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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLFN12
Full Name:
Schlafen family member 12
Alias:
FLJ10260; Schlafen family 12; SLFN3; SLN12
Type:
Uncharacterized protein
Mass (Da):
66972
Number AA:
578
UniProt ID:
Q8IYM2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
V
L
D
V
G
R
V
T
L
G
E
N
S
R
K
Site 2
S43
L
R
K
K
Q
N
E
S
V
S
R
A
M
C
A
Site 3
Y68
A
E
I
E
N
E
D
Y
S
Y
T
K
D
G
I
Site 4
S69
E
I
E
N
E
D
Y
S
Y
T
K
D
G
I
G
Site 5
Y70
I
E
N
E
D
Y
S
Y
T
K
D
G
I
G
L
Site 6
S115
K
S
W
S
L
N
T
S
G
L
R
I
T
T
L
Site 7
T120
N
T
S
G
L
R
I
T
T
L
S
S
N
L
Y
Site 8
T121
T
S
G
L
R
I
T
T
L
S
S
N
L
Y
K
Site 9
S123
G
L
R
I
T
T
L
S
S
N
L
Y
K
R
D
Site 10
Y127
T
T
L
S
S
N
L
Y
K
R
D
I
T
S
A
Site 11
T132
N
L
Y
K
R
D
I
T
S
A
K
V
M
N
A
Site 12
Y157
K
K
T
R
G
R
L
Y
L
R
P
E
L
L
A
Site 13
T188
A
G
V
F
F
D
R
T
E
L
D
R
K
E
K
Site 14
T197
L
D
R
K
E
K
L
T
F
T
E
S
T
H
V
Site 15
S201
E
K
L
T
F
T
E
S
T
H
V
E
I
K
N
Site 16
S227
E
I
L
P
Q
Y
V
S
A
F
A
N
T
D
G
Site 17
S255
I
G
F
K
A
E
M
S
D
L
D
D
L
E
R
Site 18
S267
L
E
R
E
I
E
K
S
I
R
K
M
P
V
H
Site 19
Y285
M
E
K
K
K
I
N
Y
S
C
K
F
L
G
V
Site 20
S321
V
F
A
K
E
P
D
S
W
H
V
K
D
N
R
Site 21
T333
D
N
R
V
M
Q
L
T
R
K
E
W
I
Q
F
Site 22
S349
V
E
A
E
P
K
F
S
S
S
Y
E
E
V
I
Site 23
S350
E
A
E
P
K
F
S
S
S
Y
E
E
V
I
S
Site 24
S351
A
E
P
K
F
S
S
S
Y
E
E
V
I
S
Q
Site 25
Y352
E
P
K
F
S
S
S
Y
E
E
V
I
S
Q
I
Site 26
S357
S
S
Y
E
E
V
I
S
Q
I
N
T
S
L
P
Site 27
T361
E
V
I
S
Q
I
N
T
S
L
P
A
P
H
S
Site 28
S362
V
I
S
Q
I
N
T
S
L
P
A
P
H
S
W
Site 29
S368
T
S
L
P
A
P
H
S
W
P
L
L
E
W
Q
Site 30
S385
R
H
H
C
P
G
L
S
G
R
I
T
Y
T
P
Site 31
T389
P
G
L
S
G
R
I
T
Y
T
P
E
N
L
C
Site 32
Y390
G
L
S
G
R
I
T
Y
T
P
E
N
L
C
R
Site 33
T391
L
S
G
R
I
T
Y
T
P
E
N
L
C
R
K
Site 34
S421
M
D
S
V
R
K
G
S
L
I
F
S
R
S
W
Site 35
S425
R
K
G
S
L
I
F
S
R
S
W
S
V
D
L
Site 36
T457
D
S
P
P
V
L
Y
T
F
H
M
V
Q
D
E
Site 37
Y469
Q
D
E
E
F
K
G
Y
S
T
Q
T
A
L
T
Site 38
T476
Y
S
T
Q
T
A
L
T
L
K
Q
K
L
A
K
Site 39
Y487
K
L
A
K
I
G
G
Y
T
K
K
V
C
V
M
Site 40
Y499
C
V
M
T
K
I
F
Y
L
S
P
E
G
M
T
Site 41
S507
L
S
P
E
G
M
T
S
C
Q
Y
D
L
R
S
Site 42
Y510
E
G
M
T
S
C
Q
Y
D
L
R
S
Q
V
I
Site 43
S514
S
C
Q
Y
D
L
R
S
Q
V
I
Y
P
E
S
Site 44
Y518
D
L
R
S
Q
V
I
Y
P
E
S
Y
Y
F
T
Site 45
S521
S
Q
V
I
Y
P
E
S
Y
Y
F
T
R
R
K
Site 46
Y522
Q
V
I
Y
P
E
S
Y
Y
F
T
R
R
K
Y
Site 47
Y523
V
I
Y
P
E
S
Y
Y
F
T
R
R
K
Y
L
Site 48
T525
Y
P
E
S
Y
Y
F
T
R
R
K
Y
L
L
K
Site 49
Y529
Y
Y
F
T
R
R
K
Y
L
L
K
A
L
F
K
Site 50
S543
K
A
L
K
R
L
K
S
L
R
D
Q
F
S
F
Site 51
S549
K
S
L
R
D
Q
F
S
F
A
E
N
L
Y
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation