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Updated November 2019
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Protein Info
Short Name:
ULK2
Full Name:
Serine/threonine-protein kinase ULK2
Alias:
EC 2.7.11.1; KIAA0623
Type:
Protein-serine kinase, Other group, ULK family
Mass (Da):
112726
Number AA:
1036
UniProt ID:
Q8IYT8
International Prot ID:
IPI00479399
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007409
GO:0006468
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Unc 51 (C. elegans) like kinase 2 pan-specific antibody AB-NK354-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK354-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
E
V
V
G
D
F
E
Y
S
K
R
D
L
V
G
Site 2
S10
V
V
G
D
F
E
Y
S
K
R
D
L
V
G
H
Site 3
T32
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
Site 4
S40
D
W
E
V
A
I
K
S
I
N
K
K
N
L
S
Site 5
S47
S
I
N
K
K
N
L
S
K
S
Q
I
L
L
G
Site 6
S49
N
K
K
N
L
S
K
S
Q
I
L
L
G
K
E
Site 7
Y72
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
N
Site 8
Y96
N
G
G
D
L
A
D
Y
L
Q
A
K
G
T
L
Site 9
S104
L
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
Site 10
T107
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
Site 11
S140
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
Site 12
Y141
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
Site 13
S147
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
Site 14
S148
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
Site 15
S150
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
Site 16
S218
K
P
P
F
Q
A
N
S
P
Q
D
L
R
M
F
Site 17
Y226
P
Q
D
L
R
M
F
Y
E
K
N
R
S
L
M
Site 18
S231
M
F
Y
E
K
N
R
S
L
M
P
S
I
P
R
Site 19
S235
K
N
R
S
L
M
P
S
I
P
R
E
T
S
P
Site 20
T240
M
P
S
I
P
R
E
T
S
P
Y
L
A
N
L
Site 21
S241
P
S
I
P
R
E
T
S
P
Y
L
A
N
L
L
Site 22
S279
E
Q
G
P
V
K
K
S
C
P
V
P
V
P
M
Site 23
S288
P
V
P
V
P
M
Y
S
G
S
V
S
G
S
S
Site 24
S290
P
V
P
M
Y
S
G
S
V
S
G
S
S
C
G
Site 25
S292
P
M
Y
S
G
S
V
S
G
S
S
C
G
S
S
Site 26
S294
Y
S
G
S
V
S
G
S
S
C
G
S
S
P
S
Site 27
S295
S
G
S
V
S
G
S
S
C
G
S
S
P
S
C
Site 28
S298
V
S
G
S
S
C
G
S
S
P
S
C
R
F
A
Site 29
S299
S
G
S
S
C
G
S
S
P
S
C
R
F
A
S
Site 30
S301
S
S
C
G
S
S
P
S
C
R
F
A
S
P
P
Site 31
S306
S
P
S
C
R
F
A
S
P
P
S
L
P
D
M
Site 32
S309
C
R
F
A
S
P
P
S
L
P
D
M
Q
H
I
Site 33
S322
H
I
Q
E
E
N
L
S
S
P
P
L
G
P
P
Site 34
S323
I
Q
E
E
N
L
S
S
P
P
L
G
P
P
N
Site 35
Y331
P
P
L
G
P
P
N
Y
L
Q
V
S
K
D
S
Site 36
S335
P
P
N
Y
L
Q
V
S
K
D
S
A
S
T
S
Site 37
S338
Y
L
Q
V
S
K
D
S
A
S
T
S
S
K
N
Site 38
S340
Q
V
S
K
D
S
A
S
T
S
S
K
N
S
S
Site 39
S342
S
K
D
S
A
S
T
S
S
K
N
S
S
C
D
Site 40
S343
K
D
S
A
S
T
S
S
K
N
S
S
C
D
T
Site 41
S346
A
S
T
S
S
K
N
S
S
C
D
T
D
D
F
Site 42
S347
S
T
S
S
K
N
S
S
C
D
T
D
D
F
V
Site 43
T350
S
K
N
S
S
C
D
T
D
D
F
V
L
V
P
Site 44
S362
L
V
P
H
N
I
S
S
D
H
S
C
D
M
P
Site 45
S365
H
N
I
S
S
D
H
S
C
D
M
P
V
G
T
Site 46
S378
G
T
A
G
R
R
A
S
N
E
F
L
V
C
G
Site 47
T391
C
G
G
Q
C
Q
P
T
V
S
P
H
S
E
T
Site 48
S393
G
Q
C
Q
P
T
V
S
P
H
S
E
T
A
P
Site 49
S396
Q
P
T
V
S
P
H
S
E
T
A
P
I
P
V
Site 50
Y410
V
P
T
Q
I
R
N
Y
Q
R
I
E
Q
N
L
Site 51
T418
Q
R
I
E
Q
N
L
T
S
T
A
S
S
G
T
Site 52
S419
R
I
E
Q
N
L
T
S
T
A
S
S
G
T
N
Site 53
S422
Q
N
L
T
S
T
A
S
S
G
T
N
V
H
G
Site 54
S423
N
L
T
S
T
A
S
S
G
T
N
V
H
G
S
Site 55
S430
S
G
T
N
V
H
G
S
P
R
S
A
V
V
R
Site 56
S433
N
V
H
G
S
P
R
S
A
V
V
R
R
S
N
Site 57
S439
R
S
A
V
V
R
R
S
N
T
S
P
M
G
F
Site 58
T441
A
V
V
R
R
S
N
T
S
P
M
G
F
L
R
Site 59
S442
V
V
R
R
S
N
T
S
P
M
G
F
L
R
P
Site 60
S451
M
G
F
L
R
P
G
S
C
S
P
V
P
A
D
Site 61
S453
F
L
R
P
G
S
C
S
P
V
P
A
D
T
A
Site 62
T462
V
P
A
D
T
A
Q
T
V
G
R
R
L
S
T
Site 63
S468
Q
T
V
G
R
R
L
S
T
G
S
S
R
P
Y
Site 64
T469
T
V
G
R
R
L
S
T
G
S
S
R
P
Y
S
Site 65
S471
G
R
R
L
S
T
G
S
S
R
P
Y
S
P
S
Site 66
S472
R
R
L
S
T
G
S
S
R
P
Y
S
P
S
P
Site 67
Y475
S
T
G
S
S
R
P
Y
S
P
S
P
L
V
G
Site 68
S476
T
G
S
S
R
P
Y
S
P
S
P
L
V
G
T
Site 69
S478
S
S
R
P
Y
S
P
S
P
L
V
G
T
I
P
Site 70
S501
G
H
P
Q
G
H
D
S
R
S
R
N
S
S
G
Site 71
S503
P
Q
G
H
D
S
R
S
R
N
S
S
G
S
P
Site 72
S506
H
D
S
R
S
R
N
S
S
G
S
P
V
P
Q
Site 73
S507
D
S
R
S
R
N
S
S
G
S
P
V
P
Q
A
Site 74
S509
R
S
R
N
S
S
G
S
P
V
P
Q
A
Q
S
Site 75
S516
S
P
V
P
Q
A
Q
S
P
Q
S
L
L
S
G
Site 76
S519
P
Q
A
Q
S
P
Q
S
L
L
S
G
A
R
L
Site 77
S522
Q
S
P
Q
S
L
L
S
G
A
R
L
Q
S
A
Site 78
S528
L
S
G
A
R
L
Q
S
A
P
T
L
T
D
I
Site 79
Y536
A
P
T
L
T
D
I
Y
Q
N
K
Q
K
L
R
Site 80
S547
Q
K
L
R
K
Q
H
S
D
P
V
C
P
S
H
Site 81
S553
H
S
D
P
V
C
P
S
H
T
G
A
G
Y
S
Site 82
S560
S
H
T
G
A
G
Y
S
Y
S
P
Q
P
S
R
Site 83
S562
T
G
A
G
Y
S
Y
S
P
Q
P
S
R
P
G
Site 84
S566
Y
S
Y
S
P
Q
P
S
R
P
G
S
L
G
T
Site 85
S570
P
Q
P
S
R
P
G
S
L
G
T
S
P
T
K
Site 86
S574
R
P
G
S
L
G
T
S
P
T
K
H
L
G
S
Site 87
T576
G
S
L
G
T
S
P
T
K
H
L
G
S
S
P
Site 88
S581
S
P
T
K
H
L
G
S
S
P
R
S
S
D
W
Site 89
S582
P
T
K
H
L
G
S
S
P
R
S
S
D
W
F
Site 90
S585
H
L
G
S
S
P
R
S
S
D
W
F
F
K
T
Site 91
S586
L
G
S
S
P
R
S
S
D
W
F
F
K
T
P
Site 92
S600
P
L
P
T
I
I
G
S
P
T
K
T
T
A
P
Site 93
T602
P
T
I
I
G
S
P
T
K
T
T
A
P
F
K
Site 94
T613
A
P
F
K
I
P
K
T
Q
A
S
S
N
L
L
Site 95
S616
K
I
P
K
T
Q
A
S
S
N
L
L
A
L
V
Site 96
S651
H
C
L
L
V
Q
G
S
E
R
Q
R
A
E
Q
Site 97
S660
R
Q
R
A
E
Q
Q
S
K
A
V
F
G
R
S
Site 98
S667
S
K
A
V
F
G
R
S
V
S
T
G
K
L
S
Site 99
S669
A
V
F
G
R
S
V
S
T
G
K
L
S
D
Q
Site 100
T680
L
S
D
Q
Q
G
K
T
P
I
C
R
H
Q
G
Site 101
S688
P
I
C
R
H
Q
G
S
T
D
S
L
N
T
E
Site 102
T689
I
C
R
H
Q
G
S
T
D
S
L
N
T
E
R
Site 103
S691
R
H
Q
G
S
T
D
S
L
N
T
E
R
P
M
Site 104
S719
P
P
A
G
T
A
A
S
S
K
A
V
L
F
T
Site 105
T726
S
S
K
A
V
L
F
T
V
G
S
P
P
H
S
Site 106
S729
A
V
L
F
T
V
G
S
P
P
H
S
A
A
A
Site 107
S733
T
V
G
S
P
P
H
S
A
A
A
P
T
C
T
Site 108
T748
H
M
F
L
R
T
R
T
T
S
V
G
P
S
N
Site 109
T749
M
F
L
R
T
R
T
T
S
V
G
P
S
N
S
Site 110
S750
F
L
R
T
R
T
T
S
V
G
P
S
N
S
G
Site 111
S754
R
T
T
S
V
G
P
S
N
S
G
G
S
L
C
Site 112
S759
G
P
S
N
S
G
G
S
L
C
A
M
S
G
R
Site 113
S771
S
G
R
V
C
V
G
S
P
P
G
P
G
F
G
Site 114
S779
P
P
G
P
G
F
G
S
S
P
P
G
A
E
A
Site 115
S780
P
G
P
G
F
G
S
S
P
P
G
A
E
A
A
Site 116
S789
P
G
A
E
A
A
P
S
L
R
Y
V
P
Y
G
Site 117
Y792
E
A
A
P
S
L
R
Y
V
P
Y
G
A
S
P
Site 118
Y795
P
S
L
R
Y
V
P
Y
G
A
S
P
P
S
L
Site 119
S798
R
Y
V
P
Y
G
A
S
P
P
S
L
E
G
L
Site 120
T824
T
L
M
E
R
E
H
T
D
T
L
R
H
L
N
Site 121
T826
M
E
R
E
H
T
D
T
L
R
H
L
N
V
M
Site 122
T844
T
E
C
V
L
D
L
T
A
M
R
G
G
N
P
Site 123
T855
G
G
N
P
E
L
C
T
S
A
V
S
L
Y
Q
Site 124
S873
S
V
V
V
D
Q
I
S
Q
L
S
K
D
W
G
Site 125
S908
L
A
K
A
Q
I
K
S
G
K
L
S
P
S
T
Site 126
S912
Q
I
K
S
G
K
L
S
P
S
T
A
V
K
Q
Site 127
S914
K
S
G
K
L
S
P
S
T
A
V
K
Q
V
V
Site 128
T915
S
G
K
L
S
P
S
T
A
V
K
Q
V
V
K
Site 129
S947
E
K
L
N
R
F
F
S
D
K
Q
R
F
I
D
Site 130
Y990
Q
Q
T
E
D
I
V
Y
R
Y
H
K
A
A
L
Site 131
Y1018
D
I
E
N
V
H
K
Y
K
C
S
I
E
R
R
Site 132
S1021
N
V
H
K
Y
K
C
S
I
E
R
R
L
S
A
Site 133
S1027
C
S
I
E
R
R
L
S
A
L
C
H
S
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation