KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
THNSL1
Full Name:
Threonine synthase-like 1
Alias:
FLJ22002; THNS1
Type:
Mass (Da):
83052
Number AA:
743
UniProt ID:
Q8IYQ7
International Prot ID:
IPI00016287
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004765
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006519
GO:0006520
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
K
I
T
Q
K
C
F
S
S
I
H
V
K
T
D
Site 2
S34
K
H
A
Q
R
F
L
S
R
T
F
A
L
A
E
Site 3
T36
A
Q
R
F
L
S
R
T
F
A
L
A
E
L
R
Site 4
S45
A
L
A
E
L
R
K
S
W
Y
S
T
H
S
L
Site 5
Y47
A
E
L
R
K
S
W
Y
S
T
H
S
L
V
G
Site 6
S48
E
L
R
K
S
W
Y
S
T
H
S
L
V
G
D
Site 7
T49
L
R
K
S
W
Y
S
T
H
S
L
V
G
D
K
Site 8
S51
K
S
W
Y
S
T
H
S
L
V
G
D
K
N
I
Site 9
T69
G
P
P
G
A
G
K
T
T
V
G
R
I
I
G
Site 10
T70
P
P
G
A
G
K
T
T
V
G
R
I
I
G
Q
Site 11
T94
D
D
D
I
L
E
K
T
W
N
M
S
V
S
E
Site 12
S98
L
E
K
T
W
N
M
S
V
S
E
K
L
Q
D
Site 13
S100
K
T
W
N
M
S
V
S
E
K
L
Q
D
V
G
Site 14
T132
S
G
S
V
I
S
L
T
G
S
N
P
M
H
D
Site 15
S134
S
V
I
S
L
T
G
S
N
P
M
H
D
A
S
Site 16
T170
C
R
L
K
L
M
K
T
D
R
I
V
G
Q
N
Site 17
Y192
L
L
K
F
R
R
Q
Y
Y
K
K
W
Y
D
A
Site 18
Y193
L
K
F
R
R
Q
Y
Y
K
K
W
Y
D
A
R
Site 19
Y197
R
Q
Y
Y
K
K
W
Y
D
A
R
V
F
C
E
Site 20
S205
D
A
R
V
F
C
E
S
G
A
S
P
E
E
V
Site 21
S208
V
F
C
E
S
G
A
S
P
E
E
V
A
D
K
Site 22
S228
K
R
Y
Q
D
V
D
S
E
T
F
I
S
T
R
Site 23
T230
Y
Q
D
V
D
S
E
T
F
I
S
T
R
H
V
Site 24
S233
V
D
S
E
T
F
I
S
T
R
H
V
W
P
E
Site 25
S247
E
D
C
E
Q
K
V
S
A
K
F
F
S
E
A
Site 26
S276
A
K
E
F
P
K
L
S
C
G
E
W
K
S
L
Site 27
T316
R
L
G
E
M
I
E
T
A
Y
G
E
N
F
A
Site 28
Y318
G
E
M
I
E
T
A
Y
G
E
N
F
A
C
S
Site 29
S349
L
F
H
G
P
T
G
S
F
K
D
L
S
L
Q
Site 30
S384
A
T
S
G
D
T
G
S
A
V
L
N
G
F
S
Site 31
S413
F
F
P
E
N
G
V
S
D
F
Q
K
A
Q
I
Site 32
S423
Q
K
A
Q
I
I
G
S
Q
R
E
N
G
W
A
Site 33
S451
I
K
R
I
F
N
D
S
D
F
T
G
F
L
T
Site 34
S466
V
E
Y
G
T
I
L
S
S
A
N
S
I
N
W
Site 35
S467
E
Y
G
T
I
L
S
S
A
N
S
I
N
W
G
Site 36
T541
S
N
Q
N
H
V
L
T
D
F
I
K
T
G
H
Site 37
Y549
D
F
I
K
T
G
H
Y
D
L
R
E
R
K
L
Site 38
T559
R
E
R
K
L
A
Q
T
F
S
P
S
I
D
I
Site 39
S561
R
K
L
A
Q
T
F
S
P
S
I
D
I
L
K
Site 40
S569
P
S
I
D
I
L
K
S
S
N
L
E
R
H
L
Site 41
S570
S
I
D
I
L
K
S
S
N
L
E
R
H
L
H
Site 42
S596
E
L
F
N
R
L
E
S
Q
H
H
F
Q
I
E
Site 43
S630
E
C
L
A
A
I
N
S
T
Y
N
T
S
G
Y
Site 44
T634
A
I
N
S
T
Y
N
T
S
G
Y
I
L
D
P
Site 45
T657
A
D
R
V
Q
D
K
T
C
P
V
I
I
S
S
Site 46
T687
K
I
K
E
I
N
E
T
S
S
S
Q
L
Y
L
Site 47
S690
E
I
N
E
T
S
S
S
Q
L
Y
L
L
G
S
Site 48
Y693
E
T
S
S
S
Q
L
Y
L
L
G
S
Y
N
A
Site 49
Y720
K
Q
Q
E
K
M
E
Y
Q
V
C
A
A
D
M
Site 50
S732
A
D
M
N
V
L
K
S
H
V
E
Q
L
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation