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Updated November 2019
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Protein Info
Short Name:
PNPLA6
Full Name:
Neuropathy target esterase
Alias:
Patatin-like phospholipase domain-containing protein 6
Type:
Enzyme, hydrolase, esterase
Mass (Da):
149995
Number AA:
1366
UniProt ID:
Q8IY17
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004622
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0016042
GO:0046470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
S
H
G
L
A
T
N
S
S
G
A
K
V
A
E
Site 2
S13
H
G
L
A
T
N
S
S
G
A
K
V
A
E
R
Site 3
T79
R
R
L
R
V
P
K
T
P
A
P
D
G
P
R
Site 4
Y87
P
A
P
D
G
P
R
Y
R
F
R
K
R
D
K
Site 5
Y98
K
R
D
K
V
L
F
Y
G
R
K
I
M
R
K
Site 6
S107
R
K
I
M
R
K
V
S
Q
S
T
S
S
L
V
Site 7
S109
I
M
R
K
V
S
Q
S
T
S
S
L
V
D
T
Site 8
S111
R
K
V
S
Q
S
T
S
S
L
V
D
T
S
V
Site 9
S112
K
V
S
Q
S
T
S
S
L
V
D
T
S
V
S
Site 10
T116
S
T
S
S
L
V
D
T
S
V
S
A
T
S
R
Site 11
S117
T
S
S
L
V
D
T
S
V
S
A
T
S
R
P
Site 12
S119
S
L
V
D
T
S
V
S
A
T
S
R
P
R
M
Site 13
T121
V
D
T
S
V
S
A
T
S
R
P
R
M
R
K
Site 14
S122
D
T
S
V
S
A
T
S
R
P
R
M
R
K
K
Site 15
T146
I
L
R
I
Q
K
E
T
P
T
L
Q
R
K
E
Site 16
T148
R
I
Q
K
E
T
P
T
L
Q
R
K
E
P
P
Site 17
S171
T
E
G
D
L
A
N
S
H
L
P
S
E
V
L
Site 18
Y212
Q
R
L
G
Q
G
D
Y
V
F
R
P
G
Q
P
Site 19
S222
R
P
G
Q
P
D
A
S
I
Y
V
V
Q
D
G
Site 20
T265
L
S
I
L
D
V
I
T
G
H
Q
H
P
Q
R
Site 21
T273
G
H
Q
H
P
Q
R
T
V
S
A
R
A
A
R
Site 22
S275
Q
H
P
Q
R
T
V
S
A
R
A
A
R
D
S
Site 23
S282
S
A
R
A
A
R
D
S
T
V
L
R
L
P
V
Site 24
T283
A
R
A
A
R
D
S
T
V
L
R
L
P
V
E
Site 25
T329
L
H
N
Y
L
G
L
T
N
E
L
F
S
H
E
Site 26
S345
Q
P
L
R
L
F
P
S
P
G
L
P
T
R
T
Site 27
T350
F
P
S
P
G
L
P
T
R
T
S
P
V
R
G
Site 28
T352
S
P
G
L
P
T
R
T
S
P
V
R
G
S
K
Site 29
S353
P
G
L
P
T
R
T
S
P
V
R
G
S
K
R
Site 30
S358
R
T
S
P
V
R
G
S
K
R
M
V
S
T
S
Site 31
S363
R
G
S
K
R
M
V
S
T
S
A
T
D
E
P
Site 32
T364
G
S
K
R
M
V
S
T
S
A
T
D
E
P
R
Site 33
S365
S
K
R
M
V
S
T
S
A
T
D
E
P
R
E
Site 34
T367
R
M
V
S
T
S
A
T
D
E
P
R
E
T
P
Site 35
T373
A
T
D
E
P
R
E
T
P
G
R
P
P
D
P
Site 36
T381
P
G
R
P
P
D
P
T
G
A
P
L
P
G
P
Site 37
S397
G
D
P
V
K
P
T
S
L
E
T
P
S
A
P
Site 38
T400
V
K
P
T
S
L
E
T
P
S
A
P
L
L
S
Site 39
S402
P
T
S
L
E
T
P
S
A
P
L
L
S
R
C
Site 40
S411
P
L
L
S
R
C
V
S
M
P
G
D
I
S
G
Site 41
S417
V
S
M
P
G
D
I
S
G
L
Q
G
G
P
R
Site 42
S425
G
L
Q
G
G
P
R
S
D
F
D
M
A
Y
E
Site 43
Y431
Q
P
A
G
A
C
E
Y
S
Y
C
E
D
E
S
Site 44
S437
A
Y
E
R
G
R
I
S
V
S
L
Q
E
E
A
Site 45
S439
E
R
G
R
I
S
V
S
L
Q
E
E
A
S
G
Site 46
S445
V
S
L
Q
E
E
A
S
G
G
S
L
A
A
P
Site 47
T455
S
L
A
A
P
A
R
T
P
T
Q
E
P
R
E
Site 48
T457
A
A
P
A
R
T
P
T
Q
E
P
R
E
Q
P
Site 49
Y470
Q
P
A
G
A
C
E
Y
S
Y
C
E
D
E
S
Site 50
S471
P
A
G
A
C
E
Y
S
Y
C
E
D
E
S
A
Site 51
Y472
A
G
A
C
E
Y
S
Y
C
E
D
E
S
A
T
Site 52
Y487
G
G
C
P
F
G
P
Y
Q
G
R
Q
T
S
S
Site 53
T492
G
P
Y
Q
G
R
Q
T
S
S
I
F
E
A
A
Site 54
S493
P
Y
Q
G
R
Q
T
S
S
I
F
E
A
A
K
Site 55
S517
E
D
P
S
L
L
N
S
R
V
L
L
H
H
A
Site 56
S539
R
Q
G
D
Q
D
V
S
L
H
F
V
L
W
G
Site 57
T586
T
G
E
P
L
I
F
T
L
R
A
Q
R
D
C
Site 58
T594
L
R
A
Q
R
D
C
T
F
L
R
I
S
K
S
Site 59
S599
D
C
T
F
L
R
I
S
K
S
D
F
Y
E
I
Site 60
S601
T
F
L
R
I
S
K
S
D
F
Y
E
I
M
R
Site 61
Y604
R
I
S
K
S
D
F
Y
E
I
M
R
A
Q
P
Site 62
S626
H
T
V
A
A
R
M
S
P
F
V
R
Q
M
D
Site 63
Y648
V
E
A
G
R
A
L
Y
R
Q
G
D
R
S
D
Site 64
S654
L
Y
R
Q
G
D
R
S
D
C
T
Y
I
V
L
Site 65
T657
Q
G
D
R
S
D
C
T
Y
I
V
L
N
G
R
Site 66
Y658
G
D
R
S
D
C
T
Y
I
V
L
N
G
R
L
Site 67
S667
V
L
N
G
R
L
R
S
V
I
Q
R
G
S
G
Site 68
S673
R
S
V
I
Q
R
G
S
G
K
K
E
L
V
G
Site 69
Y682
K
K
E
L
V
G
E
Y
G
R
G
D
L
I
G
Site 70
T695
I
G
V
V
E
A
L
T
R
Q
P
R
A
T
T
Site 71
T701
L
T
R
Q
P
R
A
T
T
V
H
A
V
R
D
Site 72
T702
T
R
Q
P
R
A
T
T
V
H
A
V
R
D
T
Site 73
T709
T
V
H
A
V
R
D
T
E
L
A
K
L
P
E
Site 74
T718
L
A
K
L
P
E
G
T
L
G
H
I
K
R
R
Site 75
Y726
L
G
H
I
K
R
R
Y
P
Q
V
V
T
R
L
Site 76
S756
Q
G
P
F
P
A
G
S
G
L
G
V
P
P
H
Site 77
S764
G
L
G
V
P
P
H
S
E
L
T
N
P
A
S
Site 78
T767
V
P
P
H
S
E
L
T
N
P
A
S
N
L
A
Site 79
S809
G
P
T
L
L
L
N
S
D
I
I
R
A
R
L
Site 80
S819
I
R
A
R
L
G
A
S
A
L
D
S
I
Q
E
Site 81
S830
S
I
Q
E
F
R
L
S
G
W
L
A
Q
Q
E
Site 82
Y845
D
A
H
R
I
V
L
Y
Q
T
D
A
S
L
T
Site 83
S850
V
L
Y
Q
T
D
A
S
L
T
P
W
T
V
R
Site 84
T852
Y
Q
T
D
A
S
L
T
P
W
T
V
R
C
L
Site 85
T855
D
A
S
L
T
P
W
T
V
R
C
L
R
Q
A
Site 86
T909
E
G
A
G
P
T
R
T
V
E
W
L
N
M
R
Site 87
S933
R
C
P
R
R
L
F
S
R
R
S
P
A
K
L
Site 88
S936
R
R
L
F
S
R
R
S
P
A
K
L
H
E
L
Site 89
Y944
P
A
K
L
H
E
L
Y
E
K
V
F
S
R
R
Site 90
S949
E
L
Y
E
K
V
F
S
R
R
A
D
R
H
S
Site 91
S956
S
R
R
A
D
R
H
S
D
F
S
R
L
A
R
Site 92
S959
A
D
R
H
S
D
F
S
R
L
A
R
V
L
T
Site 93
T966
S
R
L
A
R
V
L
T
G
N
T
I
A
L
V
Site 94
T969
A
R
V
L
T
G
N
T
I
A
L
V
L
G
G
Site 95
Y1014
G
S
F
I
G
A
L
Y
A
E
E
R
S
A
S
Site 96
S1021
Y
A
E
E
R
S
A
S
R
T
K
Q
R
A
R
Site 97
T1023
E
E
R
S
A
S
R
T
K
Q
R
A
R
E
W
Site 98
S1033
R
A
R
E
W
A
K
S
M
T
S
V
L
E
P
Site 99
S1055
V
T
S
M
F
T
G
S
A
F
N
R
S
I
H
Site 100
S1060
T
G
S
A
F
N
R
S
I
H
R
V
F
Q
D
Site 101
Y1100
K
D
G
S
L
W
R
Y
V
R
A
S
M
T
L
Site 102
T1106
R
Y
V
R
A
S
M
T
L
S
G
Y
L
P
P
Site 103
Y1128
H
L
L
M
D
G
G
Y
I
N
N
L
P
A
D
Site 104
T1156
D
V
G
S
Q
D
E
T
D
L
S
T
Y
G
D
Site 105
S1159
S
Q
D
E
T
D
L
S
T
Y
G
D
S
L
S
Site 106
T1160
Q
D
E
T
D
L
S
T
Y
G
D
S
L
S
G
Site 107
Y1161
D
E
T
D
L
S
T
Y
G
D
S
L
S
G
W
Site 108
S1164
D
L
S
T
Y
G
D
S
L
S
G
W
W
L
L
Site 109
S1198
Q
S
R
L
A
Y
V
S
C
V
R
Q
L
E
V
Site 110
S1208
R
Q
L
E
V
V
K
S
S
S
Y
C
E
Y
L
Site 111
S1210
L
E
V
V
K
S
S
S
Y
C
E
Y
L
R
P
Site 112
Y1214
K
S
S
S
Y
C
E
Y
L
R
P
P
I
D
C
Site 113
Y1234
F
G
K
F
D
Q
I
Y
D
V
G
Y
Q
Y
G
Site 114
Y1238
D
Q
I
Y
D
V
G
Y
Q
Y
G
K
A
V
F
Site 115
Y1240
I
Y
D
V
G
Y
Q
Y
G
K
A
V
F
G
G
Site 116
T1259
N
V
I
E
K
M
L
T
D
R
R
S
T
D
L
Site 117
S1263
K
M
L
T
D
R
R
S
T
D
L
N
E
S
R
Site 118
T1264
M
L
T
D
R
R
S
T
D
L
N
E
S
R
R
Site 119
S1290
T
D
L
A
E
I
V
S
R
I
E
P
P
T
S
Site 120
T1296
V
S
R
I
E
P
P
T
S
Y
V
S
D
G
C
Site 121
S1297
S
R
I
E
P
P
T
S
Y
V
S
D
G
C
A
Site 122
Y1298
R
I
E
P
P
T
S
Y
V
S
D
G
C
A
D
Site 123
S1300
E
P
P
T
S
Y
V
S
D
G
C
A
D
G
E
Site 124
S1309
G
C
A
D
G
E
E
S
D
C
L
T
E
Y
E
Site 125
T1313
G
E
E
S
D
C
L
T
E
Y
E
E
D
A
G
Site 126
Y1315
E
S
D
C
L
T
E
Y
E
E
D
A
G
P
D
Site 127
S1324
E
D
A
G
P
D
C
S
R
D
E
G
G
S
P
Site 128
S1330
C
S
R
D
E
G
G
S
P
E
G
A
S
P
S
Site 129
S1335
G
G
S
P
E
G
A
S
P
S
T
A
S
E
M
Site 130
S1337
S
P
E
G
A
S
P
S
T
A
S
E
M
E
E
Site 131
S1347
S
E
M
E
E
E
K
S
I
L
R
Q
R
R
C
Site 132
S1362
L
P
Q
E
P
P
G
S
A
T
D
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation