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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCUBE3
Full Name:
Signal peptide, CUB and EGF-like domain-containing protein 3
Alias:
Type:
Mass (Da):
109282
Number AA:
993
UniProt ID:
Q8IX30
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
H
A
R
A
A
Q
Y
S
K
A
A
Q
D
V
D
Site 2
Y53
C
Q
N
T
P
R
S
Y
K
C
I
C
K
S
G
Site 3
Y61
K
C
I
C
K
S
G
Y
T
G
D
G
K
H
C
Site 4
T274
M
L
Q
P
D
R
K
T
C
K
D
I
D
E
C
Site 5
S302
T
V
G
S
F
E
C
S
C
K
K
G
Y
K
L
Site 6
Y350
C
H
R
G
Y
L
L
Y
G
I
T
H
C
G
D
Site 7
Y379
C
I
N
T
P
G
S
Y
Q
C
T
C
P
A
G
Site 8
T382
T
P
G
S
Y
Q
C
T
C
P
A
G
Q
G
R
Site 9
T398
H
W
N
G
K
D
C
T
E
P
L
K
C
Q
G
Site 10
S406
E
P
L
K
C
Q
G
S
P
G
A
S
K
A
M
Site 11
S410
C
Q
G
S
P
G
A
S
K
A
M
L
S
C
N
Site 12
S415
G
A
S
K
A
M
L
S
C
N
R
S
G
K
K
Site 13
S419
A
M
L
S
C
N
R
S
G
K
K
D
T
C
A
Site 14
T428
K
K
D
T
C
A
L
T
C
P
S
R
A
R
F
Site 15
S431
T
C
A
L
T
C
P
S
R
A
R
F
L
P
E
Site 16
S439
R
A
R
F
L
P
E
S
E
N
G
F
T
V
S
Site 17
T444
P
E
S
E
N
G
F
T
V
S
C
G
T
P
S
Site 18
S446
S
E
N
G
F
T
V
S
C
G
T
P
S
P
R
Site 19
T449
G
F
T
V
S
C
G
T
P
S
P
R
A
A
P
Site 20
S451
T
V
S
C
G
T
P
S
P
R
A
A
P
A
R
Site 21
S484
L
S
I
K
Q
R
A
S
F
K
I
K
D
A
K
Site 22
T502
H
L
R
N
K
G
K
T
E
E
A
G
R
I
T
Site 23
T509
T
E
E
A
G
R
I
T
G
P
G
G
A
P
C
Site 24
S530
F
I
H
L
K
C
D
S
S
R
K
G
K
G
R
Site 25
S531
I
H
L
K
C
D
S
S
R
K
G
K
G
R
R
Site 26
T541
G
K
G
R
R
A
R
T
P
P
G
K
E
V
T
Site 27
T551
G
K
E
V
T
R
L
T
L
E
L
E
A
E
V
Site 28
T564
E
V
R
A
E
E
T
T
A
S
C
G
L
P
C
Site 29
S566
R
A
E
E
T
T
A
S
C
G
L
P
C
L
R
Site 30
S583
M
E
R
R
L
K
G
S
L
K
M
L
R
K
S
Site 31
S590
S
L
K
M
L
R
K
S
I
N
Q
D
R
F
L
Site 32
Y605
L
R
L
A
G
L
D
Y
E
L
A
H
K
P
G
Site 33
S624
E
R
A
E
P
M
E
S
C
R
P
G
Q
H
R
Site 34
T634
P
G
Q
H
R
A
G
T
K
C
V
S
C
P
Q
Site 35
Y645
S
C
P
Q
G
T
Y
Y
H
G
Q
T
E
Q
C
Site 36
S668
Q
E
R
E
G
Q
L
S
C
D
L
C
P
G
S
Site 37
S675
S
C
D
L
C
P
G
S
D
A
H
G
P
L
G
Site 38
S699
Q
C
P
P
G
Q
H
S
V
D
G
F
K
P
C
Site 39
T713
C
Q
P
C
P
R
G
T
Y
Q
P
E
A
G
R
Site 40
Y714
Q
P
C
P
R
G
T
Y
Q
P
E
A
G
R
T
Site 41
T721
Y
Q
P
E
A
G
R
T
L
C
F
P
C
G
G
Site 42
S739
T
K
H
E
G
A
I
S
F
Q
D
C
D
T
K
Site 43
T745
I
S
F
Q
D
C
D
T
K
V
Q
C
S
P
G
Site 44
Y754
V
Q
C
S
P
G
H
Y
Y
N
T
S
I
H
R
Site 45
T786
C
S
R
C
P
G
N
T
S
T
D
F
D
G
S
Site 46
T788
R
C
P
G
N
T
S
T
D
F
D
G
S
T
S
Site 47
S793
T
S
T
D
F
D
G
S
T
S
V
A
Q
C
K
Site 48
T794
S
T
D
F
D
G
S
T
S
V
A
Q
C
K
N
Site 49
S795
T
D
F
D
G
S
T
S
V
A
Q
C
K
N
R
Site 50
T812
G
G
E
L
G
E
F
T
G
Y
I
E
S
P
N
Site 51
Y814
E
L
G
E
F
T
G
Y
I
E
S
P
N
Y
P
Site 52
Y820
G
Y
I
E
S
P
N
Y
P
G
N
Y
P
A
G
Site 53
Y824
S
P
N
Y
P
G
N
Y
P
A
G
V
E
C
I
Site 54
S853
V
P
E
I
F
L
P
S
E
D
E
C
G
D
V
Site 55
S867
V
L
V
M
R
K
N
S
S
P
S
S
I
T
T
Site 56
S868
L
V
M
R
K
N
S
S
P
S
S
I
T
T
Y
Site 57
S871
R
K
N
S
S
P
S
S
I
T
T
Y
E
T
C
Site 58
T874
S
S
P
S
S
I
T
T
Y
E
T
C
Q
T
Y
Site 59
Y875
S
P
S
S
I
T
T
Y
E
T
C
Q
T
Y
E
Site 60
T880
T
T
Y
E
T
C
Q
T
Y
E
R
P
I
A
F
Site 61
Y881
T
Y
E
T
C
Q
T
Y
E
R
P
I
A
F
T
Site 62
T888
Y
E
R
P
I
A
F
T
A
R
S
R
K
L
W
Site 63
T900
K
L
W
I
N
F
K
T
S
E
A
N
S
A
R
Site 64
S901
L
W
I
N
F
K
T
S
E
A
N
S
A
R
G
Site 65
S905
F
K
T
S
E
A
N
S
A
R
G
F
Q
I
P
Site 66
Y913
A
R
G
F
Q
I
P
Y
V
T
Y
D
E
D
Y
Site 67
Y920
Y
V
T
Y
D
E
D
Y
E
Q
L
V
E
D
I
Site 68
Y934
I
V
R
D
G
R
L
Y
A
S
E
N
H
Q
E
Site 69
S936
R
D
G
R
L
Y
A
S
E
N
H
Q
E
I
L
Site 70
Y962
V
L
A
H
P
Q
N
Y
F
K
Y
T
E
K
H
Site 71
Y965
H
P
Q
N
Y
F
K
Y
T
E
K
H
K
E
M
Site 72
S976
H
K
E
M
L
P
K
S
F
I
K
L
L
R
S
Site 73
S986
K
L
L
R
S
K
V
S
S
F
L
R
P
Y
K
Site 74
S987
L
L
R
S
K
V
S
S
F
L
R
P
Y
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation