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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GPR112
Full Name:
Probable G-protein coupled receptor 112
Alias:
GP112; PGR17
Type:
Receptor, GPCR
Mass (Da):
300967
Number AA:
2799
UniProt ID:
Q8IZF6
International Prot ID:
IPI00552840
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004930
PhosphoSite+
KinaseNET
Biological Process:
GO:0007218
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
S
F
I
F
L
S
D
T
L
S
L
K
G
K
K
Site 2
S27
I
F
L
S
D
T
L
S
L
K
G
K
K
L
D
Site 3
T41
D
F
F
G
R
G
D
T
Y
V
S
L
I
D
T
Site 4
S44
G
R
G
D
T
Y
V
S
L
I
D
T
I
P
E
Site 5
Y102
D
H
Q
Q
L
I
L
Y
R
L
G
K
T
F
S
Site 6
T107
I
L
Y
R
L
G
K
T
F
S
I
R
H
H
L
Site 7
S109
Y
R
L
G
K
T
F
S
I
R
H
H
L
A
S
Site 8
T146
K
E
R
I
L
E
V
T
D
Q
P
H
N
L
T
Site 9
T153
T
D
Q
P
H
N
L
T
P
H
G
T
L
F
L
Site 10
S168
G
H
F
L
K
N
E
S
S
E
V
K
S
M
M
Site 11
S169
H
F
L
K
N
E
S
S
E
V
K
S
M
M
R
Site 12
S173
N
E
S
S
E
V
K
S
M
M
R
S
F
P
G
Site 13
S177
E
V
K
S
M
M
R
S
F
P
G
S
L
Y
Y
Site 14
Y183
R
S
F
P
G
S
L
Y
Y
F
Q
L
W
D
H
Site 15
Y184
S
F
P
G
S
L
Y
Y
F
Q
L
W
D
H
I
Site 16
S240
N
M
T
I
Q
E
K
S
T
T
V
S
Q
Q
I
Site 17
T242
T
I
Q
E
K
S
T
T
V
S
Q
Q
I
D
M
Site 18
S244
Q
E
K
S
T
T
V
S
Q
Q
I
D
M
T
T
Site 19
T250
V
S
Q
Q
I
D
M
T
T
P
S
Q
I
T
G
Site 20
T251
S
Q
Q
I
D
M
T
T
P
S
Q
I
T
G
V
Site 21
S253
Q
I
D
M
T
T
P
S
Q
I
T
G
V
K
P
Site 22
T263
T
G
V
K
P
Q
N
T
A
H
S
S
T
L
L
Site 23
S267
P
Q
N
T
A
H
S
S
T
L
L
S
Q
S
I
Site 24
T282
P
I
F
A
T
D
Y
T
T
I
S
Y
S
N
T
Site 25
T283
I
F
A
T
D
Y
T
T
I
S
Y
S
N
T
T
Site 26
S285
A
T
D
Y
T
T
I
S
Y
S
N
T
T
S
P
Site 27
S287
D
Y
T
T
I
S
Y
S
N
T
T
S
P
P
L
Site 28
T289
T
T
I
S
Y
S
N
T
T
S
P
P
L
E
T
Site 29
S291
I
S
Y
S
N
T
T
S
P
P
L
E
T
M
T
Site 30
T305
T
A
Q
K
I
L
K
T
L
V
D
E
T
A
T
Site 31
T328
S
S
A
I
S
L
P
T
Q
S
I
S
I
D
N
Site 32
S332
S
L
P
T
Q
S
I
S
I
D
N
T
T
N
S
Site 33
T336
Q
S
I
S
I
D
N
T
T
N
S
M
K
K
T
Site 34
T337
S
I
S
I
D
N
T
T
N
S
M
K
K
T
K
Site 35
S339
S
I
D
N
T
T
N
S
M
K
K
T
K
S
P
Site 36
T343
T
T
N
S
M
K
K
T
K
S
P
S
S
E
S
Site 37
S345
N
S
M
K
K
T
K
S
P
S
S
E
S
T
K
Site 38
S348
K
K
T
K
S
P
S
S
E
S
T
K
T
T
K
Site 39
T351
K
S
P
S
S
E
S
T
K
T
T
K
M
V
E
Site 40
T353
P
S
S
E
S
T
K
T
T
K
M
V
E
A
M
Site 41
T354
S
S
E
S
T
K
T
T
K
M
V
E
A
M
A
Site 42
T362
K
M
V
E
A
M
A
T
E
I
F
Q
P
P
T
Site 43
T369
T
E
I
F
Q
P
P
T
P
S
N
F
L
S
T
Site 44
S371
I
F
Q
P
P
T
P
S
N
F
L
S
T
S
R
Site 45
S375
P
T
P
S
N
F
L
S
T
S
R
F
T
K
N
Site 46
S377
P
S
N
F
L
S
T
S
R
F
T
K
N
S
V
Site 47
T380
F
L
S
T
S
R
F
T
K
N
S
V
V
S
T
Site 48
S383
T
S
R
F
T
K
N
S
V
V
S
T
T
S
A
Site 49
T387
T
K
N
S
V
V
S
T
T
S
A
I
K
S
Q
Site 50
S389
N
S
V
V
S
T
T
S
A
I
K
S
Q
S
A
Site 51
S393
S
T
T
S
A
I
K
S
Q
S
A
V
T
K
T
Site 52
S395
T
S
A
I
K
S
Q
S
A
V
T
K
T
T
S
Site 53
T400
S
Q
S
A
V
T
K
T
T
S
L
F
S
T
I
Site 54
S402
S
A
V
T
K
T
T
S
L
F
S
T
I
E
S
Site 55
S405
T
K
T
T
S
L
F
S
T
I
E
S
T
S
M
Site 56
T406
K
T
T
S
L
F
S
T
I
E
S
T
S
M
S
Site 57
S409
S
L
F
S
T
I
E
S
T
S
M
S
T
T
P
Site 58
S413
T
I
E
S
T
S
M
S
T
T
P
C
L
K
Q
Site 59
T415
E
S
T
S
M
S
T
T
P
C
L
K
Q
K
S
Site 60
S422
T
P
C
L
K
Q
K
S
T
N
T
G
A
L
P
Site 61
T450
A
G
T
V
P
W
F
T
V
E
K
T
S
P
A
Site 62
T454
P
W
F
T
V
E
K
T
S
P
A
S
T
H
V
Site 63
S455
W
F
T
V
E
K
T
S
P
A
S
T
H
V
G
Site 64
S458
V
E
K
T
S
P
A
S
T
H
V
G
T
A
S
Site 65
T459
E
K
T
S
P
A
S
T
H
V
G
T
A
S
S
Site 66
T463
P
A
S
T
H
V
G
T
A
S
S
F
P
P
E
Site 67
S466
T
H
V
G
T
A
S
S
F
P
P
E
P
V
L
Site 68
S482
S
T
A
A
P
V
D
S
V
F
P
R
N
Q
T
Site 69
T489
S
V
F
P
R
N
Q
T
A
F
P
L
A
T
T
Site 70
T511
V
H
S
L
T
L
P
T
R
L
I
E
T
T
P
Site 71
T517
P
T
R
L
I
E
T
T
P
A
P
R
T
A
E
Site 72
T525
P
A
P
R
T
A
E
T
E
L
T
S
T
N
F
Site 73
T528
R
T
A
E
T
E
L
T
S
T
N
F
Q
D
V
Site 74
T530
A
E
T
E
L
T
S
T
N
F
Q
D
V
S
L
Site 75
S536
S
T
N
F
Q
D
V
S
L
P
R
V
E
D
A
Site 76
S545
P
R
V
E
D
A
M
S
T
S
M
S
K
E
T
Site 77
S547
V
E
D
A
M
S
T
S
M
S
K
E
T
S
S
Site 78
S549
D
A
M
S
T
S
M
S
K
E
T
S
S
K
T
Site 79
S553
T
S
M
S
K
E
T
S
S
K
T
F
S
F
L
Site 80
S554
S
M
S
K
E
T
S
S
K
T
F
S
F
L
T
Site 81
T556
S
K
E
T
S
S
K
T
F
S
F
L
T
S
F
Site 82
S558
E
T
S
S
K
T
F
S
F
L
T
S
F
S
F
Site 83
S562
K
T
F
S
F
L
T
S
F
S
F
T
G
T
E
Site 84
T573
T
G
T
E
S
V
Q
T
V
I
D
A
E
A
T
Site 85
T585
E
A
T
R
T
A
L
T
P
E
I
T
L
A
S
Site 86
T604
T
M
L
S
S
T
I
T
G
R
V
Y
T
Q
N
Site 87
Y608
S
T
I
T
G
R
V
Y
T
Q
N
T
P
T
A
Site 88
T609
T
I
T
G
R
V
Y
T
Q
N
T
P
T
A
D
Site 89
T612
G
R
V
Y
T
Q
N
T
P
T
A
D
G
H
L
Site 90
T621
T
A
D
G
H
L
L
T
L
M
S
T
R
S
A
Site 91
S624
G
H
L
L
T
L
M
S
T
R
S
A
S
T
S
Site 92
T625
H
L
L
T
L
M
S
T
R
S
A
S
T
S
K
Site 93
S627
L
T
L
M
S
T
R
S
A
S
T
S
K
A
P
Site 94
S629
L
M
S
T
R
S
A
S
T
S
K
A
P
E
S
Site 95
S631
S
T
R
S
A
S
T
S
K
A
P
E
S
G
P
Site 96
S636
S
T
S
K
A
P
E
S
G
P
T
S
T
T
D
Site 97
S640
A
P
E
S
G
P
T
S
T
T
D
E
A
A
H
Site 98
S651
E
A
A
H
L
F
S
S
N
E
T
I
W
T
S
Site 99
T654
H
L
F
S
S
N
E
T
I
W
T
S
R
P
D
Site 100
T657
S
S
N
E
T
I
W
T
S
R
P
D
Q
A
L
Site 101
Y692
A
F
H
E
N
T
T
Y
T
E
Y
L
S
A
T
Site 102
Y695
E
N
T
T
Y
T
E
Y
L
S
A
T
T
N
I
Site 103
T703
L
S
A
T
T
N
I
T
P
L
K
A
S
P
E
Site 104
S708
N
I
T
P
L
K
A
S
P
E
G
K
G
T
T
Site 105
T715
S
P
E
G
K
G
T
T
A
N
D
A
T
T
A
Site 106
T721
T
T
A
N
D
A
T
T
A
R
Y
T
T
A
V
Site 107
T725
D
A
T
T
A
R
Y
T
T
A
V
S
K
L
T
Site 108
T726
A
T
T
A
R
Y
T
T
A
V
S
K
L
T
S
Site 109
S729
A
R
Y
T
T
A
V
S
K
L
T
S
P
W
F
Site 110
S767
L
L
K
T
I
P
M
S
T
K
P
A
N
E
L
Site 111
T777
P
A
N
E
L
P
L
T
P
R
E
T
V
V
P
Site 112
S800
A
C
I
Q
P
N
F
S
T
E
E
S
A
S
E
Site 113
S804
P
N
F
S
T
E
E
S
A
S
E
T
T
Q
T
Site 114
S806
F
S
T
E
E
S
A
S
E
T
T
Q
T
E
I
Site 115
T811
S
A
S
E
T
T
Q
T
E
I
N
G
A
I
V
Site 116
S829
T
T
T
P
V
P
K
S
A
T
T
Q
R
L
N
Site 117
T838
T
T
Q
R
L
N
A
T
V
T
R
K
E
A
T
Site 118
S846
V
T
R
K
E
A
T
S
H
Y
L
M
R
K
S
Site 119
Y848
R
K
E
A
T
S
H
Y
L
M
R
K
S
T
I
Site 120
S853
S
H
Y
L
M
R
K
S
T
I
A
A
V
A
E
Site 121
T866
A
E
V
S
P
F
S
T
M
L
E
V
T
D
E
Site 122
T879
D
E
S
A
Q
R
V
T
A
S
V
T
V
S
S
Site 123
T895
P
D
I
E
K
L
S
T
P
L
D
N
K
T
A
Site 124
T901
S
T
P
L
D
N
K
T
A
T
T
E
V
R
E
Site 125
T904
L
D
N
K
T
A
T
T
E
V
R
E
S
W
L
Site 126
T913
V
R
E
S
W
L
L
T
K
L
V
K
T
T
P
Site 127
T918
L
L
T
K
L
V
K
T
T
P
R
S
S
Y
N
Site 128
T919
L
T
K
L
V
K
T
T
P
R
S
S
Y
N
E
Site 129
S923
V
K
T
T
P
R
S
S
Y
N
E
M
T
E
M
Site 130
Y924
K
T
T
P
R
S
S
Y
N
E
M
T
E
M
F
Site 131
S950
S
E
T
S
E
G
I
S
A
G
S
P
T
S
G
Site 132
S953
S
E
G
I
S
A
G
S
P
T
S
G
S
T
H
Site 133
S956
I
S
A
G
S
P
T
S
G
S
T
H
I
F
G
Site 134
S958
A
G
S
P
T
S
G
S
T
H
I
F
G
E
P
Site 135
S969
F
G
E
P
L
G
A
S
T
T
R
I
S
E
T
Site 136
T970
G
E
P
L
G
A
S
T
T
R
I
S
E
T
S
Site 137
T971
E
P
L
G
A
S
T
T
R
I
S
E
T
S
F
Site 138
S974
G
A
S
T
T
R
I
S
E
T
S
F
S
T
T
Site 139
S977
T
T
R
I
S
E
T
S
F
S
T
T
P
T
D
Site 140
S979
R
I
S
E
T
S
F
S
T
T
P
T
D
R
T
Site 141
T981
S
E
T
S
F
S
T
T
P
T
D
R
T
A
T
Site 142
T983
T
S
F
S
T
T
P
T
D
R
T
A
T
S
L
Site 143
T986
S
T
T
P
T
D
R
T
A
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S1952
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S1956
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T1967
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T1974
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T1980
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T1983
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S2018
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A
Site 447
S3053
A
T
S
S
T
F
K
S
L
G
S
A
Q
G
T
Site 448
S3056
S
T
F
K
S
L
G
S
A
Q
G
T
P
S
E
Site 449
T3060
S
L
G
S
A
Q
G
T
P
S
E
I
S
F
P
Site 450
S3062
G
S
A
Q
G
T
P
S
E
I
S
F
P
N
D
Site 451
S3065
Q
G
T
P
S
E
I
S
F
P
N
D
D
F
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation