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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MMP21
Full Name:
Matrix metalloproteinase-21
Alias:
Type:
Mass (Da):
65015
Number AA:
569
UniProt ID:
Q8N119
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
W
L
A
A
P
W
P
T
Q
P
E
S
L
F
H
Site 2
S26
P
W
P
T
Q
P
E
S
L
F
H
S
R
D
R
Site 3
S30
Q
P
E
S
L
F
H
S
R
D
R
S
D
L
E
Site 4
S34
L
F
H
S
R
D
R
S
D
L
E
P
S
P
L
Site 5
S39
D
R
S
D
L
E
P
S
P
L
R
Q
A
K
P
Site 6
S58
H
A
A
Q
R
F
L
S
R
Y
G
W
S
G
V
Site 7
Y60
A
Q
R
F
L
S
R
Y
G
W
S
G
V
W
A
Site 8
S72
V
W
A
A
W
G
P
S
P
E
G
P
P
E
T
Site 9
T79
S
P
E
G
P
P
E
T
P
K
G
A
A
L
A
Site 10
S101
R
A
N
A
L
P
A
S
G
E
L
D
A
A
T
Site 11
T108
S
G
E
L
D
A
A
T
L
A
A
M
N
R
P
Site 12
S128
D
M
R
P
P
P
P
S
A
P
P
S
P
P
G
Site 13
S132
P
P
P
S
A
P
P
S
P
P
G
P
P
P
R
Site 14
S142
G
P
P
P
R
A
R
S
R
R
S
P
R
A
P
Site 15
S145
P
R
A
R
S
R
R
S
P
R
A
P
L
S
L
Site 16
S151
R
S
P
R
A
P
L
S
L
S
R
R
G
W
Q
Site 17
S153
P
R
A
P
L
S
L
S
R
R
G
W
Q
P
R
Site 18
Y162
R
G
W
Q
P
R
G
Y
P
D
G
G
A
A
Q
Site 19
S172
G
G
A
A
Q
A
F
S
K
R
T
L
S
W
R
Site 20
S177
A
F
S
K
R
T
L
S
W
R
L
L
G
E
A
Site 21
S186
R
L
L
G
E
A
L
S
S
Q
L
S
A
A
D
Site 22
S190
E
A
L
S
S
Q
L
S
A
A
D
Q
R
R
I
Site 23
S206
A
L
A
F
R
M
W
S
E
V
T
P
L
D
F
Site 24
T209
F
R
M
W
S
E
V
T
P
L
D
F
R
E
D
Site 25
S245
C
P
R
A
F
D
G
S
G
Q
E
F
A
H
A
Site 26
T267
F
D
D
D
E
H
F
T
P
P
T
S
D
T
G
Site 27
S271
E
H
F
T
P
P
T
S
D
T
G
I
S
L
L
Site 28
Y305
G
S
I
M
Q
P
N
Y
I
P
Q
E
P
A
F
Site 29
S317
P
A
F
E
L
D
W
S
D
R
K
A
I
Q
K
Site 30
Y326
R
K
A
I
Q
K
L
Y
G
S
C
E
G
S
F
Site 31
S328
A
I
Q
K
L
Y
G
S
C
E
G
S
F
D
T
Site 32
Y347
I
R
K
E
R
N
Q
Y
G
E
V
M
V
R
F
Site 33
Y376
N
R
N
N
R
T
R
Y
G
D
P
I
Q
I
L
Site 34
Y409
T
W
K
R
D
E
R
Y
F
F
Q
G
N
Q
Y
Site 35
Y416
Y
F
F
Q
G
N
Q
Y
W
R
Y
D
S
D
K
Site 36
Y419
Q
G
N
Q
Y
W
R
Y
D
S
D
K
D
Q
A
Site 37
S435
T
E
D
E
Q
G
K
S
Y
P
K
L
I
S
E
Site 38
Y436
E
D
E
Q
G
K
S
Y
P
K
L
I
S
E
G
Site 39
S441
K
S
Y
P
K
L
I
S
E
G
F
P
G
I
P
Site 40
S449
E
G
F
P
G
I
P
S
P
L
D
T
A
F
Y
Site 41
T453
G
I
P
S
P
L
D
T
A
F
Y
D
R
R
Q
Site 42
Y456
S
P
L
D
T
A
F
Y
D
R
R
Q
K
L
I
Site 43
Y464
D
R
R
Q
K
L
I
Y
F
F
K
E
S
L
V
Site 44
S469
L
I
Y
F
F
K
E
S
L
V
F
A
F
D
V
Site 45
Y485
R
N
R
V
L
N
S
Y
P
K
R
I
T
E
V
Site 46
T490
N
S
Y
P
K
R
I
T
E
V
F
P
A
V
I
Site 47
Y510
F
R
N
I
D
S
A
Y
Y
S
Y
A
Y
N
S
Site 48
Y511
R
N
I
D
S
A
Y
Y
S
Y
A
Y
N
S
I
Site 49
Y515
S
A
Y
Y
S
Y
A
Y
N
S
I
F
F
F
K
Site 50
Y526
F
F
F
K
G
N
A
Y
W
K
V
V
N
D
K
Site 51
S539
D
K
D
K
Q
Q
N
S
W
L
P
A
N
G
L
Site 52
S553
L
F
P
K
K
F
I
S
E
K
W
F
D
V
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation