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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ENTHD1
Full Name:
ENTH domain-containing protein 1
Alias:
Epsin-2B
Type:
Mass (Da):
67538
Number AA:
607
UniProt ID:
Q8IYW4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
K
N
F
V
K
N
Y
S
D
A
E
I
K
V
R
Site 2
T25
E
I
K
V
R
E
A
T
S
N
D
P
W
G
P
Site 3
S33
S
N
D
P
W
G
P
S
S
S
L
M
L
D
I
Site 4
S34
N
D
P
W
G
P
S
S
S
L
M
L
D
I
S
Site 5
S35
D
P
W
G
P
S
S
S
L
M
L
D
I
S
D
Site 6
Y72
G
K
N
W
R
H
V
Y
K
S
L
T
L
M
D
Site 7
T76
R
H
V
Y
K
S
L
T
L
M
D
Y
L
I
K
Site 8
Y80
K
S
L
T
L
M
D
Y
L
I
K
N
G
S
K
Site 9
Y118
E
A
G
K
D
Q
G
Y
Y
I
R
E
K
S
K
Site 10
Y119
A
G
K
D
Q
G
Y
Y
I
R
E
K
S
K
Q
Site 11
S124
G
Y
Y
I
R
E
K
S
K
Q
V
I
T
L
L
Site 12
T147
E
R
E
V
A
C
R
T
R
Q
R
T
S
H
S
Site 13
T151
A
C
R
T
R
Q
R
T
S
H
S
I
L
F
S
Site 14
S152
C
R
T
R
Q
R
T
S
H
S
I
L
F
S
K
Site 15
S154
T
R
Q
R
T
S
H
S
I
L
F
S
K
R
Q
Site 16
S158
T
S
H
S
I
L
F
S
K
R
Q
L
G
S
S
Site 17
S164
F
S
K
R
Q
L
G
S
S
N
S
L
T
A
C
Site 18
S165
S
K
R
Q
L
G
S
S
N
S
L
T
A
C
T
Site 19
S167
R
Q
L
G
S
S
N
S
L
T
A
C
T
S
A
Site 20
T169
L
G
S
S
N
S
L
T
A
C
T
S
A
P
T
Site 21
T172
S
N
S
L
T
A
C
T
S
A
P
T
P
D
I
Site 22
S173
N
S
L
T
A
C
T
S
A
P
T
P
D
I
S
Site 23
T176
T
A
C
T
S
A
P
T
P
D
I
S
A
S
E
Site 24
S180
S
A
P
T
P
D
I
S
A
S
E
K
K
Y
K
Site 25
S182
P
T
P
D
I
S
A
S
E
K
K
Y
K
L
P
Site 26
Y186
I
S
A
S
E
K
K
Y
K
L
P
K
F
G
R
Site 27
S222
L
P
T
E
T
M
L
S
Q
E
T
L
P
L
K
Site 28
T241
K
S
T
E
D
L
M
T
F
L
D
D
D
P
E
Site 29
T282
S
G
A
D
A
V
P
T
L
S
E
N
S
P
S
Site 30
S284
A
D
A
V
P
T
L
S
E
N
S
P
S
G
Q
Site 31
S287
V
P
T
L
S
E
N
S
P
S
G
Q
R
D
V
Site 32
S289
T
L
S
E
N
S
P
S
G
Q
R
D
V
S
L
Site 33
S295
P
S
G
Q
R
D
V
S
L
D
K
R
S
D
G
Site 34
S300
D
V
S
L
D
K
R
S
D
G
I
F
T
N
T
Site 35
T307
S
D
G
I
F
T
N
T
V
T
E
N
L
L
E
Site 36
T315
V
T
E
N
L
L
E
T
P
L
E
K
Q
S
A
Site 37
S338
I
L
P
A
C
W
S
S
K
E
E
F
I
S
P
Site 38
S344
S
S
K
E
E
F
I
S
P
D
L
R
V
S
K
Site 39
S350
I
S
P
D
L
R
V
S
K
S
D
S
T
F
H
Site 40
S352
P
D
L
R
V
S
K
S
D
S
T
F
H
N
Q
Site 41
S354
L
R
V
S
K
S
D
S
T
F
H
N
Q
A
S
Site 42
T355
R
V
S
K
S
D
S
T
F
H
N
Q
A
S
V
Site 43
S361
S
T
F
H
N
Q
A
S
V
E
T
L
C
L
S
Site 44
T364
H
N
Q
A
S
V
E
T
L
C
L
S
P
S
F
Site 45
Y386
E
I
V
I
N
K
A
Y
Q
K
P
A
Q
S
S
Site 46
T403
M
D
D
K
I
L
K
T
T
T
R
V
S
T
A
Site 47
T404
D
D
K
I
L
K
T
T
T
R
V
S
T
A
S
Site 48
S408
L
K
T
T
T
R
V
S
T
A
S
E
G
A
S
Site 49
T409
K
T
T
T
R
V
S
T
A
S
E
G
A
S
S
Site 50
S411
T
T
R
V
S
T
A
S
E
G
A
S
S
F
S
Site 51
S415
S
T
A
S
E
G
A
S
S
F
S
P
L
S
M
Site 52
S416
T
A
S
E
G
A
S
S
F
S
P
L
S
M
S
Site 53
S418
S
E
G
A
S
S
F
S
P
L
S
M
S
S
P
Site 54
S421
A
S
S
F
S
P
L
S
M
S
S
P
D
L
A
Site 55
S423
S
F
S
P
L
S
M
S
S
P
D
L
A
S
P
Site 56
S424
F
S
P
L
S
M
S
S
P
D
L
A
S
P
E
Site 57
S429
M
S
S
P
D
L
A
S
P
E
K
S
A
H
L
Site 58
S433
D
L
A
S
P
E
K
S
A
H
L
L
S
P
I
Site 59
S438
E
K
S
A
H
L
L
S
P
I
L
A
G
P
S
Site 60
S445
S
P
I
L
A
G
P
S
F
W
T
L
S
H
Q
Site 61
S450
G
P
S
F
W
T
L
S
H
Q
Q
L
S
S
T
Site 62
S455
T
L
S
H
Q
Q
L
S
S
T
S
F
K
D
E
Site 63
S456
L
S
H
Q
Q
L
S
S
T
S
F
K
D
E
D
Site 64
S458
H
Q
Q
L
S
S
T
S
F
K
D
E
D
K
T
Site 65
T465
S
F
K
D
E
D
K
T
A
K
L
H
H
S
F
Site 66
S471
K
T
A
K
L
H
H
S
F
A
S
R
G
P
V
Site 67
S474
K
L
H
H
S
F
A
S
R
G
P
V
S
S
D
Site 68
S479
F
A
S
R
G
P
V
S
S
D
V
E
E
N
D
Site 69
S480
A
S
R
G
P
V
S
S
D
V
E
E
N
D
S
Site 70
S487
S
D
V
E
E
N
D
S
L
N
L
L
G
I
L
Site 71
S500
I
L
P
N
N
S
D
S
A
K
K
N
I
S
H
Site 72
S506
D
S
A
K
K
N
I
S
H
I
S
S
S
H
W
Site 73
S509
K
K
N
I
S
H
I
S
S
S
H
W
G
E
F
Site 74
S510
K
N
I
S
H
I
S
S
S
H
W
G
E
F
S
Site 75
S511
N
I
S
H
I
S
S
S
H
W
G
E
F
S
T
Site 76
S530
Q
F
I
P
L
S
C
S
G
F
Q
S
T
K
D
Site 77
S534
L
S
C
S
G
F
Q
S
T
K
D
F
P
Q
E
Site 78
S547
Q
E
P
E
A
K
N
S
I
S
V
L
L
R
E
Site 79
S549
P
E
A
K
N
S
I
S
V
L
L
R
E
V
K
Site 80
S567
A
R
L
H
E
D
L
S
T
V
I
Q
E
L
N
Site 81
T568
R
L
H
E
D
L
S
T
V
I
Q
E
L
N
V
Site 82
S584
N
N
I
L
M
S
M
S
L
N
S
S
Q
I
S
Site 83
S587
L
M
S
M
S
L
N
S
S
Q
I
S
Q
S
S
Site 84
S588
M
S
M
S
L
N
S
S
Q
I
S
Q
S
S
Q
Site 85
S591
S
L
N
S
S
Q
I
S
Q
S
S
Q
V
P
Q
Site 86
S593
N
S
S
Q
I
S
Q
S
S
Q
V
P
Q
S
S
Site 87
S594
S
S
Q
I
S
Q
S
S
Q
V
P
Q
S
S
E
Site 88
S599
Q
S
S
Q
V
P
Q
S
S
E
G
S
S
D
Q
Site 89
S600
S
S
Q
V
P
Q
S
S
E
G
S
S
D
Q
I
Site 90
S603
V
P
Q
S
S
E
G
S
S
D
Q
I
_
_
_
Site 91
S604
P
Q
S
S
E
G
S
S
D
Q
I
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation