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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MGC39518
Full Name:
Protein FAM126B
Alias:
F126B; Family with sequence similarity 126, member B; HYCC2
Type:
Mass (Da):
58647
Number AA:
530
UniProt ID:
Q8IXS8
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
E
F
K
A
L
P
D
T
Q
I
T
S
Y
A
A
Site 2
S26
L
P
D
T
Q
I
T
S
Y
A
A
T
L
H
R
Site 3
T30
Q
I
T
S
Y
A
A
T
L
H
R
K
K
T
L
Site 4
T36
A
T
L
H
R
K
K
T
L
V
P
A
L
Y
K
Site 5
Y42
K
T
L
V
P
A
L
Y
K
V
I
Q
D
S
N
Site 6
S48
L
Y
K
V
I
Q
D
S
N
N
E
L
L
E
P
Site 7
Y64
C
H
Q
L
F
E
L
Y
R
S
S
E
V
R
L
Site 8
S66
Q
L
F
E
L
Y
R
S
S
E
V
R
L
K
R
Site 9
S67
L
F
E
L
Y
R
S
S
E
V
R
L
K
R
F
Site 10
T75
E
V
R
L
K
R
F
T
L
Q
F
L
P
E
L
Site 11
T90
M
W
V
Y
L
R
L
T
V
S
R
D
R
Q
S
Site 12
S92
V
Y
L
R
L
T
V
S
R
D
R
Q
S
N
G
Site 13
S97
T
V
S
R
D
R
Q
S
N
G
C
I
E
A
L
Site 14
S124
D
G
N
N
K
V
L
S
F
T
I
P
S
L
S
Site 15
S131
S
F
T
I
P
S
L
S
K
P
S
I
Y
H
E
Site 16
S134
I
P
S
L
S
K
P
S
I
Y
H
E
P
S
T
Site 17
Y136
S
L
S
K
P
S
I
Y
H
E
P
S
T
I
G
Site 18
S140
P
S
I
Y
H
E
P
S
T
I
G
S
M
A
L
Site 19
T141
S
I
Y
H
E
P
S
T
I
G
S
M
A
L
T
Site 20
S144
H
E
P
S
T
I
G
S
M
A
L
T
E
G
A
Site 21
Y162
H
D
L
I
R
V
V
Y
S
D
L
H
P
Q
R
Site 22
T171
D
L
H
P
Q
R
E
T
F
T
A
Q
N
R
F
Site 23
Y194
C
Y
N
S
A
I
V
Y
M
P
A
S
S
Y
Q
Site 24
S202
M
P
A
S
S
Y
Q
S
L
C
R
M
G
S
R
Site 25
S213
M
G
S
R
V
C
V
S
G
F
P
R
Q
H
E
Site 26
Y246
Q
L
L
T
G
V
Y
Y
A
M
Y
N
G
Q
W
Site 27
Y249
T
G
V
Y
Y
A
M
Y
N
G
Q
W
D
L
G
Site 28
S293
L
P
F
D
A
P
D
S
T
Q
E
G
Q
K
V
Site 29
T294
P
F
D
A
P
D
S
T
Q
E
G
Q
K
V
L
Site 30
T306
K
V
L
K
V
E
V
T
P
T
V
P
R
I
S
Site 31
T308
L
K
V
E
V
T
P
T
V
P
R
I
S
R
T
Site 32
S313
T
P
T
V
P
R
I
S
R
T
A
I
T
T
A
Site 33
T319
I
S
R
T
A
I
T
T
A
S
I
R
R
H
R
Site 34
S321
R
T
A
I
T
T
A
S
I
R
R
H
R
W
R
Site 35
S341
G
V
N
G
G
E
E
S
V
N
L
N
D
A
D
Site 36
S352
N
D
A
D
E
G
F
S
S
G
A
S
L
S
S
Site 37
S353
D
A
D
E
G
F
S
S
G
A
S
L
S
S
Q
Site 38
S356
E
G
F
S
S
G
A
S
L
S
S
Q
P
I
G
Site 39
S358
F
S
S
G
A
S
L
S
S
Q
P
I
G
T
K
Site 40
S359
S
S
G
A
S
L
S
S
Q
P
I
G
T
K
P
Site 41
T364
L
S
S
Q
P
I
G
T
K
P
S
S
S
S
Q
Site 42
S367
Q
P
I
G
T
K
P
S
S
S
S
Q
R
G
S
Site 43
S368
P
I
G
T
K
P
S
S
S
S
Q
R
G
S
L
Site 44
S369
I
G
T
K
P
S
S
S
S
Q
R
G
S
L
R
Site 45
S370
G
T
K
P
S
S
S
S
Q
R
G
S
L
R
K
Site 46
S374
S
S
S
S
Q
R
G
S
L
R
K
V
A
T
G
Site 47
T380
G
S
L
R
K
V
A
T
G
R
S
A
K
D
K
Site 48
T389
R
S
A
K
D
K
E
T
A
S
A
I
K
S
S
Site 49
S391
A
K
D
K
E
T
A
S
A
I
K
S
S
E
S
Site 50
S395
E
T
A
S
A
I
K
S
S
E
S
P
R
D
S
Site 51
S396
T
A
S
A
I
K
S
S
E
S
P
R
D
S
V
Site 52
S398
S
A
I
K
S
S
E
S
P
R
D
S
V
V
R
Site 53
S402
S
S
E
S
P
R
D
S
V
V
R
K
Q
Y
V
Site 54
Y408
D
S
V
V
R
K
Q
Y
V
Q
Q
P
T
D
L
Site 55
S416
V
Q
Q
P
T
D
L
S
V
D
S
V
E
L
T
Site 56
S419
P
T
D
L
S
V
D
S
V
E
L
T
P
M
K
Site 57
T423
S
V
D
S
V
E
L
T
P
M
K
K
H
L
S
Site 58
S430
T
P
M
K
K
H
L
S
L
P
A
G
Q
V
V
Site 59
S442
Q
V
V
P
K
I
N
S
L
S
L
I
R
T
A
Site 60
T448
N
S
L
S
L
I
R
T
A
S
A
S
S
S
K
Site 61
S450
L
S
L
I
R
T
A
S
A
S
S
S
K
S
F
Site 62
S452
L
I
R
T
A
S
A
S
S
S
K
S
F
D
Y
Site 63
S454
R
T
A
S
A
S
S
S
K
S
F
D
Y
V
N
Site 64
S456
A
S
A
S
S
S
K
S
F
D
Y
V
N
G
S
Site 65
Y459
S
S
S
K
S
F
D
Y
V
N
G
S
Q
A
S
Site 66
S463
S
F
D
Y
V
N
G
S
Q
A
S
T
S
I
G
Site 67
T467
V
N
G
S
Q
A
S
T
S
I
G
V
G
T
E
Site 68
S468
N
G
S
Q
A
S
T
S
I
G
V
G
T
E
G
Site 69
Y487
A
A
N
N
A
N
R
Y
S
T
V
S
L
Q
E
Site 70
S488
A
N
N
A
N
R
Y
S
T
V
S
L
Q
E
D
Site 71
T489
N
N
A
N
R
Y
S
T
V
S
L
Q
E
D
R
Site 72
S491
A
N
R
Y
S
T
V
S
L
Q
E
D
R
L
G
Site 73
S508
G
E
G
K
E
L
L
S
P
G
A
P
L
T
K
Site 74
T514
L
S
P
G
A
P
L
T
K
Q
S
R
S
P
S
Site 75
S517
G
A
P
L
T
K
Q
S
R
S
P
S
F
N
M
Site 76
S519
P
L
T
K
Q
S
R
S
P
S
F
N
M
Q
L
Site 77
S521
T
K
Q
S
R
S
P
S
F
N
M
Q
L
I
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation