KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PELP1
Full Name:
Proline-, glutamic acid- and leucine-rich protein 1
Alias:
MNAR; Modulator of non-genomic activity of estrogen receptor; Proline, glutamate and leucine rich protein 1; Proline-, glutamic acid- and leucine-rich protein 1; Transcription factor HMX3
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
119700
Number AA:
1130
UniProt ID:
Q8IZL8
International Prot ID:
IPI00006702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
A
A
V
L
S
G
P
S
A
G
S
A
Site 2
S10
A
A
V
L
S
G
P
S
A
G
S
A
A
G
V
Site 3
S13
L
S
G
P
S
A
G
S
A
A
G
V
P
G
G
Site 4
S25
P
G
G
T
G
G
L
S
A
V
S
S
G
P
R
Site 5
S28
T
G
G
L
S
A
V
S
S
G
P
R
L
R
L
Site 6
S62
P
V
H
P
P
N
R
S
A
P
H
L
P
G
L
Site 7
S86
V
G
G
A
Q
N
L
S
A
L
G
A
L
V
S
Site 8
S100
S
L
S
N
A
R
L
S
S
I
K
T
R
F
E
Site 9
S101
L
S
N
A
R
L
S
S
I
K
T
R
F
E
G
Site 10
T104
A
R
L
S
S
I
K
T
R
F
E
G
L
C
L
Site 11
T141
S
I
Q
Q
V
L
Q
T
Q
D
P
P
A
T
M
Site 12
S194
L
R
P
E
C
E
Q
S
A
L
E
G
M
K
A
Site 13
S212
Y
F
P
R
A
C
G
S
L
K
G
K
L
A
S
Site 14
S229
L
S
R
V
D
A
L
S
P
Q
L
Q
Q
L
A
Site 15
Y240
Q
Q
L
A
C
E
C
Y
S
R
L
P
S
L
G
Site 16
S245
E
C
Y
S
R
L
P
S
L
G
A
G
F
S
Q
Site 17
S251
P
S
L
G
A
G
F
S
Q
G
L
K
H
T
E
Site 18
S259
Q
G
L
K
H
T
E
S
W
E
Q
E
L
H
S
Site 19
S266
S
W
E
Q
E
L
H
S
L
L
A
S
L
H
T
Site 20
T284
A
L
Y
E
G
A
E
T
A
P
V
Q
N
E
G
Site 21
S299
P
G
V
E
M
L
L
S
S
E
D
G
D
A
H
Site 22
S316
L
Q
L
R
Q
R
F
S
G
L
A
R
C
L
G
Site 23
S350
D
F
I
C
R
T
L
S
V
S
S
K
N
I
S
Site 24
S353
C
R
T
L
S
V
S
S
K
N
I
S
L
H
G
Site 25
S357
S
V
S
S
K
N
I
S
L
H
G
D
G
P
L
Site 26
S408
L
L
P
Q
V
L
N
S
W
S
I
G
R
D
S
Site 27
S410
P
Q
V
L
N
S
W
S
I
G
R
D
S
L
S
Site 28
S415
S
W
S
I
G
R
D
S
L
S
P
G
Q
E
R
Site 29
S417
S
I
G
R
D
S
L
S
P
G
Q
E
R
P
Y
Site 30
Y424
S
P
G
Q
E
R
P
Y
S
T
V
R
T
K
V
Site 31
S425
P
G
Q
E
R
P
Y
S
T
V
R
T
K
V
Y
Site 32
T426
G
Q
E
R
P
Y
S
T
V
R
T
K
V
Y
A
Site 33
T429
R
P
Y
S
T
V
R
T
K
V
Y
A
I
L
E
Site 34
S467
T
H
L
L
S
D
I
S
P
P
A
D
A
L
K
Site 35
S477
A
D
A
L
K
L
R
S
P
R
G
S
P
D
G
Site 36
S481
K
L
R
S
P
R
G
S
P
D
G
S
L
Q
T
Site 37
S485
P
R
G
S
P
D
G
S
L
Q
T
G
K
P
S
Site 38
T488
S
P
D
G
S
L
Q
T
G
K
P
S
A
P
K
Site 39
S492
S
L
Q
T
G
K
P
S
A
P
K
K
L
K
L
Site 40
S509
G
E
A
M
A
P
P
S
H
R
K
G
D
S
N
Site 41
S515
P
S
H
R
K
G
D
S
N
A
N
S
D
V
C
Site 42
S519
K
G
D
S
N
A
N
S
D
V
C
A
A
A
L
Site 43
T544
G
P
L
I
K
E
E
T
H
R
R
L
H
D
L
Site 44
S567
Q
Q
G
E
V
L
G
S
S
P
Y
T
S
S
R
Site 45
S568
Q
G
E
V
L
G
S
S
P
Y
T
S
S
R
C
Site 46
T571
V
L
G
S
S
P
Y
T
S
S
R
C
R
R
E
Site 47
S572
L
G
S
S
P
Y
T
S
S
R
C
R
R
E
L
Site 48
S573
G
S
S
P
Y
T
S
S
R
C
R
R
E
L
Y
Site 49
S613
S
L
G
Q
R
E
D
S
L
E
V
S
S
F
C
Site 50
S617
R
E
D
S
L
E
V
S
S
F
C
S
E
A
L
Site 51
T647
P
M
G
P
T
C
P
T
P
A
P
V
P
P
P
Site 52
S658
V
P
P
P
E
A
P
S
P
F
R
A
P
P
F
Site 53
S673
H
P
P
G
P
M
P
S
V
G
S
M
P
S
A
Site 54
S676
G
P
M
P
S
V
G
S
M
P
S
A
G
P
M
Site 55
S679
P
S
V
G
S
M
P
S
A
G
P
M
P
S
A
Site 56
S685
P
S
A
G
P
M
P
S
A
G
P
M
P
S
A
Site 57
S691
P
S
A
G
P
M
P
S
A
G
P
V
P
S
A
Site 58
S697
P
S
A
G
P
V
P
S
A
R
P
G
P
P
T
Site 59
T704
S
A
R
P
G
P
P
T
T
A
N
H
L
G
L
Site 60
T705
A
R
P
G
P
P
T
T
A
N
H
L
G
L
S
Site 61
S734
P
E
N
H
R
A
G
S
N
E
D
P
I
L
A
Site 62
S743
E
D
P
I
L
A
P
S
G
T
P
P
P
T
I
Site 63
T745
P
I
L
A
P
S
G
T
P
P
P
T
I
P
P
Site 64
T749
P
S
G
T
P
P
P
T
I
P
P
D
E
T
F
Site 65
T755
P
T
I
P
P
D
E
T
F
G
G
R
V
P
R
Site 66
S774
H
Y
D
K
E
E
A
S
D
V
E
I
S
L
E
Site 67
S779
E
A
S
D
V
E
I
S
L
E
S
D
S
D
D
Site 68
S782
D
V
E
I
S
L
E
S
D
S
D
D
S
V
V
Site 69
S787
L
E
S
D
S
D
D
S
V
V
I
V
P
E
G
Site 70
S804
P
L
P
P
P
P
P
S
G
A
T
P
P
P
I
Site 71
T807
P
P
P
P
S
G
A
T
P
P
P
I
A
P
T
Site 72
T814
T
P
P
P
I
A
P
T
G
P
P
T
A
S
P
Site 73
S820
P
T
G
P
P
T
A
S
P
P
V
P
A
K
E
Site 74
T865
P
Q
L
V
P
E
G
T
P
G
G
G
G
P
P
Site 75
T879
P
A
L
E
E
D
L
T
V
I
N
I
N
S
S
Site 76
Y920
E
E
E
D
E
E
E
Y
F
E
E
E
E
E
E
Site 77
T981
E
G
A
P
P
P
P
T
L
P
P
A
L
P
P
Site 78
S991
P
A
L
P
P
P
E
S
P
P
K
V
Q
P
E
Site 79
T1014
L
E
V
E
E
P
G
T
E
E
E
R
G
A
D
Site 80
T1022
E
E
E
R
G
A
D
T
A
P
T
L
A
P
E
Site 81
T1025
R
G
A
D
T
A
P
T
L
A
P
E
A
L
P
Site 82
S1033
L
A
P
E
A
L
P
S
Q
G
E
V
E
R
E
Site 83
S1043
E
V
E
R
E
G
E
S
P
A
A
G
P
P
P
Site 84
S1059
E
L
V
E
E
E
P
S
A
P
P
T
L
L
E
Site 85
T1063
E
E
P
S
A
P
P
T
L
L
E
E
E
T
E
Site 86
T1069
P
T
L
L
E
E
E
T
E
D
G
S
D
K
V
Site 87
S1073
E
E
E
T
E
D
G
S
D
K
V
Q
P
P
P
Site 88
T1082
K
V
Q
P
P
P
E
T
P
A
E
E
E
M
E
Site 89
T1090
P
A
E
E
E
M
E
T
E
T
E
A
E
A
L
Site 90
T1105
Q
E
K
E
Q
D
D
T
A
A
M
L
A
D
F
Site 91
T1126
D
E
K
P
P
P
P
T
E
P
D
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation