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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MIER1
Full Name:
Mesoderm induction early response protein 1
Alias:
HMI-ER1; KIAA1610; Mesoderm induction early response 1; Mesoderm induction early response 1 N1-beta; Mesoderm induction early response 1 N1-beta- ii; Mesoderm induction early response 1 N1-beta-i; MI-ER1; Q9HCG2
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
60654
Number AA:
536
UniProt ID:
Q8N108
International Prot ID:
IPI00477825
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0043123
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
G
L
F
S
C
Q
I
T
Q
P
S
V
E
S
S
Site 2
S29
S
C
Q
I
T
Q
P
S
V
E
S
S
S
P
G
Site 3
S32
I
T
Q
P
S
V
E
S
S
S
P
G
G
S
A
Site 4
S33
T
Q
P
S
V
E
S
S
S
P
G
G
S
A
T
Site 5
S34
Q
P
S
V
E
S
S
S
P
G
G
S
A
T
S
Site 6
S38
E
S
S
S
P
G
G
S
A
T
S
D
D
H
E
Site 7
S41
S
P
G
G
S
A
T
S
D
D
H
E
F
D
P
Site 8
S49
D
D
H
E
F
D
P
S
A
D
M
L
V
H
D
Site 9
T62
H
D
F
D
D
E
R
T
L
E
E
E
E
M
M
Site 10
S76
M
E
G
E
T
N
F
S
S
E
I
E
D
L
A
Site 11
S77
E
G
E
T
N
F
S
S
E
I
E
D
L
A
R
Site 12
S101
L
S
L
Y
G
Y
G
S
T
V
R
L
P
E
E
Site 13
T102
S
L
Y
G
Y
G
S
T
V
R
L
P
E
E
D
Site 14
S131
D
A
D
N
D
D
N
S
G
C
S
G
E
N
K
Site 15
S145
K
E
E
N
I
K
D
S
S
G
Q
E
D
E
T
Site 16
S146
E
E
N
I
K
D
S
S
G
Q
E
D
E
T
Q
Site 17
T152
S
S
G
Q
E
D
E
T
Q
S
S
N
D
D
P
Site 18
S154
G
Q
E
D
E
T
Q
S
S
N
D
D
P
S
Q
Site 19
S155
Q
E
D
E
T
Q
S
S
N
D
D
P
S
Q
S
Site 20
S160
Q
S
S
N
D
D
P
S
Q
S
V
A
S
Q
D
Site 21
S162
S
N
D
D
P
S
Q
S
V
A
S
Q
D
A
Q
Site 22
S165
D
P
S
Q
S
V
A
S
Q
D
A
Q
E
I
I
Site 23
Y179
I
R
P
R
R
C
K
Y
F
D
T
N
S
E
V
Site 24
T182
R
R
C
K
Y
F
D
T
N
S
E
V
E
E
E
Site 25
S184
C
K
Y
F
D
T
N
S
E
V
E
E
E
S
E
Site 26
S190
N
S
E
V
E
E
E
S
E
E
D
E
D
Y
I
Site 27
Y196
E
S
E
E
D
E
D
Y
I
P
S
E
D
W
K
Site 28
Y242
Q
L
L
W
D
P
E
Y
L
P
E
D
K
V
I
Site 29
S256
I
I
F
L
K
D
A
S
R
R
T
G
D
E
K
Site 30
T259
L
K
D
A
S
R
R
T
G
D
E
K
G
V
E
Site 31
Y282
K
D
N
E
Q
A
L
Y
E
L
V
K
C
N
F
Site 32
T291
L
V
K
C
N
F
D
T
E
E
A
L
R
R
L
Site 33
S310
K
A
A
R
E
E
L
S
V
W
T
E
E
E
C
Site 34
S343
A
N
K
V
R
T
R
S
V
G
E
C
V
A
F
Site 35
Y351
V
G
E
C
V
A
F
Y
Y
M
W
K
K
S
E
Site 36
Y352
G
E
C
V
A
F
Y
Y
M
W
K
K
S
E
R
Site 37
Y360
M
W
K
K
S
E
R
Y
D
F
F
A
Q
Q
T
Site 38
T367
Y
D
F
F
A
Q
Q
T
R
F
G
K
K
K
Y
Site 39
Y374
T
R
F
G
K
K
K
Y
N
L
H
P
G
V
T
Site 40
T381
Y
N
L
H
P
G
V
T
D
Y
M
D
R
L
L
Site 41
Y383
L
H
P
G
V
T
D
Y
M
D
R
L
L
D
E
Site 42
S391
M
D
R
L
L
D
E
S
E
S
A
A
S
S
R
Site 43
S393
R
L
L
D
E
S
E
S
A
A
S
S
R
A
P
Site 44
S396
D
E
S
E
S
A
A
S
S
R
A
P
S
P
P
Site 45
S397
E
S
E
S
A
A
S
S
R
A
P
S
P
P
P
Site 46
S401
A
A
S
S
R
A
P
S
P
P
P
T
A
S
N
Site 47
T405
R
A
P
S
P
P
P
T
A
S
N
S
S
N
S
Site 48
S407
P
S
P
P
P
T
A
S
N
S
S
N
S
Q
S
Site 49
S409
P
P
P
T
A
S
N
S
S
N
S
Q
S
E
K
Site 50
S410
P
P
T
A
S
N
S
S
N
S
Q
S
E
K
E
Site 51
S412
T
A
S
N
S
S
N
S
Q
S
E
K
E
D
G
Site 52
S414
S
N
S
S
N
S
Q
S
E
K
E
D
G
T
V
Site 53
T420
Q
S
E
K
E
D
G
T
V
S
T
A
N
Q
N
Site 54
S431
A
N
Q
N
G
V
S
S
N
G
P
G
E
I
L
Site 55
T467
P
L
H
A
D
M
D
T
N
G
Y
E
T
D
N
Site 56
Y470
A
D
M
D
T
N
G
Y
E
T
D
N
L
T
T
Site 57
T476
G
Y
E
T
D
N
L
T
T
D
P
K
L
A
H
Site 58
S496
E
N
D
F
D
E
K
S
E
R
P
A
K
R
R
Site 59
S507
A
K
R
R
R
V
N
S
N
G
K
E
S
P
G
Site 60
S512
V
N
S
N
G
K
E
S
P
G
S
S
E
F
F
Site 61
S515
N
G
K
E
S
P
G
S
S
E
F
F
Q
E
A
Site 62
S516
G
K
E
S
P
G
S
S
E
F
F
Q
E
A
V
Site 63
S524
E
F
F
Q
E
A
V
S
H
G
K
F
E
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation