KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TRIM22
Full Name:
E3 ubiquitin-protein ligase TRIM22
Alias:
50 kDa-stimulated trans-acting factor; GPSTAF50; RING finger protein 94; RNF94; STAF50; Staf-50; TRI22; Tripartite motif 22; Tripartite motif-containing 22
Type:
Transcription, coactivator/corepressor
Mass (Da):
56947
Number AA:
498
UniProt ID:
Q8IYM9
International Prot ID:
IPI00477398
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003714
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0070206
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
I
T
A
K
I
K
E
S
V
I
I
S
R
G
E
Site 2
S50
I
K
E
S
V
I
I
S
R
G
E
S
S
C
P
Site 3
S87
R
V
K
E
V
K
M
S
P
Q
E
G
Q
K
R
Site 4
T130
Q
E
H
Q
G
H
Q
T
F
R
I
N
E
V
V
Site 5
S231
V
Q
Q
R
Q
D
A
S
T
L
I
S
D
L
Q
Site 6
T232
Q
Q
R
Q
D
A
S
T
L
I
S
D
L
Q
R
Site 7
S235
Q
D
A
S
T
L
I
S
D
L
Q
R
R
L
R
Site 8
S244
L
Q
R
R
L
R
G
S
S
V
E
M
L
Q
D
Site 9
S245
Q
R
R
L
R
G
S
S
V
E
M
L
Q
D
V
Site 10
S261
D
V
M
K
R
S
E
S
W
T
L
K
K
P
K
Site 11
T263
M
K
R
S
E
S
W
T
L
K
K
P
K
S
V
Site 12
S269
W
T
L
K
K
P
K
S
V
S
K
K
L
K
S
Site 13
S271
L
K
K
P
K
S
V
S
K
K
L
K
S
V
F
Site 14
S276
S
V
S
K
K
L
K
S
V
F
R
V
P
D
L
Site 15
Y298
K
E
L
T
D
V
Q
Y
Y
W
V
D
V
M
L
Site 16
Y299
E
L
T
D
V
Q
Y
Y
W
V
D
V
M
L
N
Site 17
T325
V
D
Q
R
Q
V
K
T
V
R
T
C
T
F
K
Site 18
T330
V
K
T
V
R
T
C
T
F
K
N
S
N
P
C
Site 19
Y349
F
G
V
F
G
C
Q
Y
F
S
S
G
K
Y
Y
Site 20
Y355
Q
Y
F
S
S
G
K
Y
Y
W
E
V
D
V
S
Site 21
Y356
Y
F
S
S
G
K
Y
Y
W
E
V
D
V
S
G
Site 22
S373
A
W
I
L
G
V
H
S
K
I
S
S
L
N
K
Site 23
S377
G
V
H
S
K
I
S
S
L
N
K
R
K
S
S
Site 24
S383
S
S
L
N
K
R
K
S
S
G
F
A
F
D
P
Site 25
S384
S
L
N
K
R
K
S
S
G
F
A
F
D
P
S
Site 26
S391
S
G
F
A
F
D
P
S
V
N
Y
S
K
V
Y
Site 27
Y394
A
F
D
P
S
V
N
Y
S
K
V
Y
S
R
Y
Site 28
S395
F
D
P
S
V
N
Y
S
K
V
Y
S
R
Y
R
Site 29
Y398
S
V
N
Y
S
K
V
Y
S
R
Y
R
P
Q
Y
Site 30
S399
V
N
Y
S
K
V
Y
S
R
Y
R
P
Q
Y
G
Site 31
Y401
Y
S
K
V
Y
S
R
Y
R
P
Q
Y
G
Y
W
Site 32
Y405
Y
S
R
Y
R
P
Q
Y
G
Y
W
V
I
G
L
Site 33
Y407
R
Y
R
P
Q
Y
G
Y
W
V
I
G
L
Q
N
Site 34
Y418
G
L
Q
N
T
C
E
Y
N
A
F
E
D
S
S
Site 35
S424
E
Y
N
A
F
E
D
S
S
S
S
D
P
K
V
Site 36
S426
N
A
F
E
D
S
S
S
S
D
P
K
V
L
T
Site 37
S427
A
F
E
D
S
S
S
S
D
P
K
V
L
T
L
Site 38
Y467
T
N
H
G
A
L
I
Y
K
F
S
G
C
R
F
Site 39
S470
G
A
L
I
Y
K
F
S
G
C
R
F
S
R
P
Site 40
S475
K
F
S
G
C
R
F
S
R
P
A
Y
P
Y
F
Site 41
Y481
F
S
R
P
A
Y
P
Y
F
N
P
W
N
C
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation