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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FANCM
Full Name:
Fanconi anemia group M protein
Alias:
ATP-dependent RNA helicase FANCM; FAAP250; FACM; Fanconi anemia, complementation group M; Fanconi anemia-associated polypeptide of 250 kDa; Hef; KIAA1596
Type:
EC 3.6.1.-; Helicase
Mass (Da):
232190
Number AA:
UniProt ID:
Q8IYD8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
S
G
R
Q
R
T
L
F
Q
T
W
G
S
Site 2
T11
R
Q
R
T
L
F
Q
T
W
G
S
S
I
S
R
Site 3
S14
T
L
F
Q
T
W
G
S
S
I
S
R
S
S
G
Site 4
S15
L
F
Q
T
W
G
S
S
I
S
R
S
S
G
T
Site 5
S17
Q
T
W
G
S
S
I
S
R
S
S
G
T
P
G
Site 6
S19
W
G
S
S
I
S
R
S
S
G
T
P
G
C
S
Site 7
S20
G
S
S
I
S
R
S
S
G
T
P
G
C
S
S
Site 8
T22
S
I
S
R
S
S
G
T
P
G
C
S
S
G
T
Site 9
S27
S
G
T
P
G
C
S
S
G
T
E
R
P
Q
S
Site 10
T29
T
P
G
C
S
S
G
T
E
R
P
Q
S
P
G
Site 11
S34
S
G
T
E
R
P
Q
S
P
G
S
S
K
A
P
Site 12
S37
E
R
P
Q
S
P
G
S
S
K
A
P
L
P
A
Site 13
S38
R
P
Q
S
P
G
S
S
K
A
P
L
P
A
A
Site 14
Y94
T
N
C
P
V
R
D
Y
Q
L
H
I
S
R
A
Site 15
Y129
A
V
V
M
Y
N
F
Y
R
W
F
P
S
G
K
Site 16
Y155
T
Q
Q
I
E
A
C
Y
Q
V
M
G
I
P
Q
Site 17
S171
H
M
A
E
M
T
G
S
T
Q
A
S
T
R
K
Site 18
Y225
K
A
L
G
N
Y
A
Y
C
Q
V
V
R
E
L
Site 19
S250
A
L
S
A
T
P
G
S
D
I
K
A
V
Q
Q
Site 20
S274
I
E
L
R
S
E
D
S
P
D
I
L
T
Y
S
Site 21
T279
E
D
S
P
D
I
L
T
Y
S
H
E
R
K
V
Site 22
S281
S
P
D
I
L
T
Y
S
H
E
R
K
V
E
K
Site 23
S310
T
Y
I
Q
I
L
E
S
F
A
R
S
L
I
Q
Site 24
Y332
D
I
P
N
L
T
K
Y
Q
I
I
L
A
R
D
Site 25
S346
D
Q
F
R
K
N
P
S
P
N
I
V
G
I
Q
Site 26
S399
G
T
K
G
M
T
R
S
K
N
E
L
G
R
N
Site 27
S425
C
M
F
A
R
T
R
S
T
S
A
N
G
I
S
Site 28
T426
M
F
A
R
T
R
S
T
S
A
N
G
I
S
A
Site 29
S427
F
A
R
T
R
S
T
S
A
N
G
I
S
A
I
Site 30
Y445
D
K
N
K
K
F
V
Y
S
H
P
K
L
K
K
Site 31
T470
S
W
N
A
E
N
T
T
E
K
K
R
D
E
T
Site 32
T477
T
E
K
K
R
D
E
T
R
V
M
I
F
S
S
Site 33
S483
E
T
R
V
M
I
F
S
S
F
R
D
S
V
Q
Site 34
S484
T
R
V
M
I
F
S
S
F
R
D
S
V
Q
E
Site 35
S488
I
F
S
S
F
R
D
S
V
Q
E
I
A
E
M
Site 36
S497
Q
E
I
A
E
M
L
S
Q
H
Q
P
I
I
R
Site 37
S516
V
G
H
A
S
G
K
S
T
K
G
F
T
Q
K
Site 38
T517
G
H
A
S
G
K
S
T
K
G
F
T
Q
K
E
Site 39
Y537
K
Q
F
R
D
G
G
Y
N
T
L
V
S
T
C
Site 40
T539
F
R
D
G
G
Y
N
T
L
V
S
T
C
V
G
Site 41
S542
G
G
Y
N
T
L
V
S
T
C
V
G
E
E
G
Site 42
S566
I
C
F
D
S
Q
K
S
P
I
R
L
V
Q
R
Site 43
S590
G
R
I
V
I
I
L
S
E
G
R
E
E
R
I
Site 44
Y598
E
G
R
E
E
R
I
Y
N
Q
S
Q
S
N
K
Site 45
S601
E
E
R
I
Y
N
Q
S
Q
S
N
K
R
S
I
Site 46
S603
R
I
Y
N
Q
S
Q
S
N
K
R
S
I
Y
K
Site 47
S607
Q
S
Q
S
N
K
R
S
I
Y
K
A
I
S
S
Site 48
Y609
Q
S
N
K
R
S
I
Y
K
A
I
S
S
N
R
Site 49
S614
S
I
Y
K
A
I
S
S
N
R
Q
V
L
H
F
Site 50
Y622
N
R
Q
V
L
H
F
Y
Q
R
S
P
R
M
V
Site 51
S625
V
L
H
F
Y
Q
R
S
P
R
M
V
P
D
G
Site 52
Y647
M
F
I
T
H
G
V
Y
E
P
E
K
P
S
R
Site 53
S660
S
R
N
L
Q
R
K
S
S
I
F
S
Y
R
D
Site 54
S661
R
N
L
Q
R
K
S
S
I
F
S
Y
R
D
G
Site 55
S664
Q
R
K
S
S
I
F
S
Y
R
D
G
M
R
Q
Site 56
S672
Y
R
D
G
M
R
Q
S
S
L
K
K
D
W
F
Site 57
S673
R
D
G
M
R
Q
S
S
L
K
K
D
W
F
L
Site 58
S681
L
K
K
D
W
F
L
S
E
E
E
F
K
L
W
Site 59
Y692
F
K
L
W
N
R
L
Y
R
L
R
D
S
D
E
Site 60
S697
R
L
Y
R
L
R
D
S
D
E
I
K
E
I
T
Site 61
S712
L
P
Q
V
Q
F
S
S
L
Q
N
E
E
N
K
Site 62
S732
T
T
G
I
H
Q
L
S
L
S
E
W
R
L
W
Site 63
S776
R
H
E
E
G
E
C
S
Y
E
L
E
V
E
S
Site 64
Y784
Y
E
L
E
V
E
S
Y
L
Q
M
E
D
V
T
Site 65
S792
L
Q
M
E
D
V
T
S
T
F
I
A
P
R
N
Site 66
S801
F
I
A
P
R
N
E
S
N
N
L
A
S
D
T
Site 67
S806
N
E
S
N
N
L
A
S
D
T
F
I
T
H
K
Site 68
T808
S
N
N
L
A
S
D
T
F
I
T
H
K
K
S
Site 69
T811
L
A
S
D
T
F
I
T
H
K
K
S
S
F
I
Site 70
S825
I
K
N
I
N
Q
G
S
S
S
S
V
I
E
S
Site 71
S827
N
I
N
Q
G
S
S
S
S
V
I
E
S
D
E
Site 72
S828
I
N
Q
G
S
S
S
S
V
I
E
S
D
E
E
Site 73
S832
S
S
S
S
V
I
E
S
D
E
E
C
A
E
I
Site 74
T848
K
Q
T
H
I
K
P
T
K
I
V
S
L
K
K
Site 75
S852
I
K
P
T
K
I
V
S
L
K
K
K
V
S
K
Site 76
S858
V
S
L
K
K
K
V
S
K
E
I
K
K
D
Q
Site 77
S877
N
N
H
G
I
I
D
S
V
D
N
D
R
N
S
Site 78
S884
S
V
D
N
D
R
N
S
T
V
E
N
I
F
Q
Site 79
T885
V
D
N
D
R
N
S
T
V
E
N
I
F
Q
E
Site 80
S901
L
P
N
D
K
R
T
S
D
T
D
E
I
A
A
Site 81
T909
D
T
D
E
I
A
A
T
C
T
I
N
E
N
V
Site 82
T925
K
E
P
C
V
L
L
T
E
C
Q
F
T
N
K
Site 83
T930
L
L
T
E
C
Q
F
T
N
K
S
T
S
S
L
Site 84
S933
E
C
Q
F
T
N
K
S
T
S
S
L
A
G
N
Site 85
S936
F
T
N
K
S
T
S
S
L
A
G
N
V
L
D
Site 86
S944
L
A
G
N
V
L
D
S
G
Y
N
S
F
N
D
Site 87
Y946
G
N
V
L
D
S
G
Y
N
S
F
N
D
E
K
Site 88
S948
V
L
D
S
G
Y
N
S
F
N
D
E
K
S
V
Site 89
S954
N
S
F
N
D
E
K
S
V
S
S
N
L
F
L
Site 90
S956
F
N
D
E
K
S
V
S
S
N
L
F
L
P
F
Site 91
Y968
L
P
F
E
E
E
L
Y
I
V
R
T
D
D
Q
Site 92
T972
E
E
L
Y
I
V
R
T
D
D
Q
F
Y
N
C
Site 93
Y977
V
R
T
D
D
Q
F
Y
N
C
H
S
L
T
K
Site 94
S995
A
N
V
E
R
F
L
S
Y
S
P
P
P
L
S
Site 95
Y996
N
V
E
R
F
L
S
Y
S
P
P
P
L
S
G
Site 96
S997
V
E
R
F
L
S
Y
S
P
P
P
L
S
G
L
Site 97
S1002
S
Y
S
P
P
P
L
S
G
L
S
D
L
E
Y
Site 98
S1005
P
P
P
L
S
G
L
S
D
L
E
Y
E
I
A
Site 99
Y1009
S
G
L
S
D
L
E
Y
E
I
A
K
G
T
A
Site 100
S1031
P
C
A
E
H
L
R
S
D
K
C
T
C
L
L
Site 101
T1035
H
L
R
S
D
K
C
T
C
L
L
S
H
S
A
Site 102
S1039
D
K
C
T
C
L
L
S
H
S
A
V
N
S
Q
Site 103
S1041
C
T
C
L
L
S
H
S
A
V
N
S
Q
Q
N
Site 104
S1045
L
S
H
S
A
V
N
S
Q
Q
N
L
E
L
N
Site 105
Y1059
N
S
L
K
C
I
N
Y
P
S
E
K
S
C
L
Site 106
Y1067
P
S
E
K
S
C
L
Y
D
I
P
N
D
N
I
Site 107
S1075
D
I
P
N
D
N
I
S
D
E
P
S
L
C
D
Site 108
S1079
D
N
I
S
D
E
P
S
L
C
D
C
D
V
H
Site 109
S1105
N
R
V
Q
I
H
R
S
P
A
Q
N
L
V
G
Site 110
S1121
N
N
H
D
V
D
N
S
D
L
P
V
L
S
T
Site 111
S1127
N
S
D
L
P
V
L
S
T
D
Q
D
E
S
L
Site 112
T1128
S
D
L
P
V
L
S
T
D
Q
D
E
S
L
L
Site 113
S1133
L
S
T
D
Q
D
E
S
L
L
L
F
E
D
V
Site 114
S1148
N
T
E
F
D
D
V
S
L
S
P
L
N
S
K
Site 115
S1150
E
F
D
D
V
S
L
S
P
L
N
S
K
S
E
Site 116
S1154
V
S
L
S
P
L
N
S
K
S
E
S
L
P
V
Site 117
S1156
L
S
P
L
N
S
K
S
E
S
L
P
V
S
D
Site 118
S1158
P
L
N
S
K
S
E
S
L
P
V
S
D
K
T
Site 119
S1162
K
S
E
S
L
P
V
S
D
K
T
A
I
S
E
Site 120
T1165
S
L
P
V
S
D
K
T
A
I
S
E
T
P
L
Site 121
S1168
V
S
D
K
T
A
I
S
E
T
P
L
V
S
Q
Site 122
T1170
D
K
T
A
I
S
E
T
P
L
V
S
Q
F
L
Site 123
S1188
E
L
L
L
D
N
N
S
E
L
Q
D
Q
I
T
Site 124
T1195
S
E
L
Q
D
Q
I
T
R
D
A
N
S
F
K
Site 125
S1200
Q
I
T
R
D
A
N
S
F
K
S
R
D
Q
R
Site 126
S1203
R
D
A
N
S
F
K
S
R
D
Q
R
G
V
Q
Site 127
S1238
T
F
D
L
G
F
C
S
P
D
S
D
D
E
I
Site 128
S1241
L
G
F
C
S
P
D
S
D
D
E
I
L
E
H
Site 129
S1250
D
E
I
L
E
H
T
S
D
S
N
R
P
L
D
Site 130
S1252
I
L
E
H
T
S
D
S
N
R
P
L
D
D
L
Site 131
Y1260
N
R
P
L
D
D
L
Y
G
R
Y
L
E
I
K
Site 132
Y1263
L
D
D
L
Y
G
R
Y
L
E
I
K
E
I
S
Site 133
S1270
Y
L
E
I
K
E
I
S
D
A
N
Y
V
S
N
Site 134
Y1274
K
E
I
S
D
A
N
Y
V
S
N
Q
A
L
I
Site 135
S1286
A
L
I
P
R
D
H
S
K
N
F
T
S
G
T
Site 136
T1290
R
D
H
S
K
N
F
T
S
G
T
V
I
I
P
Site 137
T1293
S
K
N
F
T
S
G
T
V
I
I
P
S
N
E
Site 138
Y1307
E
D
M
Q
N
P
N
Y
V
H
L
P
L
S
A
Site 139
S1313
N
Y
V
H
L
P
L
S
A
A
K
N
E
E
L
Site 140
S1322
A
K
N
E
E
L
L
S
P
G
Y
S
Q
F
S
Site 141
Y1325
E
E
L
L
S
P
G
Y
S
Q
F
S
L
P
V
Site 142
S1326
E
L
L
S
P
G
Y
S
Q
F
S
L
P
V
Q
Site 143
S1329
S
P
G
Y
S
Q
F
S
L
P
V
Q
K
K
V
Site 144
S1338
P
V
Q
K
K
V
M
S
T
P
L
S
K
S
N
Site 145
T1339
V
Q
K
K
V
M
S
T
P
L
S
K
S
N
T
Site 146
S1342
K
V
M
S
T
P
L
S
K
S
N
T
L
N
S
Site 147
S1344
M
S
T
P
L
S
K
S
N
T
L
N
S
F
S
Site 148
T1346
T
P
L
S
K
S
N
T
L
N
S
F
S
K
I
Site 149
S1349
S
K
S
N
T
L
N
S
F
S
K
I
R
K
E
Site 150
S1351
S
N
T
L
N
S
F
S
K
I
R
K
E
I
L
Site 151
T1360
I
R
K
E
I
L
K
T
P
D
S
S
K
E
K
Site 152
S1363
E
I
L
K
T
P
D
S
S
K
E
K
V
N
L
Site 153
S1379
R
F
K
E
A
L
N
S
T
F
D
Y
S
E
F
Site 154
T1380
F
K
E
A
L
N
S
T
F
D
Y
S
E
F
S
Site 155
Y1383
A
L
N
S
T
F
D
Y
S
E
F
S
L
E
K
Site 156
S1387
T
F
D
Y
S
E
F
S
L
E
K
S
K
S
S
Site 157
S1391
S
E
F
S
L
E
K
S
K
S
S
G
P
M
Y
Site 158
S1393
F
S
L
E
K
S
K
S
S
G
P
M
Y
L
H
Site 159
S1394
S
L
E
K
S
K
S
S
G
P
M
Y
L
H
K
Site 160
Y1398
S
K
S
S
G
P
M
Y
L
H
K
S
C
H
S
Site 161
T1413
V
E
D
G
Q
L
L
T
S
N
E
S
E
D
D
Site 162
S1414
E
D
G
Q
L
L
T
S
N
E
S
E
D
D
E
Site 163
S1417
Q
L
L
T
S
N
E
S
E
D
D
E
I
F
R
Site 164
S1437
A
K
G
N
V
L
N
S
P
E
D
Q
K
N
S
Site 165
S1444
S
P
E
D
Q
K
N
S
E
V
D
S
P
L
H
Site 166
S1448
Q
K
N
S
E
V
D
S
P
L
H
A
V
K
K
Site 167
S1463
R
R
F
P
I
N
R
S
E
L
S
S
S
D
E
Site 168
S1466
P
I
N
R
S
E
L
S
S
S
D
E
S
E
N
Site 169
S1467
I
N
R
S
E
L
S
S
S
D
E
S
E
N
F
Site 170
S1468
N
R
S
E
L
S
S
S
D
E
S
E
N
F
P
Site 171
S1471
E
L
S
S
S
D
E
S
E
N
F
P
K
P
C
Site 172
S1479
E
N
F
P
K
P
C
S
Q
L
E
D
F
K
V
Site 173
S1502
I
K
V
P
K
R
Q
S
H
L
K
H
V
A
R
Site 174
S1519
L
D
D
E
A
E
L
S
E
E
D
A
E
Y
V
Site 175
Y1525
L
S
E
E
D
A
E
Y
V
S
S
D
E
N
D
Site 176
S1528
E
D
A
E
Y
V
S
S
D
E
N
D
E
S
E
Site 177
S1534
S
S
D
E
N
D
E
S
E
N
E
Q
D
S
S
Site 178
S1541
S
E
N
E
Q
D
S
S
L
L
D
F
L
N
D
Site 179
T1550
L
D
F
L
N
D
E
T
Q
L
S
Q
A
I
N
Site 180
S1553
L
N
D
E
T
Q
L
S
Q
A
I
N
D
S
E
Site 181
Y1565
D
S
E
M
R
A
I
Y
M
K
S
L
R
S
P
Site 182
S1592
H
K
N
I
N
I
F
S
Q
I
P
E
Q
D
E
Site 183
T1600
Q
I
P
E
Q
D
E
T
Y
L
E
D
S
F
C
Site 184
Y1601
I
P
E
Q
D
E
T
Y
L
E
D
S
F
C
V
Site 185
S1605
D
E
T
Y
L
E
D
S
F
C
V
D
E
E
E
Site 186
S1613
F
C
V
D
E
E
E
S
C
K
G
Q
S
S
E
Site 187
S1619
E
S
C
K
G
Q
S
S
E
E
E
V
C
V
D
Site 188
T1643
A
N
S
K
K
Y
K
T
R
R
A
V
M
L
K
Site 189
S1673
R
I
I
L
P
D
D
S
S
E
E
E
N
N
V
Site 190
S1674
I
I
L
P
D
D
S
S
E
E
E
N
N
V
N
Site 191
S1686
N
V
N
D
K
R
E
S
N
I
A
V
N
P
S
Site 192
S1693
S
N
I
A
V
N
P
S
T
V
K
K
N
K
Q
Site 193
T1694
N
I
A
V
N
P
S
T
V
K
K
N
K
Q
Q
Site 194
S1707
Q
Q
D
H
C
L
N
S
V
P
S
G
S
S
A
Site 195
S1710
H
C
L
N
S
V
P
S
G
S
S
A
Q
S
K
Site 196
S1712
L
N
S
V
P
S
G
S
S
A
Q
S
K
V
R
Site 197
S1716
P
S
G
S
S
A
Q
S
K
V
R
S
T
P
R
Site 198
S1720
S
A
Q
S
K
V
R
S
T
P
R
V
N
P
L
Site 199
T1721
A
Q
S
K
V
R
S
T
P
R
V
N
P
L
A
Site 200
S1731
V
N
P
L
A
K
Q
S
K
Q
T
S
L
N
L
Site 201
S1735
A
K
Q
S
K
Q
T
S
L
N
L
K
D
T
I
Site 202
T1741
T
S
L
N
L
K
D
T
I
S
E
V
S
D
F
Site 203
S1743
L
N
L
K
D
T
I
S
E
V
S
D
F
K
P
Site 204
T1759
N
H
N
E
V
Q
S
T
T
P
P
F
T
T
V
Site 205
T1760
H
N
E
V
Q
S
T
T
P
P
F
T
T
V
D
Site 206
T1764
Q
S
T
T
P
P
F
T
T
V
D
S
Q
K
D
Site 207
S1768
P
P
F
T
T
V
D
S
Q
K
D
C
R
K
F
Site 208
S1783
P
V
P
Q
K
D
G
S
A
L
E
D
S
S
T
Site 209
S1788
D
G
S
A
L
E
D
S
S
T
S
G
A
S
C
Site 210
S1789
G
S
A
L
E
D
S
S
T
S
G
A
S
C
S
Site 211
T1790
S
A
L
E
D
S
S
T
S
G
A
S
C
S
K
Site 212
S1791
A
L
E
D
S
S
T
S
G
A
S
C
S
K
S
Site 213
S1794
D
S
S
T
S
G
A
S
C
S
K
S
R
P
H
Site 214
S1796
S
T
S
G
A
S
C
S
K
S
R
P
H
L
A
Site 215
S1798
S
G
A
S
C
S
K
S
R
P
H
L
A
G
T
Site 216
T1807
P
H
L
A
G
T
H
T
S
L
R
L
P
Q
E
Site 217
S1808
H
L
A
G
T
H
T
S
L
R
L
P
Q
E
G
Site 218
S1867
R
M
V
V
E
R
R
S
Q
S
E
M
L
N
S
Site 219
S1869
V
V
E
R
R
S
Q
S
E
M
L
N
S
V
N
Site 220
S1874
S
Q
S
E
M
L
N
S
V
N
K
N
K
F
I
Site 221
T1905
V
E
K
D
R
E
K
T
G
D
T
S
R
M
F
Site 222
T1908
D
R
E
K
T
G
D
T
S
R
M
F
R
R
T
Site 223
S1909
R
E
K
T
G
D
T
S
R
M
F
R
R
T
K
Site 224
T1915
T
S
R
M
F
R
R
T
K
S
Y
D
S
L
L
Site 225
S1917
R
M
F
R
R
T
K
S
Y
D
S
L
L
T
T
Site 226
Y1918
M
F
R
R
T
K
S
Y
D
S
L
L
T
T
L
Site 227
S1920
R
R
T
K
S
Y
D
S
L
L
T
T
L
I
G
Site 228
S1936
G
I
R
I
L
F
S
S
C
Q
E
E
T
A
D
Site 229
S1949
A
D
L
L
K
E
L
S
L
V
E
Q
R
K
N
Site 230
T1963
N
V
G
I
H
V
P
T
V
V
N
S
N
K
S
Site 231
Y1976
K
S
E
A
L
Q
F
Y
L
S
I
P
N
I
S
Site 232
S2004
V
K
R
M
A
N
S
S
L
Q
E
I
S
M
Y
Site 233
Y2011
S
L
Q
E
I
S
M
Y
A
Q
V
T
H
Q
K
Site 234
Y2025
K
A
E
E
I
Y
R
Y
I
H
Y
V
F
D
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation