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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGI2
Full Name:
Leucine-rich repeat LGI family member 2
Alias:
LGI1-like protein 2;Leucine-rich glioma-inactivated protein 2
Type:
Mass (Da):
62298
Number AA:
545
UniProt ID:
Q8N0V4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T39
R
L
A
R
C
P
A
T
C
S
C
T
K
E
S
Site 2
S41
A
R
C
P
A
T
C
S
C
T
K
E
S
I
I
Site 3
S74
S
L
V
N
G
T
F
S
E
I
K
D
R
M
F
Site 4
S82
E
I
K
D
R
M
F
S
H
L
P
S
L
Q
L
Site 5
T136
F
R
G
L
R
D
L
T
H
L
S
L
A
N
N
Site 6
S139
L
R
D
L
T
H
L
S
L
A
N
N
H
I
K
Site 7
Y200
L
C
I
G
P
P
E
Y
Q
E
K
K
L
N
D
Site 8
T209
E
K
K
L
N
D
V
T
S
F
D
Y
E
C
T
Site 9
S210
K
K
L
N
D
V
T
S
F
D
Y
E
C
T
T
Site 10
Y213
N
D
V
T
S
F
D
Y
E
C
T
T
T
D
F
Site 11
T225
T
D
F
V
V
H
Q
T
L
P
Y
Q
S
V
S
Site 12
Y228
V
V
H
Q
T
L
P
Y
Q
S
V
S
V
D
T
Site 13
S230
H
Q
T
L
P
Y
Q
S
V
S
V
D
T
F
N
Site 14
S232
T
L
P
Y
Q
S
V
S
V
D
T
F
N
S
K
Site 15
T235
Y
Q
S
V
S
V
D
T
F
N
S
K
N
D
V
Site 16
Y243
F
N
S
K
N
D
V
Y
V
A
I
A
Q
P
S
Site 17
Y269
I
E
M
N
F
R
S
Y
D
N
I
T
G
Q
S
Site 18
T273
F
R
S
Y
D
N
I
T
G
Q
S
I
V
G
C
Site 19
Y303
L
F
G
G
S
H
I
Y
K
Y
D
E
S
W
T
Site 20
Y305
G
G
S
H
I
Y
K
Y
D
E
S
W
T
K
F
Site 21
S324
D
I
E
V
S
R
I
S
K
P
N
D
I
E
L
Site 22
S351
D
S
S
K
A
G
L
S
T
V
Y
K
W
N
S
Site 23
T352
S
S
K
A
G
L
S
T
V
Y
K
W
N
S
K
Site 24
Y354
K
A
G
L
S
T
V
Y
K
W
N
S
K
G
F
Site 25
Y362
K
W
N
S
K
G
F
Y
S
Y
Q
S
L
H
E
Site 26
Y364
N
S
K
G
F
Y
S
Y
Q
S
L
H
E
W
F
Site 27
S385
F
V
D
I
D
G
K
S
H
L
I
L
S
S
R
Site 28
S390
G
K
S
H
L
I
L
S
S
R
S
Q
V
P
I
Site 29
S425
E
D
V
L
A
V
K
S
F
R
M
Q
N
T
L
Site 30
T431
K
S
F
R
M
Q
N
T
L
Y
L
S
L
T
R
Site 31
T437
N
T
L
Y
L
S
L
T
R
F
I
G
D
S
R
Site 32
T466
L
P
S
R
G
A
M
T
L
Q
P
F
S
F
K
Site 33
Y477
F
S
F
K
D
N
H
Y
L
A
L
G
S
D
Y
Site 34
S482
N
H
Y
L
A
L
G
S
D
Y
T
F
S
Q
I
Site 35
Y484
Y
L
A
L
G
S
D
Y
T
F
S
Q
I
Y
Q
Site 36
T485
L
A
L
G
S
D
Y
T
F
S
Q
I
Y
Q
W
Site 37
Y490
D
Y
T
F
S
Q
I
Y
Q
W
D
K
E
K
Q
Site 38
Y506
F
K
K
F
K
E
I
Y
V
Q
A
P
R
S
F
Site 39
S512
I
Y
V
Q
A
P
R
S
F
T
A
V
S
T
D
Site 40
T514
V
Q
A
P
R
S
F
T
A
V
S
T
D
R
R
Site 41
S517
P
R
S
F
T
A
V
S
T
D
R
R
D
F
F
Site 42
T518
R
S
F
T
A
V
S
T
D
R
R
D
F
F
F
Site 43
S528
R
D
F
F
F
A
S
S
F
K
G
K
T
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation