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Updated November 2019
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Protein Info
Short Name:
WDFY3
Full Name:
WD repeat and FYVE domain-containing protein 3
Alias:
Alfy; Autophagy-linked FYVE protein; KIAA0993; WD repeat and FYVE domain containing 3; ZFYVE25
Type:
Unknown function
Mass (Da):
395258
Number AA:
3526
UniProt ID:
Q8IZQ1
International Prot ID:
IPI00218052
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0044444
GO:0019898
GO:0005635
Uniprot
OncoNet
Molecular Function:
GO:0005545
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
R
P
R
Q
E
E
C
S
P
Q
D
N
A
L
G
Site 2
T33
M
H
L
R
R
L
F
T
E
L
C
H
P
P
R
Site 3
T43
C
H
P
P
R
H
M
T
Q
K
E
Q
E
E
K
Site 4
Y52
K
E
Q
E
E
K
L
Y
M
M
L
P
V
F
N
Site 5
T69
F
G
N
A
P
P
N
T
M
T
E
K
F
S
D
Site 6
S97
T
E
I
R
R
R
A
S
N
K
S
T
E
A
A
Site 7
S100
R
R
R
A
S
N
K
S
T
E
A
A
S
R
A
Site 8
T101
R
R
A
S
N
K
S
T
E
A
A
S
R
A
I
Site 9
S117
Q
F
L
E
I
N
Q
S
E
E
A
S
R
G
W
Site 10
S121
I
N
Q
S
E
E
A
S
R
G
W
M
L
L
T
Site 11
T140
L
A
S
S
G
Q
K
T
V
D
C
M
T
T
M
Site 12
T145
Q
K
T
V
D
C
M
T
T
M
S
V
P
S
T
Site 13
Y227
I
T
S
W
C
P
P
Y
N
L
P
W
R
K
S
Site 14
S234
Y
N
L
P
W
R
K
S
A
G
E
V
L
M
T
Site 15
T241
S
A
G
E
V
L
M
T
I
S
R
H
G
L
S
Site 16
S262
I
H
E
K
E
C
L
S
T
C
V
Q
N
M
Q
Site 17
S271
C
V
Q
N
M
Q
Q
S
D
D
L
S
P
L
E
Site 18
S275
M
Q
Q
S
D
D
L
S
P
L
E
I
V
E
M
Site 19
S293
L
S
C
F
L
K
D
S
S
D
V
S
Q
T
L
Site 20
S294
S
C
F
L
K
D
S
S
D
V
S
Q
T
L
L
Site 21
S297
L
K
D
S
S
D
V
S
Q
T
L
L
D
D
F
Site 22
S377
Q
P
A
G
K
G
H
S
V
R
N
V
Q
A
F
Site 23
Y411
L
D
A
I
T
N
I
Y
M
A
D
N
A
N
Y
Site 24
Y418
Y
M
A
D
N
A
N
Y
F
I
L
E
S
Q
H
Site 25
S423
A
N
Y
F
I
L
E
S
Q
H
T
L
S
Q
F
Site 26
T426
F
I
L
E
S
Q
H
T
L
S
Q
F
A
E
K
Site 27
S428
L
E
S
Q
H
T
L
S
Q
F
A
E
K
I
S
Site 28
Y444
L
P
E
V
Q
N
K
Y
F
E
M
L
E
F
V
Site 29
S465
I
P
C
K
E
L
I
S
V
S
I
L
L
K
S
Site 30
S467
C
K
E
L
I
S
V
S
I
L
L
K
S
S
S
Site 31
S472
S
V
S
I
L
L
K
S
S
S
S
Y
H
C
S
Site 32
S474
S
I
L
L
K
S
S
S
S
Y
H
C
S
I
I
Site 33
Y494
L
K
F
T
R
H
D
Y
I
F
K
D
V
F
R
Site 34
T524
A
A
L
L
K
D
P
T
Q
A
L
N
E
Q
G
Site 35
S533
A
L
N
E
Q
G
D
S
R
N
N
S
S
V
E
Site 36
S537
Q
G
D
S
R
N
N
S
S
V
E
D
Q
K
H
Site 37
S599
T
I
Q
Q
L
V
L
S
P
N
G
D
D
D
M
Site 38
T608
N
G
D
D
D
M
G
T
L
L
G
L
M
H
S
Site 39
T619
L
M
H
S
A
P
P
T
E
L
Q
L
K
T
D
Site 40
S633
D
I
L
R
A
L
L
S
V
L
R
E
S
H
R
Site 41
S638
L
L
S
V
L
R
E
S
H
R
S
R
T
V
F
Site 42
S641
V
L
R
E
S
H
R
S
R
T
V
F
R
K
V
Site 43
T643
R
E
S
H
R
S
R
T
V
F
R
K
V
G
G
Site 44
Y653
R
K
V
G
G
F
V
Y
I
T
S
L
L
V
A
Site 45
S664
L
L
V
A
M
E
R
S
L
S
C
P
P
K
N
Site 46
S666
V
A
M
E
R
S
L
S
C
P
P
K
N
G
W
Site 47
Y698
T
L
T
A
A
M
R
Y
E
P
A
N
S
H
F
Site 48
S732
F
S
D
L
R
K
I
S
A
M
N
V
F
P
S
Site 49
S757
E
D
V
I
S
I
E
S
V
S
P
T
L
R
H
Site 50
T761
S
I
E
S
V
S
P
T
L
R
H
C
S
K
L
Site 51
T777
I
Y
L
Y
K
V
A
T
D
S
F
D
S
R
A
Site 52
S779
L
Y
K
V
A
T
D
S
F
D
S
R
A
E
Q
Site 53
T792
E
Q
I
P
P
C
L
T
S
E
S
S
L
P
S
Site 54
S793
Q
I
P
P
C
L
T
S
E
S
S
L
P
S
P
Site 55
S795
P
P
C
L
T
S
E
S
S
L
P
S
P
W
G
Site 56
S796
P
C
L
T
S
E
S
S
L
P
S
P
W
G
T
Site 57
S799
T
S
E
S
S
L
P
S
P
W
G
T
P
A
L
Site 58
T803
S
L
P
S
P
W
G
T
P
A
L
S
R
K
R
Site 59
S807
P
W
G
T
P
A
L
S
R
K
R
H
A
Y
H
Site 60
Y813
L
S
R
K
R
H
A
Y
H
S
V
S
T
P
P
Site 61
S815
R
K
R
H
A
Y
H
S
V
S
T
P
P
V
Y
Site 62
S817
R
H
A
Y
H
S
V
S
T
P
P
V
Y
P
P
Site 63
T818
H
A
Y
H
S
V
S
T
P
P
V
Y
P
P
K
Site 64
Y822
S
V
S
T
P
P
V
Y
P
P
K
N
V
A
D
Site 65
T835
A
D
L
K
L
H
V
T
T
S
S
L
Q
S
S
Site 66
S837
L
K
L
H
V
T
T
S
S
L
Q
S
S
D
A
Site 67
S838
K
L
H
V
T
T
S
S
L
Q
S
S
D
A
V
Site 68
S842
T
T
S
S
L
Q
S
S
D
A
V
I
I
H
P
Site 69
S864
D
L
L
A
S
V
G
S
V
T
Q
P
E
H
A
Site 70
S884
A
V
A
N
I
L
Q
S
L
V
H
T
E
R
N
Site 71
T888
I
L
Q
S
L
V
H
T
E
R
N
Q
Q
V
M
Site 72
S909
A
R
L
L
Q
R
C
S
A
A
L
A
D
E
D
Site 73
S918
A
L
A
D
E
D
H
S
L
H
P
P
L
Q
R
Site 74
S932
R
M
F
E
R
L
A
S
Q
A
L
E
P
M
V
Site 75
S948
R
E
F
L
R
L
A
S
P
L
N
C
G
A
W
Site 76
Y963
D
K
K
L
L
K
Q
Y
R
V
H
K
P
S
S
Site 77
S969
Q
Y
R
V
H
K
P
S
S
L
S
Y
E
P
E
Site 78
S970
Y
R
V
H
K
P
S
S
L
S
Y
E
P
E
M
Site 79
S972
V
H
K
P
S
S
L
S
Y
E
P
E
M
R
S
Site 80
Y973
H
K
P
S
S
L
S
Y
E
P
E
M
R
S
S
Site 81
S980
Y
E
P
E
M
R
S
S
M
I
T
S
L
E
G
Site 82
T983
E
M
R
S
S
M
I
T
S
L
E
G
L
G
T
Site 83
S984
M
R
S
S
M
I
T
S
L
E
G
L
G
T
D
Site 84
T990
T
S
L
E
G
L
G
T
D
N
V
F
S
L
H
Site 85
S995
L
G
T
D
N
V
F
S
L
H
E
D
N
H
Y
Site 86
Y1002
S
L
H
E
D
N
H
Y
R
I
S
K
S
L
V
Site 87
S1005
E
D
N
H
Y
R
I
S
K
S
L
V
K
S
A
Site 88
S1007
N
H
Y
R
I
S
K
S
L
V
K
S
A
E
G
Site 89
S1011
I
S
K
S
L
V
K
S
A
E
G
S
T
V
P
Site 90
S1015
L
V
K
S
A
E
G
S
T
V
P
L
T
R
V
Site 91
T1016
V
K
S
A
E
G
S
T
V
P
L
T
R
V
K
Site 92
T1020
E
G
S
T
V
P
L
T
R
V
K
C
L
V
S
Site 93
T1030
K
C
L
V
S
M
T
T
P
H
D
I
R
L
H
Site 94
T1042
R
L
H
G
S
S
V
T
P
A
F
V
E
F
D
Site 95
T1073
H
N
A
P
T
N
N
T
V
T
T
G
L
I
D
Site 96
S1098
E
R
F
F
P
P
P
S
G
L
S
Y
S
S
W
Site 97
Y1102
P
P
P
S
G
L
S
Y
S
S
W
F
C
I
E
Site 98
S1103
P
P
S
G
L
S
Y
S
S
W
F
C
I
E
H
Site 99
T1124
N
H
P
V
R
L
L
T
V
V
R
R
A
N
S
Site 100
S1131
T
V
V
R
R
A
N
S
S
E
Q
H
Y
V
C
Site 101
S1132
V
V
R
R
A
N
S
S
E
Q
H
Y
V
C
L
Site 102
S1149
V
L
S
A
K
D
R
S
L
I
V
S
T
K
E
Site 103
S1153
K
D
R
S
L
I
V
S
T
K
E
E
L
L
Q
Site 104
Y1162
K
E
E
L
L
Q
N
Y
V
D
D
F
S
E
E
Site 105
S1167
Q
N
Y
V
D
D
F
S
E
E
S
S
F
Y
E
Site 106
S1171
D
D
F
S
E
E
S
S
F
Y
E
I
L
P
C
Site 107
S1208
S
K
G
M
L
K
N
S
T
A
A
L
Y
I
D
Site 108
Y1213
K
N
S
T
A
A
L
Y
I
D
G
Q
L
V
N
Site 109
Y1226
V
N
T
V
K
L
H
Y
V
H
S
T
P
G
G
Site 110
S1229
V
K
L
H
Y
V
H
S
T
P
G
G
S
G
S
Site 111
T1230
K
L
H
Y
V
H
S
T
P
G
G
S
G
S
A
Site 112
S1234
V
H
S
T
P
G
G
S
G
S
A
N
P
P
V
Site 113
S1236
S
T
P
G
G
S
G
S
A
N
P
P
V
V
S
Site 114
T1251
T
V
Y
A
Y
I
G
T
P
P
A
Q
R
Q
I
Site 115
S1260
P
A
Q
R
Q
I
A
S
L
V
W
R
L
G
P
Site 116
S1278
L
E
E
V
L
P
S
S
N
V
T
T
I
Y
E
Site 117
T1282
L
P
S
S
N
V
T
T
I
Y
E
L
G
P
N
Site 118
Y1284
S
S
N
V
T
T
I
Y
E
L
G
P
N
Y
V
Site 119
S1306
M
P
C
K
D
A
K
S
E
G
V
V
P
S
P
Site 120
S1312
K
S
E
G
V
V
P
S
P
V
S
L
V
P
E
Site 121
Y1343
V
A
R
I
R
K
V
Y
N
K
L
D
S
K
A
Site 122
S1359
A
K
Q
L
G
I
S
S
H
E
N
A
T
P
V
Site 123
T1364
I
S
S
H
E
N
A
T
P
V
K
L
I
H
N
Site 124
S1379
S
A
G
H
L
N
G
S
A
R
T
I
G
A
A
Site 125
S1445
V
K
S
N
P
L
A
S
K
E
M
E
R
I
K
Site 126
S1466
M
L
L
K
K
K
R
S
L
L
N
S
H
I
L
Site 127
S1470
K
K
R
S
L
L
N
S
H
I
L
H
L
T
F
Site 128
T1489
T
V
D
S
G
H
E
T
S
I
I
P
N
S
T
Site 129
S1490
V
D
S
G
H
E
T
S
I
I
P
N
S
T
A
Site 130
T1528
E
H
F
I
E
L
L
T
E
S
S
E
A
S
K
Site 131
S1530
F
I
E
L
L
T
E
S
S
E
A
S
K
N
A
Site 132
S1531
I
E
L
L
T
E
S
S
E
A
S
K
N
A
K
Site 133
S1534
L
T
E
S
S
E
A
S
K
N
A
K
L
M
R
Site 134
S1580
L
L
Q
G
F
P
S
S
N
D
L
L
R
F
G
Site 135
T1616
N
N
E
E
K
L
D
T
G
T
E
E
E
F
G
Site 136
T1618
E
E
K
L
D
T
G
T
E
E
E
F
G
G
L
Site 137
Y1646
D
I
L
L
K
L
I
Y
T
S
K
E
K
T
S
Site 138
S1648
L
L
K
L
I
Y
T
S
K
E
K
T
S
I
N
Site 139
T1652
I
Y
T
S
K
E
K
T
S
I
N
L
Q
A
C
Site 140
S1696
R
I
L
V
V
L
L
S
N
Q
S
I
L
I
K
Site 141
S1699
V
V
L
L
S
N
Q
S
I
L
I
K
F
K
E
Site 142
S1709
I
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Q
P
Site 294
S3438
R
G
R
V
F
S
W
S
V
S
D
Q
P
G
R
Site 295
S3440
R
V
F
S
W
S
V
S
D
Q
P
G
R
S
A
Site 296
S3459
V
K
D
E
G
G
D
S
C
S
G
C
S
V
R
Site 297
S3461
D
E
G
G
D
S
C
S
G
C
S
V
R
F
S
Site 298
S3464
G
D
S
C
S
G
C
S
V
R
F
S
L
T
E
Site 299
S3468
S
G
C
S
V
R
F
S
L
T
E
R
R
H
H
Site 300
S3492
Q
K
C
S
R
F
Q
S
E
I
K
R
L
K
I
Site 301
S3501
I
K
R
L
K
I
S
S
P
V
R
V
C
Q
N
Site 302
Y3510
V
R
V
C
Q
N
C
Y
Y
N
L
Q
H
E
R
Site 303
S3519
N
L
Q
H
E
R
G
S
E
D
G
P
R
N
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation