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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPAS3
Full Name:
Neuronal PAS domain-containing protein 3
Alias:
Basic-helix-loop-helix-PAS protein MOP6; Member of PAS protein 6; PASD6
Type:
Transcription factor
Mass (Da):
100805
Number AA:
933
UniProt ID:
Q8IXF0
International Prot ID:
IPI00217513
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0004871
GO:0030528
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0007165
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
P
T
K
P
S
F
Q
Q
D
P
S
R
Site 2
S13
P
S
F
Q
Q
D
P
S
R
R
E
R
I
T
A
Site 3
T19
P
S
R
R
E
R
I
T
A
Q
H
P
L
P
N
Site 4
Y34
Q
S
E
C
R
K
I
Y
R
Y
D
G
I
Y
C
Site 5
Y36
E
C
R
K
I
Y
R
Y
D
G
I
Y
C
E
S
Site 6
Y40
I
Y
R
Y
D
G
I
Y
C
E
S
T
Y
Q
N
Site 7
Y45
G
I
Y
C
E
S
T
Y
Q
N
L
Q
A
L
R
Site 8
S56
Q
A
L
R
K
E
K
S
R
D
A
A
R
S
R
Site 9
S62
K
S
R
D
A
A
R
S
R
R
G
K
E
N
F
Site 10
Y72
G
K
E
N
F
E
F
Y
E
L
A
K
L
L
P
Site 11
S126
E
G
P
P
P
N
T
S
V
K
V
I
G
A
Q
Site 12
S137
I
G
A
Q
R
R
R
S
P
S
A
L
A
I
E
Site 13
S139
A
Q
R
R
R
S
P
S
A
L
A
I
E
V
F
Site 14
Y173
N
Q
E
G
K
F
L
Y
I
S
E
T
V
S
I
Site 15
S192
S
Q
V
E
L
T
G
S
S
V
F
D
Y
V
H
Site 16
Y197
T
G
S
S
V
F
D
Y
V
H
P
G
D
H
V
Site 17
S222
P
P
G
R
G
L
L
S
Q
G
T
A
E
D
G
Site 18
T225
R
G
L
L
S
Q
G
T
A
E
D
G
A
S
S
Site 19
S231
G
T
A
E
D
G
A
S
S
A
S
S
S
S
Q
Site 20
S232
T
A
E
D
G
A
S
S
A
S
S
S
S
Q
S
Site 21
S234
E
D
G
A
S
S
A
S
S
S
S
Q
S
E
T
Site 22
S235
D
G
A
S
S
A
S
S
S
S
Q
S
E
T
P
Site 23
S236
G
A
S
S
A
S
S
S
S
Q
S
E
T
P
E
Site 24
S237
A
S
S
A
S
S
S
S
Q
S
E
T
P
E
P
Site 25
S239
S
A
S
S
S
S
Q
S
E
T
P
E
P
V
E
Site 26
T241
S
S
S
S
Q
S
E
T
P
E
P
V
E
S
T
Site 27
S247
E
T
P
E
P
V
E
S
T
S
P
S
L
L
T
Site 28
S249
P
E
P
V
E
S
T
S
P
S
L
L
T
T
D
Site 29
S251
P
V
E
S
T
S
P
S
L
L
T
T
D
N
T
Site 30
T254
S
T
S
P
S
L
L
T
T
D
N
T
L
E
R
Site 31
T255
T
S
P
S
L
L
T
T
D
N
T
L
E
R
S
Site 32
S262
T
D
N
T
L
E
R
S
F
F
I
R
M
K
S
Site 33
S269
S
F
F
I
R
M
K
S
T
L
T
K
R
G
V
Site 34
T272
I
R
M
K
S
T
L
T
K
R
G
V
H
I
K
Site 35
S280
K
R
G
V
H
I
K
S
S
G
Y
K
V
I
H
Site 36
S281
R
G
V
H
I
K
S
S
G
Y
K
V
I
H
I
Site 37
S297
G
R
L
R
L
R
V
S
L
S
H
G
R
T
V
Site 38
S299
L
R
L
R
V
S
L
S
H
G
R
T
V
P
S
Site 39
T303
V
S
L
S
H
G
R
T
V
P
S
Q
I
M
G
Site 40
Y345
N
M
D
L
N
I
I
Y
C
E
N
R
I
S
D
Site 41
Y353
C
E
N
R
I
S
D
Y
M
D
L
T
P
V
D
Site 42
Y367
D
I
V
G
K
R
C
Y
H
F
I
H
A
E
D
Site 43
S381
D
V
E
G
I
R
H
S
H
L
D
L
L
N
K
Site 44
Y431
K
N
I
I
W
V
N
Y
L
L
S
N
P
E
Y
Site 45
Y438
Y
L
L
S
N
P
E
Y
K
D
T
P
M
D
I
Site 46
T441
S
N
P
E
Y
K
D
T
P
M
D
I
A
Q
L
Site 47
T455
L
P
H
L
P
E
K
T
S
E
S
S
E
T
S
Site 48
S456
P
H
L
P
E
K
T
S
E
S
S
E
T
S
D
Site 49
S459
P
E
K
T
S
E
S
S
E
T
S
D
S
E
S
Site 50
T461
K
T
S
E
S
S
E
T
S
D
S
E
S
D
S
Site 51
S462
T
S
E
S
S
E
T
S
D
S
E
S
D
S
K
Site 52
S464
E
S
S
E
T
S
D
S
E
S
D
S
K
D
T
Site 53
S466
S
E
T
S
D
S
E
S
D
S
K
D
T
S
G
Site 54
S468
T
S
D
S
E
S
D
S
K
D
T
S
G
I
T
Site 55
S472
E
S
D
S
K
D
T
S
G
I
T
E
D
N
E
Site 56
S483
E
D
N
E
N
S
K
S
D
E
K
G
N
Q
S
Site 57
S493
K
G
N
Q
S
E
N
S
E
D
P
E
P
D
R
Site 58
S503
P
E
P
D
R
K
K
S
G
N
A
C
D
N
D
Site 59
S519
N
C
N
D
D
G
H
S
S
S
N
P
D
S
R
Site 60
S520
C
N
D
D
G
H
S
S
S
N
P
D
S
R
D
Site 61
S521
N
D
D
G
H
S
S
S
N
P
D
S
R
D
S
Site 62
S525
H
S
S
S
N
P
D
S
R
D
S
D
D
S
F
Site 63
S528
S
N
P
D
S
R
D
S
D
D
S
F
E
H
S
Site 64
S531
D
S
R
D
S
D
D
S
F
E
H
S
D
F
E
Site 65
S535
S
D
D
S
F
E
H
S
D
F
E
N
P
K
A
Site 66
Y560
M
Q
I
K
V
E
R
Y
V
E
S
E
S
D
L
Site 67
S563
K
V
E
R
Y
V
E
S
E
S
D
L
R
L
Q
Site 68
S565
E
R
Y
V
E
S
E
S
D
L
R
L
Q
N
C
Site 69
S574
L
R
L
Q
N
C
E
S
L
T
S
D
S
A
K
Site 70
S577
Q
N
C
E
S
L
T
S
D
S
A
K
D
S
D
Site 71
S579
C
E
S
L
T
S
D
S
A
K
D
S
D
S
A
Site 72
S583
T
S
D
S
A
K
D
S
D
S
A
G
E
A
G
Site 73
S585
D
S
A
K
D
S
D
S
A
G
E
A
G
A
Q
Site 74
S611
R
K
R
Q
K
G
G
S
A
S
R
R
R
L
S
Site 75
S613
R
Q
K
G
G
S
A
S
R
R
R
L
S
S
A
Site 76
S618
S
A
S
R
R
R
L
S
S
A
S
S
P
G
G
Site 77
S619
A
S
R
R
R
L
S
S
A
S
S
P
G
G
L
Site 78
S621
R
R
R
L
S
S
A
S
S
P
G
G
L
D
A
Site 79
S622
R
R
L
S
S
A
S
S
P
G
G
L
D
A
G
Site 80
S638
V
E
P
P
R
L
L
S
S
P
N
S
A
S
V
Site 81
S639
E
P
P
R
L
L
S
S
P
N
S
A
S
V
L
Site 82
S642
R
L
L
S
S
P
N
S
A
S
V
L
K
I
K
Site 83
S644
L
S
S
P
N
S
A
S
V
L
K
I
K
T
E
Site 84
T650
A
S
V
L
K
I
K
T
E
I
S
E
P
I
N
Site 85
S653
L
K
I
K
T
E
I
S
E
P
I
N
F
D
N
Site 86
Y667
N
D
S
S
I
W
N
Y
P
P
N
R
E
I
S
Site 87
S674
Y
P
P
N
R
E
I
S
R
N
E
S
P
Y
S
Site 88
S678
R
E
I
S
R
N
E
S
P
Y
S
M
T
K
P
Site 89
Y680
I
S
R
N
E
S
P
Y
S
M
T
K
P
P
S
Site 90
S681
S
R
N
E
S
P
Y
S
M
T
K
P
P
S
S
Site 91
T683
N
E
S
P
Y
S
M
T
K
P
P
S
S
E
H
Site 92
S687
Y
S
M
T
K
P
P
S
S
E
H
F
P
S
P
Site 93
S688
S
M
T
K
P
P
S
S
E
H
F
P
S
P
Q
Site 94
S693
P
S
S
E
H
F
P
S
P
Q
G
G
G
G
G
Site 95
T729
D
G
A
A
A
R
K
T
Q
F
G
A
S
A
T
Site 96
S734
R
K
T
Q
F
G
A
S
A
T
A
A
L
A
P
Site 97
S748
P
V
A
S
D
P
L
S
P
P
L
S
A
S
P
Site 98
S752
D
P
L
S
P
P
L
S
A
S
P
R
D
K
H
Site 99
S754
L
S
P
P
L
S
A
S
P
R
D
K
H
P
G
Site 100
S779
G
A
G
G
G
G
P
S
A
S
N
S
L
L
Y
Site 101
S781
G
G
G
G
P
S
A
S
N
S
L
L
Y
T
G
Site 102
S783
G
G
P
S
A
S
N
S
L
L
Y
T
G
D
L
Site 103
T787
A
S
N
S
L
L
Y
T
G
D
L
E
A
L
Q
Site 104
Y824
S
T
A
A
Q
R
V
Y
T
T
G
T
I
R
Y
Site 105
T825
T
A
A
Q
R
V
Y
T
T
G
T
I
R
Y
A
Site 106
T828
Q
R
V
Y
T
T
G
T
I
R
Y
A
P
A
E
Site 107
T837
R
Y
A
P
A
E
V
T
L
A
M
Q
S
N
L
Site 108
T867
G
F
G
L
D
P
K
T
P
M
E
M
L
Y
H
Site 109
Y873
K
T
P
M
E
M
L
Y
H
H
V
H
R
L
N
Site 110
S882
H
V
H
R
L
N
M
S
G
P
F
G
G
A
V
Site 111
T927
N
G
I
H
A
A
Q
T
L
E
R
K
E
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation