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Updated November 2019
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Protein Info
Short Name:
CCDC146
Full Name:
Coiled-coil domain-containing protein 146
Alias:
Type:
Mass (Da):
112806
Number AA:
955
UniProt ID:
Q8IYE0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
D
S
S
T
D
T
E
K
E
E
E
Site 2
T8
M
E
D
S
S
T
D
T
E
K
E
E
E
E
E
Site 3
Y25
E
K
D
Q
E
P
I
Y
A
I
V
P
T
I
N
Site 4
S42
D
E
R
F
V
D
L
S
E
T
P
A
F
I
F
Site 5
S80
L
L
H
D
A
V
M
S
T
Q
E
S
E
V
Q
Site 6
S84
A
V
M
S
T
Q
E
S
E
V
Q
L
L
Q
N
Site 7
T96
L
Q
N
A
K
R
F
T
E
Q
I
Q
Q
Q
Q
Site 8
S117
D
N
F
P
E
A
F
S
T
E
V
S
K
M
R
Site 9
T118
N
F
P
E
A
F
S
T
E
V
S
K
M
R
E
Site 10
S121
E
A
F
S
T
E
V
S
K
M
R
E
Q
L
L
Site 11
Y130
M
R
E
Q
L
L
K
Y
Q
N
E
Y
N
A
V
Site 12
Y146
E
R
E
F
H
N
Q
Y
R
L
N
S
L
K
E
Site 13
S150
H
N
Q
Y
R
L
N
S
L
K
E
E
K
I
I
Site 14
T166
V
K
E
F
E
K
I
T
K
P
G
E
M
E
K
Site 15
S181
K
M
K
I
L
R
E
S
T
E
E
L
R
K
E
Site 16
T182
M
K
I
L
R
E
S
T
E
E
L
R
K
E
I
Site 17
S205
N
L
R
E
D
L
A
S
K
Q
K
Q
L
L
K
Site 18
T268
V
L
E
Q
E
V
K
T
L
N
D
S
L
K
K
Site 19
S272
E
V
K
T
L
N
D
S
L
K
K
V
E
N
K
Site 20
T324
L
A
R
E
N
E
A
T
S
L
T
E
R
G
I
Site 21
T327
E
N
E
A
T
S
L
T
E
R
G
I
L
D
L
Site 22
S339
L
D
L
N
L
R
N
S
L
I
D
K
Q
N
Y
Site 23
Y346
S
L
I
D
K
Q
N
Y
H
D
E
L
S
R
K
Site 24
S351
Q
N
Y
H
D
E
L
S
R
K
Q
R
E
K
E
Site 25
T381
S
W
D
A
L
R
Q
T
Q
A
L
H
Q
R
L
Site 26
S400
E
A
I
P
K
D
D
S
T
L
S
E
R
R
R
Site 27
T401
A
I
P
K
D
D
S
T
L
S
E
R
R
R
E
Site 28
S403
P
K
D
D
S
T
L
S
E
R
R
R
E
L
H
Site 29
S431
K
I
I
S
E
M
E
S
K
L
V
E
Q
Q
L
Site 30
T462
V
V
N
L
L
R
M
T
Q
I
K
I
D
E
K
Site 31
S473
I
D
E
K
E
Q
K
S
K
D
F
L
K
A
Q
Site 32
Y508
K
K
K
K
C
E
I
Y
R
R
L
R
E
F
A
Site 33
Y518
L
R
E
F
A
K
L
Y
D
T
I
R
N
E
R
Site 34
T520
E
F
A
K
L
Y
D
T
I
R
N
E
R
N
K
Site 35
S549
I
K
E
R
H
K
M
S
L
N
E
L
E
I
L
Site 36
S559
E
L
E
I
L
R
N
S
A
V
S
Q
E
R
K
Site 37
S562
I
L
R
N
S
A
V
S
Q
E
R
K
L
Q
N
Site 38
S570
Q
E
R
K
L
Q
N
S
M
L
K
H
A
N
N
Site 39
T579
L
K
H
A
N
N
V
T
I
R
E
S
M
Q
N
Site 40
S583
N
N
V
T
I
R
E
S
M
Q
N
D
V
R
K
Site 41
Y630
M
V
Q
L
R
K
R
Y
E
K
A
V
Q
H
R
Site 42
S640
A
V
Q
H
R
N
E
S
G
V
Q
L
I
E
R
Site 43
Y655
E
E
E
I
C
I
F
Y
E
K
I
N
I
Q
E
Site 44
T696
K
Q
R
Q
I
C
V
T
Q
K
L
L
P
A
K
Site 45
S718
A
V
L
Q
I
Q
F
S
Q
C
T
D
R
I
K
Site 46
T749
F
L
P
G
K
D
L
T
E
K
E
M
I
Q
K
Site 47
Y778
L
L
E
K
D
F
I
Y
E
Q
V
S
R
L
T
Site 48
T785
Y
E
Q
V
S
R
L
T
D
R
L
C
S
K
T
Site 49
S790
R
L
T
D
R
L
C
S
K
T
Q
G
C
K
Q
Site 50
T792
T
D
R
L
C
S
K
T
Q
G
C
K
Q
D
T
Site 51
Y809
L
A
K
K
M
N
G
Y
Q
R
R
I
K
N
A
Site 52
T817
Q
R
R
I
K
N
A
T
E
K
M
M
A
L
V
Site 53
S887
A
L
A
I
A
E
K
S
Q
E
F
L
E
A
D
Site 54
T920
Y
I
P
E
A
D
A
T
L
P
L
P
K
P
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation