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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIRREL3
Full Name:
Kin of IRRE-like protein 3
Alias:
Kin of irregular chiasm-like 3; Kin of IRRE-like 3; KIRR3; KIRRE; NEPH2; Nephrin-like 2
Type:
Plasma membrane protein
Mass (Da):
85255
Number AA:
778
UniProt ID:
Q8IZU9
International Prot ID:
IPI00218082
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030097
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y307
R
T
T
V
D
Y
T
Y
F
S
E
P
V
S
C
Site 2
Y332
L
S
R
T
V
D
V
Y
F
G
P
R
M
T
T
Site 3
S572
R
N
L
K
G
V
V
S
A
K
N
D
I
R
V
Site 4
S588
I
V
H
K
E
P
A
S
G
R
E
G
E
E
H
Site 5
S596
G
R
E
G
E
E
H
S
T
I
K
Q
L
M
M
Site 6
T597
R
E
G
E
E
H
S
T
I
K
Q
L
M
M
D
Site 7
S612
R
G
E
F
Q
Q
D
S
V
L
K
Q
L
E
V
Site 8
Y637
L
K
D
P
T
N
G
Y
Y
S
V
N
T
F
K
Site 9
Y638
K
D
P
T
N
G
Y
Y
S
V
N
T
F
K
E
Site 10
S648
N
T
F
K
E
H
H
S
T
P
T
I
S
L
S
Site 11
T649
T
F
K
E
H
H
S
T
P
T
I
S
L
S
S
Site 12
T651
K
E
H
H
S
T
P
T
I
S
L
S
S
C
Q
Site 13
S653
H
H
S
T
P
T
I
S
L
S
S
C
Q
P
D
Site 14
S655
S
T
P
T
I
S
L
S
S
C
Q
P
D
L
R
Site 15
S656
T
P
T
I
S
L
S
S
C
Q
P
D
L
R
P
Site 16
T671
A
G
K
Q
R
V
P
T
G
M
S
F
T
N
I
Site 17
S674
Q
R
V
P
T
G
M
S
F
T
N
I
Y
S
T
Site 18
Y679
G
M
S
F
T
N
I
Y
S
T
L
S
G
Q
G
Site 19
S680
M
S
F
T
N
I
Y
S
T
L
S
G
Q
G
R
Site 20
T681
S
F
T
N
I
Y
S
T
L
S
G
Q
G
R
L
Site 21
S683
T
N
I
Y
S
T
L
S
G
Q
G
R
L
Y
D
Site 22
Y689
L
S
G
Q
G
R
L
Y
D
Y
G
Q
R
F
V
Site 23
Y691
G
Q
G
R
L
Y
D
Y
G
Q
R
F
V
L
G
Site 24
S703
V
L
G
M
G
S
S
S
I
E
L
C
E
R
E
Site 25
S715
E
R
E
F
Q
R
G
S
L
S
D
S
S
S
F
Site 26
S717
E
F
Q
R
G
S
L
S
D
S
S
S
F
L
D
Site 27
S719
Q
R
G
S
L
S
D
S
S
S
F
L
D
T
Q
Site 28
S720
R
G
S
L
S
D
S
S
S
F
L
D
T
Q
C
Site 29
S721
G
S
L
S
D
S
S
S
F
L
D
T
Q
C
D
Site 30
T725
D
S
S
S
F
L
D
T
Q
C
D
S
S
V
S
Site 31
S729
F
L
D
T
Q
C
D
S
S
V
S
S
S
G
K
Site 32
S730
L
D
T
Q
C
D
S
S
V
S
S
S
G
K
Q
Site 33
S732
T
Q
C
D
S
S
V
S
S
S
G
K
Q
D
G
Site 34
S733
Q
C
D
S
S
V
S
S
S
G
K
Q
D
G
Y
Site 35
S734
C
D
S
S
V
S
S
S
G
K
Q
D
G
Y
V
Site 36
Y740
S
S
G
K
Q
D
G
Y
V
Q
F
D
K
A
S
Site 37
S747
Y
V
Q
F
D
K
A
S
K
A
S
A
S
S
S
Site 38
S750
F
D
K
A
S
K
A
S
A
S
S
S
H
H
S
Site 39
S752
K
A
S
K
A
S
A
S
S
S
H
H
S
Q
S
Site 40
S753
A
S
K
A
S
A
S
S
S
H
H
S
Q
S
S
Site 41
S754
S
K
A
S
A
S
S
S
H
H
S
Q
S
S
S
Site 42
S757
S
A
S
S
S
H
H
S
Q
S
S
S
Q
N
S
Site 43
S759
S
S
S
H
H
S
Q
S
S
S
Q
N
S
D
P
Site 44
S760
S
S
H
H
S
Q
S
S
S
Q
N
S
D
P
S
Site 45
S761
S
H
H
S
Q
S
S
S
Q
N
S
D
P
S
R
Site 46
S764
S
Q
S
S
S
Q
N
S
D
P
S
R
P
L
Q
Site 47
S767
S
S
Q
N
S
D
P
S
R
P
L
Q
R
R
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation