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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GSPT2
Full Name:
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
Alias:
eRF3b; G1 to S phase transition 2; GST2; Peptide chain release factor 3
Type:
Protein synthesis protein, GTP-binding elongation factor family. ERF3 subfamily
Mass (Da):
68883
Number AA:
628
UniProt ID:
Q8IYD1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006412
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
D
S
G
S
S
S
S
D
S
A
P
Site 2
S6
_
_
M
D
S
G
S
S
S
S
D
S
A
P
D
Site 3
S7
_
M
D
S
G
S
S
S
S
D
S
A
P
D
C
Site 4
S8
M
D
S
G
S
S
S
S
D
S
A
P
D
C
W
Site 5
S10
S
G
S
S
S
S
D
S
A
P
D
C
W
D
Q
Site 6
S22
W
D
Q
V
D
M
E
S
P
G
S
A
P
S
G
Site 7
S25
V
D
M
E
S
P
G
S
A
P
S
G
D
G
V
Site 8
S28
E
S
P
G
S
A
P
S
G
D
G
V
S
S
A
Site 9
S45
E
A
Q
R
E
P
L
S
S
A
F
S
R
K
L
Site 10
S46
A
Q
R
E
P
L
S
S
A
F
S
R
K
L
N
Site 11
S49
E
P
L
S
S
A
F
S
R
K
L
N
V
N
A
Site 12
S71
H
A
A
E
F
V
P
S
F
L
R
G
P
T
Q
Site 13
T77
P
S
F
L
R
G
P
T
Q
P
P
T
L
P
A
Site 14
T81
R
G
P
T
Q
P
P
T
L
P
A
G
S
G
S
Site 15
S86
P
P
T
L
P
A
G
S
G
S
N
D
E
T
C
Site 16
S88
T
L
P
A
G
S
G
S
N
D
E
T
C
T
G
Site 17
T92
G
S
G
S
N
D
E
T
C
T
G
A
G
Y
P
Site 18
Y98
E
T
C
T
G
A
G
Y
P
Q
G
K
R
M
G
Site 19
S113
R
G
A
P
V
E
P
S
R
E
E
P
L
V
S
Site 20
S120
S
R
E
E
P
L
V
S
L
E
G
S
N
S
A
Site 21
T129
E
G
S
N
S
A
V
T
M
E
L
S
E
P
V
Site 22
S133
S
A
V
T
M
E
L
S
E
P
V
V
E
N
G
Site 23
S149
V
E
M
A
L
E
E
S
W
E
H
S
K
E
V
Site 24
S153
L
E
E
S
W
E
H
S
K
E
V
S
E
A
E
Site 25
S157
W
E
H
S
K
E
V
S
E
A
E
P
G
G
G
Site 26
S165
E
A
E
P
G
G
G
S
S
G
D
S
G
P
P
Site 27
S169
G
G
G
S
S
G
D
S
G
P
P
E
E
S
G
Site 28
S189
E
K
E
E
I
R
K
S
K
S
V
I
V
P
S
Site 29
S191
E
E
I
R
K
S
K
S
V
I
V
P
S
G
A
Site 30
S196
S
K
S
V
I
V
P
S
G
A
P
K
K
E
H
Site 31
S217
G
H
V
D
A
G
K
S
T
I
G
G
Q
I
M
Site 32
T234
T
G
M
V
D
K
R
T
L
E
K
Y
E
R
E
Site 33
Y238
D
K
R
T
L
E
K
Y
E
R
E
A
K
E
K
Site 34
T249
A
K
E
K
N
R
E
T
W
Y
L
S
W
A
L
Site 35
Y251
E
K
N
R
E
T
W
Y
L
S
W
A
L
D
T
Site 36
T268
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Site 37
Y275
T
V
E
V
G
R
A
Y
F
E
T
E
R
K
H
Site 38
T278
V
G
R
A
Y
F
E
T
E
R
K
H
F
T
I
Site 39
S293
L
D
A
P
G
H
K
S
F
V
P
N
M
I
G
Site 40
T321
A
R
K
G
E
F
E
T
G
F
E
K
G
G
Q
Site 41
T355
I
N
K
M
D
D
P
T
V
N
W
S
I
E
R
Site 42
Y363
V
N
W
S
I
E
R
Y
E
E
C
K
E
K
L
Site 43
S380
F
L
K
K
V
G
F
S
P
K
K
D
I
H
F
Site 44
Y408
Q
S
D
F
C
P
W
Y
T
G
L
P
F
I
P
Site 45
Y439
R
L
P
I
V
D
K
Y
K
D
M
G
T
V
V
Site 46
T444
D
K
Y
K
D
M
G
T
V
V
L
G
K
L
E
Site 47
S454
L
G
K
L
E
S
G
S
I
F
K
G
Q
Q
L
Site 48
T482
I
L
S
D
D
T
E
T
D
F
V
A
P
G
E
Site 49
S518
D
P
S
N
L
C
H
S
G
R
T
F
D
V
Q
Site 50
S565
I
S
L
V
D
K
K
S
G
E
K
S
K
T
R
Site 51
S569
D
K
K
S
G
E
K
S
K
T
R
P
R
F
V
Site 52
T571
K
S
G
E
K
S
K
T
R
P
R
F
V
K
Q
Site 53
T607
F
P
Q
M
G
R
F
T
L
R
D
E
G
K
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation