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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KBTBD2
Full Name:
Kelch repeat and BTB domain-containing protein 2
Alias:
BTB and kelch domain-containing protein 1
Type:
Mass (Da):
71331
Number AA:
623
UniProt ID:
Q8IY47
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
E
R
Q
I
N
T
E
Y
A
V
S
L
L
E
Q
Site 2
S62
Y
F
R
A
M
F
M
S
G
L
S
E
S
K
Q
Site 3
S65
A
M
F
M
S
G
L
S
E
S
K
Q
T
H
V
Site 4
S67
F
M
S
G
L
S
E
S
K
Q
T
H
V
H
L
Site 5
T70
G
L
S
E
S
K
Q
T
H
V
H
L
R
N
V
Site 6
S99
G
N
L
A
M
N
D
S
T
V
E
Q
L
Y
E
Site 7
T100
N
L
A
M
N
D
S
T
V
E
Q
L
Y
E
T
Site 8
Y105
D
S
T
V
E
Q
L
Y
E
T
A
C
F
L
Q
Site 9
Y123
V
L
Q
R
C
R
E
Y
L
I
K
K
I
N
A
Site 10
S144
L
S
F
A
D
L
F
S
C
E
E
L
K
Q
S
Site 11
S151
S
C
E
E
L
K
Q
S
A
K
R
M
V
E
H
Site 12
Y164
E
H
K
F
T
A
V
Y
H
Q
D
A
F
M
Q
Site 13
T193
L
N
V
E
K
E
E
T
V
R
E
A
A
M
L
Site 14
Y204
A
A
M
L
W
L
E
Y
N
T
E
S
R
S
Q
Site 15
T206
M
L
W
L
E
Y
N
T
E
S
R
S
Q
Y
L
Site 16
S208
W
L
E
Y
N
T
E
S
R
S
Q
Y
L
S
S
Site 17
S210
E
Y
N
T
E
S
R
S
Q
Y
L
S
S
V
L
Site 18
Y212
N
T
E
S
R
S
Q
Y
L
S
S
V
L
S
Q
Site 19
S214
E
S
R
S
Q
Y
L
S
S
V
L
S
Q
I
R
Site 20
S215
S
R
S
Q
Y
L
S
S
V
L
S
Q
I
R
I
Site 21
S226
Q
I
R
I
D
A
L
S
E
V
T
Q
R
A
W
Site 22
S243
G
L
P
P
N
D
K
S
V
V
V
Q
G
L
Y
Site 23
S252
V
V
Q
G
L
Y
K
S
M
P
K
F
F
K
P
Site 24
S281
A
S
S
E
N
P
C
S
L
Y
S
S
V
C
Y
Site 25
Y283
S
E
N
P
C
S
L
Y
S
S
V
C
Y
S
P
Site 26
S284
E
N
P
C
S
L
Y
S
S
V
C
Y
S
P
Q
Site 27
S285
N
P
C
S
L
Y
S
S
V
C
Y
S
P
Q
A
Site 28
Y288
S
L
Y
S
S
V
C
Y
S
P
Q
A
E
K
V
Site 29
S289
L
Y
S
S
V
C
Y
S
P
Q
A
E
K
V
Y
Site 30
Y296
S
P
Q
A
E
K
V
Y
K
L
C
S
P
P
A
Site 31
S300
E
K
V
Y
K
L
C
S
P
P
A
D
L
H
K
Site 32
T310
A
D
L
H
K
V
G
T
V
V
T
P
D
N
D
Site 33
T313
H
K
V
G
T
V
V
T
P
D
N
D
I
Y
I
Site 34
Y319
V
T
P
D
N
D
I
Y
I
A
G
G
Q
V
P
Site 35
T332
V
P
L
K
N
T
K
T
N
H
S
K
T
S
K
Site 36
T342
S
K
T
S
K
L
Q
T
A
F
R
T
V
N
C
Site 37
S389
I
Y
A
I
G
G
D
S
V
G
G
E
L
N
R
Site 38
T398
G
G
E
L
N
R
R
T
V
E
R
Y
D
T
E
Site 39
Y402
N
R
R
T
V
E
R
Y
D
T
E
K
D
E
W
Site 40
T404
R
T
V
E
R
Y
D
T
E
K
D
E
W
T
M
Site 41
T410
D
T
E
K
D
E
W
T
M
V
S
P
L
P
C
Site 42
Y442
T
L
N
L
M
Y
C
Y
F
P
R
S
D
S
W
Site 43
T457
V
E
M
A
M
R
Q
T
S
R
S
F
A
S
A
Site 44
S458
E
M
A
M
R
Q
T
S
R
S
F
A
S
A
A
Site 45
S460
A
M
R
Q
T
S
R
S
F
A
S
A
A
A
F
Site 46
S483
G
L
H
I
A
T
N
S
G
I
R
L
P
S
G
Site 47
S489
N
S
G
I
R
L
P
S
G
T
V
D
G
S
S
Site 48
T491
G
I
R
L
P
S
G
T
V
D
G
S
S
V
T
Site 49
S496
S
G
T
V
D
G
S
S
V
T
V
E
I
Y
D
Site 50
Y502
S
S
V
T
V
E
I
Y
D
V
N
K
N
E
W
Site 51
Y520
A
N
I
P
A
K
R
Y
S
D
P
C
V
R
A
Site 52
S521
N
I
P
A
K
R
Y
S
D
P
C
V
R
A
V
Site 53
T541
L
C
V
F
M
R
E
T
H
L
N
E
R
A
K
Site 54
Y549
H
L
N
E
R
A
K
Y
V
T
Y
Q
Y
D
L
Site 55
T551
N
E
R
A
K
Y
V
T
Y
Q
Y
D
L
E
L
Site 56
S562
D
L
E
L
D
R
W
S
L
R
Q
H
I
S
E
Site 57
T582
L
G
R
D
F
R
C
T
V
G
K
L
Y
P
S
Site 58
Y587
R
C
T
V
G
K
L
Y
P
S
C
L
E
E
S
Site 59
S589
T
V
G
K
L
Y
P
S
C
L
E
E
S
P
W
Site 60
S594
Y
P
S
C
L
E
E
S
P
W
K
P
P
T
Y
Site 61
T600
E
S
P
W
K
P
P
T
Y
L
F
S
T
D
G
Site 62
Y601
S
P
W
K
P
P
T
Y
L
F
S
T
D
G
T
Site 63
S604
K
P
P
T
Y
L
F
S
T
D
G
T
E
E
F
Site 64
T608
Y
L
F
S
T
D
G
T
E
E
F
E
L
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation