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Updated November 2019
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Protein Info
Short Name:
FAM154A
Full Name:
Protein FAM154A
Alias:
Type:
Mass (Da):
54621
Number AA:
474
UniProt ID:
Q8IYX7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
P
H
L
P
T
K
I
Y
D
K
T
E
K
P
C
Site 2
T28
P
T
K
I
Y
D
K
T
E
K
P
C
L
L
S
Site 3
Y37
K
P
C
L
L
S
E
Y
T
E
N
Y
P
F
Y
Site 4
Y41
L
S
E
Y
T
E
N
Y
P
F
Y
H
S
Y
L
Site 5
Y44
Y
T
E
N
Y
P
F
Y
H
S
Y
L
P
R
E
Site 6
S46
E
N
Y
P
F
Y
H
S
Y
L
P
R
E
S
F
Site 7
Y47
N
Y
P
F
Y
H
S
Y
L
P
R
E
S
F
K
Site 8
S52
H
S
Y
L
P
R
E
S
F
K
P
R
R
E
Y
Site 9
Y59
S
F
K
P
R
R
E
Y
Q
K
G
P
I
P
M
Site 10
T70
P
I
P
M
E
G
L
T
T
S
R
R
D
F
G
Site 11
T71
I
P
M
E
G
L
T
T
S
R
R
D
F
G
P
Site 12
S72
P
M
E
G
L
T
T
S
R
R
D
F
G
P
H
Site 13
Y89
A
P
V
K
V
H
Q
Y
D
Q
F
V
P
S
E
Site 14
T103
E
E
N
M
D
L
L
T
T
Y
K
K
D
Y
N
Site 15
Y105
N
M
D
L
L
T
T
Y
K
K
D
Y
N
P
Y
Site 16
Y109
L
T
T
Y
K
K
D
Y
N
P
Y
P
V
C
R
Site 17
Y112
Y
K
K
D
Y
N
P
Y
P
V
C
R
V
D
P
Site 18
S125
D
P
I
K
P
R
D
S
K
Y
P
C
S
D
K
Site 19
Y127
I
K
P
R
D
S
K
Y
P
C
S
D
K
M
E
Site 20
S130
R
D
S
K
Y
P
C
S
D
K
M
E
C
L
P
Site 21
T138
D
K
M
E
C
L
P
T
Y
K
A
D
Y
L
P
Site 22
Y139
K
M
E
C
L
P
T
Y
K
A
D
Y
L
P
W
Site 23
Y143
L
P
T
Y
K
A
D
Y
L
P
W
N
Q
P
R
Site 24
Y160
P
L
R
L
E
H
K
Y
Q
P
A
S
V
R
F
Site 25
S164
E
H
K
Y
Q
P
A
S
V
R
F
D
N
R
T
Site 26
T171
S
V
R
F
D
N
R
T
T
H
Q
D
D
Y
P
Site 27
T172
V
R
F
D
N
R
T
T
H
Q
D
D
Y
P
I
Site 28
Y177
R
T
T
H
Q
D
D
Y
P
I
K
G
L
V
K
Site 29
T205
N
I
P
L
E
D
V
T
N
Y
K
M
S
Y
V
Site 30
Y211
V
T
N
Y
K
M
S
Y
V
A
H
P
V
E
K
Site 31
S236
P
C
E
I
P
F
E
S
L
T
T
Q
K
Q
S
Site 32
T238
E
I
P
F
E
S
L
T
T
Q
K
Q
S
Y
R
Site 33
T239
I
P
F
E
S
L
T
T
Q
K
Q
S
Y
R
G
Site 34
S243
S
L
T
T
Q
K
Q
S
Y
R
G
L
M
G
E
Site 35
S254
L
M
G
E
P
A
K
S
L
K
P
L
A
R
P
Site 36
Y278
T
T
E
F
R
D
K
Y
Q
A
W
P
M
P
R
Site 37
T293
M
F
S
K
A
P
I
T
Y
V
P
P
E
D
R
Site 38
Y294
F
S
K
A
P
I
T
Y
V
P
P
E
D
R
M
Site 39
T305
E
D
R
M
D
L
L
T
T
V
Q
A
H
Y
T
Site 40
T306
D
R
M
D
L
L
T
T
V
Q
A
H
Y
T
C
Site 41
Y311
L
T
T
V
Q
A
H
Y
T
C
P
K
G
A
P
Site 42
S321
P
K
G
A
P
A
Q
S
C
R
P
A
L
Q
I
Site 43
S337
K
C
G
R
F
E
G
S
S
T
T
K
D
D
Y
Site 44
S338
C
G
R
F
E
G
S
S
T
T
K
D
D
Y
K
Site 45
T339
G
R
F
E
G
S
S
T
T
K
D
D
Y
K
Q
Site 46
Y344
S
S
T
T
K
D
D
Y
K
Q
W
S
S
M
R
Site 47
S349
D
D
Y
K
Q
W
S
S
M
R
T
E
P
V
K
Site 48
T352
K
Q
W
S
S
M
R
T
E
P
V
K
P
V
P
Site 49
T372
T
E
P
L
D
C
L
T
T
T
R
A
H
Y
V
Site 50
T373
E
P
L
D
C
L
T
T
T
R
A
H
Y
V
P
Site 51
Y378
L
T
T
T
R
A
H
Y
V
P
H
L
P
I
N
Site 52
T386
V
P
H
L
P
I
N
T
K
S
C
K
P
H
W
Site 53
S394
K
S
C
K
P
H
W
S
G
P
R
G
N
V
P
Site 54
S404
R
G
N
V
P
V
E
S
Q
T
T
Y
T
I
S
Site 55
T407
V
P
V
E
S
Q
T
T
Y
T
I
S
F
T
P
Site 56
Y408
P
V
E
S
Q
T
T
Y
T
I
S
F
T
P
K
Site 57
S411
S
Q
T
T
Y
T
I
S
F
T
P
K
E
M
G
Site 58
T413
T
T
Y
T
I
S
F
T
P
K
E
M
G
R
C
Site 59
S423
E
M
G
R
C
L
A
S
Y
P
E
P
P
G
Y
Site 60
Y424
M
G
R
C
L
A
S
Y
P
E
P
P
G
Y
T
Site 61
Y430
S
Y
P
E
P
P
G
Y
T
F
E
E
V
D
A
Site 62
Y443
D
A
L
G
H
R
I
Y
K
P
V
S
Q
A
G
Site 63
S447
H
R
I
Y
K
P
V
S
Q
A
G
S
Q
Q
S
Site 64
S451
K
P
V
S
Q
A
G
S
Q
Q
S
S
H
L
S
Site 65
S455
Q
A
G
S
Q
Q
S
S
H
L
S
V
D
D
S
Site 66
S458
S
Q
Q
S
S
H
L
S
V
D
D
S
E
N
P
Site 67
S462
S
H
L
S
V
D
D
S
E
N
P
N
Q
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation