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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCYL3
Full Name:
Protein-associating with the carboxyl-terminal domain of ezrin
Alias:
Ezrin-binding partner PACE-1; PACE1; PACE-1; SCY1-like 3
Type:
Protein kinase, Ser/Thr (non-receptor); Other group; SCY1 family
Mass (Da):
82857
Number AA:
742
UniProt ID:
Q8IZE3
International Prot ID:
IPI00237463
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030027
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0016477
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
E
N
S
A
L
K
S
Y
T
L
R
E
P
P
Site 2
Y11
E
N
S
A
L
K
S
Y
T
L
R
E
P
P
F
Site 3
T12
N
S
A
L
K
S
Y
T
L
R
E
P
P
F
T
Site 4
S38
L
Q
D
G
K
F
A
S
V
F
V
Y
K
R
E
Site 5
Y42
K
F
A
S
V
F
V
Y
K
R
E
N
E
D
K
Site 6
T59
K
A
A
K
H
L
K
T
L
R
H
P
C
L
L
Site 7
T82
A
D
G
I
H
L
V
T
E
R
V
Q
P
L
E
Site 8
T121
L
H
D
R
G
H
L
T
H
N
N
V
C
L
S
Site 9
S128
T
H
N
N
V
C
L
S
S
V
F
V
S
E
D
Site 10
S129
H
N
N
V
C
L
S
S
V
F
V
S
E
D
G
Site 11
T145
W
K
L
G
G
M
E
T
V
C
K
V
S
Q
A
Site 12
T153
V
C
K
V
S
Q
A
T
P
E
F
L
R
S
I
Site 13
S159
A
T
P
E
F
L
R
S
I
Q
S
I
R
D
P
Site 14
S162
E
F
L
R
S
I
Q
S
I
R
D
P
A
S
I
Site 15
S168
Q
S
I
R
D
P
A
S
I
P
P
E
E
M
S
Site 16
S175
S
I
P
P
E
E
M
S
P
E
F
T
T
L
P
Site 17
T179
E
E
M
S
P
E
F
T
T
L
P
E
C
H
G
Site 18
S193
G
H
A
R
D
A
F
S
F
G
T
L
V
E
S
Site 19
S215
Q
V
S
A
D
V
L
S
S
F
Q
Q
T
L
H
Site 20
S216
V
S
A
D
V
L
S
S
F
Q
Q
T
L
H
S
Site 21
S223
S
F
Q
Q
T
L
H
S
T
L
L
N
P
I
P
Site 22
S241
P
A
L
C
T
L
L
S
H
D
F
F
R
N
D
Site 23
S258
E
V
V
N
F
L
K
S
L
T
L
K
S
E
E
Site 24
T260
V
N
F
L
K
S
L
T
L
K
S
E
E
E
K
Site 25
S263
L
K
S
L
T
L
K
S
E
E
E
K
T
E
F
Site 26
T268
L
K
S
E
E
E
K
T
E
F
F
K
F
L
L
Site 27
S282
L
D
R
V
S
C
L
S
E
E
L
I
A
S
R
Site 28
Y312
A
V
K
S
F
L
P
Y
L
L
G
P
K
K
D
Site 29
T325
K
D
H
A
Q
G
E
T
P
C
L
L
S
P
A
Site 30
S330
G
E
T
P
C
L
L
S
P
A
L
F
Q
S
R
Site 31
Y364
L
L
S
H
I
E
A
Y
V
E
H
F
T
Q
E
Site 32
S389
L
L
G
L
R
D
T
S
D
S
I
V
A
I
T
Site 33
S391
G
L
R
D
T
S
D
S
I
V
A
I
T
L
H
Site 34
S405
H
S
L
A
V
L
V
S
L
L
G
P
E
V
V
Site 35
S427
I
F
K
R
T
A
P
S
F
T
K
N
T
D
L
Site 36
S435
F
T
K
N
T
D
L
S
L
E
D
S
P
M
C
Site 37
S452
C
S
H
H
S
Q
I
S
P
I
L
E
N
P
F
Site 38
S471
P
K
C
F
F
S
G
S
T
P
I
N
S
K
K
Site 39
T472
K
C
F
F
S
G
S
T
P
I
N
S
K
K
H
Site 40
Y484
K
K
H
I
Q
R
D
Y
Y
N
T
L
L
Q
T
Site 41
Y485
K
H
I
Q
R
D
Y
Y
N
T
L
L
Q
T
G
Site 42
T487
I
Q
R
D
Y
Y
N
T
L
L
Q
T
G
D
P
Site 43
T491
Y
Y
N
T
L
L
Q
T
G
D
P
F
S
Q
P
Site 44
S496
L
Q
T
G
D
P
F
S
Q
P
I
K
F
P
I
Site 45
S507
K
F
P
I
N
G
L
S
D
V
K
N
T
S
E
Site 46
S513
L
S
D
V
K
N
T
S
E
D
S
E
N
F
P
Site 47
S516
V
K
N
T
S
E
D
S
E
N
F
P
S
S
S
Site 48
S521
E
D
S
E
N
F
P
S
S
S
K
K
S
E
E
Site 49
S522
D
S
E
N
F
P
S
S
S
K
K
S
E
E
W
Site 50
S523
S
E
N
F
P
S
S
S
K
K
S
E
E
W
P
Site 51
S526
F
P
S
S
S
K
K
S
E
E
W
P
D
W
S
Site 52
S533
S
E
E
W
P
D
W
S
E
P
E
E
P
E
N
Site 53
T542
P
E
E
P
E
N
Q
T
V
N
I
Q
I
W
P
Site 54
S558
E
P
C
D
D
V
K
S
Q
C
T
T
L
D
V
Site 55
T562
D
V
K
S
Q
C
T
T
L
D
V
E
E
S
S
Site 56
S569
T
L
D
V
E
E
S
S
W
D
D
C
E
P
S
Site 57
S577
W
D
D
C
E
P
S
S
L
D
T
K
V
N
P
Site 58
T580
C
E
P
S
S
L
D
T
K
V
N
P
G
G
G
Site 59
T591
P
G
G
G
I
T
A
T
K
P
V
T
S
G
E
Site 60
S607
K
P
I
P
A
L
L
S
L
T
E
E
S
M
P
Site 61
S612
L
L
S
L
T
E
E
S
M
P
W
K
S
S
L
Site 62
S617
E
E
S
M
P
W
K
S
S
L
P
Q
K
I
S
Site 63
S618
E
S
M
P
W
K
S
S
L
P
Q
K
I
S
L
Site 64
S624
S
S
L
P
Q
K
I
S
L
V
Q
R
G
D
D
Site 65
S642
I
E
P
P
K
V
S
S
Q
E
R
P
L
K
V
Site 66
T660
L
G
L
G
E
E
F
T
I
Q
V
K
K
K
P
Site 67
S707
V
P
K
K
D
D
V
S
P
V
M
Q
F
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation