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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TCEB3B
Full Name:
RNA polymerase II transcription factor SIII subunit A2
Alias:
EloA2; Elongin A2; TCEB3L; Transcription elongation factor (SIII) elongin A2; Transcription elongation factor B polypeptide 3B; Transcription elongation factor B polypeptide 3B (elongin A2)
Type:
Nucleus, Integral membrane protein
Mass (Da):
83921
Number AA:
753
UniProt ID:
Q8IYF1
International Prot ID:
IPI00376867
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0003711
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
K
L
Q
V
R
L
A
T
K
T
E
P
K
K
L
Site 2
T22
Q
V
R
L
A
T
K
T
E
P
K
K
L
E
K
Site 3
Y30
E
P
K
K
L
E
K
Y
L
Q
K
L
S
A
L
Site 4
S35
E
K
Y
L
Q
K
L
S
A
L
P
M
T
A
D
Site 5
T52
A
E
T
G
I
R
K
T
V
K
R
L
R
K
H
Site 6
T83
L
V
L
V
D
R
N
T
R
P
G
P
Q
D
P
Site 7
S93
G
P
Q
D
P
E
E
S
A
S
R
Q
R
F
G
Site 8
S95
Q
D
P
E
E
S
A
S
R
Q
R
F
G
E
A
Site 9
T117
W
G
F
P
E
N
A
T
A
P
R
S
P
S
H
Site 10
S121
E
N
A
T
A
P
R
S
P
S
H
S
P
E
H
Site 11
S123
A
T
A
P
R
S
P
S
H
S
P
E
H
R
R
Site 12
S125
A
P
R
S
P
S
H
S
P
E
H
R
R
T
A
Site 13
T131
H
S
P
E
H
R
R
T
A
R
R
T
P
P
G
Site 14
T135
H
R
R
T
A
R
R
T
P
P
G
Q
Q
R
P
Site 15
S146
Q
Q
R
P
H
P
R
S
H
S
R
E
P
R
A
Site 16
S148
R
P
H
P
R
S
H
S
R
E
P
R
A
E
R
Site 17
S165
P
R
I
A
P
A
D
S
G
R
Y
R
A
S
P
Site 18
S171
D
S
G
R
Y
R
A
S
P
T
R
T
A
P
L
Site 19
T175
Y
R
A
S
P
T
R
T
A
P
L
R
M
P
E
Site 20
T198
K
Q
P
G
R
G
H
T
H
A
A
Q
G
G
P
Site 21
S222
P
Q
G
K
A
V
V
S
H
S
K
G
H
K
S
Site 22
S224
G
K
A
V
V
S
H
S
K
G
H
K
S
S
R
Site 23
S229
S
H
S
K
G
H
K
S
S
R
Q
E
K
R
P
Site 24
S245
C
A
Q
G
D
W
H
S
P
T
L
I
R
E
K
Site 25
T247
Q
G
D
W
H
S
P
T
L
I
R
E
K
S
C
Site 26
S253
P
T
L
I
R
E
K
S
C
G
A
C
L
R
E
Site 27
T262
G
A
C
L
R
E
E
T
P
R
M
P
S
W
A
Site 28
S267
E
E
T
P
R
M
P
S
W
A
S
A
R
D
R
Site 29
S270
P
R
M
P
S
W
A
S
A
R
D
R
Q
P
S
Site 30
S277
S
A
R
D
R
Q
P
S
D
F
K
T
D
K
E
Site 31
T281
R
Q
P
S
D
F
K
T
D
K
E
G
G
Q
A
Site 32
S290
K
E
G
G
Q
A
G
S
G
Q
R
V
P
A
L
Site 33
S303
A
L
E
E
A
P
D
S
H
Q
K
R
P
Q
H
Site 34
S313
K
R
P
Q
H
S
H
S
N
K
K
R
P
S
L
Site 35
S319
H
S
N
K
K
R
P
S
L
D
G
R
D
P
G
Site 36
T329
G
R
D
P
G
N
G
T
H
G
L
S
P
E
E
Site 37
S333
G
N
G
T
H
G
L
S
P
E
E
K
E
Q
L
Site 38
S341
P
E
E
K
E
Q
L
S
N
D
R
E
T
Q
E
Site 39
T346
Q
L
S
N
D
R
E
T
Q
E
G
K
P
P
T
Site 40
T359
P
T
A
H
L
D
R
T
S
V
S
S
L
S
E
Site 41
S360
T
A
H
L
D
R
T
S
V
S
S
L
S
E
V
Site 42
S363
L
D
R
T
S
V
S
S
L
S
E
V
E
E
V
Site 43
S365
R
T
S
V
S
S
L
S
E
V
E
E
V
D
M
Site 44
S382
E
F
E
Q
P
T
L
S
C
E
K
Y
L
T
Y
Site 45
Y386
P
T
L
S
C
E
K
Y
L
T
Y
D
Q
L
R
Site 46
T388
L
S
C
E
K
Y
L
T
Y
D
Q
L
R
K
Q
Site 47
Y389
S
C
E
K
Y
L
T
Y
D
Q
L
R
K
Q
K
Site 48
S402
Q
K
K
K
T
G
K
S
A
T
T
A
L
G
D
Site 49
S417
K
Q
R
K
A
N
E
S
K
G
T
R
E
S
W
Site 50
S423
E
S
K
G
T
R
E
S
W
D
S
A
K
K
L
Site 51
S426
G
T
R
E
S
W
D
S
A
K
K
L
P
P
V
Site 52
S436
K
L
P
P
V
Q
E
S
Q
S
E
R
L
Q
A
Site 53
S438
P
P
V
Q
E
S
Q
S
E
R
L
Q
A
A
G
Site 54
S448
L
Q
A
A
G
A
D
S
A
G
P
K
T
V
P
Site 55
T453
A
D
S
A
G
P
K
T
V
P
S
H
V
F
S
Site 56
S456
A
G
P
K
T
V
P
S
H
V
F
S
E
L
W
Site 57
S460
T
V
P
S
H
V
F
S
E
L
W
D
L
S
E
Site 58
Y474
E
A
W
M
Q
A
N
Y
D
P
L
S
D
S
D
Site 59
S478
Q
A
N
Y
D
P
L
S
D
S
D
S
M
T
S
Site 60
S480
N
Y
D
P
L
S
D
S
D
S
M
T
S
Q
A
Site 61
S482
D
P
L
S
D
S
D
S
M
T
S
Q
A
K
P
Site 62
T484
L
S
D
S
D
S
M
T
S
Q
A
K
P
E
A
Site 63
S485
S
D
S
D
S
M
T
S
Q
A
K
P
E
A
L
Site 64
S494
A
K
P
E
A
L
S
S
P
K
F
R
E
E
A
Site 65
Y515
V
N
A
K
M
P
V
Y
S
G
S
R
P
A
C
Site 66
S516
N
A
K
M
P
V
Y
S
G
S
R
P
A
C
Q
Site 67
S518
K
M
P
V
Y
S
G
S
R
P
A
C
Q
L
Q
Site 68
S545
R
N
N
P
D
A
L
S
D
V
G
E
V
P
Y
Site 69
Y568
G
W
R
P
D
Q
L
Y
R
R
K
K
D
N
H
Site 70
T581
N
H
A
L
V
R
E
T
D
E
L
R
R
N
H
Site 71
T603
E
K
P
Q
E
N
K
T
W
R
E
Q
Y
L
R
Site 72
Y608
N
K
T
W
R
E
Q
Y
L
R
L
P
D
A
P
Site 73
T623
E
Q
R
L
R
V
M
T
T
N
I
R
S
A
R
Site 74
T624
Q
R
L
R
V
M
T
T
N
I
R
S
A
R
G
Site 75
S628
V
M
T
T
N
I
R
S
A
R
G
N
N
P
N
Site 76
T650
C
F
K
S
V
A
K
T
P
Y
D
T
S
R
R
Site 77
T654
V
A
K
T
P
Y
D
T
S
R
R
Q
E
K
S
Site 78
S655
A
K
T
P
Y
D
T
S
R
R
Q
E
K
S
A
Site 79
S661
T
S
R
R
Q
E
K
S
A
G
D
A
D
P
E
Site 80
S676
N
G
E
I
K
P
A
S
K
P
A
G
S
S
H
Site 81
S681
P
A
S
K
P
A
G
S
S
H
T
P
S
S
Q
Site 82
S682
A
S
K
P
A
G
S
S
H
T
P
S
S
Q
S
Site 83
T684
K
P
A
G
S
S
H
T
P
S
S
Q
S
S
S
Site 84
S686
A
G
S
S
H
T
P
S
S
Q
S
S
S
G
G
Site 85
S687
G
S
S
H
T
P
S
S
Q
S
S
S
G
G
G
Site 86
S689
S
H
T
P
S
S
Q
S
S
S
G
G
G
R
D
Site 87
S690
H
T
P
S
S
Q
S
S
S
G
G
G
R
D
S
Site 88
S691
T
P
S
S
Q
S
S
S
G
G
G
R
D
S
S
Site 89
S697
S
S
G
G
G
R
D
S
S
S
S
I
L
R
W
Site 90
S698
S
G
G
G
R
D
S
S
S
S
I
L
R
W
L
Site 91
S699
G
G
G
R
D
S
S
S
S
I
L
R
W
L
P
Site 92
S700
G
G
R
D
S
S
S
S
I
L
R
W
L
P
E
Site 93
S715
K
R
A
N
P
C
L
S
S
S
N
E
H
A
A
Site 94
S717
A
N
P
C
L
S
S
S
N
E
H
A
A
P
A
Site 95
Y746
M
A
K
A
I
R
D
Y
K
R
R
F
S
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation