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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RTKN2
Full Name:
Rhotekin-2
Alias:
Pleckstrin homology domain-containing family K member 1
Type:
Mass (Da):
69304
Number AA:
609
UniProt ID:
Q8IZC4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
G
P
S
L
R
G
P
A
L
R
Site 2
S43
E
G
I
W
K
L
L
S
L
S
T
Q
K
D
Q
Site 3
S70
A
R
L
M
A
Y
T
S
E
L
Q
K
L
E
E
Site 4
T96
K
F
E
S
K
E
R
T
A
C
K
G
K
I
A
Site 5
S120
W
K
D
S
D
H
F
S
N
K
E
R
S
R
R
Site 6
Y128
N
K
E
R
S
R
R
Y
A
I
F
C
L
F
K
Site 7
S185
S
C
C
T
E
E
S
S
I
T
N
T
P
K
K
Site 8
T187
C
T
E
E
S
S
I
T
N
T
P
K
K
L
A
Site 9
T189
E
E
S
S
I
T
N
T
P
K
K
L
A
K
K
Site 10
S202
K
K
L
K
T
S
I
S
K
A
T
G
K
K
I
Site 11
T242
L
L
A
H
T
T
L
T
L
E
S
A
E
D
S
Site 12
S245
H
T
T
L
T
L
E
S
A
E
D
S
F
K
T
Site 13
S249
T
L
E
S
A
E
D
S
F
K
T
H
N
L
S
Site 14
T252
S
A
E
D
S
F
K
T
H
N
L
S
I
N
G
Site 15
S256
S
F
K
T
H
N
L
S
I
N
G
N
E
E
S
Site 16
S263
S
I
N
G
N
E
E
S
S
F
W
L
P
L
Y
Site 17
S264
I
N
G
N
E
E
S
S
F
W
L
P
L
Y
G
Site 18
Y318
V
L
R
G
G
K
L
Y
C
F
Y
S
P
E
E
Site 19
Y321
G
G
K
L
Y
C
F
Y
S
P
E
E
I
E
A
Site 20
S322
G
K
L
Y
C
F
Y
S
P
E
E
I
E
A
K
Site 21
S359
K
K
R
I
H
N
F
S
V
I
N
P
V
P
G
Site 22
T421
R
K
P
P
L
F
L
T
K
E
A
T
S
V
Y
Site 23
T425
L
F
L
T
K
E
A
T
S
V
Y
H
D
M
S
Site 24
Y428
T
K
E
A
T
S
V
Y
H
D
M
S
I
D
S
Site 25
S432
T
S
V
Y
H
D
M
S
I
D
S
P
M
K
L
Site 26
S435
Y
H
D
M
S
I
D
S
P
M
K
L
E
S
L
Site 27
S441
D
S
P
M
K
L
E
S
L
T
D
I
I
Q
K
Site 28
S465
L
I
G
Q
H
E
E
S
L
P
P
P
W
A
T
Site 29
T472
S
L
P
P
P
W
A
T
L
F
D
G
N
H
Q
Site 30
Y488
V
I
Q
K
K
V
L
Y
P
A
S
E
P
L
H
Site 31
S491
K
K
V
L
Y
P
A
S
E
P
L
H
D
E
K
Site 32
S509
R
Q
A
P
L
P
P
S
D
K
L
P
F
S
L
Site 33
S515
P
S
D
K
L
P
F
S
L
K
S
Q
S
N
T
Site 34
S518
K
L
P
F
S
L
K
S
Q
S
N
T
D
Q
L
Site 35
S520
P
F
S
L
K
S
Q
S
N
T
D
Q
L
V
K
Site 36
T522
S
L
K
S
Q
S
N
T
D
Q
L
V
K
D
N
Site 37
T533
V
K
D
N
W
G
K
T
S
V
S
Q
T
S
S
Site 38
S534
K
D
N
W
G
K
T
S
V
S
Q
T
S
S
L
Site 39
S536
N
W
G
K
T
S
V
S
Q
T
S
S
L
D
T
Site 40
T538
G
K
T
S
V
S
Q
T
S
S
L
D
T
K
L
Site 41
S540
T
S
V
S
Q
T
S
S
L
D
T
K
L
S
T
Site 42
T543
S
Q
T
S
S
L
D
T
K
L
S
T
L
M
H
Site 43
S546
S
S
L
D
T
K
L
S
T
L
M
H
H
L
Q
Site 44
T547
S
L
D
T
K
L
S
T
L
M
H
H
L
Q
K
Site 45
S571
P
A
R
R
N
R
L
S
D
G
E
H
T
D
T
Site 46
T578
S
D
G
E
H
T
D
T
K
T
N
F
E
A
K
Site 47
T580
G
E
H
T
D
T
K
T
N
F
E
A
K
P
V
Site 48
S594
V
P
A
P
R
Q
K
S
I
K
D
I
L
D
P
Site 49
S603
K
D
I
L
D
P
R
S
W
L
Q
A
Q
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation