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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNS4
Full Name:
Tensin-4
Alias:
C terminal tensin like; CTEN; C-terminal tensin-like; C-terminal tensin-like protein; TENS4; Tensin 4; Tensin-4
Type:
Apoptosis
Mass (Da):
76764
Number AA:
715
UniProt ID:
Q8IZW8
International Prot ID:
IPI00170752
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005912
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008104
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
P
C
D
E
P
R
R
T
L
H
P
A
P
S
P
Site 2
S33
R
T
L
H
P
A
P
S
P
S
L
P
P
Q
C
Site 3
S35
L
H
P
A
P
S
P
S
L
P
P
Q
C
S
Y
Site 4
S41
P
S
L
P
P
Q
C
S
Y
Y
T
T
E
G
W
Site 5
Y42
S
L
P
P
Q
C
S
Y
Y
T
T
E
G
W
G
Site 6
Y43
L
P
P
Q
C
S
Y
Y
T
T
E
G
W
G
A
Site 7
T77
P
Q
V
E
A
K
A
T
C
F
L
P
S
P
G
Site 8
S82
K
A
T
C
F
L
P
S
P
G
E
K
A
L
G
Site 9
T90
P
G
E
K
A
L
G
T
P
E
D
L
D
S
Y
Site 10
S96
G
T
P
E
D
L
D
S
Y
I
D
F
S
L
E
Site 11
Y97
T
P
E
D
L
D
S
Y
I
D
F
S
L
E
S
Site 12
S101
L
D
S
Y
I
D
F
S
L
E
S
L
N
Q
M
Site 13
S126
L
P
P
G
T
G
G
S
Q
A
E
L
A
Q
S
Site 14
S133
S
Q
A
E
L
A
Q
S
T
M
S
M
R
K
K
Site 15
S136
E
L
A
Q
S
T
M
S
M
R
K
K
E
E
S
Site 16
S143
S
M
R
K
K
E
E
S
E
A
L
D
I
K
Y
Site 17
Y150
S
E
A
L
D
I
K
Y
I
E
V
T
S
A
R
Site 18
T154
D
I
K
Y
I
E
V
T
S
A
R
S
R
C
H
Site 19
S155
I
K
Y
I
E
V
T
S
A
R
S
R
C
H
D
Site 20
S168
H
D
G
P
Q
H
C
S
S
P
S
V
T
P
P
Site 21
S169
D
G
P
Q
H
C
S
S
P
S
V
T
P
P
F
Site 22
S171
P
Q
H
C
S
S
P
S
V
T
P
P
F
G
S
Site 23
T173
H
C
S
S
P
S
V
T
P
P
F
G
S
L
R
Site 24
S181
P
P
F
G
S
L
R
S
G
G
L
L
L
S
R
Site 25
S187
R
S
G
G
L
L
L
S
R
D
V
P
R
E
T
Site 26
T194
S
R
D
V
P
R
E
T
R
S
S
S
E
S
L
Site 27
S196
D
V
P
R
E
T
R
S
S
S
E
S
L
I
F
Site 28
S197
V
P
R
E
T
R
S
S
S
E
S
L
I
F
S
Site 29
S198
P
R
E
T
R
S
S
S
E
S
L
I
F
S
G
Site 30
S200
E
T
R
S
S
S
E
S
L
I
F
S
G
N
Q
Site 31
S204
S
S
E
S
L
I
F
S
G
N
Q
G
R
G
H
Site 32
S218
H
Q
R
P
L
P
P
S
E
G
L
S
P
R
P
Site 33
S222
L
P
P
S
E
G
L
S
P
R
P
P
N
S
P
Site 34
S228
L
S
P
R
P
P
N
S
P
S
I
S
I
P
C
Site 35
S230
P
R
P
P
N
S
P
S
I
S
I
P
C
M
G
Site 36
S232
P
P
N
S
P
S
I
S
I
P
C
M
G
S
K
Site 37
S238
I
S
I
P
C
M
G
S
K
A
S
S
P
H
G
Site 38
S241
P
C
M
G
S
K
A
S
S
P
H
G
L
G
S
Site 39
S242
C
M
G
S
K
A
S
S
P
H
G
L
G
S
P
Site 40
S248
S
S
P
H
G
L
G
S
P
L
V
A
S
P
R
Site 41
S253
L
G
S
P
L
V
A
S
P
R
L
E
K
R
L
Site 42
S269
G
L
A
P
Q
R
G
S
R
I
S
V
L
S
A
Site 43
S272
P
Q
R
G
S
R
I
S
V
L
S
A
S
P
V
Site 44
S283
A
S
P
V
S
D
V
S
Y
M
F
G
S
S
Q
Site 45
Y284
S
P
V
S
D
V
S
Y
M
F
G
S
S
Q
S
Site 46
S288
D
V
S
Y
M
F
G
S
S
Q
S
L
L
H
S
Site 47
S289
V
S
Y
M
F
G
S
S
Q
S
L
L
H
S
S
Site 48
S291
Y
M
F
G
S
S
Q
S
L
L
H
S
S
N
S
Site 49
S295
S
S
Q
S
L
L
H
S
S
N
S
S
H
Q
S
Site 50
S296
S
Q
S
L
L
H
S
S
N
S
S
H
Q
S
S
Site 51
S298
S
L
L
H
S
S
N
S
S
H
Q
S
S
S
R
Site 52
S299
L
L
H
S
S
N
S
S
H
Q
S
S
S
R
S
Site 53
S302
S
S
N
S
S
H
Q
S
S
S
R
S
L
E
S
Site 54
S303
S
N
S
S
H
Q
S
S
S
R
S
L
E
S
P
Site 55
S304
N
S
S
H
Q
S
S
S
R
S
L
E
S
P
A
Site 56
S306
S
H
Q
S
S
S
R
S
L
E
S
P
A
N
S
Site 57
S309
S
S
S
R
S
L
E
S
P
A
N
S
S
S
S
Site 58
S313
S
L
E
S
P
A
N
S
S
S
S
L
H
S
L
Site 59
S314
L
E
S
P
A
N
S
S
S
S
L
H
S
L
G
Site 60
S315
E
S
P
A
N
S
S
S
S
L
H
S
L
G
S
Site 61
S316
S
P
A
N
S
S
S
S
L
H
S
L
G
S
V
Site 62
S319
N
S
S
S
S
L
H
S
L
G
S
V
S
L
C
Site 63
S322
S
S
L
H
S
L
G
S
V
S
L
C
T
R
P
Site 64
S324
L
H
S
L
G
S
V
S
L
C
T
R
P
S
D
Site 65
S330
V
S
L
C
T
R
P
S
D
F
Q
A
P
R
N
Site 66
T339
F
Q
A
P
R
N
P
T
L
T
M
G
Q
P
R
Site 67
T341
A
P
R
N
P
T
L
T
M
G
Q
P
R
T
P
Site 68
T347
L
T
M
G
Q
P
R
T
P
H
S
P
P
L
A
Site 69
S350
G
Q
P
R
T
P
H
S
P
P
L
A
K
E
H
Site 70
S359
P
L
A
K
E
H
A
S
S
C
P
P
S
I
T
Site 71
S360
L
A
K
E
H
A
S
S
C
P
P
S
I
T
N
Site 72
S364
H
A
S
S
C
P
P
S
I
T
N
S
M
V
D
Site 73
T366
S
S
C
P
P
S
I
T
N
S
M
V
D
I
P
Site 74
S385
N
G
C
P
E
P
G
S
S
P
P
Q
R
T
P
Site 75
S386
G
C
P
E
P
G
S
S
P
P
Q
R
T
P
G
Site 76
T391
G
S
S
P
P
Q
R
T
P
G
H
Q
N
S
V
Site 77
S397
R
T
P
G
H
Q
N
S
V
Q
P
G
A
A
S
Site 78
S404
S
V
Q
P
G
A
A
S
P
S
N
P
C
P
A
Site 79
S406
Q
P
G
A
A
S
P
S
N
P
C
P
A
T
R
Site 80
T412
P
S
N
P
C
P
A
T
R
S
N
S
Q
T
L
Site 81
S414
N
P
C
P
A
T
R
S
N
S
Q
T
L
S
D
Site 82
S416
C
P
A
T
R
S
N
S
Q
T
L
S
D
A
P
Site 83
T418
A
T
R
S
N
S
Q
T
L
S
D
A
P
F
T
Site 84
S420
R
S
N
S
Q
T
L
S
D
A
P
F
T
T
C
Site 85
T425
T
L
S
D
A
P
F
T
T
C
P
E
G
P
A
Site 86
T426
L
S
D
A
P
F
T
T
C
P
E
G
P
A
R
Site 87
Y448
F
V
M
D
T
S
K
Y
W
F
K
P
N
I
T
Site 88
S476
G
A
F
V
I
R
D
S
S
S
Y
R
G
S
F
Site 89
S477
A
F
V
I
R
D
S
S
S
Y
R
G
S
F
G
Site 90
S478
F
V
I
R
D
S
S
S
Y
R
G
S
F
G
L
Site 91
Y479
V
I
R
D
S
S
S
Y
R
G
S
F
G
L
A
Site 92
S482
D
S
S
S
Y
R
G
S
F
G
L
A
L
K
V
Site 93
S495
K
V
Q
E
V
P
A
S
A
Q
S
R
P
G
E
Site 94
S504
Q
S
R
P
G
E
D
S
N
D
L
I
R
H
F
Site 95
Y530
K
G
A
D
E
E
P
Y
F
G
S
L
S
A
F
Site 96
S533
D
E
E
P
Y
F
G
S
L
S
A
F
V
C
Q
Site 97
S535
E
P
Y
F
G
S
L
S
A
F
V
C
Q
H
S
Site 98
S566
L
G
G
A
D
G
A
S
D
S
T
D
S
P
A
Site 99
S568
G
A
D
G
A
S
D
S
T
D
S
P
A
S
C
Site 100
T569
A
D
G
A
S
D
S
T
D
S
P
A
S
C
Q
Site 101
S571
G
A
S
D
S
T
D
S
P
A
S
C
Q
K
K
Site 102
S574
D
S
T
D
S
P
A
S
C
Q
K
K
S
A
G
Site 103
T584
K
K
S
A
G
C
H
T
L
Y
L
S
S
V
S
Site 104
T608
V
Q
K
A
I
S
T
T
F
E
R
D
I
L
P
Site 105
T616
F
E
R
D
I
L
P
T
P
T
V
V
H
F
K
Site 106
T630
K
V
T
E
Q
G
I
T
L
T
D
V
Q
R
K
Site 107
Y644
K
V
F
F
R
R
H
Y
P
L
T
T
L
R
F
Site 108
T647
F
R
R
H
Y
P
L
T
T
L
R
F
C
G
M
Site 109
T648
R
R
H
Y
P
L
T
T
L
R
F
C
G
M
D
Site 110
S677
I
F
G
F
V
A
K
S
Q
T
E
P
Q
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation