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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF168
Full Name:
E3 ubiquitin-protein ligase RNF168
Alias:
FLJ35794; RING finger protein 168; RN168
Type:
Unknown function
Mass (Da):
65020
Number AA:
571
UniProt ID:
Q8IYW5
International Prot ID:
IPI00217899
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005634
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0042393
GO:0043130
PhosphoSite+
KinaseNET
Biological Process:
GO:0006302
GO:0070535
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
P
K
D
A
I
P
S
L
S
E
C
Q
C
G
Site 2
T43
C
K
P
C
F
Q
S
T
V
E
K
A
S
L
C
Site 3
S60
F
C
R
R
R
V
S
S
W
T
R
Y
H
T
R
Site 4
T62
R
R
R
V
S
S
W
T
R
Y
H
T
R
R
N
Site 5
Y64
R
V
S
S
W
T
R
Y
H
T
R
R
N
S
L
Site 6
T66
S
S
W
T
R
Y
H
T
R
R
N
S
L
V
N
Site 7
S70
R
Y
H
T
R
R
N
S
L
V
N
V
E
L
W
Site 8
Y84
W
T
I
I
Q
K
H
Y
P
R
E
C
K
L
R
Site 9
S93
R
E
C
K
L
R
A
S
G
Q
E
S
E
E
V
Site 10
S97
L
R
A
S
G
Q
E
S
E
E
V
A
D
D
Y
Site 11
Y104
S
E
E
V
A
D
D
Y
Q
P
V
R
L
L
S
Site 12
S111
Y
Q
P
V
R
L
L
S
K
P
G
E
L
R
R
Site 13
Y120
P
G
E
L
R
R
E
Y
E
E
E
I
S
K
V
Site 14
S125
R
E
Y
E
E
E
I
S
K
V
A
A
E
R
R
Site 15
S134
V
A
A
E
R
R
A
S
E
E
E
E
N
K
A
Site 16
S142
E
E
E
E
N
K
A
S
E
E
Y
I
Q
R
L
Site 17
S174
A
M
E
E
Q
L
K
S
D
E
E
L
A
R
K
Site 18
S183
E
E
L
A
R
K
L
S
I
D
I
N
N
F
C
Site 19
S193
I
N
N
F
C
E
G
S
I
S
A
S
P
L
N
Site 20
S195
N
F
C
E
G
S
I
S
A
S
P
L
N
S
R
Site 21
S197
C
E
G
S
I
S
A
S
P
L
N
S
R
K
S
Site 22
S201
I
S
A
S
P
L
N
S
R
K
S
D
P
V
T
Site 23
S204
S
P
L
N
S
R
K
S
D
P
V
T
P
K
S
Site 24
T208
S
R
K
S
D
P
V
T
P
K
S
E
K
K
S
Site 25
S211
S
D
P
V
T
P
K
S
E
K
K
S
K
N
K
Site 26
S215
T
P
K
S
E
K
K
S
K
N
K
Q
R
N
T
Site 27
T222
S
K
N
K
Q
R
N
T
G
D
I
Q
K
Y
L
Site 28
Y228
N
T
G
D
I
Q
K
Y
L
T
P
K
S
Q
F
Site 29
T230
G
D
I
Q
K
Y
L
T
P
K
S
Q
F
G
S
Site 30
S233
Q
K
Y
L
T
P
K
S
Q
F
G
S
A
S
H
Site 31
S237
T
P
K
S
Q
F
G
S
A
S
H
S
E
A
V
Site 32
S239
K
S
Q
F
G
S
A
S
H
S
E
A
V
Q
E
Site 33
S241
Q
F
G
S
A
S
H
S
E
A
V
Q
E
V
R
Site 34
S251
V
Q
E
V
R
K
D
S
V
S
K
D
I
D
S
Site 35
S253
E
V
R
K
D
S
V
S
K
D
I
D
S
S
D
Site 36
S258
S
V
S
K
D
I
D
S
S
D
R
K
S
P
T
Site 37
S259
V
S
K
D
I
D
S
S
D
R
K
S
P
T
G
Site 38
S263
I
D
S
S
D
R
K
S
P
T
G
Q
D
T
E
Site 39
T269
K
S
P
T
G
Q
D
T
E
I
E
D
M
P
T
Site 40
T276
T
E
I
E
D
M
P
T
L
S
P
Q
I
S
L
Site 41
S282
P
T
L
S
P
Q
I
S
L
G
V
G
E
Q
G
Site 42
S292
V
G
E
Q
G
A
D
S
S
I
E
S
P
M
P
Site 43
S293
G
E
Q
G
A
D
S
S
I
E
S
P
M
P
W
Site 44
S296
G
A
D
S
S
I
E
S
P
M
P
W
L
C
A
Site 45
S319
G
N
V
K
T
R
P
S
N
H
G
K
E
L
C
Site 46
S329
G
K
E
L
C
V
L
S
H
E
R
P
K
T
R
Site 47
T335
L
S
H
E
R
P
K
T
R
V
P
Y
S
K
E
Site 48
Y339
R
P
K
T
R
V
P
Y
S
K
E
T
A
V
M
Site 49
S340
P
K
T
R
V
P
Y
S
K
E
T
A
V
M
P
Site 50
S353
M
P
C
G
R
T
E
S
G
C
A
P
T
S
G
Site 51
S359
E
S
G
C
A
P
T
S
G
V
T
Q
T
N
G
Site 52
S377
G
E
T
E
N
E
E
S
C
L
L
I
S
K
E
Site 53
S382
E
E
S
C
L
L
I
S
K
E
I
S
K
R
K
Site 54
S386
L
L
I
S
K
E
I
S
K
R
K
N
Q
E
S
Site 55
S393
S
K
R
K
N
Q
E
S
S
F
E
A
V
K
D
Site 56
S394
K
R
K
N
Q
E
S
S
F
E
A
V
K
D
P
Site 57
S404
A
V
K
D
P
C
F
S
A
K
R
R
K
V
S
Site 58
S411
S
A
K
R
R
K
V
S
P
E
S
S
P
D
Q
Site 59
S414
R
R
K
V
S
P
E
S
S
P
D
Q
E
E
T
Site 60
S415
R
K
V
S
P
E
S
S
P
D
Q
E
E
T
E
Site 61
T421
S
S
P
D
Q
E
E
T
E
I
N
F
T
Q
K
Site 62
T426
E
E
T
E
I
N
F
T
Q
K
L
I
D
L
E
Site 63
S470
V
P
N
R
Q
K
G
S
P
D
E
Y
H
L
R
Site 64
Y474
Q
K
G
S
P
D
E
Y
H
L
R
A
T
S
S
Site 65
T479
D
E
Y
H
L
R
A
T
S
S
P
P
D
K
V
Site 66
S480
E
Y
H
L
R
A
T
S
S
P
P
D
K
V
L
Site 67
S481
Y
H
L
R
A
T
S
S
P
P
D
K
V
L
N
Site 68
T503
D
G
N
F
K
R
Q
T
H
T
K
H
P
T
P
Site 69
T505
N
F
K
R
Q
T
H
T
K
H
P
T
P
E
R
Site 70
T509
Q
T
H
T
K
H
P
T
P
E
R
G
S
R
D
Site 71
S514
H
P
T
P
E
R
G
S
R
D
K
N
R
Q
V
Site 72
S522
R
D
K
N
R
Q
V
S
L
K
M
Q
L
K
Q
Site 73
S530
L
K
M
Q
L
K
Q
S
V
N
R
R
K
M
P
Site 74
S539
N
R
R
K
M
P
N
S
T
R
D
H
C
K
V
Site 75
S547
T
R
D
H
C
K
V
S
K
S
A
H
S
L
Q
Site 76
S549
D
H
C
K
V
S
K
S
A
H
S
L
Q
P
S
Site 77
S552
K
V
S
K
S
A
H
S
L
Q
P
S
I
S
Q
Site 78
S556
S
A
H
S
L
Q
P
S
I
S
Q
K
S
V
F
Site 79
S558
H
S
L
Q
P
S
I
S
Q
K
S
V
F
Q
M
Site 80
S561
Q
P
S
I
S
Q
K
S
V
F
Q
M
F
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation