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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCA6
Full Name:
ATP-binding cassette sub-family A member 6
Alias:
Type:
Membrane, Integral membrane protein
Mass (Da):
184286
Number AA:
1617
UniProt ID:
Q8N139
International Prot ID:
IPI00295640
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
K
W
R
M
K
R
E
S
L
L
E
W
G
L
S
Site 2
S72
G
R
V
D
K
F
N
S
S
S
L
M
V
V
Y
Site 3
T132
M
G
I
I
F
N
E
T
F
S
Y
K
L
I
F
Site 4
Y135
I
F
N
E
T
F
S
Y
K
L
I
F
F
Q
G
Site 5
Y143
K
L
I
F
F
Q
G
Y
N
S
P
L
W
K
E
Site 6
S153
P
L
W
K
E
D
F
S
A
H
C
W
D
G
Y
Site 7
Y160
S
A
H
C
W
D
G
Y
G
E
F
S
C
T
L
Site 8
Y170
F
S
C
T
L
T
K
Y
W
N
R
G
F
V
A
Site 9
T243
Y
F
I
S
L
N
V
T
K
E
R
K
K
S
K
Site 10
S249
V
T
K
E
R
K
K
S
K
N
L
M
K
M
M
Site 11
S393
F
P
D
P
S
G
D
S
Y
T
M
I
A
T
F
Site 12
Y394
P
D
P
S
G
D
S
Y
T
M
I
A
T
F
S
Site 13
T395
D
P
S
G
D
S
Y
T
M
I
A
T
F
S
M
Site 14
Y429
P
Y
G
D
E
R
H
Y
S
P
L
F
F
L
N
Site 15
S430
Y
G
D
E
R
H
Y
S
P
L
F
F
L
N
S
Site 16
S437
S
P
L
F
F
L
N
S
S
S
C
F
Q
H
Q
Site 17
S461
E
I
D
A
E
H
P
S
D
D
Y
F
E
P
V
Site 18
Y464
A
E
H
P
S
D
D
Y
F
E
P
V
A
P
E
Site 19
Y487
I
R
N
V
K
K
E
Y
K
G
K
S
G
K
V
Site 20
S491
K
K
E
Y
K
G
K
S
G
K
V
E
A
L
K
Site 21
S521
G
H
S
G
A
G
K
S
S
L
L
N
I
L
N
Site 22
S522
H
S
G
A
G
K
S
S
L
L
N
I
L
N
G
Site 23
T539
V
P
T
E
G
S
V
T
I
Y
N
K
N
L
S
Site 24
Y541
T
E
G
S
V
T
I
Y
N
K
N
L
S
E
M
Site 25
T558
L
E
E
I
R
K
I
T
G
V
C
P
Q
F
N
Site 26
S616
D
N
L
A
K
H
L
S
E
G
Q
K
R
K
L
Site 27
T624
E
G
Q
K
R
K
L
T
F
G
I
T
I
L
G
Site 28
T642
I
L
L
L
D
E
P
T
T
G
L
D
P
F
S
Site 29
S649
T
T
G
L
D
P
F
S
R
D
Q
V
W
S
L
Site 30
S655
F
S
R
D
Q
V
W
S
L
L
R
E
R
R
A
Site 31
S687
A
D
R
K
V
I
M
S
N
G
R
L
K
C
A
Site 32
S696
G
R
L
K
C
A
G
S
S
M
F
L
K
R
R
Site 33
Y708
K
R
R
W
G
L
G
Y
H
L
S
L
H
R
N
Site 34
Y746
E
N
K
E
K
L
V
Y
T
L
P
L
E
R
T
Site 35
T755
L
P
L
E
R
T
N
T
F
P
D
L
F
S
D
Site 36
S761
N
T
F
P
D
L
F
S
D
L
D
K
C
S
D
Site 37
S767
F
S
D
L
D
K
C
S
D
Q
G
V
T
G
Y
Site 38
Y774
S
D
Q
G
V
T
G
Y
D
I
S
M
S
T
L
Site 39
T793
M
K
L
E
G
Q
S
T
I
E
Q
D
F
E
Q
Site 40
S807
Q
V
E
M
I
R
D
S
E
S
L
N
E
M
E
Site 41
S809
E
M
I
R
D
S
E
S
L
N
E
M
E
L
A
Site 42
S818
N
E
M
E
L
A
H
S
S
F
S
E
M
Q
T
Site 43
S819
E
M
E
L
A
H
S
S
F
S
E
M
Q
T
A
Site 44
T825
S
S
F
S
E
M
Q
T
A
V
S
D
M
G
L
Site 45
T852
F
L
K
L
K
R
Q
T
K
V
L
L
T
L
L
Site 46
Y892
W
E
F
K
N
E
L
Y
F
L
S
P
G
Q
L
Site 47
S895
K
N
E
L
Y
F
L
S
P
G
Q
L
P
Q
E
Site 48
S906
L
P
Q
E
P
R
T
S
L
L
I
I
N
N
T
Site 49
T942
D
F
E
N
R
N
G
T
D
G
L
S
Y
N
G
Site 50
S946
R
N
G
T
D
G
L
S
Y
N
G
A
I
I
V
Site 51
Y960
V
S
G
K
Q
K
D
Y
R
F
S
V
V
C
N
Site 52
S963
K
Q
K
D
Y
R
F
S
V
V
C
N
T
K
R
Site 53
S999
T
Q
H
I
R
I
E
S
S
P
F
P
L
S
H
Site 54
S1000
Q
H
I
R
I
E
S
S
P
F
P
L
S
H
I
Site 55
S1005
E
S
S
P
F
P
L
S
H
I
G
L
W
T
G
Site 56
S1035
S
P
Y
I
T
M
G
S
I
S
D
Y
K
K
N
Site 57
Y1039
T
M
G
S
I
S
D
Y
K
K
N
A
K
S
Q
Site 58
S1045
D
Y
K
K
N
A
K
S
Q
L
W
I
S
G
L
Site 59
S1050
A
K
S
Q
L
W
I
S
G
L
Y
T
S
A
Y
Site 60
S1127
F
R
K
R
R
K
N
S
G
L
W
S
F
Y
F
Site 61
T1172
Y
T
L
L
G
F
K
T
F
L
E
V
R
D
Q
Site 62
Y1182
E
V
R
D
Q
E
H
Y
R
E
F
P
E
A
N
Site 63
S1235
K
D
P
V
F
R
I
S
P
Q
S
R
D
A
K
Site 64
S1238
V
F
R
I
S
P
Q
S
R
D
A
K
P
N
P
Site 65
T1257
D
E
D
E
D
I
Q
T
E
R
I
R
T
A
T
Site 66
T1262
I
Q
T
E
R
I
R
T
A
T
A
L
T
T
S
Site 67
Y1286
A
S
C
L
H
K
E
Y
A
G
Q
K
K
S
C
Site 68
S1292
E
Y
A
G
Q
K
K
S
C
F
S
K
R
K
K
Site 69
S1295
G
Q
K
K
S
C
F
S
K
R
K
K
K
I
A
Site 70
S1307
K
I
A
A
R
N
I
S
F
C
V
Q
E
G
E
Site 71
S1327
G
P
N
G
A
G
K
S
S
S
I
R
M
I
S
Site 72
S1328
P
N
G
A
G
K
S
S
S
I
R
M
I
S
G
Site 73
S1329
N
G
A
G
K
S
S
S
I
R
M
I
S
G
I
Site 74
S1334
S
S
S
I
R
M
I
S
G
I
T
K
P
T
A
Site 75
Y1378
L
R
E
H
L
E
V
Y
A
A
V
K
G
L
R
Site 76
T1446
P
S
T
G
I
D
P
T
G
Q
Q
Q
M
W
Q
Site 77
T1469
T
E
R
G
V
L
L
T
T
H
N
L
A
E
A
Site 78
S1496
G
R
L
R
C
I
G
S
I
Q
H
L
K
N
K
Site 79
Y1508
K
N
K
L
G
K
D
Y
I
L
E
L
K
V
K
Site 80
S1518
E
L
K
V
K
E
T
S
Q
V
T
L
V
H
T
Site 81
S1541
A
A
G
Q
E
R
Y
S
S
L
L
T
Y
K
L
Site 82
S1542
A
G
Q
E
R
Y
S
S
L
L
T
Y
K
L
P
Site 83
T1545
E
R
Y
S
S
L
L
T
Y
K
L
P
V
A
D
Site 84
Y1546
R
Y
S
S
L
L
T
Y
K
L
P
V
A
D
V
Site 85
Y1554
K
L
P
V
A
D
V
Y
P
L
S
Q
T
F
H
Site 86
S1557
V
A
D
V
Y
P
L
S
Q
T
F
H
K
L
E
Site 87
T1559
D
V
Y
P
L
S
Q
T
F
H
K
L
E
A
V
Site 88
S1576
N
F
N
L
E
E
Y
S
L
S
Q
C
T
L
E
Site 89
S1578
N
L
E
E
Y
S
L
S
Q
C
T
L
E
K
V
Site 90
S1590
E
K
V
F
L
E
L
S
K
E
Q
E
V
G
N
Site 91
T1604
N
F
D
E
E
I
D
T
T
M
R
W
K
L
L
Site 92
T1605
F
D
E
E
I
D
T
T
M
R
W
K
L
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation