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Updated November 2019
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Protein Info
Short Name:
FAM186B
Full Name:
Protein FAM186B
Alias:
Type:
Mass (Da):
103722
Number AA:
893
UniProt ID:
Q8IYM0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
D
D
P
P
Q
L
V
T
P
T
S
V
K
A
I
Site 2
S35
T
R
A
Q
E
D
I
S
T
Q
L
S
D
I
L
Site 3
T36
R
A
Q
E
D
I
S
T
Q
L
S
D
I
L
D
Site 4
S39
E
D
I
S
T
Q
L
S
D
I
L
D
N
V
N
Site 5
Y58
R
F
Q
E
E
L
G
Y
D
L
K
E
N
A
K
Site 6
S66
D
L
K
E
N
A
K
S
Q
Q
R
D
P
K
G
Site 7
Y98
M
M
K
E
K
H
L
Y
D
I
L
R
W
L
G
Site 8
T112
G
D
W
G
D
T
L
T
Y
E
I
G
P
R
K
Site 9
S120
Y
E
I
G
P
R
K
S
E
E
E
A
A
A
L
Site 10
S167
I
E
G
Q
K
K
R
S
Q
V
S
K
R
T
F
Site 11
S170
Q
K
K
R
S
Q
V
S
K
R
T
F
W
Q
G
Site 12
S182
W
Q
G
W
Q
G
R
S
P
Q
T
S
P
S
H
Site 13
S186
Q
G
R
S
P
Q
T
S
P
S
H
P
Q
P
L
Site 14
S188
R
S
P
Q
T
S
P
S
H
P
Q
P
L
S
P
Site 15
S194
P
S
H
P
Q
P
L
S
P
E
Q
M
L
Q
D
Site 16
T204
Q
M
L
Q
D
Q
H
T
M
N
T
K
A
S
E
Site 17
S210
H
T
M
N
T
K
A
S
E
V
T
S
M
L
Q
Site 18
S214
T
K
A
S
E
V
T
S
M
L
Q
E
L
L
D
Site 19
S222
M
L
Q
E
L
L
D
S
T
M
F
S
K
G
E
Site 20
T223
L
Q
E
L
L
D
S
T
M
F
S
K
G
E
V
Site 21
Y235
G
E
V
R
A
I
R
Y
M
A
T
V
V
E
N
Site 22
T238
R
A
I
R
Y
M
A
T
V
V
E
N
L
N
K
Site 23
T269
R
H
L
Q
M
Q
A
T
K
E
L
S
S
Q
R
Site 24
S274
Q
A
T
K
E
L
S
S
Q
R
L
H
F
Q
Q
Site 25
S288
Q
F
M
E
V
L
E
S
R
R
D
A
L
L
K
Site 26
S335
A
E
D
L
A
E
V
S
V
D
S
P
G
P
S
Site 27
S338
L
A
E
V
S
V
D
S
P
G
P
S
E
R
E
Site 28
S342
S
V
D
S
P
G
P
S
E
R
E
T
L
P
R
Site 29
T346
P
G
P
S
E
R
E
T
L
P
R
K
E
T
V
Site 30
T352
E
T
L
P
R
K
E
T
V
M
E
E
S
Q
Q
Site 31
S357
K
E
T
V
M
E
E
S
Q
Q
E
P
M
K
E
Site 32
S369
M
K
E
E
Q
L
F
S
P
L
P
P
S
P
M
Site 33
S393
A
A
G
H
Q
P
L
S
T
M
T
V
R
S
R
Site 34
T394
A
G
H
Q
P
L
S
T
M
T
V
R
S
R
V
Site 35
T396
H
Q
P
L
S
T
M
T
V
R
S
R
V
A
D
Site 36
S407
R
V
A
D
V
F
G
S
K
D
T
E
S
L
E
Site 37
T410
D
V
F
G
S
K
D
T
E
S
L
E
P
V
L
Site 38
S412
F
G
S
K
D
T
E
S
L
E
P
V
L
L
P
Site 39
S436
W
E
R
P
V
A
E
S
L
G
H
K
D
K
D
Site 40
Y447
K
D
K
D
Q
E
D
Y
F
Q
K
G
G
L
Q
Site 41
S460
L
Q
I
K
F
H
C
S
K
Q
L
S
L
E
S
Site 42
S464
F
H
C
S
K
Q
L
S
L
E
S
S
R
Q
V
Site 43
S467
S
K
Q
L
S
L
E
S
S
R
Q
V
T
S
E
Site 44
S468
K
Q
L
S
L
E
S
S
R
Q
V
T
S
E
S
Site 45
T472
L
E
S
S
R
Q
V
T
S
E
S
Q
E
E
P
Site 46
S473
E
S
S
R
Q
V
T
S
E
S
Q
E
E
P
W
Site 47
S475
S
R
Q
V
T
S
E
S
Q
E
E
P
W
E
E
Site 48
S543
Q
L
E
K
E
Q
E
S
P
R
R
E
P
E
Q
Site 49
T561
D
V
E
R
R
I
F
T
P
T
S
R
W
R
D
Site 50
T563
E
R
R
I
F
T
P
T
S
R
W
R
D
L
E
Site 51
S564
R
R
I
F
T
P
T
S
R
W
R
D
L
E
K
Site 52
S575
D
L
E
K
A
E
L
S
L
V
P
A
P
S
R
Site 53
S581
L
S
L
V
P
A
P
S
R
T
Q
S
A
H
Q
Site 54
T583
L
V
P
A
P
S
R
T
Q
S
A
H
Q
S
R
Site 55
S585
P
A
P
S
R
T
Q
S
A
H
Q
S
R
R
P
Site 56
S589
R
T
Q
S
A
H
Q
S
R
R
P
H
L
P
M
Site 57
S597
R
R
P
H
L
P
M
S
P
S
T
Q
Q
P
A
Site 58
S599
P
H
L
P
M
S
P
S
T
Q
Q
P
A
L
G
Site 59
T600
H
L
P
M
S
P
S
T
Q
Q
P
A
L
G
K
Site 60
S612
L
G
K
Q
R
P
M
S
S
V
E
F
T
Y
R
Site 61
S613
G
K
Q
R
P
M
S
S
V
E
F
T
Y
R
P
Site 62
T617
P
M
S
S
V
E
F
T
Y
R
P
R
T
R
R
Site 63
T622
E
F
T
Y
R
P
R
T
R
R
V
P
T
K
P
Site 64
T627
P
R
T
R
R
V
P
T
K
P
K
K
S
A
S
Site 65
S632
V
P
T
K
P
K
K
S
A
S
F
P
V
T
G
Site 66
S634
T
K
P
K
K
S
A
S
F
P
V
T
G
T
S
Site 67
T638
K
S
A
S
F
P
V
T
G
T
S
I
R
R
L
Site 68
S641
S
F
P
V
T
G
T
S
I
R
R
L
T
W
P
Site 69
T646
G
T
S
I
R
R
L
T
W
P
S
L
Q
I
S
Site 70
S649
I
R
R
L
T
W
P
S
L
Q
I
S
P
A
N
Site 71
S653
T
W
P
S
L
Q
I
S
P
A
N
I
K
K
K
Site 72
S677
R
K
N
L
Q
L
L
S
E
E
S
E
L
R
L
Site 73
S680
L
Q
L
L
S
E
E
S
E
L
R
L
P
H
Y
Site 74
Y687
S
E
L
R
L
P
H
Y
L
R
S
K
A
L
E
Site 75
Y714
L
Q
Y
L
C
H
K
Y
I
F
Y
R
R
L
Q
Site 76
Y717
L
C
H
K
Y
I
F
Y
R
R
L
Q
S
L
R
Site 77
S722
I
F
Y
R
R
L
Q
S
L
R
Q
E
A
I
N
Site 78
S740
I
M
K
E
T
E
A
S
Y
K
A
Q
N
L
Y
Site 79
Y747
S
Y
K
A
Q
N
L
Y
I
F
L
E
N
I
D
Site 80
S758
E
N
I
D
R
L
Q
S
L
R
L
Q
A
W
T
Site 81
T765
S
L
R
L
Q
A
W
T
D
K
Q
K
G
L
E
Site 82
S781
K
H
R
E
C
L
S
S
M
V
T
M
F
P
K
Site 83
S804
L
N
I
P
E
V
T
S
P
K
P
K
K
C
K
Site 84
S816
K
C
K
L
P
A
A
S
P
R
H
I
R
P
S
Site 85
S823
S
P
R
H
I
R
P
S
G
P
T
Y
K
Q
P
Site 86
Y827
I
R
P
S
G
P
T
Y
K
Q
P
F
L
S
R
Site 87
T857
Q
M
E
A
V
W
K
T
E
V
A
S
S
S
Y
Site 88
S863
K
T
E
V
A
S
S
S
Y
A
I
E
K
K
T
Site 89
T870
S
Y
A
I
E
K
K
T
P
A
S
L
P
R
D
Site 90
S873
I
E
K
K
T
P
A
S
L
P
R
D
Q
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation