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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMYD4
Full Name:
SET and MYND domain-containing protein 4
Alias:
Type:
Mass (Da):
89225
Number AA:
804
UniProt ID:
Q8IYR2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
P
V
D
E
W
K
S
Y
L
L
Q
K
W
A
S
Site 2
S28
T
S
V
Q
V
T
I
S
T
A
E
T
L
R
D
Site 3
S40
L
R
D
I
F
L
H
S
S
S
L
L
Q
P
E
Site 4
S42
D
I
F
L
H
S
S
S
L
L
Q
P
E
D
E
Site 5
S56
E
L
F
L
K
R
L
S
K
G
Y
L
V
G
K
Site 6
Y59
L
K
R
L
S
K
G
Y
L
V
G
K
D
S
D
Site 7
S65
G
Y
L
V
G
K
D
S
D
A
P
L
F
Y
R
Site 8
Y84
K
K
F
Q
E
K
D
Y
T
G
A
A
V
L
Y
Site 9
T85
K
F
Q
E
K
D
Y
T
G
A
A
V
L
Y
S
Site 10
Y91
Y
T
G
A
A
V
L
Y
S
K
G
V
S
H
S
Site 11
S92
T
G
A
A
V
L
Y
S
K
G
V
S
H
S
R
Site 12
S96
V
L
Y
S
K
G
V
S
H
S
R
P
N
T
E
Site 13
S98
Y
S
K
G
V
S
H
S
R
P
N
T
E
D
M
Site 14
T102
V
S
H
S
R
P
N
T
E
D
M
S
L
C
H
Site 15
S106
R
P
N
T
E
D
M
S
L
C
H
A
N
R
S
Site 16
Y137
N
I
A
Q
T
H
G
Y
P
E
R
L
Q
P
K
Site 17
S163
L
G
R
L
Q
E
A
S
Q
T
I
S
D
L
E
Site 18
T165
R
L
Q
E
A
S
Q
T
I
S
D
L
E
R
N
Site 19
S167
Q
E
A
S
Q
T
I
S
D
L
E
R
N
F
T
Site 20
T174
S
D
L
E
R
N
F
T
A
T
P
A
L
A
D
Site 21
T186
L
A
D
V
L
P
Q
T
L
Q
R
N
L
H
R
Site 22
S203
M
K
M
Q
E
K
D
S
L
T
E
S
F
P
A
Site 23
T205
M
Q
E
K
D
S
L
T
E
S
F
P
A
A
L
Site 24
S207
E
K
D
S
L
T
E
S
F
P
A
A
L
A
K
Site 25
S229
R
E
E
N
E
Q
L
S
N
A
S
S
S
I
G
Site 26
S233
E
Q
L
S
N
A
S
S
S
I
G
L
C
V
D
Site 27
T250
K
G
R
C
L
V
A
T
K
D
I
L
P
G
E
Site 28
S283
P
P
H
H
G
L
D
S
K
W
D
T
R
V
T
Site 29
T287
G
L
D
S
K
W
D
T
R
V
T
N
G
D
L
Site 30
Y295
R
V
T
N
G
D
L
Y
C
H
R
C
L
K
H
Site 31
Y317
D
G
C
S
Y
A
K
Y
C
S
Q
E
C
L
Q
Site 32
Y330
L
Q
Q
A
W
E
L
Y
H
R
T
E
C
P
L
Site 33
T333
A
W
E
L
Y
H
R
T
E
C
P
L
G
G
L
Site 34
S384
K
D
I
C
L
P
E
S
N
N
Q
V
K
T
L
Site 35
T390
E
S
N
N
Q
V
K
T
L
N
Y
G
L
G
E
Site 36
T407
K
N
G
N
I
V
E
T
P
I
P
G
C
D
I
Site 37
Y418
G
C
D
I
N
G
K
Y
E
N
N
Y
N
A
V
Site 38
Y422
N
G
K
Y
E
N
N
Y
N
A
V
F
N
L
L
Site 39
T432
V
F
N
L
L
P
H
T
E
N
H
S
P
E
H
Site 40
S436
L
P
H
T
E
N
H
S
P
E
H
K
F
L
C
Site 41
T464
A
S
L
Q
A
I
P
T
E
R
I
V
N
S
S
Site 42
S471
T
E
R
I
V
N
S
S
Q
L
K
A
A
V
T
Site 43
S517
Q
H
T
G
P
K
G
S
I
V
T
D
S
R
Q
Site 44
S522
K
G
S
I
V
T
D
S
R
Q
V
R
L
A
T
Site 45
S543
S
L
L
N
H
S
C
S
P
N
T
S
V
S
F
Site 46
T546
N
H
S
C
S
P
N
T
S
V
S
F
I
S
T
Site 47
S547
H
S
C
S
P
N
T
S
V
S
F
I
S
T
V
Site 48
S560
T
V
A
T
I
R
A
S
Q
R
I
R
K
G
Q
Site 49
Y573
G
Q
E
I
L
H
C
Y
G
P
H
K
S
R
M
Site 50
S591
E
R
Q
Q
K
L
R
S
Q
Y
F
F
D
C
A
Site 51
Y593
Q
Q
K
L
R
S
Q
Y
F
F
D
C
A
C
P
Site 52
S637
D
D
V
L
R
C
G
S
R
S
C
A
E
S
A
Site 53
S643
G
S
R
S
C
A
E
S
A
V
S
R
D
H
L
Site 54
S646
S
C
A
E
S
A
V
S
R
D
H
L
V
S
R
Site 55
S652
V
S
R
D
H
L
V
S
R
L
Q
D
L
Q
Q
Site 56
S681
E
R
A
V
Q
R
L
S
G
C
Q
R
D
A
E
Site 57
S718
A
L
G
D
W
Q
K
S
A
T
H
L
Q
R
S
Site 58
S737
E
V
R
H
G
P
S
S
V
E
M
G
H
E
L
Site 59
T763
A
V
P
E
A
L
S
T
I
Q
K
A
E
E
V
Site 60
S772
Q
K
A
E
E
V
L
S
L
H
C
G
P
W
D
Site 61
S790
Q
E
L
Q
K
M
K
S
C
L
L
D
L
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation