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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX60
Full Name:
Probable ATP-dependent RNA helicase DDX60
Alias:
ATP-dependent RNA helicase DDX60; DEAD (Asp-Glu-Ala-Asp) box polypeptide 60; DEAD box protein 60; FLJ20035
Type:
EC 3.6.1.-; Hydrolase
Mass (Da):
197810
Number AA:
UniProt ID:
Q8IY21
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
R
N
V
L
T
T
F
S
Q
E
M
S
Q
Site 2
S10
R
N
V
L
T
T
F
S
Q
E
M
S
Q
L
I
Site 3
S14
T
T
F
S
Q
E
M
S
Q
L
I
L
N
E
M
Site 4
Y92
V
F
F
K
D
A
E
Y
A
Y
F
N
F
P
E
Site 5
Y94
F
K
D
A
E
Y
A
Y
F
N
F
P
E
L
L
Site 6
T116
L
H
L
Q
K
N
T
T
I
D
V
R
T
T
F
Site 7
T122
T
T
I
D
V
R
T
T
F
S
R
C
L
S
K
Site 8
S124
I
D
V
R
T
T
F
S
R
C
L
S
K
E
W
Site 9
S128
T
T
F
S
R
C
L
S
K
E
W
G
S
F
L
Site 10
S133
C
L
S
K
E
W
G
S
F
L
E
E
S
Y
P
Site 11
S175
R
K
V
N
V
V
L
S
S
G
Q
E
S
D
V
Site 12
Y194
A
Y
L
L
P
S
M
Y
R
H
Q
I
F
S
W
Site 13
Y211
K
Q
N
I
K
D
A
Y
T
T
L
L
N
Q
L
Site 14
S247
E
E
A
H
K
T
V
S
L
L
T
Q
V
W
P
Site 15
Y275
C
S
L
S
L
R
M
Y
H
R
F
L
G
N
R
Site 16
S285
F
L
G
N
R
E
P
S
S
G
Q
E
T
E
I
Site 17
S286
L
G
N
R
E
P
S
S
G
Q
E
T
E
I
Q
Site 18
T290
E
P
S
S
G
Q
E
T
E
I
Q
Q
V
N
S
Site 19
T301
Q
V
N
S
N
C
L
T
L
Q
E
M
E
D
L
Site 20
Y387
L
L
K
N
I
A
F
Y
Y
E
N
E
N
V
K
Site 21
Y388
L
K
N
I
A
F
Y
Y
E
N
E
N
V
K
G
Site 22
T403
L
H
L
N
L
G
D
T
I
M
K
D
Y
E
Y
Site 23
Y408
G
D
T
I
M
K
D
Y
E
Y
L
W
N
T
V
Site 24
Y410
T
I
M
K
D
Y
E
Y
L
W
N
T
V
S
K
Site 25
T414
D
Y
E
Y
L
W
N
T
V
S
K
L
V
R
D
Site 26
T433
Q
P
F
P
L
R
T
T
K
V
C
F
L
G
K
Site 27
S443
C
F
L
G
K
K
P
S
P
I
K
D
S
S
N
Site 28
S449
P
S
P
I
K
D
S
S
N
E
M
V
P
N
L
Site 29
S482
K
D
L
P
F
L
K
S
D
D
P
I
V
T
S
Site 30
S489
S
D
D
P
I
V
T
S
L
V
K
Q
K
E
F
Site 31
S504
D
E
L
V
H
W
H
S
H
K
P
L
S
D
D
Site 32
S509
W
H
S
H
K
P
L
S
D
D
Y
D
R
S
R
Site 33
Y512
H
K
P
L
S
D
D
Y
D
R
S
R
C
Q
F
Site 34
S515
L
S
D
D
Y
D
R
S
R
C
Q
F
D
E
K
Site 35
S523
R
C
Q
F
D
E
K
S
R
D
P
R
V
L
R
Site 36
S531
R
D
P
R
V
L
R
S
V
Q
K
Y
H
V
F
Site 37
Y535
V
L
R
S
V
Q
K
Y
H
V
F
Q
R
F
Y
Site 38
Y542
Y
H
V
F
Q
R
F
Y
G
N
S
L
E
T
V
Site 39
S545
F
Q
R
F
Y
G
N
S
L
E
T
V
S
S
K
Site 40
S551
N
S
L
E
T
V
S
S
K
I
I
V
T
Q
T
Site 41
S561
I
V
T
Q
T
I
K
S
K
K
D
F
S
G
P
Site 42
S566
I
K
S
K
K
D
F
S
G
P
K
S
K
K
A
Site 43
S570
K
D
F
S
G
P
K
S
K
K
A
H
E
T
K
Site 44
S605
E
Q
K
W
N
A
L
S
F
S
I
E
E
Q
L
Site 45
S607
K
W
N
A
L
S
F
S
I
E
E
Q
L
K
E
Site 46
S618
Q
L
K
E
N
L
H
S
G
I
K
S
L
E
D
Site 47
S622
N
L
H
S
G
I
K
S
L
E
D
F
L
K
S
Site 48
S629
S
L
E
D
F
L
K
S
C
K
S
S
C
V
K
Site 49
S632
D
F
L
K
S
C
K
S
S
C
V
K
L
Q
V
Site 50
S633
F
L
K
S
C
K
S
S
C
V
K
L
Q
V
E
Site 51
S657
A
W
K
E
H
C
R
S
E
E
G
K
T
T
K
Site 52
T662
C
R
S
E
E
G
K
T
T
K
D
L
S
I
A
Site 53
T663
R
S
E
E
G
K
T
T
K
D
L
S
I
A
V
Site 54
S667
G
K
T
T
K
D
L
S
I
A
V
Q
V
M
K
Site 55
S678
Q
V
M
K
R
I
H
S
L
M
E
K
Y
S
E
Site 56
S710
G
F
D
E
L
A
S
S
L
H
P
A
Q
D
A
Site 57
Y729
K
V
K
K
R
N
K
Y
S
V
G
I
G
P
A
Site 58
S730
V
K
K
R
N
K
Y
S
V
G
I
G
P
A
R
Site 59
Y742
P
A
R
F
Q
L
Q
Y
M
G
H
Y
L
I
R
Site 60
Y746
Q
L
Q
Y
M
G
H
Y
L
I
R
D
E
R
K
Site 61
T766
V
Q
D
F
I
P
D
T
W
Q
R
E
L
L
D
Site 62
T792
A
P
T
S
S
G
K
T
Y
A
S
Y
Y
C
M
Site 63
Y793
P
T
S
S
G
K
T
Y
A
S
Y
Y
C
M
E
Site 64
Y796
S
G
K
T
Y
A
S
Y
Y
C
M
E
K
V
L
Site 65
Y797
G
K
T
Y
A
S
Y
Y
C
M
E
K
V
L
K
Site 66
T833
A
T
V
Q
N
R
F
T
K
N
L
P
S
G
E
Site 67
Y850
C
G
V
F
T
R
E
Y
R
H
D
A
L
N
C
Site 68
Y885
N
W
V
K
K
I
R
Y
V
I
F
D
E
V
H
Site 69
S922
L
A
L
S
A
T
I
S
N
P
E
H
L
T
E
Site 70
T949
D
K
I
I
E
N
N
T
A
S
K
R
H
V
G
Site 71
S951
I
I
E
N
N
T
A
S
K
R
H
V
G
R
Q
Site 72
Y965
Q
A
G
F
P
K
D
Y
L
Q
V
K
Q
S
Y
Site 73
S971
D
Y
L
Q
V
K
Q
S
Y
K
V
R
L
V
L
Site 74
Y979
Y
K
V
R
L
V
L
Y
G
E
R
Y
N
D
L
Site 75
Y983
L
V
L
Y
G
E
R
Y
N
D
L
E
K
H
V
Site 76
Y1017
T
T
D
H
I
E
R
Y
G
F
P
P
D
L
T
Site 77
T1024
Y
G
F
P
P
D
L
T
L
S
P
R
E
S
I
Site 78
S1026
F
P
P
D
L
T
L
S
P
R
E
S
I
Q
L
Site 79
S1030
L
T
L
S
P
R
E
S
I
Q
L
Y
D
A
M
Site 80
Y1034
P
R
E
S
I
Q
L
Y
D
A
M
F
Q
I
W
Site 81
Y1072
K
K
M
D
A
R
K
Y
E
E
S
L
K
A
E
Site 82
S1075
D
A
R
K
Y
E
E
S
L
K
A
E
L
T
S
Site 83
S1100
R
M
V
L
Q
N
L
S
P
E
A
D
L
S
P
Site 84
S1106
L
S
P
E
A
D
L
S
P
E
N
M
I
T
M
Site 85
T1112
L
S
P
E
N
M
I
T
M
F
P
L
L
V
E
Site 86
S1145
A
V
E
N
A
A
E
S
V
S
T
F
L
K
K
Site 87
T1148
N
A
A
E
S
V
S
T
F
L
K
K
K
Q
E
Site 88
S1179
K
L
R
K
V
K
K
S
I
E
K
Q
K
I
I
Site 89
S1190
Q
K
I
I
D
E
K
S
Q
K
K
T
R
N
V
Site 90
S1200
K
T
R
N
V
D
Q
S
L
I
H
E
A
E
H
Site 91
T1225
L
E
I
P
Q
D
C
T
Y
A
D
Q
K
A
V
Site 92
Y1226
E
I
P
Q
D
C
T
Y
A
D
Q
K
A
V
D
Site 93
T1236
Q
K
A
V
D
T
E
T
L
Q
K
V
F
G
R
Site 94
Y1263
L
A
E
R
G
I
G
Y
H
H
S
A
M
S
F
Site 95
S1266
R
G
I
G
Y
H
H
S
A
M
S
F
K
E
K
Site 96
S1269
G
Y
H
H
S
A
M
S
F
K
E
K
Q
L
V
Site 97
Y1313
V
F
A
Q
N
S
V
Y
L
D
A
L
N
Y
R
Site 98
Y1319
V
Y
L
D
A
L
N
Y
R
Q
M
S
G
R
A
Site 99
S1323
A
L
N
Y
R
Q
M
S
G
R
A
G
R
R
G
Site 100
S1353
K
I
G
K
L
I
K
S
N
V
P
E
L
R
G
Site 101
S1377
L
R
L
M
L
L
A
S
K
G
D
D
P
E
D
Site 102
T1385
K
G
D
D
P
E
D
T
K
A
K
V
L
S
V
Site 103
Y1425
Q
F
L
V
K
E
G
Y
L
D
Q
E
G
N
P
Site 104
Y1444
G
L
V
S
H
L
H
Y
H
E
P
S
N
L
V
Site 105
S1472
C
Q
P
T
R
K
G
S
K
H
F
S
Q
D
V
Site 106
S1476
R
K
G
S
K
H
F
S
Q
D
V
M
E
K
L
Site 107
Y1495
A
H
L
F
G
R
R
Y
F
P
P
K
F
Q
D
Site 108
Y1508
Q
D
A
H
F
E
F
Y
Q
S
K
V
F
L
D
Site 109
S1522
D
D
L
P
E
D
F
S
D
A
L
D
E
Y
N
Site 110
Y1528
F
S
D
A
L
D
E
Y
N
M
K
I
M
E
D
Site 111
Y1553
L
A
D
M
N
Q
E
Y
Q
L
P
L
S
K
I
Site 112
S1558
Q
E
Y
Q
L
P
L
S
K
I
K
F
T
G
K
Site 113
S1570
T
G
K
E
C
E
D
S
Q
L
V
S
H
L
M
Site 114
S1574
C
E
D
S
Q
L
V
S
H
L
M
S
C
K
E
Site 115
S1578
Q
L
V
S
H
L
M
S
C
K
E
G
R
V
A
Site 116
T1605
D
D
L
L
R
L
E
T
P
N
H
V
T
L
G
Site 117
S1626
S
Q
A
P
V
L
L
S
Q
K
F
D
N
R
G
Site 118
S1637
D
N
R
G
R
K
M
S
L
N
A
Y
A
L
D
Site 119
Y1641
R
K
M
S
L
N
A
Y
A
L
D
F
Y
K
H
Site 120
Y1646
N
A
Y
A
L
D
F
Y
K
H
G
S
L
I
G
Site 121
Y1666
R
M
N
E
G
D
A
Y
Y
L
L
K
D
F
A
Site 122
Y1667
M
N
E
G
D
A
Y
Y
L
L
K
D
F
A
L
Site 123
S1682
T
I
K
S
I
S
V
S
L
R
E
L
C
E
N
Site 124
T1703
L
A
F
E
Q
L
S
T
T
F
W
E
K
L
N
Site 125
T1704
A
F
E
Q
L
S
T
T
F
W
E
K
L
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation