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Updated November 2019
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Protein Info
Short Name:
ASXL1
Full Name:
Putative Polycomb group protein ASXL1
Alias:
Additional sex combs like 1; Additional sex combs-like 1; Additional sex combs-like protein 1; KIAA0978; Polycomb group protein ASXL1
Type:
Unknown function
Mass (Da):
165432
Number AA:
1541
UniProt ID:
Q8IXJ9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
R
L
V
L
E
N
Y
S
D
A
P
M
T
P
K
Site 2
T30
N
Y
S
D
A
P
M
T
P
K
Q
I
L
Q
V
Site 3
S48
E
G
L
K
E
M
R
S
G
T
S
P
L
A
C
Site 4
T50
L
K
E
M
R
S
G
T
S
P
L
A
C
L
N
Site 5
S51
K
E
M
R
S
G
T
S
P
L
A
C
L
N
A
Site 6
S62
C
L
N
A
M
L
H
S
N
S
R
G
G
E
G
Site 7
S64
N
A
M
L
H
S
N
S
R
G
G
E
G
L
F
Site 8
Y72
R
G
G
E
G
L
F
Y
K
L
P
G
R
I
S
Site 9
S79
Y
K
L
P
G
R
I
S
L
F
T
L
K
K
D
Site 10
T82
P
G
R
I
S
L
F
T
L
K
K
D
A
L
Q
Site 11
T96
Q
W
S
R
H
P
A
T
V
E
G
E
E
P
E
Site 12
T105
E
G
E
E
P
E
D
T
A
D
V
E
S
C
G
Site 13
S110
E
D
T
A
D
V
E
S
C
G
S
N
E
A
S
Site 14
S113
A
D
V
E
S
C
G
S
N
E
A
S
T
V
S
Site 15
S117
S
C
G
S
N
E
A
S
T
V
S
G
E
N
D
Site 16
T118
C
G
S
N
E
A
S
T
V
S
G
E
N
D
V
Site 17
S120
S
N
E
A
S
T
V
S
G
E
N
D
V
S
L
Site 18
S126
V
S
G
E
N
D
V
S
L
D
E
T
S
S
N
Site 19
T130
N
D
V
S
L
D
E
T
S
S
N
A
S
C
S
Site 20
S131
D
V
S
L
D
E
T
S
S
N
A
S
C
S
T
Site 21
S132
V
S
L
D
E
T
S
S
N
A
S
C
S
T
E
Site 22
S135
D
E
T
S
S
N
A
S
C
S
T
E
S
Q
S
Site 23
S137
T
S
S
N
A
S
C
S
T
E
S
Q
S
R
P
Site 24
T138
S
S
N
A
S
C
S
T
E
S
Q
S
R
P
L
Site 25
S140
N
A
S
C
S
T
E
S
Q
S
R
P
L
S
N
Site 26
S142
S
C
S
T
E
S
Q
S
R
P
L
S
N
P
R
Site 27
S146
E
S
Q
S
R
P
L
S
N
P
R
D
S
Y
R
Site 28
S151
P
L
S
N
P
R
D
S
Y
R
A
S
S
Q
A
Site 29
Y152
L
S
N
P
R
D
S
Y
R
A
S
S
Q
A
N
Site 30
S155
P
R
D
S
Y
R
A
S
S
Q
A
N
K
Q
K
Site 31
S156
R
D
S
Y
R
A
S
S
Q
A
N
K
Q
K
K
Site 32
T165
A
N
K
Q
K
K
K
T
G
V
M
L
P
R
V
Site 33
S188
G
A
H
V
E
S
A
S
G
F
S
G
C
H
A
Site 34
S199
G
C
H
A
D
G
E
S
G
S
P
S
S
S
S
Site 35
S201
H
A
D
G
E
S
G
S
P
S
S
S
S
S
G
Site 36
S203
D
G
E
S
G
S
P
S
S
S
S
S
G
S
L
Site 37
S204
G
E
S
G
S
P
S
S
S
S
S
G
S
L
A
Site 38
S205
E
S
G
S
P
S
S
S
S
S
G
S
L
A
L
Site 39
S206
S
G
S
P
S
S
S
S
S
G
S
L
A
L
G
Site 40
S207
G
S
P
S
S
S
S
S
G
S
L
A
L
G
S
Site 41
S209
P
S
S
S
S
S
G
S
L
A
L
G
S
A
A
Site 42
T224
I
R
G
Q
A
E
V
T
Q
D
P
A
P
L
L
Site 43
T239
R
G
F
R
K
P
A
T
G
Q
M
K
R
N
R
Site 44
T254
G
E
E
I
D
F
E
T
P
G
S
I
L
V
N
Site 45
S270
N
L
R
A
L
I
N
S
R
T
F
H
A
L
P
Site 46
T272
R
A
L
I
N
S
R
T
F
H
A
L
P
S
H
Site 47
S304
T
D
G
L
L
R
L
S
S
S
A
L
N
N
E
Site 48
S305
D
G
L
L
R
L
S
S
S
A
L
N
N
E
F
Site 49
S319
F
F
T
H
A
A
Q
S
W
R
E
R
L
A
D
Site 50
Y358
K
E
K
F
F
E
D
Y
Y
G
Q
K
L
G
L
Site 51
Y359
E
K
F
F
E
D
Y
Y
G
Q
K
L
G
L
T
Site 52
T366
Y
G
Q
K
L
G
L
T
K
E
E
S
L
Q
Q
Site 53
S370
L
G
L
T
K
E
E
S
L
Q
Q
N
V
G
Q
Site 54
S392
G
L
C
V
P
G
E
S
V
R
I
Q
R
G
P
Site 55
T401
R
I
Q
R
G
P
A
T
R
Q
R
D
G
H
F
Site 56
S412
D
G
H
F
K
K
R
S
R
P
D
L
R
T
R
Site 57
T418
R
S
R
P
D
L
R
T
R
A
R
R
N
L
Y
Site 58
Y425
T
R
A
R
R
N
L
Y
K
K
Q
E
S
E
Q
Site 59
Y449
V
A
S
D
V
P
L
Y
K
D
G
E
A
K
T
Site 60
T456
Y
K
D
G
E
A
K
T
D
P
A
G
L
S
S
Site 61
S462
K
T
D
P
A
G
L
S
S
P
H
L
P
G
T
Site 62
S463
T
D
P
A
G
L
S
S
P
H
L
P
G
T
S
Site 63
T469
S
S
P
H
L
P
G
T
S
S
A
A
P
D
L
Site 64
S471
P
H
L
P
G
T
S
S
A
A
P
D
L
E
G
Site 65
S485
G
P
E
F
P
V
E
S
V
A
S
R
I
Q
A
Site 66
S501
P
D
N
L
A
R
A
S
A
S
P
D
R
I
P
Site 67
S503
N
L
A
R
A
S
A
S
P
D
R
I
P
S
L
Site 68
S509
A
S
P
D
R
I
P
S
L
P
Q
E
T
V
D
Site 69
S526
P
K
D
Q
K
R
K
S
F
E
Q
A
A
S
A
Site 70
S532
K
S
F
E
Q
A
A
S
A
S
F
P
E
K
K
Site 71
S534
F
E
Q
A
A
S
A
S
F
P
E
K
K
P
R
Site 72
S547
P
R
L
E
D
R
Q
S
F
R
N
T
I
E
S
Site 73
T551
D
R
Q
S
F
R
N
T
I
E
S
V
H
T
E
Site 74
S554
S
F
R
N
T
I
E
S
V
H
T
E
K
P
Q
Site 75
T557
N
T
I
E
S
V
H
T
E
K
P
Q
P
T
K
Site 76
S577
P
P
I
R
I
Q
L
S
R
I
K
P
P
W
V
Site 77
T600
I
C
P
R
I
I
P
T
T
E
S
S
C
R
G
Site 78
T601
C
P
R
I
I
P
T
T
E
S
S
C
R
G
W
Site 79
S603
R
I
I
P
T
T
E
S
S
C
R
G
W
T
G
Site 80
S604
I
I
P
T
T
E
S
S
C
R
G
W
T
G
A
Site 81
T609
E
S
S
C
R
G
W
T
G
A
R
T
L
A
D
Site 82
T613
R
G
W
T
G
A
R
T
L
A
D
I
K
A
R
Site 83
T639
C
H
R
E
A
A
T
T
A
I
G
G
G
G
G
Site 84
T655
G
G
G
G
G
G
A
T
D
E
G
G
G
R
G
Site 85
S663
D
E
G
G
G
R
G
S
S
S
G
D
G
G
E
Site 86
S664
E
G
G
G
R
G
S
S
S
G
D
G
G
E
A
Site 87
S665
G
G
G
R
G
S
S
S
G
D
G
G
E
A
C
Site 88
S682
P
E
P
R
G
G
P
S
T
P
G
K
C
T
S
Site 89
T683
E
P
R
G
G
P
S
T
P
G
K
C
T
S
D
Site 90
S689
S
T
P
G
K
C
T
S
D
L
Q
R
T
Q
L
Site 91
Y700
R
T
Q
L
L
P
P
Y
P
L
N
G
E
H
T
Site 92
S723
A
R
R
E
D
L
P
S
L
R
K
E
E
S
C
Site 93
S729
P
S
L
R
K
E
E
S
C
L
L
Q
R
A
T
Site 94
S747
T
D
G
L
G
D
A
S
Q
L
P
V
A
P
T
Site 95
S767
Q
A
L
P
L
L
S
S
Q
T
S
V
A
E
R
Site 96
S770
P
L
L
S
S
Q
T
S
V
A
E
R
L
V
E
Site 97
T787
Q
L
H
P
D
V
R
T
E
C
E
S
G
T
T
Site 98
S791
D
V
R
T
E
C
E
S
G
T
T
S
W
E
S
Site 99
S795
E
C
E
S
G
T
T
S
W
E
S
D
D
E
E
Site 100
S798
S
G
T
T
S
W
E
S
D
D
E
E
Q
G
P
Site 101
T806
D
D
E
E
Q
G
P
T
V
P
A
D
N
G
P
Site 102
T822
P
S
L
V
G
D
D
T
L
E
K
G
T
G
Q
Site 103
S833
G
T
G
Q
A
L
D
S
H
P
T
M
K
D
P
Site 104
T844
M
K
D
P
V
N
V
T
P
S
S
T
P
E
S
Site 105
S846
D
P
V
N
V
T
P
S
S
T
P
E
S
S
P
Site 106
S847
P
V
N
V
T
P
S
S
T
P
E
S
S
P
T
Site 107
T848
V
N
V
T
P
S
S
T
P
E
S
S
P
T
D
Site 108
S851
T
P
S
S
T
P
E
S
S
P
T
D
C
L
Q
Site 109
S852
P
S
S
T
P
E
S
S
P
T
D
C
L
Q
N
Site 110
T854
S
T
P
E
S
S
P
T
D
C
L
Q
N
R
A
Site 111
S871
D
E
L
G
L
G
G
S
C
P
P
M
R
E
S
Site 112
S878
S
C
P
P
M
R
E
S
D
T
R
Q
E
N
L
Site 113
T887
T
R
Q
E
N
L
K
T
K
A
L
V
S
N
S
Site 114
S915
V
K
Q
P
K
P
E
S
R
E
H
I
P
S
V
Site 115
S921
E
S
R
E
H
I
P
S
V
E
P
Q
V
G
E
Site 116
T936
E
W
E
K
A
A
P
T
P
P
A
L
P
G
D
Site 117
T945
P
A
L
P
G
D
L
T
A
E
E
G
L
D
P
Site 118
S958
D
P
L
D
S
L
T
S
L
W
T
V
P
S
R
Site 119
T961
D
S
L
T
S
L
W
T
V
P
S
R
G
G
S
Site 120
S964
T
S
L
W
T
V
P
S
R
G
G
S
D
S
N
Site 121
S968
T
V
P
S
R
G
G
S
D
S
N
G
S
Y
C
Site 122
S970
P
S
R
G
G
S
D
S
N
G
S
Y
C
Q
Q
Site 123
S973
G
G
S
D
S
N
G
S
Y
C
Q
Q
V
D
I
Site 124
Y974
G
S
D
S
N
G
S
Y
C
Q
Q
V
D
I
E
Site 125
S989
K
L
K
I
N
G
D
S
E
A
L
S
P
H
G
Site 126
S993
N
G
D
S
E
A
L
S
P
H
G
E
S
T
D
Site 127
T999
L
S
P
H
G
E
S
T
D
T
A
S
D
F
E
Site 128
T1001
P
H
G
E
S
T
D
T
A
S
D
F
E
G
H
Site 129
S1003
G
E
S
T
D
T
A
S
D
F
E
G
H
L
T
Site 130
T1010
S
D
F
E
G
H
L
T
E
D
S
S
E
A
D
Site 131
S1013
E
G
H
L
T
E
D
S
S
E
A
D
T
R
E
Site 132
S1014
G
H
L
T
E
D
S
S
E
A
D
T
R
E
A
Site 133
T1018
E
D
S
S
E
A
D
T
R
E
A
A
V
T
K
Site 134
T1024
D
T
R
E
A
A
V
T
K
G
S
S
V
D
K
Site 135
S1028
A
A
V
T
K
G
S
S
V
D
K
D
E
K
P
Site 136
S1040
E
K
P
N
W
N
Q
S
A
P
L
S
K
V
N
Site 137
S1044
W
N
Q
S
A
P
L
S
K
V
N
G
D
M
R
Site 138
T1054
N
G
D
M
R
L
V
T
R
T
D
G
M
V
A
Site 139
T1056
D
M
R
L
V
T
R
T
D
G
M
V
A
P
Q
Site 140
S1079
V
R
Q
K
I
P
D
S
L
L
L
A
S
T
E
Site 141
S1095
Q
P
R
A
V
C
L
S
M
P
G
S
S
V
E
Site 142
S1129
L
P
P
A
H
D
D
S
M
S
E
S
P
Q
V
Site 143
S1131
P
A
H
D
D
S
M
S
E
S
P
Q
V
P
L
Site 144
S1133
H
D
D
S
M
S
E
S
P
Q
V
P
L
T
K
Site 145
T1139
E
S
P
Q
V
P
L
T
K
D
Q
S
H
G
S
Site 146
S1143
V
P
L
T
K
D
Q
S
H
G
S
L
R
M
G
Site 147
S1146
T
K
D
Q
S
H
G
S
L
R
M
G
S
L
H
Site 148
S1151
H
G
S
L
R
M
G
S
L
H
G
L
G
K
N
Site 149
S1159
L
H
G
L
G
K
N
S
G
M
V
D
G
S
S
Site 150
S1165
N
S
G
M
V
D
G
S
S
P
S
S
L
R
A
Site 151
S1166
S
G
M
V
D
G
S
S
P
S
S
L
R
A
L
Site 152
S1169
V
D
G
S
S
P
S
S
L
R
A
L
K
E
P
Site 153
S1181
K
E
P
L
L
P
D
S
C
E
T
G
T
G
L
Site 154
T1194
G
L
A
R
I
E
A
T
Q
A
P
G
A
P
Q
Site 155
S1209
K
N
C
K
A
V
P
S
F
D
S
L
H
P
V
Site 156
S1212
K
A
V
P
S
F
D
S
L
H
P
V
T
N
P
Site 157
T1217
F
D
S
L
H
P
V
T
N
P
I
T
S
S
R
Site 158
T1221
H
P
V
T
N
P
I
T
S
S
R
K
L
E
E
Site 159
S1222
P
V
T
N
P
I
T
S
S
R
K
L
E
E
M
Site 160
S1231
R
K
L
E
E
M
D
S
K
E
Q
F
S
S
F
Site 161
S1237
D
S
K
E
Q
F
S
S
F
S
C
E
D
Q
K
Site 162
S1250
Q
K
E
V
R
A
M
S
Q
D
S
N
S
N
A
Site 163
S1253
V
R
A
M
S
Q
D
S
N
S
N
A
A
P
G
Site 164
S1255
A
M
S
Q
D
S
N
S
N
A
A
P
G
K
S
Site 165
S1262
S
N
A
A
P
G
K
S
P
G
D
L
T
T
S
Site 166
T1267
G
K
S
P
G
D
L
T
T
S
R
T
P
R
F
Site 167
T1268
K
S
P
G
D
L
T
T
S
R
T
P
R
F
S
Site 168
S1269
S
P
G
D
L
T
T
S
R
T
P
R
F
S
S
Site 169
T1271
G
D
L
T
T
S
R
T
P
R
F
S
S
P
N
Site 170
S1275
T
S
R
T
P
R
F
S
S
P
N
V
I
S
F
Site 171
S1276
S
R
T
P
R
F
S
S
P
N
V
I
S
F
G
Site 172
S1281
F
S
S
P
N
V
I
S
F
G
P
E
Q
T
G
Site 173
S1295
G
R
A
L
G
D
Q
S
N
V
T
G
Q
G
K
Site 174
S1307
Q
G
K
K
L
F
G
S
G
N
V
A
A
T
L
Site 175
T1313
G
S
G
N
V
A
A
T
L
Q
R
P
R
P
A
Site 176
S1335
E
I
P
P
V
F
P
S
G
K
L
G
P
S
T
Site 177
S1341
P
S
G
K
L
G
P
S
T
N
S
M
S
G
G
Site 178
T1342
S
G
K
L
G
P
S
T
N
S
M
S
G
G
V
Site 179
S1344
K
L
G
P
S
T
N
S
M
S
G
G
V
Q
T
Site 180
S1346
G
P
S
T
N
S
M
S
G
G
V
Q
T
P
R
Site 181
T1351
S
M
S
G
G
V
Q
T
P
R
E
D
W
A
P
Site 182
S1366
K
P
H
A
F
V
G
S
V
K
N
E
K
T
F
Site 183
T1372
G
S
V
K
N
E
K
T
F
V
G
G
P
L
K
Site 184
T1388
N
A
E
N
R
K
A
T
G
H
S
P
L
E
L
Site 185
S1391
N
R
K
A
T
G
H
S
P
L
E
L
V
G
H
Site 186
S1422
R
E
P
G
K
G
L
S
E
P
L
E
P
S
S
Site 187
S1428
L
S
E
P
L
E
P
S
S
L
P
S
Q
L
S
Site 188
S1429
S
E
P
L
E
P
S
S
L
P
S
Q
L
S
I
Site 189
S1432
L
E
P
S
S
L
P
S
Q
L
S
I
K
Q
A
Site 190
S1435
S
S
L
P
S
Q
L
S
I
K
Q
A
F
Y
G
Site 191
S1445
Q
A
F
Y
G
K
L
S
K
L
Q
L
S
S
T
Site 192
S1450
K
L
S
K
L
Q
L
S
S
T
S
F
N
Y
S
Site 193
S1451
L
S
K
L
Q
L
S
S
T
S
F
N
Y
S
S
Site 194
T1452
S
K
L
Q
L
S
S
T
S
F
N
Y
S
S
S
Site 195
S1453
K
L
Q
L
S
S
T
S
F
N
Y
S
S
S
S
Site 196
Y1456
L
S
S
T
S
F
N
Y
S
S
S
S
P
T
F
Site 197
S1457
S
S
T
S
F
N
Y
S
S
S
S
P
T
F
P
Site 198
S1458
S
T
S
F
N
Y
S
S
S
S
P
T
F
P
K
Site 199
S1459
T
S
F
N
Y
S
S
S
S
P
T
F
P
K
G
Site 200
S1460
S
F
N
Y
S
S
S
S
P
T
F
P
K
G
L
Site 201
T1462
N
Y
S
S
S
S
P
T
F
P
K
G
L
A
G
Site 202
S1470
F
P
K
G
L
A
G
S
V
V
Q
L
S
H
K
Site 203
S1483
H
K
A
N
F
G
A
S
H
S
A
S
L
S
L
Site 204
S1489
A
S
H
S
A
S
L
S
L
Q
M
F
T
D
S
Site 205
S1496
S
L
Q
M
F
T
D
S
S
T
V
E
S
I
S
Site 206
T1498
Q
M
F
T
D
S
S
T
V
E
S
I
S
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation