site 14
S92
F
P
G
P
S
F
R
S
S
N
P
S
I
S
D
Site 15
S93
P
G
P
S
F
R
S
S
N
P
S
I
S
D
D
Site 16
S96
S
F
R
S
S
N
P
S
I
S
D
D
S
Y
F
Site 17
S98
R
S
S
N
P
S
I
S
D
D
S
Y
F
R
K
Site 18
S101
N
P
S
I
S
D
D
S
Y
F
R
K
E
C
G
Site 19
Y102
P
S
I
S
D
D
S
Y
F
R
K
E
C
G
R
Site 20
S114
C
G
R
D
L
E
F
S
H
S
D
S
R
D
Q
Site 21
S116
R
D
L
E
F
S
H
S
D
S
R
D
Q
V
I
Site 22
S118
L
E
F
S
H
S
D
S
R
D
Q
V
I
G
H
Site 23
S133
R
K
L
G
H
F
R
S
Q
D
W
K
F
A
L
Site 24
S153
Q
D
F
G
H
P
V
S
Q
E
S
S
W
S
Q
Site 25
S156
G
H
P
V
S
Q
E
S
S
W
S
Q
E
Y
S
Site 26
S157
H
P
V
S
Q
E
S
S
W
S
Q
E
Y
S
F
Site 27
S159
V
S
Q
E
S
S
W
S
Q
E
Y
S
F
G
P
Site 28
S163
S
S
W
S
Q
E
Y
S
F
G
P
S
A
V
L
Site 29
S167
Q
E
Y
S
F
G
P
S
A
V
L
G
D
F
G
Site 30
S175
A
V
L
G
D
F
G
S
S
R
L
I
E
K
E
Site 31
Y191
L
E
K
E
S
R
D
Y
D
V
D
H
P
G
E
Site 32
S201
D
H
P
G
E
A
D
S
V
L
R
G
S
S
Q
Site 33
S206
A
D
S
V
L
R
G
S
S
Q
V
Q
A
R
G
Site 34
S207
D
S
V
L
R
G
S
S
Q
V
Q
A
R
G
R
Site 35
S224
N
I
V
D
Q
E
G
S
L
L
G
K
G
E
T
Site 36
T231
S
L
L
G
K
G
E
T
Q
G
L
L
T
A
K
Site 37
T246
G
G
V
G
K
L
V
T
L
R
N
V
S
T
K
Site 38
T257
V
S
T
K
K
I
P
T
V
N
R
I
T
P
K
Site 39
T262
I
P
T
V
N
R
I
T
P
K
T
Q
G
T
N
Site 40
T265
V
N
R
I
T
P
K
T
Q
G
T
N
Q
I
Q
Site 41
T275
T
N
Q
I
Q
K
N
T
P
S
P
D
V
T
L
Site 42
S277
Q
I
Q
K
N
T
P
S
P
D
V
T
L
G
T
Site 43
T281
N
T
P
S
P
D
V
T
L
G
T
N
P
G
T
Site 44
T284
S
P
D
V
T
L
G
T
N
P
G
T
E
D
I
Site 45
S315
R
L
P
R
R
K
M
S
F
D
I
I
D
K
S
Site 46
S322
S
F
D
I
I
D
K
S
D
V
F
S
R
F
G
Site 47
S348
I
K
D
D
I
K
F
S
Q
L
F
Q
T
L
F
Site 48
T353
K
F
S
Q
L
F
Q
T
L
F
E
L
E
T
E
Site 49
S372
M
L
A
S
F
K
C
S
L
K
P
E
H
R
D
Site 50
T395
L
K
H
S
A
L
K
T
P
R
V
D
N
E
F
Site 51
Y428
I
I
K
P
F
D
K
Y
I
M
R
L
Q
D
R
Site 52
S453
A
C
N
A
Y
E
L
S
V
K
M
K
T
L
S
Site 53
T458
E
L
S
V
K
M
K
T
L
S
N
P
L
D
L
Site 54
S479
T
N
S
L
C
R
K
S
L
A
L
L
G
Q
T
Site 55
S492
Q
T
F
S
L
A
S
S
F
R
Q
E
K
I
L
Site 56
S520
A
F
P
N
F
E
D
S
T
L
F
G
R
E
Y
Site 57
T521
F
P
N
F
E
D
S
T
L
F
G
R
E
Y
I
Site 58
Y527
S
T
L
F
G
R
E
Y
I
D
H
L
K
A
W
Site 59
T562
E
E
K
M
I
P
P
T
K
P
E
I
Q
A
K
Site 60
S573
I
Q
A
K
A
P
S
S
L
S
D
A
V
P
Q
Site 61
S575
A
K
A
P
S
S
L
S
D
A
V
P
Q
R
A
Site 62
S601
V
K
R
V
I
E
G
S
L
S
P
K
E
R
T
Site 63
S603
R
V
I
E
G
S
L
S
P
K
E
R
T
L
L
Site 64
Y616
L
L
K
E
D
P
A
Y
W
F
L
S
D
E
N
Site 65
S620
D
P
A
Y
W
F
L
S
D
E
N
S
L
E
Y
Site 66
Y629
E
N
S
L
E
Y
K
Y
Y
K
L
K
L
A
E
Site 67
Y630
N
S
L
E
Y
K
Y
Y
K
L
K
L
A
E
M
Site 68
S641
L
A
E
M
Q
R
M
S
E
N
L
R
G
A
D
Site 69
S653
G
A
D
Q
K
P
T
S
A
D
C
A
V
R
A
Site 70
S664
A
V
R
A
M
L
Y
S
R
A
V
R
N
L
K
Site 71
T697
G
W
K
A
R
R
A
T
T
G
T
Q
T
L
L
Site 72
T698
W
K
A
R
R
A
T
T
G
T
Q
T
L
L
S
Site 73
T700
A
R
R
A
T
T
G
T
Q
T
L
L
S
S
G
Site 74
T702
R
A
T
T
G
T
Q
T
L
L
S
S
G
T
R
Site 75
S706
G
T
Q
T
L
L
S
S
G
T
R
L
K
H
H
Site 76
S721
G
R
Q
A
P
G
L
S
Q
A
K
P
S
L
P
Site 77
S745
P
P
D
P
V
G
P
S
P
Q
D
P
S
L
E
Site 78
S750
G
P
S
P
Q
D
P
S
L
E
A
S
G
P
S
Site 79
S754
Q
D
P
S
L
E
A
S
G
P
S
P
K
P
A
Site 80
S757
S
L
E
A
S
G
P
S
P
K
P
A
G
V
D
Site 81
S766
K
P
A
G
V
D
I
S
E
A
P
Q
T
S
S
Site 82
T771
D
I
S
E
A
P
Q
T
S
S
P
C
P
S
A
Site 83
S772
I
S
E
A
P
Q
T
S
S
P
C
P
S
A
D
Site 84
S773
S
E
A
P
Q
T
S
S
P
C
P
S
A
D
I
Site 85
S777
Q
T
S
S
P
C
P
S
A
D
I
D
M
K
T
Site 86
T784
S
A
D
I
D
M
K
T
M
E
T
A
E
K
L
Site 87
S806
G
P
E
I
E
Q
F
S
I
E
N
S
T
D
N
Site 88
S810
E
Q
F
S
I
E
N
S
T
D
N
P
D
L
W
Site 89
T811
Q
F
S
I
E
N
S
T
D
N
P
D
L
W
F
Site 90
S846
P
S
I
C
F
T
S
S
P
H
N
L
H
T
G
Site 91
T852
S
S
P
H
N
L
H
T
G
G
G
D
T
T
G
Site 92
T858
H
T
G
G
G
D
T
T
G
S
Q
E
S
P
V
Site 93
S860
G
G
G
D
T
T
G
S
Q
E
S
P
V
D
L
Site 94
S863
D
T
T
G
S
Q
E
S
P
V
D
L
M
E
G
Site 95
S887
P
R
E
A
E
L
E
S
P
E
V
M
P
E
E
Site 96
S915
A
P
G
G
A
G
K
S
E
G
S
T
P
A
D
Site 97
T919
A
G
K
S
E
G
S
T
P
A
D
G
L
P
G
Site 98
S940
L
A
G
A
P
A
L
S
Q
A
S
S
G
T
C
Site 99
S944
P
A
L
S
Q
A
S
S
G
T
C
F
P
R
K
Site 100
S954
C
F
P
R
K
R
I
S
S
K
S
L
K
V
G
Site 101
S955
F
P
R
K
R
I
S
S
K
S
L
K
V
G
M
Site 102
S957
R
K
R
I
S
S
K
S
L
K
V
G
M
I
P
Site 103
Y985
H
E
P
V
R
I
A
Y
D
R
P
R
G
R
P
Site 104
S994
R
P
R
G
R
P
M
S
K
K
K
K
P
K
D
Site 105
S1032
K
E
G
H
G
L
G
S
L
G
K
G
I
R
E
Site 106
S1042
K
G
I
R
E
P
V
S
V
G
T
P
S
E
G
Site 107
T1045
R
E
P
V
S
V
G
T
P
S
E
G
E
G
L
Site 108
S1047
P
V
S
V
G
T
P
S
E
G
E
G
L
G
A
Site 109
T1063
G
Q
E
H
K
E
D
T
F
D
V
F
R
Q
R
Site 110
Y1075
R
Q
R
M
M
Q
M
Y
R
H
K
R
A
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation