KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TTC5
Full Name:
Tetratricopeptide repeat protein 5
Alias:
Strap; tetratricopeptide repeat 5; tetratricopeptide repeat domain 5; TPR repeat 5
Type:
Adaptor/scaffold
Mass (Da):
48956
Number AA:
440
UniProt ID:
Q8N0Z6
International Prot ID:
IPI00166123
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y24
Q
E
L
V
D
Q
L
Y
S
F
R
D
C
Y
F
Site 2
Y30
L
Y
S
F
R
D
C
Y
F
E
T
H
S
V
E
Site 3
S35
D
C
Y
F
E
T
H
S
V
E
D
A
G
R
K
Site 4
T53
V
Q
K
E
M
E
K
T
L
Q
Q
M
E
E
V
Site 5
S63
Q
M
E
E
V
V
G
S
V
Q
G
K
A
Q
V
Site 6
T81
T
G
K
A
L
N
V
T
P
D
Y
S
P
K
A
Site 7
Y84
A
L
N
V
T
P
D
Y
S
P
K
A
E
E
L
Site 8
S85
L
N
V
T
P
D
Y
S
P
K
A
E
E
L
L
Site 9
S93
P
K
A
E
E
L
L
S
K
A
V
K
L
E
P
Site 10
T131
T
C
F
S
G
A
L
T
H
C
R
N
K
V
S
Site 11
S138
T
H
C
R
N
K
V
S
L
Q
N
L
S
M
V
Site 12
S143
K
V
S
L
Q
N
L
S
M
V
L
R
Q
L
R
Site 13
T153
L
R
Q
L
R
T
D
T
E
D
E
H
S
H
H
Site 14
S164
H
S
H
H
V
M
D
S
V
R
Q
A
K
L
A
Site 15
Y183
V
H
D
G
R
S
W
Y
I
L
G
N
S
Y
L
Site 16
Y193
G
N
S
Y
L
S
L
Y
F
S
T
G
Q
N
P
Site 17
S195
S
Y
L
S
L
Y
F
S
T
G
Q
N
P
K
I
Site 18
S203
T
G
Q
N
P
K
I
S
Q
Q
A
L
S
A
Y
Site 19
S221
E
K
V
D
R
K
A
S
S
N
P
D
L
H
L
Site 20
S222
K
V
D
R
K
A
S
S
N
P
D
L
H
L
N
Site 21
T232
D
L
H
L
N
R
A
T
L
H
K
Y
E
E
S
Site 22
Y236
N
R
A
T
L
H
K
Y
E
E
S
Y
G
E
A
Site 23
S239
T
L
H
K
Y
E
E
S
Y
G
E
A
L
E
G
Site 24
T275
L
E
F
L
D
R
L
T
S
L
L
E
S
K
G
Site 25
S276
E
F
L
D
R
L
T
S
L
L
E
S
K
G
K
Site 26
S280
R
L
T
S
L
L
E
S
K
G
K
V
K
T
K
Site 27
T286
E
S
K
G
K
V
K
T
K
K
L
Q
S
M
L
Site 28
S291
V
K
T
K
K
L
Q
S
M
L
G
S
L
R
P
Site 29
S295
K
L
Q
S
M
L
G
S
L
R
P
A
H
L
G
Site 30
S305
P
A
H
L
G
P
C
S
D
G
H
Y
Q
S
A
Site 31
Y309
G
P
C
S
D
G
H
Y
Q
S
A
S
G
Q
K
Site 32
S311
C
S
D
G
H
Y
Q
S
A
S
G
Q
K
V
T
Site 33
S313
D
G
H
Y
Q
S
A
S
G
Q
K
V
T
L
E
Site 34
S325
T
L
E
L
K
P
L
S
T
L
Q
P
G
V
N
Site 35
T326
L
E
L
K
P
L
S
T
L
Q
P
G
V
N
S
Site 36
T354
T
E
E
K
V
P
F
T
F
G
L
V
D
S
D
Site 37
Y403
I
Q
H
K
G
K
D
Y
S
F
S
S
V
R
V
Site 38
S404
Q
H
K
G
K
D
Y
S
F
S
S
V
R
V
E
Site 39
S406
K
G
K
D
Y
S
F
S
S
V
R
V
E
T
P
Site 40
S407
G
K
D
Y
S
F
S
S
V
R
V
E
T
P
L
Site 41
S427
G
K
P
Q
G
S
S
S
Q
A
V
A
T
V
A
Site 42
T432
S
S
S
Q
A
V
A
T
V
A
S
R
P
Q
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation