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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSEL
Full Name:
Dermatan-sulfate epimerase-like protein
Alias:
Type:
Mass (Da):
139238
Number AA:
1212
UniProt ID:
Q8IZU8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
F
S
T
F
E
E
S
V
S
N
Y
S
E
W
Site 2
S27
S
T
F
E
E
S
V
S
N
Y
S
E
W
A
V
Site 3
Y29
F
E
E
S
V
S
N
Y
S
E
W
A
V
F
T
Site 4
T44
D
D
I
D
Q
F
K
T
Q
K
V
Q
D
F
R
Site 5
S59
P
N
Q
K
L
K
K
S
M
L
H
P
S
L
Y
Site 6
Y66
S
M
L
H
P
S
L
Y
F
D
A
G
E
I
Q
Site 7
S79
I
Q
A
M
R
Q
K
S
R
A
S
H
L
H
L
Site 8
S82
M
R
Q
K
S
R
A
S
H
L
H
L
F
R
A
Site 9
Y103
V
M
L
S
N
P
T
Y
Y
L
P
P
P
K
H
Site 10
Y104
M
L
S
N
P
T
Y
Y
L
P
P
P
K
H
A
Site 11
Y121
A
A
K
W
N
E
I
Y
G
N
N
L
P
P
L
Site 12
Y185
A
T
A
F
D
F
L
Y
N
L
L
D
N
H
R
Site 13
Y196
D
N
H
R
R
Q
K
Y
L
E
K
I
W
V
I
Site 14
Y208
W
V
I
T
E
E
M
Y
E
Y
S
K
V
R
S
Site 15
Y210
I
T
E
E
M
Y
E
Y
S
K
V
R
S
W
G
Site 16
S215
Y
E
Y
S
K
V
R
S
W
G
K
Q
L
L
H
Site 17
Y279
S
L
D
E
G
V
A
Y
G
S
Y
T
A
K
S
Site 18
S281
D
E
G
V
A
Y
G
S
Y
T
A
K
S
V
T
Site 19
Y282
E
G
V
A
Y
G
S
Y
T
A
K
S
V
T
Q
Site 20
S286
Y
G
S
Y
T
A
K
S
V
T
Q
Y
V
F
L
Site 21
T288
S
Y
T
A
K
S
V
T
Q
Y
V
F
L
A
Q
Site 22
Y290
T
A
K
S
V
T
Q
Y
V
F
L
A
Q
R
H
Site 23
Y334
V
G
I
A
D
S
N
Y
N
W
F
Y
G
P
E
Site 24
Y338
D
S
N
Y
N
W
F
Y
G
P
E
S
Q
L
V
Site 25
S377
K
D
G
P
M
V
P
S
T
A
Q
R
W
S
T
Site 26
T378
D
G
P
M
V
P
S
T
A
Q
R
W
S
T
L
Site 27
S383
P
S
T
A
Q
R
W
S
T
L
H
T
E
Y
I
Site 28
T384
S
T
A
Q
R
W
S
T
L
H
T
E
Y
I
W
Site 29
Y392
L
H
T
E
Y
I
W
Y
D
P
Q
L
T
P
Q
Site 30
T397
I
W
Y
D
P
Q
L
T
P
Q
P
P
A
D
Y
Site 31
Y404
T
P
Q
P
P
A
D
Y
G
T
A
K
I
H
T
Site 32
Y420
P
N
W
G
V
V
T
Y
G
A
G
L
P
N
T
Site 33
T427
Y
G
A
G
L
P
N
T
Q
T
N
T
F
V
S
Site 34
T429
A
G
L
P
N
T
Q
T
N
T
F
V
S
F
K
Site 35
T431
L
P
N
T
Q
T
N
T
F
V
S
F
K
S
G
Site 36
S434
T
Q
T
N
T
F
V
S
F
K
S
G
K
L
G
Site 37
S437
N
T
F
V
S
F
K
S
G
K
L
G
G
R
A
Site 38
Y446
K
L
G
G
R
A
V
Y
D
I
V
H
F
Q
P
Site 39
S474
H
E
H
P
D
Q
N
S
F
T
F
A
P
N
G
Site 40
T476
H
P
D
Q
N
S
F
T
F
A
P
N
G
Q
V
Site 41
S486
P
N
G
Q
V
F
V
S
E
A
L
Y
G
P
K
Site 42
S506
N
V
L
V
F
A
P
S
P
S
S
Q
C
N
K
Site 43
S509
V
F
A
P
S
P
S
S
Q
C
N
K
P
W
E
Site 44
Y560
S
G
E
A
V
S
A
Y
S
S
A
M
R
L
K
Site 45
S562
E
A
V
S
A
Y
S
S
A
M
R
L
K
S
V
Site 46
Y570
A
M
R
L
K
S
V
Y
R
A
L
L
L
L
N
Site 47
S593
H
I
E
R
Q
E
D
S
P
I
N
S
V
S
A
Site 48
S597
Q
E
D
S
P
I
N
S
V
S
A
F
F
H
N
Site 49
Y611
N
L
D
I
D
F
K
Y
I
P
Y
K
F
M
N
Site 50
S647
H
G
N
S
P
M
A
S
I
Q
E
A
E
Q
A
Site 51
T662
A
E
F
K
K
R
W
T
Q
F
V
N
V
T
F
Site 52
T676
F
Q
M
E
P
T
I
T
R
I
A
Y
V
F
Y
Site 53
S691
G
P
Y
I
N
V
S
S
C
R
F
I
D
S
S
Site 54
S697
S
S
C
R
F
I
D
S
S
N
P
G
L
Q
I
Site 55
S698
S
C
R
F
I
D
S
S
N
P
G
L
Q
I
S
Site 56
S705
S
N
P
G
L
Q
I
S
L
N
V
N
N
T
E
Site 57
Y730
N
L
K
T
R
F
N
Y
L
G
F
G
G
F
A
Site 58
S839
T
R
T
E
A
E
G
S
K
K
S
L
S
S
E
Site 59
S842
E
A
E
G
S
K
K
S
L
S
S
E
G
H
H
Site 60
S844
E
G
S
K
K
S
L
S
S
E
G
H
H
M
D
Site 61
Y880
F
N
S
S
D
F
L
Y
I
R
V
P
T
A
Y
Site 62
Y887
Y
I
R
V
P
T
A
Y
I
D
I
P
E
T
E
Site 63
S899
E
T
E
L
E
I
D
S
F
V
D
A
C
E
W
Site 64
S913
W
K
V
S
D
I
R
S
G
H
F
R
L
L
R
Site 65
Y950
N
R
G
K
L
A
Q
Y
F
A
M
N
K
D
K
Site 66
S966
R
K
F
K
R
R
E
S
L
P
E
Q
R
S
Q
Site 67
S972
E
S
L
P
E
Q
R
S
Q
M
K
G
A
F
D
Site 68
Y984
A
F
D
R
D
A
E
Y
I
R
A
L
R
R
H
Site 69
Y994
A
L
R
R
H
L
V
Y
Y
P
S
A
R
P
V
Site 70
Y995
L
R
R
H
L
V
Y
Y
P
S
A
R
P
V
L
Site 71
S997
R
H
L
V
Y
Y
P
S
A
R
P
V
L
S
L
Site 72
S1003
P
S
A
R
P
V
L
S
L
S
S
G
S
W
T
Site 73
S1005
A
R
P
V
L
S
L
S
S
G
S
W
T
L
K
Site 74
T1010
S
L
S
S
G
S
W
T
L
K
L
H
F
F
Q
Site 75
Y1028
G
A
S
M
R
A
L
Y
I
V
R
D
P
R
A
Site 76
Y1038
R
D
P
R
A
W
I
Y
S
M
L
Y
N
S
K
Site 77
Y1042
A
W
I
Y
S
M
L
Y
N
S
K
P
S
L
Y
Site 78
S1044
I
Y
S
M
L
Y
N
S
K
P
S
L
Y
S
L
Site 79
S1047
M
L
Y
N
S
K
P
S
L
Y
S
L
K
N
V
Site 80
S1050
N
S
K
P
S
L
Y
S
L
K
N
V
P
E
H
Site 81
S1089
E
P
L
R
K
E
L
S
K
S
K
S
N
A
V
Site 82
S1091
L
R
K
E
L
S
K
S
K
S
N
A
V
S
L
Site 83
S1093
K
E
L
S
K
S
K
S
N
A
V
S
L
L
S
Site 84
S1097
K
S
K
S
N
A
V
S
L
L
S
H
L
W
L
Site 85
S1121
N
T
D
L
L
P
T
S
Y
Q
L
V
K
F
E
Site 86
Y1122
T
D
L
L
P
T
S
Y
Q
L
V
K
F
E
D
Site 87
Y1167
A
T
S
T
N
L
F
Y
L
P
Y
E
G
E
I
Site 88
Y1170
T
N
L
F
Y
L
P
Y
E
G
E
I
S
P
T
Site 89
S1175
L
P
Y
E
G
E
I
S
P
T
N
T
N
V
W
Site 90
T1177
Y
E
G
E
I
S
P
T
N
T
N
V
W
K
Q
Site 91
T1179
G
E
I
S
P
T
N
T
N
V
W
K
Q
N
L
Site 92
Y1207
T
L
M
D
R
L
G
Y
P
K
F
M
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation