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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRAMD1C
Full Name:
GRAM domain-containing protein 1C
Alias:
GRAM domain-containing 1C; GRM1C
Type:
Membrane, Integral membrane protein
Mass (Da):
76035
Number AA:
662
UniProt ID:
Q8IYS0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
V
M
N
E
G
D
S
S
L
A
T
D
L
Q
E
Site 2
T20
E
G
D
S
S
L
A
T
D
L
Q
E
D
V
E
Site 3
S31
E
D
V
E
E
N
P
S
P
T
V
E
E
N
N
Site 4
Y64
F
W
I
S
S
S
T
Y
K
D
R
N
E
E
Y
Site 5
Y71
Y
K
D
R
N
E
E
Y
R
R
Q
F
T
H
L
Site 6
T76
E
E
Y
R
R
Q
F
T
H
L
P
D
T
E
R
Site 7
T81
Q
F
T
H
L
P
D
T
E
R
L
I
A
D
Y
Site 8
Y88
T
E
R
L
I
A
D
Y
A
C
A
L
Q
R
D
Site 9
T130
S
I
A
L
K
N
I
T
F
M
T
K
E
K
T
Site 10
T137
T
F
M
T
K
E
K
T
A
R
L
I
P
N
A
Site 11
S151
A
I
Q
I
V
T
E
S
E
K
F
F
F
T
S
Site 12
S158
S
E
K
F
F
F
T
S
F
G
A
R
D
R
S
Site 13
S165
S
F
G
A
R
D
R
S
Y
L
S
I
F
R
L
Site 14
Y166
F
G
A
R
D
R
S
Y
L
S
I
F
R
L
W
Site 15
S168
A
R
D
R
S
Y
L
S
I
F
R
L
W
Q
N
Site 16
S181
Q
N
V
L
L
D
K
S
L
T
R
Q
E
F
W
Site 17
T183
V
L
L
D
K
S
L
T
R
Q
E
F
W
Q
L
Site 18
S210
A
E
E
M
E
N
L
S
L
S
I
E
D
V
Q
Site 19
S212
E
M
E
N
L
S
L
S
I
E
D
V
Q
P
R
Site 20
S220
I
E
D
V
Q
P
R
S
P
G
R
S
S
L
D
Site 21
S224
Q
P
R
S
P
G
R
S
S
L
D
D
S
G
E
Site 22
S225
P
R
S
P
G
R
S
S
L
D
D
S
G
E
R
Site 23
S229
G
R
S
S
L
D
D
S
G
E
R
D
E
K
L
Site 24
S237
G
E
R
D
E
K
L
S
K
S
I
S
F
T
S
Site 25
S239
R
D
E
K
L
S
K
S
I
S
F
T
S
E
S
Site 26
S241
E
K
L
S
K
S
I
S
F
T
S
E
S
I
S
Site 27
T243
L
S
K
S
I
S
F
T
S
E
S
I
S
R
V
Site 28
S244
S
K
S
I
S
F
T
S
E
S
I
S
R
V
S
Site 29
S246
S
I
S
F
T
S
E
S
I
S
R
V
S
E
T
Site 30
S248
S
F
T
S
E
S
I
S
R
V
S
E
T
E
S
Site 31
S251
S
E
S
I
S
R
V
S
E
T
E
S
F
D
G
Site 32
S255
S
R
V
S
E
T
E
S
F
D
G
N
S
S
K
Site 33
S260
T
E
S
F
D
G
N
S
S
K
G
G
L
G
K
Site 34
S270
G
G
L
G
K
E
E
S
Q
N
E
K
Q
T
K
Site 35
S279
N
E
K
Q
T
K
K
S
L
L
P
T
L
E
K
Site 36
T283
T
K
K
S
L
L
P
T
L
E
K
K
L
T
R
Site 37
T289
P
T
L
E
K
K
L
T
R
V
P
S
K
S
L
Site 38
S293
K
K
L
T
R
V
P
S
K
S
L
D
L
N
K
Site 39
S295
L
T
R
V
P
S
K
S
L
D
L
N
K
N
E
Site 40
Y303
L
D
L
N
K
N
E
Y
L
S
L
D
K
S
S
Site 41
S305
L
N
K
N
E
Y
L
S
L
D
K
S
S
T
S
Site 42
S309
E
Y
L
S
L
D
K
S
S
T
S
D
S
V
D
Site 43
S310
Y
L
S
L
D
K
S
S
T
S
D
S
V
D
E
Site 44
S312
S
L
D
K
S
S
T
S
D
S
V
D
E
E
N
Site 45
S314
D
K
S
S
T
S
D
S
V
D
E
E
N
V
P
Site 46
T348
R
M
F
E
L
L
F
T
S
S
R
F
M
Q
K
Site 47
S358
R
F
M
Q
K
F
A
S
S
R
N
I
I
D
V
Site 48
T371
D
V
V
S
T
P
W
T
A
E
L
G
G
D
Q
Site 49
T383
G
D
Q
L
R
T
M
T
Y
T
I
V
L
N
S
Site 50
Y384
D
Q
L
R
T
M
T
Y
T
I
V
L
N
S
P
Site 51
Y406
A
T
E
K
Q
T
L
Y
K
E
S
R
E
A
R
Site 52
Y415
E
S
R
E
A
R
F
Y
L
V
D
S
E
V
L
Site 53
T423
L
V
D
S
E
V
L
T
H
D
V
P
Y
H
D
Site 54
Y428
V
L
T
H
D
V
P
Y
H
D
Y
F
Y
T
V
Site 55
Y431
H
D
V
P
Y
H
D
Y
F
Y
T
V
N
R
Y
Site 56
Y438
Y
F
Y
T
V
N
R
Y
C
I
I
R
S
S
K
Site 57
S453
Q
K
C
R
L
R
V
S
T
D
L
K
Y
R
K
Site 58
T454
K
C
R
L
R
V
S
T
D
L
K
Y
R
K
Q
Site 59
Y458
R
V
S
T
D
L
K
Y
R
K
Q
P
W
G
L
Site 60
S468
Q
P
W
G
L
V
K
S
L
I
E
K
N
S
W
Site 61
S474
K
S
L
I
E
K
N
S
W
S
S
L
E
D
Y
Site 62
S476
L
I
E
K
N
S
W
S
S
L
E
D
Y
F
K
Site 63
Y481
S
W
S
S
L
E
D
Y
F
K
Q
L
E
S
D
Site 64
S487
D
Y
F
K
Q
L
E
S
D
L
L
I
E
E
S
Site 65
T515
G
L
R
R
R
R
R
T
F
N
R
T
A
E
T
Site 66
T519
R
R
R
T
F
N
R
T
A
E
T
V
P
K
L
Site 67
T522
T
F
N
R
T
A
E
T
V
P
K
L
S
S
Q
Site 68
S527
A
E
T
V
P
K
L
S
S
Q
H
S
S
G
D
Site 69
S528
E
T
V
P
K
L
S
S
Q
H
S
S
G
D
V
Site 70
S531
P
K
L
S
S
Q
H
S
S
G
D
V
G
L
G
Site 71
S532
K
L
S
S
Q
H
S
S
G
D
V
G
L
G
A
Site 72
T544
L
G
A
K
G
D
I
T
G
K
K
K
E
M
E
Site 73
Y553
K
K
K
E
M
E
N
Y
N
V
T
L
I
V
V
Site 74
S588
K
I
E
H
A
A
Q
S
F
Y
R
L
R
L
Q
Site 75
S599
L
R
L
Q
E
E
K
S
L
N
L
A
S
D
M
Site 76
S604
E
K
S
L
N
L
A
S
D
M
V
S
R
A
E
Site 77
S608
N
L
A
S
D
M
V
S
R
A
E
T
I
Q
K
Site 78
T612
D
M
V
S
R
A
E
T
I
Q
K
N
K
D
Q
Site 79
T647
S
L
I
M
L
Q
K
T
F
D
L
L
N
K
N
Site 80
T656
D
L
L
N
K
N
K
T
G
M
A
V
E
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation