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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AMOTL1
Full Name:
Angiomotin-like protein 1
Alias:
AMOL1; Angiomotin like 1; JEAP; Junction-enriched and associated protein
Type:
Adaptor/scaffold
Mass (Da):
106574
Number AA:
956
UniProt ID:
Q8IY63
International Prot ID:
IPI00217664
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005911
GO:0005923
GO:0030054
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
R
A
K
L
R
R
G
T
C
E
P
A
V
K
G
Site 2
S18
C
E
P
A
V
K
G
S
P
S
A
C
Y
S
P
Site 3
S20
P
A
V
K
G
S
P
S
A
C
Y
S
P
S
S
Site 4
Y23
K
G
S
P
S
A
C
Y
S
P
S
S
P
V
Q
Site 5
S24
G
S
P
S
A
C
Y
S
P
S
S
P
V
Q
V
Site 6
S26
P
S
A
C
Y
S
P
S
S
P
V
Q
V
L
E
Site 7
S27
S
A
C
Y
S
P
S
S
P
V
Q
V
L
E
D
Site 8
S35
P
V
Q
V
L
E
D
S
T
Y
F
S
P
D
F
Site 9
Y37
Q
V
L
E
D
S
T
Y
F
S
P
D
F
Q
L
Site 10
S39
L
E
D
S
T
Y
F
S
P
D
F
Q
L
Y
S
Site 11
Y45
F
S
P
D
F
Q
L
Y
S
G
R
H
E
T
S
Site 12
S46
S
P
D
F
Q
L
Y
S
G
R
H
E
T
S
A
Site 13
T51
L
Y
S
G
R
H
E
T
S
A
L
T
V
E
A
Site 14
T55
R
H
E
T
S
A
L
T
V
E
A
T
S
S
I
Site 15
S61
L
T
V
E
A
T
S
S
I
R
E
K
V
V
E
Site 16
S76
D
P
L
C
N
F
H
S
P
N
F
L
R
I
S
Site 17
S83
S
P
N
F
L
R
I
S
E
V
E
M
R
G
S
Site 18
S90
S
E
V
E
M
R
G
S
E
D
A
A
A
G
T
Site 19
T97
S
E
D
A
A
A
G
T
V
L
Q
R
L
I
Q
Site 20
Y109
L
I
Q
E
Q
L
R
Y
G
T
P
T
E
N
M
Site 21
T111
Q
E
Q
L
R
Y
G
T
P
T
E
N
M
N
L
Site 22
T113
Q
L
R
Y
G
T
P
T
E
N
M
N
L
L
A
Site 23
T135
S
A
G
P
A
H
P
T
N
N
F
S
S
T
E
Site 24
Y153
Q
E
D
P
Q
M
V
Y
Q
S
A
R
Q
E
P
Site 25
S155
D
P
Q
M
V
Y
Q
S
A
R
Q
E
P
Q
G
Site 26
T170
Q
E
H
Q
V
D
N
T
V
M
E
K
Q
V
R
Site 27
T179
M
E
K
Q
V
R
S
T
Q
P
Q
Q
N
N
E
Site 28
T190
Q
N
N
E
E
L
P
T
Y
E
E
A
K
A
Q
Site 29
Y191
N
N
E
E
L
P
T
Y
E
E
A
K
A
Q
S
Site 30
Y218
Q
G
A
V
G
H
G
Y
Y
M
A
G
G
T
S
Site 31
Y219
G
A
V
G
H
G
Y
Y
M
A
G
G
T
S
Q
Site 32
T224
G
Y
Y
M
A
G
G
T
S
Q
K
S
R
T
E
Site 33
S225
Y
Y
M
A
G
G
T
S
Q
K
S
R
T
E
G
Site 34
S228
A
G
G
T
S
Q
K
S
R
T
E
G
R
P
T
Site 35
T235
S
R
T
E
G
R
P
T
V
N
R
A
N
S
G
Site 36
S241
P
T
V
N
R
A
N
S
G
Q
A
H
K
D
E
Site 37
S260
L
K
Q
G
H
V
R
S
L
S
E
R
I
M
Q
Site 38
S262
Q
G
H
V
R
S
L
S
E
R
I
M
Q
L
S
Site 39
S269
S
E
R
I
M
Q
L
S
L
E
R
N
G
A
K
Site 40
S282
A
K
Q
H
L
P
G
S
G
N
G
K
G
F
K
Site 41
S295
F
K
V
G
G
G
P
S
P
A
Q
P
A
G
K
Site 42
Y313
P
R
G
P
P
P
E
Y
P
F
K
T
K
Q
M
Site 43
T317
P
P
E
Y
P
F
K
T
K
Q
M
M
S
P
V
Site 44
S322
F
K
T
K
Q
M
M
S
P
V
S
K
T
Q
E
Site 45
S325
K
Q
M
M
S
P
V
S
K
T
Q
E
H
G
L
Site 46
T327
M
M
S
P
V
S
K
T
Q
E
H
G
L
F
Y
Site 47
Y334
T
Q
E
H
G
L
F
Y
G
D
Q
H
P
G
M
Site 48
Y349
L
H
E
M
V
K
P
Y
P
A
P
Q
P
V
R
Site 49
T357
P
A
P
Q
P
V
R
T
D
V
A
V
L
R
Y
Site 50
Y364
T
D
V
A
V
L
R
Y
Q
P
P
P
E
Y
G
Site 51
Y370
R
Y
Q
P
P
P
E
Y
G
V
T
S
R
P
C
Site 52
T373
P
P
P
E
Y
G
V
T
S
R
P
C
Q
L
P
Site 53
S374
P
P
E
Y
G
V
T
S
R
P
C
Q
L
P
F
Site 54
S383
P
C
Q
L
P
F
P
S
T
M
Q
Q
H
S
P
Site 55
S389
P
S
T
M
Q
Q
H
S
P
M
S
S
Q
T
S
Site 56
S392
M
Q
Q
H
S
P
M
S
S
Q
T
S
S
A
S
Site 57
S393
Q
Q
H
S
P
M
S
S
Q
T
S
S
A
S
G
Site 58
T395
H
S
P
M
S
S
Q
T
S
S
A
S
G
P
L
Site 59
S396
S
P
M
S
S
Q
T
S
S
A
S
G
P
L
H
Site 60
S397
P
M
S
S
Q
T
S
S
A
S
G
P
L
H
S
Site 61
S399
S
S
Q
T
S
S
A
S
G
P
L
H
S
V
S
Site 62
S425
P
Q
P
P
P
A
A
S
P
S
Q
Q
L
G
P
Site 63
S427
P
P
P
A
A
S
P
S
Q
Q
L
G
P
D
A
Site 64
Y462
L
H
Q
E
L
Q
G
Y
Y
D
N
A
D
K
L
Site 65
S480
E
K
E
L
Q
R
I
S
E
A
Y
E
S
L
V
Site 66
Y483
L
Q
R
I
S
E
A
Y
E
S
L
V
K
S
T
Site 67
S485
R
I
S
E
A
Y
E
S
L
V
K
S
T
T
K
Site 68
S489
A
Y
E
S
L
V
K
S
T
T
K
R
E
S
L
Site 69
T491
E
S
L
V
K
S
T
T
K
R
E
S
L
D
K
Site 70
S495
K
S
T
T
K
R
E
S
L
D
K
A
M
R
N
Site 71
T524
D
L
R
D
R
L
E
T
A
N
R
Q
L
S
S
Site 72
S530
E
T
A
N
R
Q
L
S
S
R
E
Y
E
G
H
Site 73
S531
T
A
N
R
Q
L
S
S
R
E
Y
E
G
H
E
Site 74
Y534
R
Q
L
S
S
R
E
Y
E
G
H
E
D
K
A
Site 75
S548
A
A
E
G
H
Y
A
S
Q
N
K
E
F
L
K
Site 76
S571
L
A
A
V
R
T
A
S
E
D
H
R
R
H
I
Site 77
Y605
E
L
R
E
K
Q
A
Y
V
E
K
V
E
K
L
Site 78
T617
E
K
L
Q
Q
A
L
T
Q
L
Q
S
A
C
E
Site 79
S621
Q
A
L
T
Q
L
Q
S
A
C
E
K
R
E
Q
Site 80
T635
Q
M
E
R
R
L
R
T
W
L
E
R
E
L
D
Site 81
T646
R
E
L
D
A
L
R
T
Q
Q
K
H
G
N
G
Site 82
Y661
Q
P
A
N
M
P
E
Y
N
A
P
A
L
L
E
Site 83
T685
L
A
L
E
A
D
M
T
K
W
E
Q
K
Y
L
Site 84
Y691
M
T
K
W
E
Q
K
Y
L
E
E
S
T
I
R
Site 85
T696
Q
K
Y
L
E
E
S
T
I
R
H
F
A
M
N
Site 86
T714
T
A
A
A
E
R
D
T
T
I
I
N
H
S
R
Site 87
T715
A
A
A
E
R
D
T
T
I
I
N
H
S
R
N
Site 88
S720
D
T
T
I
I
N
H
S
R
N
G
S
Y
G
E
Site 89
S724
I
N
H
S
R
N
G
S
Y
G
E
S
S
L
E
Site 90
S728
R
N
G
S
Y
G
E
S
S
L
E
A
H
I
W
Site 91
S729
N
G
S
Y
G
E
S
S
L
E
A
H
I
W
Q
Site 92
Y753
R
R
C
Q
D
M
E
Y
T
I
K
N
L
H
A
Site 93
T783
S
R
K
D
A
G
K
T
D
S
S
S
L
R
P
Site 94
S785
K
D
A
G
K
T
D
S
S
S
L
R
P
A
R
Site 95
S787
A
G
K
T
D
S
S
S
L
R
P
A
R
S
V
Site 96
S793
S
S
L
R
P
A
R
S
V
P
S
I
A
A
A
Site 97
S796
R
P
A
R
S
V
P
S
I
A
A
A
T
G
T
Site 98
T803
S
I
A
A
A
T
G
T
H
S
R
Q
T
S
L
Site 99
S805
A
A
A
T
G
T
H
S
R
Q
T
S
L
T
S
Site 100
T808
T
G
T
H
S
R
Q
T
S
L
T
S
S
Q
L
Site 101
S809
G
T
H
S
R
Q
T
S
L
T
S
S
Q
L
A
Site 102
T811
H
S
R
Q
T
S
L
T
S
S
Q
L
A
E
E
Site 103
S813
R
Q
T
S
L
T
S
S
Q
L
A
E
E
K
K
Site 104
T824
E
E
K
K
E
E
K
T
W
K
G
S
I
G
L
Site 105
S828
E
E
K
T
W
K
G
S
I
G
L
L
L
G
K
Site 106
S842
K
E
H
H
E
H
A
S
A
P
L
L
P
P
P
Site 107
S855
P
P
P
T
S
A
L
S
S
I
A
S
T
T
A
Site 108
S859
S
A
L
S
S
I
A
S
T
T
A
A
S
S
A
Site 109
S864
I
A
S
T
T
A
A
S
S
A
H
A
K
T
G
Site 110
S865
A
S
T
T
A
A
S
S
A
H
A
K
T
G
S
Site 111
T870
A
S
S
A
H
A
K
T
G
S
K
D
S
S
T
Site 112
S872
S
A
H
A
K
T
G
S
K
D
S
S
T
Q
T
Site 113
S876
K
T
G
S
K
D
S
S
T
Q
T
D
K
S
A
Site 114
T877
T
G
S
K
D
S
S
T
Q
T
D
K
S
A
E
Site 115
T879
S
K
D
S
S
T
Q
T
D
K
S
A
E
L
F
Site 116
S882
S
S
T
Q
T
D
K
S
A
E
L
F
W
P
S
Site 117
S889
S
A
E
L
F
W
P
S
M
A
S
L
P
S
R
Site 118
S892
L
F
W
P
S
M
A
S
L
P
S
R
G
R
L
Site 119
S895
P
S
M
A
S
L
P
S
R
G
R
L
S
T
T
Site 120
S900
L
P
S
R
G
R
L
S
T
T
P
A
H
S
P
Site 121
T901
P
S
R
G
R
L
S
T
T
P
A
H
S
P
V
Site 122
T902
S
R
G
R
L
S
T
T
P
A
H
S
P
V
L
Site 123
S906
L
S
T
T
P
A
H
S
P
V
L
K
H
P
A
Site 124
T917
K
H
P
A
A
K
G
T
A
E
K
L
E
N
S
Site 125
S924
T
A
E
K
L
E
N
S
P
G
H
G
K
S
P
Site 126
S930
N
S
P
G
H
G
K
S
P
D
H
R
G
R
V
Site 127
S938
P
D
H
R
G
R
V
S
S
L
L
H
K
P
E
Site 128
S939
D
H
R
G
R
V
S
S
L
L
H
K
P
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation